Published November 29, 2023 | Version v1

Sustained liver HBsAg loss and clonal T and B cell expansion upon therapeutic DNA vaccination require low HBsAg levels

Description

C57BL/6 mice samples transduced with AAV-HBV, followed by treatment with siRNA+TxTv, control siRNA+TxVx or control siRNA+empty plasmid. 10x genomics (VDJ) was performed in liver IHIC.

An rds object with the raw and normalised counts, the annotations is available.

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References

  • Sustained liver HBsAg loss and clonal T and B cell expansion upon therapeutic DNA vaccination require low HBsAg levels Nádia Conceição-Neto, Wim Pierson, Maurizio Vacca, Matthias Beyens, Ben De Clerck, Liese Aerts, Birgit Voeten, Dorien De Pooter, Lore Verschueren, Koen Dockx, Mathias Vandenberk, Ewoud De Troyer, Kato Verwilt, Carl Van Hove, Mieke Verslegers, Leslie Bosseler, Marjolein Crabbe, Vinod Krishna, Isabel Nájera, Ellen Van Gulck bioRxiv 2023.09.04.556204; doi: https://doi.org/10.1101/2023.09.04.556204