Dataset Open Access

Structural Analysis of USP5 Zf-UBD

Mann, Mandeep; Harding, Rachel; Schapira, Matthieu; Arrowsmith, Cheryl; Edwards, Aled

Analysis of the solved structure of USP5 zinc finger ubiquitin binding domain (Zf-UBD) in crystallization conditions of 1.8 M ammonium sulfate, 0.2 M sodium acetate, 0.1 M sodium cacodylate pH 5.5, 1.7 mM l-glutathione reduced, l-glutathione-oxidized to determine if the ubiquitin binding pocket is accessible through solvent channels for inhibitor screening. 

Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
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