Clinical Bioinformatics desiderata for Molecular Tumor Boards
Authors/Creators
-
1.
Institute for Experimental Endocrinology and Oncology
- 2. IRCCS Istituto Nazionale Tumori Regina Elena
- 3. Center for OMICS Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.
-
4.
European Institute of Oncology
- 5. Functional Genomics of Cancer Unit, Division of Experimental Oncology, and Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy
Description
Clinical Bioinformatics is a knowledge framework required to interpret data of medical interest via computational methods. This area became of dramatic importance in Precision Oncology, fueled by cancer genomic profiling: most definitions of Molecular Tumor Boards require the presence of bioinformaticians. However, all available literature remained rather vague on what are the specific needs in terms of digital tools and expertise to tackle and interpret genomics data to assign novel targeted or biomarker-driven targeted therapies to cancer patients. To fill this gap, in this article we present a catalogue of Software Families and Human Skills required for the Tumor Board Bioinformatician, with specific examples on real-world applications associated with each element presented.