XPP model
This model was converted from XPP ode format to SBML using sbmlutils-0.1.5a6
.
# PARAMETERS p is=2.5,ton=200,toff=1000 p gm=0 p gnap=0.04,gh=0.05 p gna=100.0,gkdr=20.0,gahp=10.0,gl=0.12 p Cm=1,Vna=55.0,Vk=-90,Vh=-27.4,Vl=-70 p THm=-28.0,Km=-7.8,THh=-50.0,Kh=7.0 p THn=-23.0,Kn=-15.0 p THp=-53.0,Kp=-5.0 p THu=-25.0,Ku=-3,tauu=75.0 p THz=-45.0,Kz=-4.25,tauz=75.0 p THr=-83.9,Kr=7.4 # # # INITIAL CONDITIONS V(0)=-65.84 h(0)=0.92141213 n(0)=0.0497938 z(0)=0.00040176 u(0)=0.00040176 r(0)=0.095137881 # # # FUNCTIONS Ina(V,h)=gna*(minf(V)^3)*h*(V-Vna) minf(V)=1.0/(1.0+exp((V-THm)/Km)) hinf(V)=1.0/(1.0+exp((V-THh)/Kh)) tauh(V)=30.0/(exp((V+50.0)/15.0)+exp(-(V+50.0)/16.0)) # Ikdr(V,n)=gkdr*(n^4)*(V-Vk) ninf(V)=1.0/(1.0+exp((V-THn)/Kn)) taun(V)=7.0/(exp((V+40.0)/40.0)+exp(-(V+40.0)/50.0)) # Inap(V)=gnap*pinf(V)*(V-Vna) pinf(V)=1.0/(1+exp((V-THp)/Kp)) # Im(V,z)=gm*z*(V-Vk) zinf(V)=1.0/(1+exp((V-THz)/Kz)) # Iahp(V,u)=gahp*u*(V-Vk) uinf(V)=1.0/(1+exp((V-THu)/Ku)) # Ih(V,r)=gh*r*(V-Vh) rinf(V)=1.0/(1+exp((V-THr)/Kr)) taur(V)=6000.0/(exp((V+140.0)/21.6)+exp(-(V+40.0)/22.7)) # Il(V)=gl*(V-Vl) # Iapp(t)=is*heav(t-ton)*heav(toff-t) aux I = Iapp(t) # # # # # EQUATIONS V'=(-Ina(V,h)-Ikdr(V,n)-Iahp(V,u)-Im(V,z)-Inap(V)-Ih(V,r)-Il(V)+Iapp(t))/Cm h'=(hinf(v)-h)/tauh(v) n'=(ninf(v)-n)/taun(v) z'=(zinf(v)-z)/tauz u'=(uinf(v)-u)/tauu r'=(rinf(v)-r)/taur(v) # # # # # # xpp formatting @ XP=t @ YP=vs @ TOTAL=1200,DT=0.01 @ MAXSTOR=8000000,BOUNDS=10000,method=runge-kutta @ xlo=0,xhi=1200,ylo=-92,yhi=53 # @ NTST=250,NMAX=55000,NPR=50 @ DS=0.2,DSMIN=0.001,DSMAX=0.3 @ PARMIN=-30,PARMAX=400,NORMMIN=0.0,NORMMAX=10000.0 @ AUTOVAR=vs,AUTOXMIN=-25.0,AUTOXMAX=400.0,AUTOYMIN=-80.0,AUTOYMAX=55.0 done
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Copyright © 2017 Matthias Koenig
Redistribution and use of any part of this model, with or without modification, are permitted provided that the following conditions are met:
- Redistributions of this SBML file must retain the above copyright notice, this list of conditions and the following disclaimer.
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Model :
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type | FunctionDefinitions [22] | name | math | sbo | cvterm |
---|---|---|---|---|---|
FunctionDefinition | max
|
minimum | |||
FunctionDefinition | min
|
maximum | |||
FunctionDefinition | heav
|
heavyside | |||
FunctionDefinition | mod
|
modulo | |||
FunctionDefinition | ina
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FunctionDefinition | minf
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FunctionDefinition | hinf
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FunctionDefinition | tauh
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FunctionDefinition | ikdr
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FunctionDefinition | ninf
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FunctionDefinition | taun
|
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FunctionDefinition | inap
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FunctionDefinition | pinf
|
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FunctionDefinition | im
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FunctionDefinition | zinf
|
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FunctionDefinition | iahp
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FunctionDefinition | uinf
|
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FunctionDefinition | ih
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FunctionDefinition | rinf
|
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FunctionDefinition | taur
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FunctionDefinition | il
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FunctionDefinition | iapp
|
type | Parameters [39] | name | constant | value | unit | derived unit | sbo | cvterm |
---|---|---|---|---|---|---|---|---|
Parameter | is
|
is = 2.5 | F | 2.5 | None | |||
Parameter | ton
|
ton = 200 | F | 200.0 | None | |||
Parameter | toff
|
toff = 1000 | F | 1000.0 | None | |||
Parameter | gm
|
gm = 0 | F | 0.0 | None | |||
Parameter | gnap
|
gnap = 0.04 | F | 0.04 | None | |||
Parameter | gh
|
gh = 0.05 | F | 0.05 | None | |||
Parameter | gna
|
gna = 100.0 | F | 100.0 | None | |||
Parameter | gkdr
|
gkdr = 20.0 | F | 20.0 | None | |||
Parameter | gahp
|
gahp = 10.0 | F | 10.0 | None | |||
Parameter | gl
|
gl = 0.12 | F | 0.12 | None | |||
Parameter | cm
|
cm = 1 | F | 1.0 | None | |||
Parameter | vna
|
vna = 55.0 | F | 55.0 | None | |||
Parameter | vk
|
vk = -90 | F | -90.0 | None | |||
Parameter | vh
|
vh = -27.4 | F | -27.4 | None | |||
Parameter | vl
|
vl = -70 | F | -70.0 | None | |||
Parameter | thm
|
thm = -28.0 | F | -28.0 | None | |||
Parameter | km
|
km = -7.8 | F | -7.8 | None | |||
Parameter | thh
|
thh = -50.0 | F | -50.0 | None | |||
Parameter | kh
|
kh = 7.0 | F | 7.0 | None | |||
Parameter | thn
|
thn = -23.0 | F | -23.0 | None | |||
Parameter | kn
|
kn = -15.0 | F | -15.0 | None | |||
Parameter | thp
|
thp = -53.0 | F | -53.0 | None | |||
Parameter | kp
|
kp = -5.0 | F | -5.0 | None | |||
Parameter | thu
|
thu = -25.0 | F | -25.0 | None | |||
Parameter | ku
|
ku = -3 | F | -3.0 | None | |||
Parameter | tauu
|
tauu = 75.0 | F | 75.0 | None | |||
Parameter | thz
|
thz = -45.0 | F | -45.0 | None | |||
Parameter | kz
|
kz = -4.25 | F | -4.25 | None | |||
Parameter | tauz
|
tauz = 75.0 | F | 75.0 | None | |||
Parameter | thr
|
thr = -83.9 | F | -83.9 | None | |||
Parameter | kr
|
kr = 7.4 | F | 7.4 | None | |||
Parameter | v
|
v = -65.84 | F | -65.84 | None | |||
Parameter | h
|
h = 0.92141213 | F | 0.92141213 | None | |||
Parameter | n
|
n = 0.0497938 | F | 0.0497938 | None | |||
Parameter | z
|
z = 0.00040176 | F | 0.00040176 | None | |||
Parameter | u
|
u = 0.00040176 | F | 0.00040176 | None | |||
Parameter | r
|
r = 0.095137881 | F | 0.095137881 | None | |||
Parameter | i
|
F | 0.0 | dimensionless | None | |||
Parameter | t
|
model time | F | 0.0 | dimensionless | None |
type | Rules [8] | assignment | name | derived units | sbo | cvterm | |
---|---|---|---|---|---|---|---|
Rule | d v/dt
|
= | None | ||||
Rule | d h/dt
|
= | None | ||||
Rule | d n/dt
|
= | None | ||||
Rule | d z/dt
|
= | None | ||||
Rule | d u/dt
|
= | None | ||||
Rule | d r/dt
|
= | None | ||||
Rule | i
|
= | None | ||||
Rule | t
|
= | None |