Genomic and functional diversity of the human-derived isolates of Faecalibacterium

Faecalibacterium is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the functions of Faecalibacterium genomes from cultured strains and the distribution of different species in populations may differ among different sources. We here performed an extensive analysis of pan-genomes, functions, and safety evaluation of 136 Faecalibacterium genomes collected from 10 countries. The genomes are clustered into 11 clusters, with only five of them were characterized and validly nomenclated.