Published December 5, 2023 | Version v1

Multivariate curve resolution -alternating least squares augmented with partial least squares baseline correction applied to mid-IR laser spectra resolves protein denaturation by reducing rotational ambiguity

Description

This record contains mid-IR spectra of a titration of beta-lactoglobulin with two detergents. Spectra are stored in the form of Matlab .mat files. More details on the data and data processing can be found in the associated publication.

  • F_smooth: Surfactant calibration spectra
  • initial_estimate_4c: Intitial estimate of spectra used for MCR-ALS
  • protein_spectra_new: Protein spectra obtained by subtracting the background surfactant titration spectra (surftitrationnewwvcorr) from the protein
  • titration spectra (prtntitrationnewwvcorr)
  • tit_concat_new_mcr: Input for standalone MCR-ALS
  • true_conc_sds_nis_pr_cal: Concentrations of SDS and C12E8 as well as protein used in training data for PLS

Files

Files (1.3 MB)

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md5:5c84f72ef5403a54f5cda1feb2438c57
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Additional details

Related works

Is published in
Journal article: 10.1016/j.saa.2024.124228 (DOI)

Funding

FWF Austrian Science Fund
P32644-N P32644-N
Austrian Research Promotion Agency
CHASE 868615
European Commission
Tumor-LN-oC - Tumor and Lymph Node on Chip for cancer studies 953234