DallaMan2006 - Glucose Insulin System
Description
This is a A simulation model of the glucose-insulin system in the postprandial state in
SBML format.
This model is described in the article:
Dalla Man C, Rizza RA, Cobelli C.
IEEE Trans Biomed Eng. 2007 Oct;54(10):1740-9.
Abstract:
Asimulation model of the glucose-insulin system in the
postprandial state can be useful in several circumstances, including
testing of glucose sensors, insulin infusion algorithms and decision
support systems for diabetes. Here, we present a new simulation
model in normal humans that describes the physiological events
that occur after a meal, by employing the quantitative knowledge
that has become available in recent years. Model parameters were
set to fit the mean data of a large normal subject database that underwent
a triple tracer meal protocol which provided quasi-modelindependent
estimates of major glucose and insulin fluxes, e.g., meal
rate of appearance, endogenous glucose production, utilization of
glucose, insulin secretion.
The content of this model has been carefully created in a manual research effort.
Terms of use
Copyright © 2021 Matthias Koenig.
Redistribution and use of any part of this model, with or without modification, are permitted provided
that the following conditions are met:
- Redistributions of this SBML file must retain the above copyright notice, this list of conditions and
the following disclaimer.
- Redistributions in a different form must reproduce the above copyright notice, this list of conditions
and the following disclaimer in the documentation and/or other materials provided
with the distribution.
This model is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the
implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.