ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF METHANOL EXTRACT OF SESUVIUM PORTULACASTRUM. (AIZOACEAE)WHOLE PLANT IN ALLOXAN INDUCED DIABETIC RATS

The methanol extract of Sesuvium portulacastrum whole plant (Family: Aizoaceae) was investigated for it antidiabetic and antihyperlipidemic effect in Wistar Albino rats. Diabetes was induced in albino rats by administration of alloxan monohydrate (150 mg/kg i.p). The Methanol extracts of Sesuvium portulacastrum at a dose of 150 and 300 mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of methanol extract of Sesuvium portulacastrum whole plant extract on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile[total cholesterol (TC) triglycerides (TG), low density lipoprotein - cholesterol (LDL -C), very low density lipoprotein – cholesterol (VLDL-C) high density lipoprotein – cholesterol (HDL-C)and phospholipid (PL)].Serum protein, albumin, globulin, serum enzymes [Serum glutamate pyruvate transaminases (SGPT), and Serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)] were measured in the diabetic rats. The Methanol extract of Sesuvium portulacastrum whole plant was non toxic at 2000 mg/kg in rats. The increased body weight, decreased blood glucose, glycosylated haemoglobin and other biochemical parameters level was observed in diabetic rats treated with both doses of methanol extract of Sesuvium portulacastrum whole plant compared to diabetic control rats. In diabetic rats, methanol extract of Sesuvium portulacastrum whole plant administration altered lipid profiles were reversed to near normal than diabetic control rats. From the above results, it is conducted that methanol extract of Sesuvium portulacastrum whole plant possess significant antidiabetic and antihyperlipidemic effects in alloxan induced diabetic rats. Keywords: Sesuvium portulacastrum, antidiabetic, Hypolipidemic, Alloxan, Glibenclamide.