Journal article Open Access

ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal Muscle

Hirose, T.; Smith, R. J.; Jetten, A. M.

In this study, we describe the identification and cloning of a novel member of the nuclear receptor superfamily. This orphan receptor, referred to as RORγ, belongs to the ROR/RZR subfamily. The open reading frame of RORγ encodes a protein of 560 amino acid residues with a predicted molecular mass of 63 kD. The amino acid sequence of RORγ exhibits a 50 and 51% identity with those of RORα/RZRα and RZRβ, respectively, whereas the DNA-binding domains were 89% identical. RORγ was localized on human chromosome 1. Northern blot analysis using RNA from multiple tissues indicated that RORγ is expressed in several tissues but is most highly expressed in skeletal muscle.

Files (450.9 kB)
Name Size
article.pdf
md5:456904e37119af260dbed00496c81cd6
450.9 kB Download
122
214
views
downloads
Views 122
Downloads 214
Data volume 96.5 MB
Unique views 119
Unique downloads 204

Share

Cite as