XPP model
This model was converted from XPP ode format to SBML using sbmlutils-0.1.5a6
.
# RatAPtest01.ode # Rat action potential is simulated (bondarenko_model_2004) # (cf. Bondarenko et al. Am J Physiol Heart Circ Physiol 2004;287: H1378-H1403) # (cf. Wang et al. Toxicol Sci 2008;106:454-463) # implemented by Dr. Sheng-Nan Wu # Constant values Number Temp=298.0, R=8.314, Fara=96.5 Number E_CaL=63.0, E_Cl=-40.0 Number Cm=1.0, Vmyo=2.584E-5, VNSR=2.098E-6, VJSR=1.2E-7 # Initial values Initial V=-82.4202, Cai=0.115001 Initial Nai=14237.1, Ki=143720.0 Initial C_Na1=2.79132E-4, C_Na2=0.020752, O_Na=7.13483E-7 Initial IF_Na=1.53176E-4, I1_Na=6.73345E-7, I2_Na=1.55787E-9 Initial IC_Na2=0.0113879, IC_Na3=0.34278 Initial ato_f=0.00265563, ito_f=0.999977 Initial ato_s=4.17069E-4, ito_s=0.998543 Initial nKs=2.62753E-4, aur=4.17069E-4, iur=0.998543 Initial aKss=4.17069E-4, iKss=1.0 Initial C_K1=9.92513E-4, C_K2=6.41229E-4 Initial O_K=1.75298E-4, I_K=3.19129E-5 Initial Cass=0.115001, CaJSR=1299.5, CaNSR=1299.5 Initial P_RyR=0.0 Initial LTRPN_Ca=11.2684, HTRPN_Ca=125.29 Initial O=9.30308E-19, O1=1.49102E-5, O2=9.51726E-11 Initial P_C2=1.6774E-4 Initial C2=1.24216E-4, C3=5.78679E-9, C4=1.19816E-13 Initial I1=4.97023E-19, I2=3.45847E-14, I3=1.85106E-14 # Stimulus protocol Par r0=1, period=300, pulse=10 Par tf=0, tp=5, tstart=10 ts=t-tstart rstar = r0 + pulse*(heav(mod(ts,period)-tf)-heav(mod(ts,period)-(tf+tp))) Par Nao=140000.0 Par LTRPN_tot=70.0 Par kf=0.023761 Par kb=0.036778 Par Km_CSQN=800.0 Par i_pCa_max=1.0 Par CMDN_tot=50.0 Par Kpc_max=0.23324 Par Km_CMDN=0.238 Par K_mCa=1380.0 Par Km_Nai=21.0 Par v1=4.5, v2=1.7E-5, v3=0.45 Par k_plus_c=0.0090 Par k_minus_ltrpn=0.196 Par g_Cab=3.67E-4 Par k_plus_b=0.00405 Par k_plus_a=0.006075 Par Km_up=0.5 Par K_mNa=87500.0 Par Km_Cl=10.0 Par CSQN_tot=15000.0 Par k_minus_htrpn =3.2E-5 Par Km_pCa=0.5 Par k_plus_ltrpn=0.0327 Par Acap=1.534E-4 Par g_Na=13.0, g_CaL=1.51729, g_Ks=0.000575, g_Kr=0.0078, g_Kur=0.0016 Par g_ClCa=10.0 Par Vss=1.485E-9 Par k_NaCa=992.8 Par k_plus_htrpn=0.00237 Par Ko=5400.0, Cao=1800.0 Par tau_xfer=8.0 Par k_sat =0.1 Par n=4.0 Par g_Kto_f=0.4067, g_Kto_s=0.01, g_Nab=0.0026 Par m=3.0 Par Km_Ko=1.5 Par g_Kss=0.05 Par HTRPN_tot=140.0 Par i_NaK_max=0.88 Par i_CaL_max=7.0 Par tau_tr=20.0 Par k_minus_c=8.0E-4 Par k_minus_b=0.965 Par k_minus_a=0.07125 Par Kpc_half=20.0 Par eta=0.35 Par Kpcb=5.0E-4 ass = (1.0 / (1.0 + exp( - (0.12987012987012986 * (22.5 + V))))) E_K = (ln((Ko / Ki)) * R * Temp / Fara) i_Ks = (g_Ks * (nKs^2.0) * (V - E_K)) E_Na = (ln((((0.9 * Nao) + (0.1 * Ko)) / ((0.9 * Nai) + (0.1 * Ki)))) * R * Temp / Fara) i_Kr = (g_Kr * O_K * (V - (ln((((0.98 * Ko) + (0.02 * Nao)) / ((0.98 * Ki) + (0.02 * Nai)))) * R * Temp / Fara))) i_Kur = (g_Kur * aur * iur * (V - E_K)) sigma = (0.14285714285714285 * (-1.0 + exp((1.4858841010401188E-5 * Nao)))) f_NaK = (1.0 / (1.0 + (0.1245 * exp( - (0.1 * V * Fara / (R * Temp)))) + (0.0365 * sigma * exp( - (Fara * V / (R * Temp)))))) J_leak = (v2 * (CaNSR - Cai)) i_NaCa = (k_NaCa * ((exp((eta * V * Fara / (R * Temp))) * (Nai^3.0) * Cao) - (exp(((-1.0 + eta) * V * Fara / (R * Temp))) * (Nao^3.0) * Cai)) / ((K_mNa^3.0) + (Nao^3.0)) / (K_mCa + Cao) / (1.0 + (k_sat * exp(((-1.0 + eta) * V * Fara / (R * Temp)))))) O_ClCa = (0.2 / (1.0 + exp( - (0.12820512820512822 * (-46.7 + V))))) i_ClCa = (g_ClCa * O_ClCa * (V - E_Cl) * Cai / (Cai + Km_Cl)) i_Nab = (g_Nab * (V - E_Na)) tau_Kss = (13.17 + (39.3 * exp( - (0.0862 * V)))) beta_i1 = (9.5E-4 * exp((0.14285714285714285 * (33.5 + V))) / (1.0 + (0.051335 * exp((0.14285714285714285 * (33.5 + V)))))) beta = (0.05 * exp( - (0.07692307692307693 * (12.0 + V)))) i_Kss = (g_Kss * aKss * iKss * (V - E_K)) i_K1 = (0.2938 * Ko * (V - E_K) / (210.0 + Ko) / (1.0 + exp((0.0896 * (V - E_K))))) i_NaK = (i_NaK_max * f_NaK * Ko / (1.0 + ((Km_Nai / Nai)^0.66667)) / (Ko + Km_Ko)) J_rel = (v1 * (O1 + O2) * (CaJSR - Cass) * P_RyR) alpha_n = (4.81333E-6 * (26.5 + V) * (1.0 - exp( - (0.128 * (26.5 + V))))) alpha_i= (0.090821 * exp((0.023391 * (5.0 + V)))) alpha_a = (0.18064 * exp((0.03577 * (30.0 + V)))) i_pCa = (i_pCa_max * (Cai^2.0) / ((Km_pCa^2.0) + (Cai^2.0))) alpha_i1 = (1.52E-4 * exp( - (0.14285714285714285 * (13.5 + V))) / (1.0 + (0.0067083 * exp( - (0.14285714285714285 * (33.5 + V)))))) # i_stim = - (10.0 * (t > 10.0) * (t < 15.0)) beta_Na13 = (0.22 * exp( - (0.04926108374384236 * (-7.5 + V)))) beta_Na12 = (0.2 * exp( - (0.04926108374384236 * (-2.5 + V)))) beta_Na11 = (0.1917 * exp( - (0.04926108374384236 * (2.5 + V)))) alpha = (0.4 * exp((0.1 * (12.0 + V))) * (1.0 - (0.75 * exp( - (0.0025 * ((20.0 + V)^2.0)))) + (0.7 * exp( - (0.1 * ((40.0 + V)^2.0))))) / (1.0 + (0.12 * exp((0.1 * (12.0 + V)))))) Bi = ((1.0 + (CMDN_tot * Km_CMDN / ((Km_CMDN + Cai)^2.0)))^(-1.0)) gamma = (Kpc_max * Cass / (Kpc_half + Cass)) P_C1= (1.0 - (P_C2 + O1 + O2)) C1= (1.0 - (O + C2 + C2 + C3 + C4 + I1 + I2 + I3)) beta_n= (9.53333E-5 * exp( - (0.038 * (26.5 + V)))) beta_i= (0.006497 * exp( - (0.03268 * (5.0 + V)))) beta_a= (0.3956 * exp( - (0.06237 * (30.0 + V)))) i_Kto_s = (g_Kto_s * ato_s * ito_s * (V - E_K)) i_Kto_f = (g_Kto_f * (ato_f^3.0) * ito_f * (V - E_K)) alpha_Na3 = (7.0E-7 * exp( - (0.12987012987012986 * (7.0 + V)))) beta_Na5 = (0.02 * alpha_Na3) beta_Na4 = alpha_Na3 beta_Na3 = (0.0084 + (2.0E-5 * (7.0 + V))) alpha_Na13 = (3.802 / ((0.1027 * exp( - (0.08333333333333333 * (2.5 + V)))) + (0.25 * exp( - (0.006666666666666667 * (2.5 + V)))))) alpha_Na2 = (1.0 / (0.393956 + (0.188495 * exp( - (0.06024096385542168 * (7.0 + V)))))) beta_Na2 = (alpha_Na13 * alpha_Na2 * alpha_Na3 / (beta_Na13 * beta_Na3)) BJSR = ((1.0 + (CSQN_tot * Km_CSQN / ((Km_CSQN + CaJSR)^2.0)))^(-1.0)) tau_iur= (1200.0 - (170.0 / (1.0 + exp((0.17543859649122806 * (45.2 + V)))))) E_CaN= (ln((Cao / Cai)) * R * Temp / (2.0 * Fara)) i_Cab= (g_Cab * (V - E_CaN)) tau_ti_s= (270.0 + (1050.0 / (1.0 + exp((0.17543859649122806 * (45.2 + V)))))) Bss= ((1.0 + (CMDN_tot * Km_CMDN / ((Km_CMDN + Cass)^2.0)))^(-1.0)) alpha_Na12= (3.802 / ((0.1027 * exp( - (0.06666666666666667 * (2.5 + V)))) + (0.23 * exp( - (0.006666666666666667 * (2.5 + V)))))) alpha_Na11= (3.802 / ((0.1027 * exp( - (0.058823529411764705 * (2.5 + V)))) + (0.2 * exp( - (0.006666666666666667 * (2.5 + V)))))) tau_aur= (2.058 + (0.493 * exp( - (0.0629 * V)))) beta_a1= (6.89E-5 * exp( - (0.04178 * V))) beta_a0= (0.047002 * exp( - (0.0631 * V))) J_xfer= ((Cass - Cai) / tau_xfer) tau_ta_s= (2.058 + (0.493 * exp( - (0.0629 * V)))) J_up= (v3 * (Cai^2.0) / ((Km_up^2.0) + (Cai^2.0))) alpha_Na5 = (1.0526315789473684E-5 * alpha_Na2) alpha_Na4 = (0.0010 * alpha_Na2) iss = (1.0 / (1.0 + exp((0.17543859649122806 * (45.2 + V))))) Kpcf = (13.0 * (1.0 - exp( - (0.01 * ((14.5 + V)^2.0))))) C_K0 = (1.0 - (C_K1 + C_K2 + O_K + I_K)) J_tr = ((CaNSR - CaJSR) / tau_tr) alpha_a1= (0.013733 * exp((0.038198 * V))) alpha_a0 = (0.022348 * exp((0.01176 * V))) J_trpn = ( - ((k_minus_htrpn * HTRPN_Ca) + (k_minus_ltrpn * LTRPN_Ca)) + (k_plus_htrpn * Cai * (HTRPN_tot - HTRPN_Ca)) + (k_plus_ltrpn * Cai * (LTRPN_tot - LTRPN_Ca))) C_Na3 = (1.0 - (O_Na + C_Na1 + C_Na2 + IF_Na + I1_Na + I2_Na + IC_Na2 + IC_Na3)) i_Na= (g_Na * O_Na * (V - E_Na)) i_CaL= (g_CaL * O * (V - E_CaL)) V'= - ((i_CaL + i_pCa + i_NaCa + i_Cab + i_Na + i_Nab + i_NaK + i_Kto_f + i_Kto_s + i_K1 + i_Ks + i_Kur + i_Kss + i_Kr + i_ClCa - rstar) / Cm) Cai'=(Bi * ( - (J_up + J_trpn + (( - (2.0 * i_NaCa) + i_Cab + i_pCa) * Acap * Cm / (2.0 * Vmyo * Fara))) + J_leak + J_xfer)) Cass'=(Bss * ((J_rel * VJSR / Vss) - ((J_xfer * Vmyo / Vss) + (i_CaL * Acap * Cm / (2.0 * Vss * Fara))))) CaJSR'=(BJSR * (J_tr - J_rel)) CaNSR'=(((J_up - J_leak) * Vmyo / VNSR) - (J_tr * VJSR / VNSR)) P_RyR'=( - (0.04 * P_RyR) - (0.1 * exp( - (0.0015432098765432098 * ((-5.0 + V)^2.0))) * i_CaL / i_CaL_max)) LTRPN_Ca'=((k_plus_ltrpn * Cai * (LTRPN_tot - LTRPN_Ca)) - (k_minus_ltrpn * LTRPN_Ca)) HTRPN_Ca'=((k_plus_htrpn * Cai * (HTRPN_tot - HTRPN_Ca)) - (k_minus_htrpn * HTRPN_Ca)) O1'=( - ((k_minus_a * O1) + (k_plus_b * (Cass^m) * O1) + (k_plus_c * O1)) + (k_plus_a * (Cass^n) * P_C1) + (k_minus_b * O2) + (k_minus_c * P_C2)) O2'=((k_plus_b * (Cass^m) * O1) - (k_minus_b * O2)) P_C2'=((k_plus_c * O1) - (k_minus_c * P_C2)) O'=( - ((4.0 * beta * O) + (gamma * O)) + (alpha * C4) + (Kpcb * I1) + (0.0010 * ((alpha * I2) - (Kpcf * O)))) C2'=( - ((beta * C2) + (3.0 * alpha * C2)) + (4.0 * alpha * C1) + (2.0 * beta * C3)) C3'=( - ((2.0 * beta * C3) + (2.0 * alpha * C3)) + (3.0 * alpha * C2) + (3.0 * beta * C4)) C4'=( - ((3.0 * beta * C4) + (alpha * C4) + (gamma * Kpcf * C4)) + (2.0 * alpha * C3) + (4.0 * beta * O) + (0.01 * ((4.0 * Kpcb * beta * I1) - (alpha * gamma * C4))) + (0.0020 * ((4.0 * beta * I2) - (Kpcf * C4))) + (4.0 * beta * Kpcb * I3)) I1'=( - (Kpcb * I1) + (gamma * O) + (0.0010 * ((alpha * I3) - (Kpcf * I1))) + (0.01 * ((alpha * gamma * C4) - (4.0 * beta * Kpcf * I1)))) I2'=( - (gamma * I2) + (0.0010 * ((Kpcf * O) - (alpha * I2))) + (Kpcb * I3) + (0.0020 * ((Kpcf * C4) - (4.0 * beta * I2)))) I3'=( - ((4.0 * beta * Kpcb * I3) + (Kpcb * I3)) + (0.0010 * ((Kpcf * I1) - (alpha * I3))) + (gamma * I2) + (gamma * Kpcf * C4)) Nai'= - (Acap * Cm * (i_Na + i_Nab + (3.0 * i_NaK) + (3.0 * i_NaCa)) / (Vmyo * Fara)) C_Na2'=( - ((beta_Na11 * C_Na2) + (alpha_Na12 * C_Na2) + (beta_Na3 * C_Na2)) + (alpha_Na11 * C_Na3) + (beta_Na12 * C_Na1) + (alpha_Na3 * IC_Na2)) C_Na1'=( - ((beta_Na12 * C_Na1) + (alpha_Na13 * C_Na1) + (beta_Na3 * C_Na1)) + (alpha_Na12 * C_Na2) + (beta_Na13 * O_Na) + (alpha_Na3 * IF_Na)) O_Na'=( - ((beta_Na13 * O_Na) + (alpha_Na2 * O_Na)) + (alpha_Na13 * C_Na1) + (beta_Na2 * IF_Na)) IF_Na'=( - ((beta_Na2 * IF_Na) + (alpha_Na3 * IF_Na) + (alpha_Na4 * IF_Na) + (beta_Na12 * IF_Na)) + (alpha_Na2 * O_Na) + (beta_Na3 * C_Na1) + (beta_Na4 * I1_Na) + (alpha_Na12 * IC_Na2)) I1_Na'=( - ((beta_Na4 * I1_Na) + (alpha_Na5 * I1_Na)) + (alpha_Na4 * IF_Na) + (beta_Na5 * I2_Na)) I2_Na'=((alpha_Na5 * I1_Na) - (beta_Na5 * I2_Na)) IC_Na2'=( - ((beta_Na11 * IC_Na2) + (alpha_Na12 * IC_Na2) + (alpha_Na3 * IC_Na2)) + (alpha_Na11 * IC_Na3) + (beta_Na12 * IF_Na) + (beta_Na3 * IC_Na2)) IC_Na3'=( - ((alpha_Na11 * IC_Na3) + (alpha_Na3 * IC_Na3)) + (beta_Na11 * IC_Na2) + (beta_Na3 * C_Na3)) Ki'= - (Acap * Cm * (i_Kto_f + i_Kto_s + i_K1 + i_Ks + i_Kss + i_Kur + i_Kr + (2.0 * i_NaK)) / (Vmyo * Fara)) ato_f'=((alpha_a * (1.0 - ato_f)) - (beta_a * ato_f)) ito_f'=((alpha_i1 * (1.0 - ito_f)) - (beta_i1 * ito_f)) ato_s' = ((ass - ato_s) / tau_ta_s) ito_s' = ((iss - ito_s) / tau_ti_s) nKs'=((alpha_n * (1.0 - nKs)) - (beta_n * nKs)) aur'=((ass - aur) / tau_aur) iur'=((iss - iur) / tau_iur) aKss'=((ass - aKss) / tau_Kss) iKss'=0.0 C_K2'=( - ((kb * C_K2) + (alpha_a1 * C_K2)) + (kf * C_K1) + (beta_a1 * O_K)) C_K1'=( - ((beta_a0 * C_K1) + (kf * C_K1)) + (alpha_a0 * C_K0) + (kb * C_K2)) O_K'=( - ((beta_a1 * O_K) + (alpha_i * O_K)) + (alpha_a1 * C_K2) + (beta_i * I_K)) I_K'=((alpha_i * O_K) - (beta_i * I_K)) aux ina=i_Na aux ical=i_CaL aux ikur=i_Kur # Numerical and plotting parameters for xpp @ maxstor=5000000, bounds=10000000, total=1100, xp=t, yp=V, trans=860 @ meth=Gear, dt=0.05, toler=0.01, xlo=860, xhi=1100, ylo=-100, yhi=60 done
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Copyright © 2017 Matthias Koenig
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Model :
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type | FunctionDefinitions [4] | name | math | sbo | cvterm |
---|---|---|---|---|---|
FunctionDefinition | max
|
minimum | |||
FunctionDefinition | min
|
maximum | |||
FunctionDefinition | heav
|
heavyside | |||
FunctionDefinition | mod
|
modulo |
type | Parameters [190] | name | constant | value | unit | derived unit | sbo | cvterm |
---|---|---|---|---|---|---|---|---|
Parameter | temp
|
temp = 298.0 | F | 298.0 | None | |||
Parameter | r
|
r = 8.314 | F | 8.314 | None | |||
Parameter | fara
|
fara = 96.5 | F | 96.5 | None | |||
Parameter | e_cal
|
e_cal = 63.0 | F | 63.0 | None | |||
Parameter | e_cl
|
e_cl = -40.0 | F | -40.0 | None | |||
Parameter | cm
|
cm = 1.0 | F | 1.0 | None | |||
Parameter | vmyo
|
vmyo = 2.584e-5 | F | 2.584e-05 | None | |||
Parameter | vnsr
|
vnsr = 2.098e-6 | F | 2.098e-06 | None | |||
Parameter | vjsr
|
vjsr = 1.2e-7 | F | 1.2e-07 | None | |||
Parameter | v
|
v = -82.4202 | F | -82.4202 | None | |||
Parameter | cai
|
cai = 0.115001 | F | 0.115001 | None | |||
Parameter | nai
|
nai = 14237.1 | F | 14237.1 | None | |||
Parameter | ki
|
ki = 143720.0 | F | 143720.0 | None | |||
Parameter | c_na1
|
c_na1 = 2.79132e-4 | F | 0.000279132 | None | |||
Parameter | c_na2
|
c_na2 = 0.020752 | F | 0.020752 | None | |||
Parameter | o_na
|
o_na = 7.13483e-7 | F | 7.13483e-07 | None | |||
Parameter | if_na
|
if_na = 1.53176e-4 | F | 0.000153176 | None | |||
Parameter | i1_na
|
i1_na = 6.73345e-7 | F | 6.73345e-07 | None | |||
Parameter | i2_na
|
i2_na = 1.55787e-9 | F | 1.55787e-09 | None | |||
Parameter | ic_na2
|
ic_na2 = 0.0113879 | F | 0.0113879 | None | |||
Parameter | ic_na3
|
ic_na3 = 0.34278 | F | 0.34278 | None | |||
Parameter | ato_f
|
ato_f = 0.00265563 | F | 0.00265563 | None | |||
Parameter | ito_f
|
ito_f = 0.999977 | F | 0.999977 | None | |||
Parameter | ato_s
|
ato_s = 4.17069e-4 | F | 0.000417069 | None | |||
Parameter | ito_s
|
ito_s = 0.998543 | F | 0.998543 | None | |||
Parameter | nks
|
nks = 2.62753e-4 | F | 0.000262753 | None | |||
Parameter | aur
|
aur = 4.17069e-4 | F | 0.000417069 | None | |||
Parameter | iur
|
iur = 0.998543 | F | 0.998543 | None | |||
Parameter | akss
|
akss = 4.17069e-4 | F | 0.000417069 | None | |||
Parameter | ikss
|
ikss = 1.0 | F | 1.0 | None | |||
Parameter | c_k1
|
c_k1 = 9.92513e-4 | F | 0.000992513 | None | |||
Parameter | c_k2
|
c_k2 = 6.41229e-4 | F | 0.000641229 | None | |||
Parameter | o_k
|
o_k = 1.75298e-4 | F | 0.000175298 | None | |||
Parameter | i_k
|
i_k = 3.19129e-5 | F | 3.19129e-05 | None | |||
Parameter | cass
|
cass = 0.115001 | F | 0.115001 | None | |||
Parameter | cajsr
|
cajsr = 1299.5 | F | 1299.5 | None | |||
Parameter | cansr
|
cansr = 1299.5 | F | 1299.5 | None | |||
Parameter | p_ryr
|
p_ryr = 0.0 | F | 0.0 | None | |||
Parameter | ltrpn_ca
|
ltrpn_ca = 11.2684 | F | 11.2684 | None | |||
Parameter | htrpn_ca
|
htrpn_ca = 125.29 | F | 125.29 | None | |||
Parameter | o
|
o = 9.30308e-19 | F | 9.30308e-19 | None | |||
Parameter | o1
|
o1 = 1.49102e-5 | F | 1.49102e-05 | None | |||
Parameter | o2
|
o2 = 9.51726e-11 | F | 9.51726e-11 | None | |||
Parameter | p_c2
|
p_c2 = 1.6774e-4 | F | 0.00016774 | None | |||
Parameter | c2
|
c2 = 1.24216e-4 | F | 0.000124216 | None | |||
Parameter | c3
|
c3 = 5.78679e-9 | F | 5.78679e-09 | None | |||
Parameter | c4
|
c4 = 1.19816e-13 | F | 1.19816e-13 | None | |||
Parameter | i1
|
i1 = 4.97023e-19 | F | 4.97023e-19 | None | |||
Parameter | i2
|
i2 = 3.45847e-14 | F | 3.45847e-14 | None | |||
Parameter | i3
|
i3 = 1.85106e-14 | F | 1.85106e-14 | None | |||
Parameter | r0
|
r0 = 1 | F | 1.0 | None | |||
Parameter | period
|
period = 300 | F | 300.0 | None | |||
Parameter | pulse
|
pulse = 10 | F | 10.0 | None | |||
Parameter | tf
|
tf = 0 | F | 0.0 | None | |||
Parameter | tp
|
tp = 5 | F | 5.0 | None | |||
Parameter | tstart
|
tstart = 10 | F | 10.0 | None | |||
Parameter | nao
|
nao = 140000.0 | F | 140000.0 | None | |||
Parameter | ltrpn_tot
|
ltrpn_tot = 70.0 | F | 70.0 | None | |||
Parameter | kf
|
kf = 0.023761 | F | 0.023761 | None | |||
Parameter | kb
|
kb = 0.036778 | F | 0.036778 | None | |||
Parameter | km_csqn
|
km_csqn = 800.0 | F | 800.0 | None | |||
Parameter | i_pca_max
|
i_pca_max = 1.0 | F | 1.0 | None | |||
Parameter | cmdn_tot
|
cmdn_tot = 50.0 | F | 50.0 | None | |||
Parameter | kpc_max
|
kpc_max = 0.23324 | F | 0.23324 | None | |||
Parameter | km_cmdn
|
km_cmdn = 0.238 | F | 0.238 | None | |||
Parameter | k_mca
|
k_mca = 1380.0 | F | 1380.0 | None | |||
Parameter | km_nai
|
km_nai = 21.0 | F | 21.0 | None | |||
Parameter | v1
|
v1 = 4.5 | F | 4.5 | None | |||
Parameter | v2
|
v2 = 1.7e-5 | F | 1.7e-05 | None | |||
Parameter | v3
|
v3 = 0.45 | F | 0.45 | None | |||
Parameter | k_plus_c
|
k_plus_c = 0.0090 | F | 0.009 | None | |||
Parameter | k_minus_ltrpn
|
k_minus_ltrpn = 0.196 | F | 0.196 | None | |||
Parameter | g_cab
|
g_cab = 3.67e-4 | F | 0.000367 | None | |||
Parameter | k_plus_b
|
k_plus_b = 0.00405 | F | 0.00405 | None | |||
Parameter | k_plus_a
|
k_plus_a = 0.006075 | F | 0.006075 | None | |||
Parameter | km_up
|
km_up = 0.5 | F | 0.5 | None | |||
Parameter | k_mna
|
k_mna = 87500.0 | F | 87500.0 | None | |||
Parameter | km_cl
|
km_cl = 10.0 | F | 10.0 | None | |||
Parameter | csqn_tot
|
csqn_tot = 15000.0 | F | 15000.0 | None | |||
Parameter | k_minus_htrpn
|
k_minus_htrpn = 3.2e-5 | F | 3.2e-05 | None | |||
Parameter | km_pca
|
km_pca = 0.5 | F | 0.5 | None | |||
Parameter | k_plus_ltrpn
|
k_plus_ltrpn = 0.0327 | F | 0.0327 | None | |||
Parameter | acap
|
acap = 1.534e-4 | F | 0.0001534 | None | |||
Parameter | g_na
|
g_na = 13.0 | F | 13.0 | None | |||
Parameter | g_cal
|
g_cal = 1.51729 | F | 1.51729 | None | |||
Parameter | g_ks
|
g_ks = 0.000575 | F | 0.000575 | None | |||
Parameter | g_kr
|
g_kr = 0.0078 | F | 0.0078 | None | |||
Parameter | g_kur
|
g_kur = 0.0016 | F | 0.0016 | None | |||
Parameter | g_clca
|
g_clca = 10.0 | F | 10.0 | None | |||
Parameter | vss
|
vss = 1.485e-9 | F | 1.485e-09 | None | |||
Parameter | k_naca
|
k_naca = 992.8 | F | 992.8 | None | |||
Parameter | k_plus_htrpn
|
k_plus_htrpn = 0.00237 | F | 0.00237 | None | |||
Parameter | ko
|
ko = 5400.0 | F | 5400.0 | None | |||
Parameter | cao
|
cao = 1800.0 | F | 1800.0 | None | |||
Parameter | tau_xfer
|
tau_xfer = 8.0 | F | 8.0 | None | |||
Parameter | k_sat
|
k_sat = 0.1 | F | 0.1 | None | |||
Parameter | n
|
n = 4.0 | F | 4.0 | None | |||
Parameter | g_kto_f
|
g_kto_f = 0.4067 | F | 0.4067 | None | |||
Parameter | g_kto_s
|
g_kto_s = 0.01 | F | 0.01 | None | |||
Parameter | g_nab
|
g_nab = 0.0026 | F | 0.0026 | None | |||
Parameter | m
|
m = 3.0 | F | 3.0 | None | |||
Parameter | km_ko
|
km_ko = 1.5 | F | 1.5 | None | |||
Parameter | g_kss
|
g_kss = 0.05 | F | 0.05 | None | |||
Parameter | htrpn_tot
|
htrpn_tot = 140.0 | F | 140.0 | None | |||
Parameter | i_nak_max
|
i_nak_max = 0.88 | F | 0.88 | None | |||
Parameter | i_cal_max
|
i_cal_max = 7.0 | F | 7.0 | None | |||
Parameter | tau_tr
|
tau_tr = 20.0 | F | 20.0 | None | |||
Parameter | k_minus_c
|
k_minus_c = 8.0e-4 | F | 0.0008 | None | |||
Parameter | k_minus_b
|
k_minus_b = 0.965 | F | 0.965 | None | |||
Parameter | k_minus_a
|
k_minus_a = 0.07125 | F | 0.07125 | None | |||
Parameter | kpc_half
|
kpc_half = 20.0 | F | 20.0 | None | |||
Parameter | eta
|
eta = 0.35 | F | 0.35 | None | |||
Parameter | kpcb
|
kpcb = 5.0e-4 | F | 0.0005 | None | |||
Parameter | ts
|
F | 0.0 | dimensionless | None | |||
Parameter | rstar
|
F | 0.0 | dimensionless | None | |||
Parameter | ass
|
F | 0.0 | dimensionless | None | |||
Parameter | e_k
|
F | 0.0 | dimensionless | None | |||
Parameter | i_ks
|
F | 0.0 | dimensionless | None | |||
Parameter | e_na
|
F | 0.0 | dimensionless | None | |||
Parameter | i_kr
|
F | 0.0 | dimensionless | None | |||
Parameter | i_kur
|
F | 0.0 | dimensionless | None | |||
Parameter | sigma
|
F | 0.0 | dimensionless | None | |||
Parameter | f_nak
|
F | 0.0 | dimensionless | None | |||
Parameter | j_leak
|
F | 0.0 | dimensionless | None | |||
Parameter | i_naca
|
F | 0.0 | dimensionless | None | |||
Parameter | o_clca
|
F | 0.0 | dimensionless | None | |||
Parameter | i_clca
|
F | 0.0 | dimensionless | None | |||
Parameter | i_nab
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_kss
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_i1
|
F | 0.0 | dimensionless | None | |||
Parameter | beta
|
F | 0.0 | dimensionless | None | |||
Parameter | i_kss
|
F | 0.0 | dimensionless | None | |||
Parameter | i_k1
|
F | 0.0 | dimensionless | None | |||
Parameter | i_nak
|
F | 0.0 | dimensionless | None | |||
Parameter | j_rel
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_n
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_i
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_a
|
F | 0.0 | dimensionless | None | |||
Parameter | i_pca
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_i1
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_na13
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_na12
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_na11
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha
|
F | 0.0 | dimensionless | None | |||
Parameter | bi
|
F | 0.0 | dimensionless | None | |||
Parameter | gamma
|
F | 0.0 | dimensionless | None | |||
Parameter | p_c1
|
F | 0.0 | dimensionless | None | |||
Parameter | c1
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_n
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_i
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_a
|
F | 0.0 | dimensionless | None | |||
Parameter | i_kto_s
|
F | 0.0 | dimensionless | None | |||
Parameter | i_kto_f
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_na3
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_na5
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_na4
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_na3
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_na13
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_na2
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_na2
|
F | 0.0 | dimensionless | None | |||
Parameter | bjsr
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_iur
|
F | 0.0 | dimensionless | None | |||
Parameter | e_can
|
F | 0.0 | dimensionless | None | |||
Parameter | i_cab
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_ti_s
|
F | 0.0 | dimensionless | None | |||
Parameter | bss
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_na12
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_na11
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_aur
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_a1
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_a0
|
F | 0.0 | dimensionless | None | |||
Parameter | j_xfer
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_ta_s
|
F | 0.0 | dimensionless | None | |||
Parameter | j_up
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_na5
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_na4
|
F | 0.0 | dimensionless | None | |||
Parameter | iss
|
F | 0.0 | dimensionless | None | |||
Parameter | kpcf
|
F | 0.0 | dimensionless | None | |||
Parameter | c_k0
|
F | 0.0 | dimensionless | None | |||
Parameter | j_tr
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_a1
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_a0
|
F | 0.0 | dimensionless | None | |||
Parameter | j_trpn
|
F | 0.0 | dimensionless | None | |||
Parameter | c_na3
|
F | 0.0 | dimensionless | None | |||
Parameter | i_na
|
F | 0.0 | dimensionless | None | |||
Parameter | i_cal
|
F | 0.0 | dimensionless | None | |||
Parameter | ina
|
F | 0.0 | dimensionless | None | |||
Parameter | ical
|
F | 0.0 | dimensionless | None | |||
Parameter | ikur
|
F | 0.0 | dimensionless | None | |||
Parameter | t
|
model time | F | 0.0 | dimensionless | None |
type | Rules [118] | assignment | name | derived units | sbo | cvterm | |
---|---|---|---|---|---|---|---|
Rule | d v/dt
|
= | None | ||||
Rule | d cai/dt
|
= | None | ||||
Rule | d cass/dt
|
= | None | ||||
Rule | d cajsr/dt
|
= | None | ||||
Rule | d cansr/dt
|
= | None | ||||
Rule | d p_ryr/dt
|
= | None | ||||
Rule | d ltrpn_ca/dt
|
= | None | ||||
Rule | d htrpn_ca/dt
|
= | None | ||||
Rule | d o1/dt
|
= | None | ||||
Rule | d o2/dt
|
= | None | ||||
Rule | d p_c2/dt
|
= | None | ||||
Rule | d o/dt
|
= | None | ||||
Rule | d c2/dt
|
= | None | ||||
Rule | d c3/dt
|
= | None | ||||
Rule | d c4/dt
|
= | None | ||||
Rule | d i1/dt
|
= | None | ||||
Rule | d i2/dt
|
= | None | ||||
Rule | d i3/dt
|
= | None | ||||
Rule | d nai/dt
|
= | None | ||||
Rule | d c_na2/dt
|
= | None | ||||
Rule | d c_na1/dt
|
= | None | ||||
Rule | d o_na/dt
|
= | None | ||||
Rule | d if_na/dt
|
= | None | ||||
Rule | d i1_na/dt
|
= | None | ||||
Rule | d i2_na/dt
|
= | None | ||||
Rule | d ic_na2/dt
|
= | None | ||||
Rule | d ic_na3/dt
|
= | None | ||||
Rule | d ki/dt
|
= | None | ||||
Rule | d ato_f/dt
|
= | None | ||||
Rule | d ito_f/dt
|
= | None | ||||
Rule | d ato_s/dt
|
= | None | ||||
Rule | d ito_s/dt
|
= | None | ||||
Rule | d nks/dt
|
= | None | ||||
Rule | d aur/dt
|
= | None | ||||
Rule | d iur/dt
|
= | None | ||||
Rule | d akss/dt
|
= | None | ||||
Rule | d ikss/dt
|
= | None | ||||
Rule | d c_k2/dt
|
= | None | ||||
Rule | d c_k1/dt
|
= | None | ||||
Rule | d o_k/dt
|
= | None | ||||
Rule | d i_k/dt
|
= | None | ||||
Rule | ts
|
= | None | ||||
Rule | rstar
|
= | None | ||||
Rule | ass
|
= | None | ||||
Rule | e_k
|
= | None | ||||
Rule | i_ks
|
= | None | ||||
Rule | e_na
|
= | None | ||||
Rule | i_kr
|
= | None | ||||
Rule | i_kur
|
= | None | ||||
Rule | sigma
|
= | None | ||||
Rule | f_nak
|
= | None | ||||
Rule | j_leak
|
= | None | ||||
Rule | i_naca
|
= | None | ||||
Rule | o_clca
|
= | None | ||||
Rule | i_clca
|
= | None | ||||
Rule | i_nab
|
= | None | ||||
Rule | tau_kss
|
= | None | ||||
Rule | beta_i1
|
= | None | ||||
Rule | beta
|
= | None | ||||
Rule | i_kss
|
= | None | ||||
Rule | i_k1
|
= | None | ||||
Rule | i_nak
|
= | None | ||||
Rule | j_rel
|
= | None | ||||
Rule | alpha_n
|
= | None | ||||
Rule | alpha_i
|
= | None | ||||
Rule | alpha_a
|
= | None | ||||
Rule | i_pca
|
= | None | ||||
Rule | alpha_i1
|
= | None | ||||
Rule | beta_na13
|
= | None | ||||
Rule | beta_na12
|
= | None | ||||
Rule | beta_na11
|
= | None | ||||
Rule | alpha
|
= | None | ||||
Rule | bi
|
= | None | ||||
Rule | gamma
|
= | None | ||||
Rule | p_c1
|
= | None | ||||
Rule | c1
|
= | None | ||||
Rule | beta_n
|
= | None | ||||
Rule | beta_i
|
= | None | ||||
Rule | beta_a
|
= | None | ||||
Rule | i_kto_s
|
= | None | ||||
Rule | i_kto_f
|
= | None | ||||
Rule | alpha_na3
|
= | None | ||||
Rule | beta_na5
|
= | None | ||||
Rule | beta_na4
|
= | None | ||||
Rule | beta_na3
|
= | None | ||||
Rule | alpha_na13
|
= | None | ||||
Rule | alpha_na2
|
= | None | ||||
Rule | beta_na2
|
= | None | ||||
Rule | bjsr
|
= | None | ||||
Rule | tau_iur
|
= | None | ||||
Rule | e_can
|
= | None | ||||
Rule | i_cab
|
= | None | ||||
Rule | tau_ti_s
|
= | None | ||||
Rule | bss
|
= | None | ||||
Rule | alpha_na12
|
= | None | ||||
Rule | alpha_na11
|
= | None | ||||
Rule | tau_aur
|
= | None | ||||
Rule | beta_a1
|
= | None | ||||
Rule | beta_a0
|
= | None | ||||
Rule | j_xfer
|
= | None | ||||
Rule | tau_ta_s
|
= | None | ||||
Rule | j_up
|
= | None | ||||
Rule | alpha_na5
|
= | None | ||||
Rule | alpha_na4
|
= | None | ||||
Rule | iss
|
= | None | ||||
Rule | kpcf
|
= | None | ||||
Rule | c_k0
|
= | None | ||||
Rule | j_tr
|
= | None | ||||
Rule | alpha_a1
|
= | None | ||||
Rule | alpha_a0
|
= | None | ||||
Rule | j_trpn
|
= | None | ||||
Rule | c_na3
|
= | None | ||||
Rule | i_na
|
= | None | ||||
Rule | i_cal
|
= | None | ||||
Rule | ina
|
= | None | ||||
Rule | ical
|
= | None | ||||
Rule | ikur
|
= | None | ||||
Rule | t
|
= | None |