What promotes longevity?

Kujawska Agnieszka, Husejko Jakub, Topka Weronika, Androsiuk-Perkowska Joanna, Skierkowska Natalia, Gajos Małgorzata, Perkowski Radosław, Karpińska Anna, Kromrych Kamila, Kotarska Marta, Zielińska Natalia, Kożuchowski Marcin, Kędziora‑Kornatowska Kornelia. What promotes longevity? Journal of Education, Health and Sport. 2017;7(9):142-154. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.888796

http://ojs.ukw.edu.pl/index.php/johs/article/view/4797

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).

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© The Authors 2017;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 01.08.2017. Revised: 10.08.2017. Accepted: 31.08.2017.

What promotes longevity?

Agnieszka Kujawska¹, Jakub Husejko¹, Weronika Topka¹, Joanna Androsiuk-Perkowska¹, Natalia Skierkowska¹, Małgorzata Gajos¹, Radosław Perkowski¹, Anna Karpińska¹, Kamila Kromrych¹, Marta Kotarska¹, Natalia Zielińska¹, Marcin Kożuchowski¹, Kornelia Kędziora-Kornatowska¹

1. Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University

Abstract

Introduction Scientists try to answer on the need of a long life with a full physical capability Nonagenarians, centenarians and their closest family members are characterized by a survival benefit throughout life. Moreover, twin studies of longevity suggest that around 25% of the variation in lifespan in developed countries may be inherited. It is therefore worth to examine the role of inter-relationship between nature vs nurture in longevity increment.

Material and methods Articles in the EBSCO database have been analyzed using keywords: longevity, gene, behavior, environment. The available literature was subjectively selected. Then, the newest version of every paper was searched for.

Results Restriction of calories as well as intake of desirable nutrients can promote adequate control of metabolic pathways and gene expression. APOE, DRD4, Paraoxonase 1, SIRT 3 and SIRT 5 genes can play an important role in longevity.

Conclusions Genetic profile and environmental factors seems to both influence on the longevity. Relationships between genetic profile, behavior pattern, quality of life, years spent free from activity limitations and longevity should be examined, to be able to give a recipe on living a long and happy life.

Keywords longevity, gene, behavior, environment