ANTIBIOTIC ACTION OF PYOCYANIN ON SOME PATHOGENIC BACTERIA ISOLATED FROM WOUND INFECTION.

Bacteria Pseudomonas aeruginosa has ability to survive in various niches due to its capacity of production and releasing some compounds, which act as inhibitory effect of bacteria, fungi and protozoa, etc. It has been reported that the synthesis of pyocyanin by many strains could be the reason for P. aeruginosa to survive and compete other microorganisms in the nature. Antibacterial activity of pigment pyocyanin that extracted from P. aerogenosa has been studied using gram negative bacteria Klebsiella oxytoca, Proteus mirabilis, Escherichia coli and gram positive bacteria staphylococcus aureus. At the same time, antibiotic susceptibility test was performed for all bacteria using 12 different antibiotics in the absence and presence of pyocyanin pigment. As a result, all bacteria were sensitive in the presence of pyocyanin, while all bacteria were resistant to used antibiotics without pyocyanin except Proteus mirabilis, which was sensitive to both antibiotics Tetracycline and Amikacin. However, the results of bacterial sensitivity test to antibiotics in the presence of pyocyanin were variable.