Published July 24, 2012 | Version v1
Journal article Open

A Versatile Synthesis of Meyers' Bicyclic Lactams from Furans: Singlet-Oxygen-Initiated Reaction Cascade

Description

All in one: Meyers' bicyclic lactams were synthesized in high yield from furans using a new and powerful method that involves a one-pot singlet-oxygen-initiated reaction cascade. This method has broad synthetic potential because of the ease of access to a wide range of furans with a variety of substituents.

Notes

This is the pre-peer reviewed version of the following article: Angew. Chem. Int. Ed. 2012, 51, 8868-8871, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/anie.201204419/abstract

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Funding

European Commission
SINOXYGEN - Advancing the Green Chemistry of Singlet Oxygen and Applying it to Synthetic Challenges 277588