CLINICAL AND LABORATORY EVALUATION OF ADRENOMEDULLIN AS A BIOMARKER IN MODERATE CHRONIC PERIODONTITIS.

Objective: The aim of this study was to determine the effect of non surgical periodontal treatment on GCF level of adrenomedullin and interleukin 1 βeta in patients with moderate chronic periodontitis. Subjects and Methods: A total of thirty subjects was included in this study; 15 subjects with moderate chronic periodontitis (group I) and 15 systemically healthy subjects with clinically healthy gingiva as a control group (group II). Periodontal parameters, including Plaque index (PI), Gingival index (GI), bleeding on probing (BOP), Periodontal probing depth (PPD) and Clinical attachment level (CAL), were recorded in all the sites from both groups. The first GCF samples were collected from both groups (study and control) at the start of study. Nonsurgical periodontal therapy was done to group I. The same periodontal parameters were recorded again and the second GCF samples were collected again after 4 weeks after phase I therapy from group I. Levels of IL-1β and adrenomedullin in GCF were quantified using ELISA. Results: At baseline the level of IL-1β and ADM in gingival crevicular fluid was significantly higher in chronic periodontitis patients than in healthy subjects. The results of the present study, showed a significant reduction in all clinical parameters (GI, PI, PPD, BOP and CAL) after phase I periodontal therapy in chronic periodontitis group. Level of IL-1β and ADM in gingival crevicular fluid were significantly decreased after a phase I periodontal therapy in moderate chronic periodontitis group when compared to their levels at baseline. Conclusions: Scaling and root planing (SRP) is the mainstay of treatment of periodontal diseases as SRP was effective in improving clinical parameters in patients with chronic periodontitis. ADM could be used as a potential diagnostic marker for periodontal disease in gingival crevicular fluid.