Published June 17, 2016
| Version 5
Dataset
Open
Human Lysine Demethylase JMJD2D (KDM4D); A Target Enabling Package
Description
There are 4 members of the Lysine Demethylase JMJD2 (KDM4) family. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD2A, JMJD2B, JMJD2C and JMJD2D as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
Notes
This document represents version 5 of the TEP datasheet and includes all updates on the project as of October 2018. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
Files
JMJD2D_TEP_datasheet_v5.pdf
Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)