Journal article Open Access

UTILIZATION OF ANTIBIOTICS IN PATIENTS WITH URINARY TRACT INFECTIONS – A STUDY

Anamika Chalise1, Bidhan Kafle1, Saman Sharifi1, Vrinda S. Kumar1, Mahesh N.M.2, Rajiv Kumar Saxena3, Shashidhar G.4

The objective of this study was to assess and analyze the prescribing pattern, rationality of antibacterial, to study medication related problems and resistance/sensitivity patterns of antibiotics in patients with urinary tract infections. The observational prospective study was conducted in 100 patients with UTI at MVJ medical college and research hospital, Bangalore, India for six months. All required patient data were collected in specially designed case report form. Prescribing patterns, medication related problems and rationality were assessed. The average number of drug per encounter was 7.02. More than 63% of prescription had more than five drugs. Brand names of drug were prescribed more than the generic names. Fluroquinolones (norfloxacin) was mostly prescribed. Female population was more. Age group of >58 years old was most prevalent. Monotherapy of antibiotic was more than combination therapy. Most of the possible drug interactions were moderate type. Norfloxacin was most frequently interacting antibiotic. No significant medication errors were identified. Rationality was assessed to be rational. The most common type of pathogen was E.coli. Antibacterial prescribing patterns and rationality of the medications were appropriate but, using drug brand names can increase the chance of medication related problems. Higher number of comorbidities was leading to polypharmacy which can increase possibility of drug-drug interactions therefore there is an increased requirement for close monitoring and management of these possible interactions. E. coli, K. pneumoniae and P. aeruginosa were more sensitive to nitrofurantoin, amikacin and norfloxacin therefore these may be the antibiotics of choice for the treatment of community-acquired UTIs.

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