SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1-(4-CHLOROPHENYL)-2-(3-SULPHOXYPHENYL-4-(4-SUBSTITUTED BENZYLIDENE)-5-IMIDAZOLONES

Imidazolones are believed to be associated with several pharmacological activities. Their significance lies in the fact that they show diverse biological activities. Which include anticancer, anticonvulsant, antiparkinsonian, CNS depressant, antimicrobial, antihelmintic, anti HIV, anti-inflammatory etc.However no work is reported on imidazolone from substituted benzoyl glycine.Therefore it was thought interesting to attempt synthesis of imidazolones containing new substituent and study there antimicrobial activity In the proposed work, we have reported eight newly synthesized sulphoxy substituted imidazolones from oxazolones and 4-chloroaniline in presence of zeolite as a catalyst. The oxazolones were obtained from 3-sulphoxy benzoyl glycine and variedly substituted aromatic aldehydes in presence of anhydrous sodium acetate and acetic anhydride. The characterisation of these compounds was made by chemical properties, elemental analysis and spectral data like IR, 1H-NMR.In order to know antimicrobial property these compounds were assayed for their antimicrobial activity against the test organisms E.coli, K.pheumoniae, S.aureus. S.epidermis. Out of eight samples tested, sample 2g and 2c each. The compound containing –OH group showed antimicrobial activity against maximum number of organisms followed by sample 2h containing -OCH3 along with -OH group. Thus it may be concluded that -OH group present on benzylidene moiety irrespective of its position shows antimicrobial property.