SleepLess ERA-NET NEURON project

New upload


SleepLess ERA-NET NEURON project

Patients with major depression benefit from therapeutic sleep deprivation. The causality of this clinically effective therapeutic measure is unknown and the underlying molecular mechanisms remain elusive. We hypothesize that prolonged wakefulness is associated with an increase in synaptic strength, and that the synaptic dysregulation is affecting long term potentiation in patients with major depression. The aim of the project is to examine the synaptic basis of the antidepressant effect of therapeutic sleep deprivation by Positron Emission Tomography (PET) imaging of the synaptic vesicle protein 2A (SV2A) as a measure of synaptic density in patients and healthy subjects as well as animal models of depression. Since both anesthesia and sleep are subject to compromise biologically valid outcomes when studying the synaptic basis of therapeutic sleep deprivation, a fully quantitative PET imaging method for awake animals will be developed.
We propose that synaptic density determined with PET has the power to become a biomarker for the success of therapeutic sleep deprivation and thus providing means for future stratifications of different therapies in major depression. Identifying and understanding the mechanisms that mediate the effects of sleep restriction is necessary to develop effective interventions. This project will test a model that can be used to improve schedule design.


Curated by:
Curation policy:

This repository is exclusively meant for SleepLess-project related open access publications, conference abstracts and data.

The project is sponsored by the Federal Ministry of Education and Research, germany, grant agreement number 01EW1808.

Further information about the project on

October 24, 2018
Harvesting API:
OAI-PMH Interface

Want your upload to appear in this community?

  • Click the button above to upload a record directly to this community.
    To add one of your existing records to the community, edit the record, add this community under the "Communities" section, save, and finally publish.
  • The community curator will then be notified to either accept or reject your upload (see community curation policy below).
  • If your upload is rejected by the curator, it will still be available on Zenodo, just not in this community.