Published April 5, 2024 | Version v1
Dataset Open

Bioactivity of small-molecule compounds against Haemonchus contortus

Authors/Creators

  • 1. University of Melbourne
  • 2. ROR icon The University of Melbourne
  • 3. ROR icon Max Rubner Institut

Contributors

Project member:

  • 1. ROR icon The University of Melbourne

Description

This dataset of small-molecule compounds and their effects on H. contortus was assembled based on the results obtained from screening two compound libraries (Medicines for Malaria Venture Pathogen Box, Compounds Australia Open Scaffolds set) to assess the effect of compounds on the motility of exsheathed third-stage larvae (xL3) of H. contortus (Preston et al., 2016, 2017). Additionally, select literature data were included to augment the in-house generated data.

Files

compounds_hcon_20201209.csv

Files (1.2 MB)

Name Size Download all
md5:7836bc6969e45d4225fcb4aad2c79348
1.2 MB Preview Download
md5:fc5c5e9297639d257dd54203dc4e6fd9
2.4 kB Preview Download

Additional details

Related works

Is supplement to
10.5281/zenodo.14511148 (DOI)

Funding

Australian Research Council
New Anti-Parasitic Drugs for a Global Veterinary Market LP190101209
Australian Research Council
Illuminating Genomic Dark Matter to Develop New Interventions for Parasites LP180101085
Australian Research Council
Artificial intelligence to explore and combat eukaryotic pathogens LP220200614

References

  • Preston, S., Jiao, Y., Jabbar, A., McGee, S.L., Laleu, B., Willis, P., Wells, T.N.C., Gasser, R.B., 2016. Screening of the 'Pathogen Box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm. Int. J. Parasitol. Drugs Drug Resist., 6, 329–334. https://doi.org/10.1016/ j.ijpddr.2016.07.004
  • Preston, S., Jiao, Y., Baell, J.B., Keiser, J., Crawford, S., Koehler, A.V., Wang, T., Simpson, M.M., Kaplan, R.M., Cowley, K.J., Simpson, K.J., Hofmann, A., Jabbar, A., Gasser, R.B., 2017. Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes. Int. J. Parasitol. Drugs Drug Resist. 7, 286–294. https://doi.org/10.1016/j.ijpddr. 2017.05.004