Genomic hut of Sickle Cell Anaemia disease in Indian children
Authors/Creators
- 1. MSc Clinical Research, Dept. of Clinical Research, Amity Medical School, Amity University, Gurgaon.
Description
A collection of genetic red blood cell disorders refers a disease called sickle cell disease (SCD). People suffering from sickle cell anaemia have abnormal haemoglobin, which is called haemoglobin S or sickle haemoglobin in their red blood cells. In the body
haemoglobin is a protein in red blood cells which carries oxygen. When the disease is delivered from parents to their children it is called genetic disease. Sickle cell anaemia is not transmissible. SCD people receives two abnormal haemoglobin genes, one from
each parent. At least, one of the two abnormal genes cause a person’s body to make haemoglobin S in every form of sickle cell disease. SCA is when a person has two haemoglobin S genes, haemoglobin SS. Haemoglobin Sβ thalassemia (thal-uh-see-me-uh) and haemoglobin SC disease are the two common forms of SCD. SCA or SCD, is a chromosomal disease of RBCs. Generally, the disc shape of RBCs gives elasticity to travel through smallest blood vessels. But the RBCs have an unusual semi-circular shape
approaching a sickle which makes them tacky or sticky and inelastic and horizontal to attainment in small vessels, which blocks different parts of the body when suffering from SCD which origin discomfort and muscle injury. RBCs encompass a molecule called
haemoglobin, which transfers oxygen in the whole body. A fit person haemoglobin is flat, curved, and elastic. That allows RBCs to slide along through bloodstream but SCD contains the hemoglobin’s unusual form and rod like arrangement that bundle with each
other which cause RBCs to convert arched and inelastic. The blood flow blocks due to odd shaped cells. This is harmful and may cause thrilling discomfort, anaemia and many indications. SCD is blood syndrome classically genetically transfers from parents. In
RBCs carrying haemoglobin S, SCA causes in abnormality in theses oxygen-carrying protein and indicates to an unbending, sickle-like shape in some definite disorders. At the age of 5 to 6 months most of the complications arise of SCD.
Files
Ritu.pdf
Files
(811.8 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:e8b1bc656e7411dc8c2504bd9f12161c
|
811.8 kB | Preview Download |
Additional details
References
- Camcioglu B, Bosnak-Guclu M, Karadalli MN, Aki SZ, Turkoz-Sucak G. The Role of Inspiratory Muscle Training in Sickle Cell Anemia Related Pulmonary Damage due to Recurrent Acute Chest Syndrome Attacks. Case Rep Hematol. 2015;2015:780159.
- Arkuszewski M, Krejza J, Chen R, Melhem ER. Sickle cell anemia: reference values of cerebral blood flow determined by continuous arterial spin labeling MRI. Neuroradiol J. 2013;26 (2):191-200.
- Benjamin LJ, Swinson GI, Nagel RL. Sickle cell anemia day hospital: an approach for the management of uncomplicated painful crises. Blood. 2000;95(4 ):1130-6.