Published June 17, 2016
| Version 2
Dataset
Open
Human Lysine Demethylase JMJD2D (KDM4D); A Target Enabling Package
Description
There are 4 members of the Lysine Demethylase JMJD2 (KDM4) family. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD2A, JMJD2B, JMJD2C and JMJD2D as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
Notes
The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766].
This deposition represents version 2 of the TEP datasheet. Changes include, but are not limited to: Addition of hyperlinks throughout the body of the datasheet; Addition of Useful Links to relevant databases; Addition of a Reference box where applicable; Other modifications necessary for page spacing and visualisation. Please note, all data and results within the document remain the same as provided in version 1.
To see version 1: https://doi.org/10.5287/bodleian:OvVavzwoq
Files
JMJD2D_TEP_datasheet_v2.pdf
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Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)