CLUSTER consortium
Published 2023 | Version v1
Dataset Open

RNAseq of PBMC and sorted subpopulations (CD4, CD8, CD14, CD19) from children

Authors/Creators

  • 1. ROR icon University of Cambridge
  • 2. ROR icon Queen Mary University of London
  • 3. ROR icon University College London

Contributors

Description

The CLUSTER consortium (https://www.clusterconsortium.org.uk/) performed RNA sequencing on bulk and sorted CD4, CD8, CD14 and CD19 cells from the peripheral blood of patients with juvenile idiopathic arthritis and healthy controls. These data were used to examine performance of algorithms to impute cell subset specific expression from the mixed cell population (PBMC). Information and processed read counts are provided here for reproducibility purposes. Raw data (FASTQ) and clinical characteristics will be released when the primary outcome paper from the study is published.

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Additional details

Related works

Is part of
Preprint: 10.1101/2023.09.11.556650 (DOI)

Funding

UK Research and Innovation
MICA: Childhood arthritis and its associated uveitis: stratification through endotypes and mechanism to deliver benefit; the CLUSTER Consortium. MR/R013926/1
Great Ormond Street Hospital Children's Charity
Childhood arthritis and its associated uveitis: stratification through endotypes and mechanism to deliver benefit; the CLUSTER Consortium: Study coordinator Ref VS0518

References

  • Lin, W-Y., Kartawinata, M., Jebson, B.R., Restuadi, R., CLUSTER Consortium, Wedderburn, L.R., Wallace, C. 2023. Imputation of cell-type specific expression using RNA-seq data from mixed cell populations. bioRxiv doi: 10.1101/2023.09.11.556650.