Antisickling, antihemolytic and radical scavenging activities of essential oil from Entandrophragma Cylindricum (Sprague) Sprague (Meliaceae)

Essential oil of  Entandrophragma Cylindricum from Masoko forest (Tshopo province, DR Congo) was extracted and tested for antisickling, antihemolytic  and radical scavenging activities. The obtained results indicate that the extraction gives a yield of  0.85%  of essential oil with a  density of 0.8581 and refractive index of 1.5025 at 20°C. The essential oil showed a good antisickling activity comparatively to methanolic and aqueous extracts of the same plant  with a  maximal rate of red blood cells normalization of 89% and minimal concentration of normalization 80 µL/mL. When methanolic and aqueous   have maximal rate of  normalization  of only 24 and 33 % respectively. The essential oil showed also the highest antihemolytic effect and a good radical scavenging effect.