# Significance
The "Significance" panel contains all the parameters for the evaluation of the statistical significance of a motif subnetwork. It consists of eight subpanels, one for each random model and one for the general settings of all models. In the top subpanel the user can choose the number of random graphs to generate for the statistical test (between 0 and 100) and compute a set of metrics for the input graph and sample random graphs, one for each model. Metrics include the average degree, the average clustering coefficient and the assortativity index. At the end of the computation, the resulting values are shown in a separate window. Values of these metrics can suggest to the user which random model best describes the features of the input network should be used. The other subpanels let the user choose the parameters of each random model. In the "Shuffling model" panel, "sw/edg" denotes the number of successful swaps per edges. The "Erdos-Renyi" panel has no parameters. In the "Watts-Strogatz" panel, "Rew prob" is the probability of rewiring beta. The "Barabasi-Albert" panel defines "Init nodes", the number of initial nodes in the complete seed network. The "Duplication Model" panel has two parameters: "Init nodes", the number of nodes in the initial seed network, and "Edg prob", the edge duplication probability. In the "Geometric Model" panel, parameter "dim" denotes the dimension of the space where points are placed. Finally, the "Forest-Fire model" panel contains parameter "Ambass num", that is the number of ambassadors nodes. For each model, all the remaining parameters are estimated based on the number of nodes and edges of the target network. To check if a query is a motif, the user must click on one of the "Start" buttons of the "Significance" panel, depending on the random model that has been chosen to perform the significance test. When the simulation ends, a window will appear with the following measures: the number of query occurrences in the real network, the mean and the standard deviation of the number of query occurrences in the random networks, the P-value and the Z-score.
| "Significance" panel options
| Compute metrics
| Set a random seed
| "Verification
| "Significance" results