Published April 1, 2024 | Version v1
Dataset Open

Analysis of variant-dependent m6A modifications within the Human genome

Authors/Creators

  • 1. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic
  • 2. Center for Computational Life Sciences, Lerner Research Institute, Cleveland Clinic

Description

Interactive and machine-readable results produced by the m6Ad-SNVs tool to asses if m6A-distal SNVs affect DRACH site accessibility, specifically by evaluating the alteration of base-pairing of nucleotides within segments of the DRACH motif.

These results contain the predicted m6Ad-SNV candidates with the length of the reference and m6Ad-SNV-containing alternate sequences limited to 250 base pairs. This constraint has been applied to maintain the reliability of the results predicted by RNAFold (ViennaRNA package). The sequence composition contains up to 100 base pairs from 3'UTRs, with the remaining base pairs limited to the last two exons.

Files

Files (1.1 MB)

Name Size
md5:b0b5b09274f0f45fa92c803c6490e930
1.1 MB Download

Additional details

Identifiers

DOI
10.5281/zenodo.10905411

Related works

Is supplement to
Software: https://github.com/cumbof/m6Ad-SNVs/tree/v0.1.0 (URL)
Requires
Software: 10.5281/zenodo.10905411 (DOI)

Dates

Created
2023-07-31

Software

Repository URL
https://github.com/cumbof/m6Ad-SNVs
Programming language
Python
Development Status
Active