Published June 17, 2016
| Version 1
Dataset
Open
Pleckstrin Homology domain Interacting Protein (PHIP); A Target Enabling Package
Description
SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
Notes
The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766].
Files
PHIP_TEP_datasheet_v1.pdf
Files
(1.2 MB)
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Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)