Published January 25, 2024
| Version v1
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Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase active EGFR oligomers
Authors/Creators
- Iyer, R. Sumanth (Project member)1, 2
- Needham, Sarah R. (Project member)
- Galdadas, Ioannis (Project member)3, 4
- Davis, Benjmin N. (Project member)1
- Roberts, Selene K. (Data collector)1
- Man, Rico C.H. (Project member)5
-
Zanetti Domingues, Laura Carolina
(Data collector)1
- Clarke, David T. (Project member)1
- Fruhwirth, Gilbert O. (Project member)6
- Parker, Peter J. (Project member)7, 8
- et al. Show all 13 authors
Authors/Creators
- Iyer, R. Sumanth (Project member)1, 2
- Needham, Sarah R. (Project member)
- Galdadas, Ioannis (Project member)3, 4
- Davis, Benjmin N. (Project member)1
- Roberts, Selene K. (Data collector)1
- Man, Rico C.H. (Project member)5
-
Zanetti Domingues, Laura Carolina
(Data collector)1
- Clarke, David T. (Project member)1
- Fruhwirth, Gilbert O. (Project member)6
- Parker, Peter J. (Project member)7, 8
- Rolfe, Daniel J. (Project member)1
- Gervasio, Francesco L. (Project member)3, 4, 9, 10
- Martin-Fernandez, Marisa L. (Contact person)1
- 1. Central Laser Facility, UKRI-STFC Rutherford Appleton Laboratory, Didcot, Oxfordshire, UK
- 2. Immunocore Limited, 92 Park Drive, Milton Park, Abingdon, UK
- 3. School of Pharmaceutical Sciences, University of Geneva, Geneva, CH
- 4. ISPSO, University of Geneva, Geneva, CH
- 5. Imaging Therapies and Cancer Group, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, Guy's Campus, King's College London, London, UK.
- 6. Imaging Therapies and Cancer Group, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, Guy's Campus, King's College London, London, UK
- 7. Protein Phosphorylation Laboratory, The Francis Crick Institute, London, UK
- 8. School of Cancer and Pharmaceutical Sciences, Guy's Campus, King's College London, London, UK
- 9. Chemistry Department, University College London, London, UK
- 10. Swiss Institute of Bioinformatics, University of Geneva, Geneva, CH
Description
Raw data tables for the box plots in Supplementary Figures 1e and 1f, referring to confocal data on binding of EGF to selected EGFR mutants.
The Matlab table (.mat) contains the pixel-wise data on fluorescence intensity, whith each condition encoded by a numeric index (1-6), while the .csv table contains the description of the condition associated to each numerical index in the .mat file.