Model : limax_53

Creator
Matthias, Koenig, Humboldt-University Berlin, Institute for Theoretical Biology, koenigmx@hu-berlin.de
Created: 2019-11-07 17:10
Modified: 2019-11-07 17:10

id limax_53 meta_limax_53
namelimax_53
timeh
substancemmole
extentmmole
volumelitre
aream2
lengthm
L3V1 fbc-V2 comp-V1

BQB_HAS_TAXON
9606
BQB_IS
BTO:0001489; 0003300

PBPK model for methacetin based liver function tests (LiMAx and MBT).

Description

This model is a physiological-base pharmacokinetic model (PBPK) for the absorption, distribution, metabolism and elimination of methacetin, bicarbonate and paracetamol encoded in SBML format.
The model is applied to the analysis of methacetin based breath tests (MBT) and LiMAx.

The content of this model has been carefully created in a manual research effort.
This file has been created by Matthias Koenig.

Terms of use

Copyright © 2019 Matthias Koenig.

Redistribution and use of any part of this model, with or without modification, are permitted provided that the following conditions are met:

  1. Redistributions of this SBML file must retain the above copyright notice, this list of conditions and the following disclaimer.
  2. Redistributions in a different form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.
This model is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.


Ports [14] name referenced element port ref id ref unit ref metaid ref sbo cvterm
Vgu_tissue_port Vgu_tissue_port Vgu_tissue_port Compartment: Vgu_tissue Vgu_tissue
Vgu_blood_port Vgu_blood_port Vgu_blood_port Compartment: Vgu_blood Vgu_blood
Vhe_tissue_port Vhe_tissue_port Vhe_tissue_port Compartment: Vhe_tissue Vhe_tissue
Vhe_blood_port Vhe_blood_port Vhe_blood_port Compartment: Vhe_blood Vhe_blood
Vki_tissue_port Vki_tissue_port Vki_tissue_port Compartment: Vki_tissue Vki_tissue
Vki_blood_port Vki_blood_port Vki_blood_port Compartment: Vki_blood Vki_blood
Vli_tissue_port Vli_tissue_port Vli_tissue_port Compartment: Vli_tissue Vli_tissue
Vli_blood_port Vli_blood_port Vli_blood_port Compartment: Vli_blood Vli_blood
Vlu_tissue_port Vlu_tissue_port Vlu_tissue_port Compartment: Vlu_tissue Vlu_tissue
Vlu_blood_port Vlu_blood_port Vlu_blood_port Compartment: Vlu_blood Vlu_blood
Vsp_tissue_port Vsp_tissue_port Vsp_tissue_port Compartment: Vsp_tissue Vsp_tissue
Vsp_blood_port Vsp_blood_port Vsp_blood_port Compartment: Vsp_blood Vsp_blood
Vre_tissue_port Vre_tissue_port Vre_tissue_port Compartment: Vre_tissue Vre_tissue
Vre_blood_port Vre_blood_port Vre_blood_port Compartment: Vre_blood Vre_blood

UnitDefinitions [35] name units sbo cvterm
h 3600 s
s s
kg 10 3 g
m m
m2 m 2
per_h 1 3600 s
per_min 1 60 s
cm 10 2 m
mg 10 3 g
mmole 10 3 mole
ml 10 3 litre
mg_per_litre 10 3 g litre
mg_per_g 10 3 g g
mg_per_h 10 3 g 3600 s
mmole_per_h 10 3 mole 3600 s
mmole_per_litre 10 3 mole litre
mmole_per_h_l 10 3 mole litre 3600 s
mM 10 3 mole litre
litre_per_h litre 3600 s
litre_per_kg litre 10 3 g
mulitre_per_min_mg 10 6 litre 10 3 g 60 s
g_per_mole g mole
m2_per_kg m 2 10 3 g
mug_per_hkg 10 6 g 10 3 g 3600 mole
mg_per_min 10 3 g 60 s
mmole_per_min 10 3 mole 60 s
mmole_per_minkg 10 3 mole 10 3 g 60 s
mmole_per_hm2 10 3 mole m 2 3600 s
ml_per_s 10 3 litre s
ml_per_skg 10 3 litre 10 3 g s
min_per_h 60 s 3600 s
s_per_min 60 s 3600 s
s_per_h s 3600 s
mulitre_per_g 10 6 litre g
ml_per_litre 10 3 litre litre

Compartments [25] name size constant spatial dimensions units derived units sbo cvterm
Vre meta_Vre rest of body 1.0 3 litre litre
Vhe meta_Vhe heart 1.0 3 litre litre
Vgu meta_Vgu gut 1.0 3 litre litre
Vki meta_Vki kidney 1.0 3 litre litre
Vli meta_Vli liver 1.0 3 litre litre
Vlu meta_Vlu lung 1.0 3 litre litre
Vsp meta_Vsp spleen 1.0 3 litre litre
Vve venous blood 1.0 3 litre litre
Var arterial blood 1.0 3 litre litre
Vbreath meta_Vbreath breath 1.0 3 litre litre
Vurine meta_Vurine urine 1.0 3 litre litre
Vgu_tissue meta_Vgu_tissue gu tissue 1.0 3 litre litre
Vgu_blood meta_Vgu_blood gu blood 1.0 3 litre litre
Vhe_tissue meta_Vhe_tissue he tissue 1.0 3 litre litre
Vhe_blood meta_Vhe_blood he blood 1.0 3 litre litre
Vki_tissue meta_Vki_tissue ki tissue 1.0 3 litre litre
Vki_blood meta_Vki_blood ki blood 1.0 3 litre litre
Vli_tissue meta_Vli_tissue li tissue 1.0 3 litre litre
Vli_blood meta_Vli_blood li blood 1.0 3 litre litre
Vlu_tissue meta_Vlu_tissue lu tissue 1.0 3 litre litre
Vlu_blood meta_Vlu_blood lu blood 1.0 3 litre litre
Vsp_tissue meta_Vsp_tissue sp tissue 1.0 3 litre litre
Vsp_blood meta_Vsp_blood sp blood 1.0 3 litre litre
Vre_tissue meta_Vre_tissue re tissue 1.0 3 litre litre
Vre_blood meta_Vre_blood re blood 1.0 3 litre litre

Species [52] name compartment hasOnlySubstanceUnits boundaryCondition constant initialAmount initialConcentration conversionFactor units substanceUnits derivedUnits sbo cvterm
Ave_metc13 meta_Ave_metc13 C13-methacetin (venous blood)
C9H11NO2
Vve 0.0 mmole mmole 10 3 mole
Agu_metc13 meta_Agu_metc13 C13-methacetin (gut)
C9H11NO2
Vgu_tissue 0.0 mmole mmole 10 3 mole
Agu_blood_metc13 meta_Agu_blood_metc13 C13-methacetin (gut blood)
C9H11NO2
Vgu_blood 0.0 mmole mmole 10 3 mole
Ahe_metc13 meta_Ahe_metc13 C13-methacetin (heart)
C9H11NO2
Vhe_tissue 0.0 mmole mmole 10 3 mole
Ahe_blood_metc13 meta_Ahe_blood_metc13 C13-methacetin (heart blood)
C9H11NO2
Vhe_blood 0.0 mmole mmole 10 3 mole
Aki_metc13 meta_Aki_metc13 C13-methacetin (kidney)
C9H11NO2
Vki_tissue 0.0 mmole mmole 10 3 mole
Aki_blood_metc13 meta_Aki_blood_metc13 C13-methacetin (kidney blood)
C9H11NO2
Vki_blood 0.0 mmole mmole 10 3 mole
Ali_metc13 meta_Ali_metc13 C13-methacetin (liver)
C9H11NO2
Vli_tissue 0.0 mmole mmole 10 3 mole
Ali_blood_metc13 meta_Ali_blood_metc13 C13-methacetin (liver blood)
C9H11NO2
Vli_blood 0.0 mmole mmole 10 3 mole
Alu_metc13 meta_Alu_metc13 C13-methacetin (lung)
C9H11NO2
Vlu_tissue 0.0 mmole mmole 10 3 mole
Alu_blood_metc13 meta_Alu_blood_metc13 C13-methacetin (lung blood)
C9H11NO2
Vlu_blood 0.0 mmole mmole 10 3 mole
Asp_metc13 meta_Asp_metc13 C13-methacetin (spleen)
C9H11NO2
Vsp_tissue 0.0 mmole mmole 10 3 mole
Asp_blood_metc13 meta_Asp_blood_metc13 C13-methacetin (spleen blood)
C9H11NO2
Vsp_blood 0.0 mmole mmole 10 3 mole
Are_metc13 meta_Are_metc13 C13-methacetin (rest)
C9H11NO2
Vre_tissue 0.0 mmole mmole 10 3 mole
Are_blood_metc13 meta_Are_blood_metc13 C13-methacetin (rest blood)
C9H11NO2
Vre_blood 0.0 mmole mmole 10 3 mole
Aar_metc13 meta_Aar_metc13 C13-methacetin (arterial blood)
C9H11NO2
Var 0.0 mmole mmole 10 3 mole
Aurine_metc13 meta_Aurine_metc13 C13-methacetin (urine)
C9H11NO2
Vurine 0.0 mmole mmole 10 3 mole
Ave_co2c13 meta_Ave_co2c13 C13-CO2 (venous blood)
CHO3 (-1)
Vve 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Agu_co2c13 meta_Agu_co2c13 C13-CO2 (gut)
CHO3 (-1)
Vgu_tissue 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Agu_blood_co2c13 meta_Agu_blood_co2c13 C13-CO2 (gut blood)
CHO3 (-1)
Vgu_blood 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Ahe_co2c13 meta_Ahe_co2c13 C13-CO2 (heart)
CHO3 (-1)
Vhe_tissue 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Ahe_blood_co2c13 meta_Ahe_blood_co2c13 C13-CO2 (heart blood)
CHO3 (-1)
Vhe_blood 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Aki_co2c13 meta_Aki_co2c13 C13-CO2 (kidney)
CHO3 (-1)
Vki_tissue 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Aki_blood_co2c13 meta_Aki_blood_co2c13 C13-CO2 (kidney blood)
CHO3 (-1)
Vki_blood 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Ali_co2c13 meta_Ali_co2c13 C13-CO2 (liver)
CHO3 (-1)
Vli_tissue 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Ali_blood_co2c13 meta_Ali_blood_co2c13 C13-CO2 (liver blood)
CHO3 (-1)
Vli_blood 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Alu_co2c13 meta_Alu_co2c13 C13-CO2 (lung)
CHO3 (-1)
Vlu_tissue 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Alu_blood_co2c13 meta_Alu_blood_co2c13 C13-CO2 (lung blood)
CHO3 (-1)
Vlu_blood 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Asp_co2c13 meta_Asp_co2c13 C13-CO2 (spleen)
CHO3 (-1)
Vsp_tissue 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Asp_blood_co2c13 meta_Asp_blood_co2c13 C13-CO2 (spleen blood)
CHO3 (-1)
Vsp_blood 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Are_co2c13 meta_Are_co2c13 C13-CO2 (rest)
CHO3 (-1)
Vre_tissue 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Are_blood_co2c13 meta_Are_blood_co2c13 C13-CO2 (rest blood)
CHO3 (-1)
Vre_blood 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Aar_co2c13 meta_Aar_co2c13 C13-CO2 (arterial blood)
CHO3 (-1)
Var 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Aurine_co2c13 meta_Aurine_co2c13 C13-CO2 (urine)
CHO3 (-1)
Vurine 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357
Ave_apap meta_Ave_apap paracetamol (venous blood)
C8H9NO2
Vve 0.0 mmole mmole 10 3 mole
Agu_apap meta_Agu_apap paracetamol (gut)
C8H9NO2
Vgu_tissue 0.0 mmole mmole 10 3 mole
Agu_blood_apap meta_Agu_blood_apap paracetamol (gut blood)
C8H9NO2
Vgu_blood 0.0 mmole mmole 10 3 mole
Ahe_apap meta_Ahe_apap paracetamol (heart)
C8H9NO2
Vhe_tissue 0.0 mmole mmole 10 3 mole
Ahe_blood_apap meta_Ahe_blood_apap paracetamol (heart blood)
C8H9NO2
Vhe_blood 0.0 mmole mmole 10 3 mole
Aki_apap meta_Aki_apap paracetamol (kidney)
C8H9NO2
Vki_tissue 0.0 mmole mmole 10 3 mole
Aki_blood_apap meta_Aki_blood_apap paracetamol (kidney blood)
C8H9NO2
Vki_blood 0.0 mmole mmole 10 3 mole
Ali_apap meta_Ali_apap paracetamol (liver)
C8H9NO2
Vli_tissue 0.0 mmole mmole 10 3 mole
Ali_blood_apap meta_Ali_blood_apap paracetamol (liver blood)
C8H9NO2
Vli_blood 0.0 mmole mmole 10 3 mole
Alu_apap meta_Alu_apap paracetamol (lung)
C8H9NO2
Vlu_tissue 0.0 mmole mmole 10 3 mole
Alu_blood_apap meta_Alu_blood_apap paracetamol (lung blood)
C8H9NO2
Vlu_blood 0.0 mmole mmole 10 3 mole
Asp_apap meta_Asp_apap paracetamol (spleen)
C8H9NO2
Vsp_tissue 0.0 mmole mmole 10 3 mole
Asp_blood_apap meta_Asp_blood_apap paracetamol (spleen blood)
C8H9NO2
Vsp_blood 0.0 mmole mmole 10 3 mole
Are_apap meta_Are_apap paracetamol (rest)
C8H9NO2
Vre_tissue 0.0 mmole mmole 10 3 mole
Are_blood_apap meta_Are_blood_apap paracetamol (rest blood)
C8H9NO2
Vre_blood 0.0 mmole mmole 10 3 mole
Aar_apap meta_Aar_apap paracetamol (arterial blood)
C8H9NO2
Var 0.0 mmole mmole 10 3 mole
Aurine_apap meta_Aurine_apap paracetamol (urine)
C8H9NO2
Vurine 0.0 mmole mmole 10 3 mole
Abreath_co2c13 meta_Abreath_co2c13 C13-CO2 (breath)
CHO3 (-1)
Vbreath 0.0 mmole mmole 10 3 mole
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
CHEBI:17544; CHEBI:139357

Parameters [152] name constant value unit derived unit sbo cvterm
BW body weight [kg] 75.0 kg 10 3 g
HEIGHT height [cm] 170.0 cm 10 2 m
HR heart rate [1/min] 70.0 per_min 1 60 s
HRrest heart rate [1/min] 70.0 per_min 1 60 s
BSA body surface area [m^2] 0.0 m2 m 2
COBW cardiac output per bodyweight [ml/s/kg] 1.548 ml_per_skg 10 3 litre 10 3 g s
CO cardiac output [ml/s] 108.33 ml_per_s 10 3 litre s
QC cardiac output [L/hr] 389988000.0 litre_per_h litre 3600 s
COHRI increase of cardiac output per heartbeat [ml/min*min] 150.0 ml 10 3 litre
Fblood blood fraction of organ volume 0.02 dimensionless None
FVhe heart fractional tissue volume 0.0047 litre_per_kg litre 10 3 g
FVgu gut fractional tissue volume 0.0171 litre_per_kg litre 10 3 g
FVki kidney fractional tissue volume 0.0044 litre_per_kg litre 10 3 g
FVli liver fractional tissue volume 0.021 litre_per_kg litre 10 3 g
FVlu lung fractional tissue volume 0.0076 litre_per_kg litre 10 3 g
FVsp spleen fractional tissue volume 0.0026 litre_per_kg litre 10 3 g
FVre rest of body fractional tissue volume 0.0 litre_per_kg litre 10 3 g
FVve venous fractional tissue volume 0.0514 litre_per_kg litre 10 3 g
FVar arterial fractional tissue volume 0.0257 litre_per_kg litre 10 3 g
FQhe heart fractional tissue blood flow 0.04 dimensionless None
FQgu gut fractional tissue blood flow 0.146 dimensionless None
FQki kidney fractional tissue blood flow 0.19 dimensionless None
FQh hepatic (venous side) fractional tissue blood flow 0.215 dimensionless None
FQlu lung fractional tissue blood flow 1.0 dimensionless None
FQsp spleen fractional tissue blood flow 0.017 dimensionless None
FQre rest of body fractional tissue blood flow 0.0 dimensionless None
F_PAR parenchymal liver fraction 0.85 dimensionless None
MPPGL mg microsomal protein per g liver parenchym 45.0 mg_per_g 10 3 g g
P_CO2BSA CO2 production per body surface area [mmole/h/m2] 300.0 mmole_per_hm2 10 3 mole m 2 3600 s
R_PDB reference value of 13CO2/12CO2 ratio 0.01123 dimensionless None
Mr_metc13 Molecular weight metc13 [g/mole] 165.19 g_per_mole g mole
IVDOSE_metc13 IV bolus dose metc13 [mg] 0.0 mg 10 3 g
PODOSE_metc13 oral bolus dose {} [mg] 0.0 mg 10 3 g
Ka_metc13 Ka [1/hr] absorption metc13 0.0061 per_h 1 3600 s
F_metc13 fraction absorbed metc13 1.0 dimensionless None
ti_metc13 injection time metc13 [s] 10.0 s s
Ki_metc13 Ki [1/hr] injection metc13 1.0 per_h 1 3600 s
Ri_metc13 Ri [mg/min] rate of injection metc13 0.0 mg_per_min 10 3 g 60 s
cum_dose_metc13 Cumulative dose due to infusion metc13 0.0 mg 10 3 g
BP_metc13 blood to plasma ratio metc13 1.0 dimensionless None
Kp_metc13 partition coefficient (tissue/plasma) metc13 1.0 dimensionless None
Vp_metc13 partition velocity (tissue/plasma) metc13 1.0 per_h 1 3600 s
CLrenal_metc13 renal clearance metc13 [L/hr] 0.0 litre_per_h litre 3600 s
Mr_co2c13 Molecular weight co2c13 [g/mole] 62.02 g_per_mole g mole
IVDOSE_co2c13 IV bolus dose co2c13 [mg] 0.0 mg 10 3 g
PODOSE_co2c13 oral bolus dose {} [mg] 0.0 mg 10 3 g
Ka_co2c13 Ka [1/hr] absorption co2c13 5.87 per_h 1 3600 s
F_co2c13 fraction absorbed co2c13 1.0 dimensionless None
ti_co2c13 injection time co2c13 [s] 10.0 s s
Ki_co2c13 Ki [1/hr] injection co2c13 1.0 per_h 1 3600 s
Ri_co2c13 Ri [mg/min] rate of injection co2c13 0.0 mg_per_min 10 3 g 60 s
cum_dose_co2c13 Cumulative dose due to infusion co2c13 0.0 mg 10 3 g
BP_co2c13 blood to plasma ratio co2c13 1.0 dimensionless None
Kp_co2c13 partition coefficient (tissue/plasma) co2c13 1.0 dimensionless None
Vp_co2c13 partition velocity (tissue/plasma) co2c13 1.0 per_h 1 3600 s
CLrenal_co2c13 renal clearance co2c13 [L/hr] 0.0 litre_per_h litre 3600 s
Mr_apap Molecular weight apap [g/mole] 151.16 g_per_mole g mole
IVDOSE_apap IV bolus dose apap [mg] 0.0 mg 10 3 g
PODOSE_apap oral bolus dose {} [mg] 0.0 mg 10 3 g
Ka_apap Ka [1/hr] absorption apap 2.47 per_h 1 3600 s
F_apap fraction absorbed apap 0.87 dimensionless None
ti_apap injection time apap [s] 10.0 s s
Ki_apap Ki [1/hr] injection apap 1.0 per_h 1 3600 s
Ri_apap Ri [mg/min] rate of injection apap 0.0 mg_per_min 10 3 g 60 s
cum_dose_apap Cumulative dose due to infusion apap 0.0 mg 10 3 g
BP_apap blood to plasma ratio apap 1.0 dimensionless None
Kp_apap partition coefficient (tissue/plasma) apap 1.0 dimensionless None
Vp_apap partition velocity (tissue/plasma) apap 1.0 per_h 1 3600 s
CLrenal_apap renal clearance apap [L/hr] 0.714 litre_per_h litre 3600 s
P_CO2 BSA P_CO2BSA 60 mmole_per_min 10 3 mole 60 s
P_CO2c13 R_PDB 1 R_PDB P_CO2 Exhalation_co2c13 60 mmole_per_min 10 3 mole 60 s
P_CO2c12 1 1 R_PDB P_CO2 mmole_per_min 10 3 mole 60 s
P_CO2R P_CO2c13 P_CO2c12 dimensionless None
P_CO2Fc13 P_CO2c13 P_CO2c12 P_CO2c13 dimensionless None
DOB P_CO2c13 P_CO2c12 R_PDB R_PDB 1000 dimensionless None
Qhe heart blood flow QC FQhe litre_per_h litre 3600 s
Qgu gut blood flow QC FQgu litre_per_h litre 3600 s
Qki kidney blood flow QC FQki litre_per_h litre 3600 s
Qh hepatic (venous side) blood flow QC FQh litre_per_h litre 3600 s
Qha hepatic artery blood flow Qh Qgu Qsp litre_per_h litre 3600 s
Qlu lung blood flow QC FQlu litre_per_h litre 3600 s
Qsp spleen blood flow QC FQsp litre_per_h litre 3600 s
Qre rest of body blood flow QC FQre litre_per_h litre 3600 s
Cpl_ve_metc13 C13-methacetin venous plasma concentration Cve_metc13 BP_metc13 mM 10 3 mole litre
Cve_metc13 C13-methacetin concentration (venous blood) Ave_metc13 Vve mM 10 3 mole litre
Mve_metc13 C13-methacetin amount (venous blood) Cve_metc13 Mr_metc13 mg_per_litre 10 3 g litre
Cgu_metc13 C13-methacetin concentration (gut) Agu_metc13 Vgu_tissue mM 10 3 mole litre
Cgu_blood_metc13 C13-methacetin concentration (gut) Agu_blood_metc13 Vgu_blood mM 10 3 mole litre
Che_metc13 C13-methacetin concentration (heart) Ahe_metc13 Vhe_tissue mM 10 3 mole litre
Che_blood_metc13 C13-methacetin concentration (heart) Ahe_blood_metc13 Vhe_blood mM 10 3 mole litre
Cki_metc13 C13-methacetin concentration (kidney) Aki_metc13 Vki_tissue mM 10 3 mole litre
Cki_blood_metc13 C13-methacetin concentration (kidney) Aki_blood_metc13 Vki_blood mM 10 3 mole litre
Cli_metc13 C13-methacetin concentration (liver) Ali_metc13 Vli_tissue mM 10 3 mole litre
Cli_blood_metc13 C13-methacetin concentration (liver) Ali_blood_metc13 Vli_blood mM 10 3 mole litre
Clu_metc13 C13-methacetin concentration (lung) Alu_metc13 Vlu_tissue mM 10 3 mole litre
Clu_blood_metc13 C13-methacetin concentration (lung) Alu_blood_metc13 Vlu_blood mM 10 3 mole litre
Csp_metc13 C13-methacetin concentration (spleen) Asp_metc13 Vsp_tissue mM 10 3 mole litre
Csp_blood_metc13 C13-methacetin concentration (spleen) Asp_blood_metc13 Vsp_blood mM 10 3 mole litre
Cre_metc13 C13-methacetin concentration (rest) Are_metc13 Vre_tissue mM 10 3 mole litre
Cre_blood_metc13 C13-methacetin concentration (rest) Are_blood_metc13 Vre_blood mM 10 3 mole litre
Car_metc13 C13-methacetin concentration (arterial blood) Aar_metc13 Var mM 10 3 mole litre
Mar_metc13 C13-methacetin amount (arterial blood) Car_metc13 Mr_metc13 mg_per_litre 10 3 g litre
Xurine_metc13 C13-methacetin amount (urine) Aurine_metc13 Mr_metc13 mg 10 3 g
Cpl_ve_co2c13 C13-CO2 venous plasma concentration Cve_co2c13 BP_co2c13 mM 10 3 mole litre
Cve_co2c13 C13-CO2 concentration (venous blood) Ave_co2c13 Vve mM 10 3 mole litre
Mve_co2c13 C13-CO2 amount (venous blood) Cve_co2c13 Mr_co2c13 mg_per_litre 10 3 g litre
Cgu_co2c13 C13-CO2 concentration (gut) Agu_co2c13 Vgu_tissue mM 10 3 mole litre
Cgu_blood_co2c13 C13-CO2 concentration (gut) Agu_blood_co2c13 Vgu_blood mM 10 3 mole litre
Che_co2c13 C13-CO2 concentration (heart) Ahe_co2c13 Vhe_tissue mM 10 3 mole litre
Che_blood_co2c13 C13-CO2 concentration (heart) Ahe_blood_co2c13 Vhe_blood mM 10 3 mole litre
Cki_co2c13 C13-CO2 concentration (kidney) Aki_co2c13 Vki_tissue mM 10 3 mole litre
Cki_blood_co2c13 C13-CO2 concentration (kidney) Aki_blood_co2c13 Vki_blood mM 10 3 mole litre
Cli_co2c13 C13-CO2 concentration (liver) Ali_co2c13 Vli_tissue mM 10 3 mole litre
Cli_blood_co2c13 C13-CO2 concentration (liver) Ali_blood_co2c13 Vli_blood mM 10 3 mole litre
Clu_co2c13 C13-CO2 concentration (lung) Alu_co2c13 Vlu_tissue mM 10 3 mole litre
Clu_blood_co2c13 C13-CO2 concentration (lung) Alu_blood_co2c13 Vlu_blood mM 10 3 mole litre
Csp_co2c13 C13-CO2 concentration (spleen) Asp_co2c13 Vsp_tissue mM 10 3 mole litre
Csp_blood_co2c13 C13-CO2 concentration (spleen) Asp_blood_co2c13 Vsp_blood mM 10 3 mole litre
Cre_co2c13 C13-CO2 concentration (rest) Are_co2c13 Vre_tissue mM 10 3 mole litre
Cre_blood_co2c13 C13-CO2 concentration (rest) Are_blood_co2c13 Vre_blood mM 10 3 mole litre
Car_co2c13 C13-CO2 concentration (arterial blood) Aar_co2c13 Var mM 10 3 mole litre
Mar_co2c13 C13-CO2 amount (arterial blood) Car_co2c13 Mr_co2c13 mg_per_litre 10 3 g litre
Xurine_co2c13 C13-CO2 amount (urine) Aurine_co2c13 Mr_co2c13 mg 10 3 g
Cpl_ve_apap paracetamol venous plasma concentration Cve_apap BP_apap mM 10 3 mole litre
Cve_apap paracetamol concentration (venous blood) Ave_apap Vve mM 10 3 mole litre
Mve_apap paracetamol amount (venous blood) Cve_apap Mr_apap mg_per_litre 10 3 g litre
Cgu_apap paracetamol concentration (gut) Agu_apap Vgu_tissue mM 10 3 mole litre
Cgu_blood_apap paracetamol concentration (gut) Agu_blood_apap Vgu_blood mM 10 3 mole litre
Che_apap paracetamol concentration (heart) Ahe_apap Vhe_tissue mM 10 3 mole litre
Che_blood_apap paracetamol concentration (heart) Ahe_blood_apap Vhe_blood mM 10 3 mole litre
Cki_apap paracetamol concentration (kidney) Aki_apap Vki_tissue mM 10 3 mole litre
Cki_blood_apap paracetamol concentration (kidney) Aki_blood_apap Vki_blood mM 10 3 mole litre
Cli_apap paracetamol concentration (liver) Ali_apap Vli_tissue mM 10 3 mole litre
Cli_blood_apap paracetamol concentration (liver) Ali_blood_apap Vli_blood mM 10 3 mole litre
Clu_apap paracetamol concentration (lung) Alu_apap Vlu_tissue mM 10 3 mole litre
Clu_blood_apap paracetamol concentration (lung) Alu_blood_apap Vlu_blood mM 10 3 mole litre
Csp_apap paracetamol concentration (spleen) Asp_apap Vsp_tissue mM 10 3 mole litre
Csp_blood_apap paracetamol concentration (spleen) Asp_blood_apap Vsp_blood mM 10 3 mole litre
Cre_apap paracetamol concentration (rest) Are_apap Vre_tissue mM 10 3 mole litre
Cre_blood_apap paracetamol concentration (rest) Are_blood_apap Vre_blood mM 10 3 mole litre
Car_apap paracetamol concentration (arterial blood) Aar_apap Var mM 10 3 mole litre
Mar_apap paracetamol amount (arterial blood) Car_apap Mr_apap mg_per_litre 10 3 g litre
Xurine_apap paracetamol amount (urine) Aurine_apap Mr_apap mg 10 3 g
Xbreath_co2c13 C13-CO2 amount (breath) Abreath_co2c13 Mr_co2c13 mg 10 3 g
CYP1A2MET_CL HLM apparent clearance by hepatic microsomes [mul/min/mg] 1.5 mulitre_per_min_mg 10 6 litre 10 3 g 60 s
CYP1A2MET_Km_met meta_CYP1A2MET_Km_met 0.02 mM 10 3 mole litre
CYP1A2MET_CLliv liver clearance [l/hr] CYP1A2MET_CL MPPGL Vli F_PAR 60 1000 litre_per_h litre 3600 s
APAPD_CL HLM apparent clearance by hepatic microsomes [mul/min/mg] 2.21 mulitre_per_min_mg 10 6 litre 10 3 g 60 s
APAPD_Km_apap meta_APAPD_Km_apap 0.35 mM 10 3 mole litre
APAPD_CLliv liver clearance [l/hr] APAPD_CL MPPGL Vli F_PAR 60 1000 litre_per_h litre 3600 s
EXHCO2_CL CO2 rate of disposal in air [mmole/min] 10.0 mmole_per_min 10 3 mole 60 s
EXHCO2_Km_co2 meta_EXHCO2_Km_co2 Km CO2 rate of disposal in air [mM] 0.5 mM 10 3 mole litre

Rules [117]   assignment name derived units sbo cvterm
FVre = 1 FVhe FVgu FVki FVli FVlu FVsp FVve FVar litre 10 3 g
FQre = 1 FQhe FQgu FQki FQh FQsp None
BSA = 0.024265 BW 1 0.5378 HEIGHT 1 0.3964 m 2
CO = BW COBW HR HRrest COHRI 60 10 3 litre s
QC = CO 1000 3600 0.000277777777777778 litre s
P_CO2 = BSA P_CO2BSA 60 0.0599999999999999 mole 3600 s
P_CO2c13 = R_PDB 1 R_PDB P_CO2 Exhalation_co2c13 60 0.001 mole 60 s
P_CO2c12 = 1 1 R_PDB P_CO2 0.001 mole 60 s
P_CO2R = P_CO2c13 P_CO2c12 None
P_CO2Fc13 = P_CO2c13 P_CO2c12 P_CO2c13 None
DOB = P_CO2c13 P_CO2c12 R_PDB R_PDB 1000 None
Vhe = BW FVhe litre
Vgu = BW FVgu litre
Vki = BW FVki litre
Vli = BW FVli litre
Vlu = BW FVlu litre
Vsp = BW FVsp litre
Vre = BW FVre litre
Vve = BW FVve FVve FVar FVve BW Fblood 1 FVve FVar litre
Var = BW FVar FVar FVar FVve BW Fblood 1 FVve FVar litre
Qhe = QC FQhe litre 3600 s
Qgu = QC FQgu litre 3600 s
Qki = QC FQki litre 3600 s
Qh = QC FQh litre 3600 s
Qha = Qh Qgu Qsp litre 3600 s
Qlu = QC FQlu litre 3600 s
Qsp = QC FQsp litre 3600 s
Qre = QC FQre litre 3600 s
Vgu_tissue = Vgu 1 Fblood litre
Vgu_blood = Vgu Fblood litre
Vhe_tissue = Vhe 1 Fblood litre
Vhe_blood = Vhe Fblood litre
Vki_tissue = Vki 1 Fblood litre
Vki_blood = Vki Fblood litre
Vli_tissue = Vli 1 Fblood litre
Vli_blood = Vli Fblood litre
Vlu_tissue = Vlu 1 Fblood litre
Vlu_blood = Vlu Fblood litre
Vsp_tissue = Vsp 1 Fblood litre
Vsp_blood = Vsp Fblood litre
Vre_tissue = Vre 1 Fblood litre
Vre_blood = Vre Fblood litre
Cpl_ve_metc13 = Cve_metc13 BP_metc13 0.001 mole litre
Ki_metc13 = 1.386 ti_metc13 3600 1 3600 s
Cve_metc13 = Ave_metc13 Vve 10 3 mole litre
Mve_metc13 = Cve_metc13 Mr_metc13 g 1000 litre
Cgu_metc13 = Agu_metc13 Vgu_tissue 10 3 mole litre
Cgu_blood_metc13 = Agu_blood_metc13 Vgu_blood 10 3 mole litre
Che_metc13 = Ahe_metc13 Vhe_tissue 10 3 mole litre
Che_blood_metc13 = Ahe_blood_metc13 Vhe_blood 10 3 mole litre
Cki_metc13 = Aki_metc13 Vki_tissue 10 3 mole litre
Cki_blood_metc13 = Aki_blood_metc13 Vki_blood 10 3 mole litre
Cli_metc13 = Ali_metc13 Vli_tissue 10 3 mole litre
Cli_blood_metc13 = Ali_blood_metc13 Vli_blood 10 3 mole litre
Clu_metc13 = Alu_metc13 Vlu_tissue 10 3 mole litre
Clu_blood_metc13 = Alu_blood_metc13 Vlu_blood 10 3 mole litre
Csp_metc13 = Asp_metc13 Vsp_tissue 10 3 mole litre
Csp_blood_metc13 = Asp_blood_metc13 Vsp_blood 10 3 mole litre
Cre_metc13 = Are_metc13 Vre_tissue 10 3 mole litre
Cre_blood_metc13 = Are_blood_metc13 Vre_blood 10 3 mole litre
Car_metc13 = Aar_metc13 Var 10 3 mole litre
Mar_metc13 = Car_metc13 Mr_metc13 g 1000 litre
Xurine_metc13 = Aurine_metc13 Mr_metc13 0.001 g
Cpl_ve_co2c13 = Cve_co2c13 BP_co2c13 0.001 mole litre
Ki_co2c13 = 1.386 ti_co2c13 3600 1 3600 s
Cve_co2c13 = Ave_co2c13 Vve 10 3 mole litre
Mve_co2c13 = Cve_co2c13 Mr_co2c13 g 1000 litre
Cgu_co2c13 = Agu_co2c13 Vgu_tissue 10 3 mole litre
Cgu_blood_co2c13 = Agu_blood_co2c13 Vgu_blood 10 3 mole litre
Che_co2c13 = Ahe_co2c13 Vhe_tissue 10 3 mole litre
Che_blood_co2c13 = Ahe_blood_co2c13 Vhe_blood 10 3 mole litre
Cki_co2c13 = Aki_co2c13 Vki_tissue 10 3 mole litre
Cki_blood_co2c13 = Aki_blood_co2c13 Vki_blood 10 3 mole litre
Cli_co2c13 = Ali_co2c13 Vli_tissue 10 3 mole litre
Cli_blood_co2c13 = Ali_blood_co2c13 Vli_blood 10 3 mole litre
Clu_co2c13 = Alu_co2c13 Vlu_tissue 10 3 mole litre
Clu_blood_co2c13 = Alu_blood_co2c13 Vlu_blood 10 3 mole litre
Csp_co2c13 = Asp_co2c13 Vsp_tissue 10 3 mole litre
Csp_blood_co2c13 = Asp_blood_co2c13 Vsp_blood 10 3 mole litre
Cre_co2c13 = Are_co2c13 Vre_tissue 10 3 mole litre
Cre_blood_co2c13 = Are_blood_co2c13 Vre_blood 10 3 mole litre
Car_co2c13 = Aar_co2c13 Var 10 3 mole litre
Mar_co2c13 = Car_co2c13 Mr_co2c13 g 1000 litre
Xurine_co2c13 = Aurine_co2c13 Mr_co2c13 0.001 g
Cpl_ve_apap = Cve_apap BP_apap 0.001 mole litre
Ki_apap = 1.386 ti_apap 3600 1 3600 s
Cve_apap = Ave_apap Vve 10 3 mole litre
Mve_apap = Cve_apap Mr_apap g 1000 litre
Cgu_apap = Agu_apap Vgu_tissue 10 3 mole litre
Cgu_blood_apap = Agu_blood_apap Vgu_blood 10 3 mole litre
Che_apap = Ahe_apap Vhe_tissue 10 3 mole litre
Che_blood_apap = Ahe_blood_apap Vhe_blood 10 3 mole litre
Cki_apap = Aki_apap Vki_tissue 10 3 mole litre
Cki_blood_apap = Aki_blood_apap Vki_blood 10 3 mole litre
Cli_apap = Ali_apap Vli_tissue 10 3 mole litre
Cli_blood_apap = Ali_blood_apap Vli_blood 10 3 mole litre
Clu_apap = Alu_apap Vlu_tissue 10 3 mole litre
Clu_blood_apap = Alu_blood_apap Vlu_blood 10 3 mole litre
Csp_apap = Asp_apap Vsp_tissue 10 3 mole litre
Csp_blood_apap = Asp_blood_apap Vsp_blood 10 3 mole litre
Cre_apap = Are_apap Vre_tissue 10 3 mole litre
Cre_blood_apap = Are_blood_apap Vre_blood 10 3 mole litre
Car_apap = Aar_apap Var 10 3 mole litre
Mar_apap = Car_apap Mr_apap g 1000 litre
Xurine_apap = Aurine_apap Mr_apap 0.001 g
Xbreath_co2c13 = Abreath_co2c13 Mr_co2c13 0.001 g
d PODOSE_metc13/dt = Absorption_metc13 Mr_metc13 g 3600000 s
d IVDOSE_metc13/dt = Injection_metc13 Mr_metc13 g 3600000 s
d cum_dose_metc13/dt = Ri_metc13 60 1.66666666666667 -5 g 60 s
d PODOSE_co2c13/dt = Absorption_co2c13 Mr_co2c13 g 3600000 s
d IVDOSE_co2c13/dt = Injection_co2c13 Mr_co2c13 g 3600000 s
d cum_dose_co2c13/dt = Ri_co2c13 60 1.66666666666667 -5 g 60 s
d PODOSE_apap/dt = Absorption_apap Mr_apap g 3600000 s
d IVDOSE_apap/dt = Injection_apap Mr_apap g 3600000 s
d cum_dose_apap/dt = Ri_apap 60 1.66666666666667 -5 g 60 s
CYP1A2MET_CLliv = CYP1A2MET_CL MPPGL Vli F_PAR 60 1000 0.0166666666666667 litre 60 s
APAPD_CLliv = APAPD_CL MPPGL Vli F_PAR 60 1000 0.0166666666666667 litre 60 s

Reactions [78] name equation modifiers kinetic law derived units sbo cvterm
CYP1A2MET meta_CYP1A2MET CYP1A2_MET (CYP1A2) [metc13 -> apap + co2c13]
Ali_metc13 ➞ Ali_apap + Ali_co2c13 CYP1A2MET_CLliv 1 Cli_metc13 Cli_metc13 CYP1A2MET_Km_met 0.001 mole 3600 s
APAPD meta_APAPD APAP clearance liver (apap -> )
Ali_apap ➞ APAPD_CLliv 1 Cli_apap Cli_apap APAPD_Km_apap 0.001 mole 3600 s
Exhalation_co2c13 meta_Exhalation_co2c13 exhalation C13-CO2
Alu_co2c13 ➞ Abreath_co2c13 EXHCO2_CL 60 Clu_co2c13 EXHCO2_Km_co2 Clu_co2c13 1.66666666666668 -5 mole 60 s
Injection_metc13 meta_Injection_metc13 injection C13-methacetin
➞ Ave_metc13 Ki_metc13 IVDOSE_metc13 Mr_metc13 mole 3600000 s
Infusion_metc13 meta_Infusion_metc13 infusion C13-methacetin
➞ Ave_metc13 Ri_metc13 Mr_metc13 60 mole 3599999.99999999 s
BQB_HAS_PROPERTY
CHEBI:139355; CHEBI:139357
Absorption_metc13 meta_Absorption_metc13 absorption C13-methacetin
➞ Agu_blood_metc13 Ka_metc13 PODOSE_metc13 Mr_metc13 F_metc13 mole 3600000 s
RenalClearance_metc13 meta_RenalClearance_metc13 clearance C13-methacetin (kidney)
Aki_metc13 ➞ Aurine_metc13 CLrenal_metc13 Cki_metc13 10 3 mole 3600 s
import_gu_metc13 meta_import_gu_metc13 import gut C13-methacetin
Agu_blood_metc13 ⇆ Agu_metc13 Vp_metc13 Vgu_tissue Kp_metc13 Cgu_blood_metc13 Cgu_metc13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:139355; CHEBI:139357
Flow_ar_gu_metc13 meta_Flow_ar_gu_metc13 inflow gut C13-methacetin
Aar_metc13 ➞ Agu_blood_metc13 Qgu Car_metc13 10 3 mole 3600 s
Flow_gu_li_metc13 meta_Flow_gu_li_metc13 outflow gut C13-methacetin
Agu_blood_metc13 ➞ Ali_blood_metc13 Qgu Cgu_blood_metc13 BP_metc13 0.001 mole 3600 s
import_he_metc13 meta_import_he_metc13 import heart C13-methacetin
Ahe_blood_metc13 ⇆ Ahe_metc13 Vp_metc13 Vhe_tissue Kp_metc13 Che_blood_metc13 Che_metc13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:139355; CHEBI:139357
Flow_ar_he_metc13 meta_Flow_ar_he_metc13 inflow heart C13-methacetin
Aar_metc13 ➞ Ahe_blood_metc13 Qhe Car_metc13 10 3 mole 3600 s
Flow_he_ve_metc13 meta_Flow_he_ve_metc13 outflow heart C13-methacetin
Ahe_blood_metc13 ➞ Ave_metc13 Qhe Che_blood_metc13 BP_metc13 0.001 mole 3600 s
import_ki_metc13 meta_import_ki_metc13 import kidney C13-methacetin
Aki_blood_metc13 ⇆ Aki_metc13 Vp_metc13 Vki_tissue Kp_metc13 Cki_blood_metc13 Cki_metc13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:139355; CHEBI:139357
Flow_ar_ki_metc13 meta_Flow_ar_ki_metc13 inflow kidney C13-methacetin
Aar_metc13 ➞ Aki_blood_metc13 Qki Car_metc13 10 3 mole 3600 s
Flow_ki_ve_metc13 meta_Flow_ki_ve_metc13 outflow kidney C13-methacetin
Aki_blood_metc13 ➞ Ave_metc13 Qki Cki_blood_metc13 BP_metc13 0.001 mole 3600 s
import_li_metc13 meta_import_li_metc13 import liver C13-methacetin
Ali_blood_metc13 ⇆ Ali_metc13 Vp_metc13 Vli_tissue Kp_metc13 Cli_blood_metc13 Cli_metc13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:139355; CHEBI:139357
Flow_ar_li_metc13 meta_Flow_ar_li_metc13 inflow liver C13-methacetin
Aar_metc13 ➞ Ali_blood_metc13 Qha Car_metc13 10 3 mole 3600 s
Flow_li_ve_metc13 meta_Flow_li_ve_metc13 outflow liver C13-methacetin
Ali_blood_metc13 ➞ Ave_metc13 Qh Cli_blood_metc13 BP_metc13 0.001 mole 3600 s
import_lu_metc13 meta_import_lu_metc13 import lung C13-methacetin
Alu_blood_metc13 ⇆ Alu_metc13 Vp_metc13 Vlu_tissue Kp_metc13 Clu_blood_metc13 Clu_metc13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:139355; CHEBI:139357
Flow_ve_lu_metc13 meta_Flow_ve_lu_metc13 inflow lung C13-methacetin
Ave_metc13 ➞ Alu_blood_metc13 Qlu Cve_metc13 10 3 mole 3600 s
Flow_lu_ar_metc13 meta_Flow_lu_ar_metc13 outflow lung C13-methacetin
Alu_blood_metc13 ➞ Aar_metc13 Qlu Clu_blood_metc13 BP_metc13 0.001 mole 3600 s
import_sp_metc13 meta_import_sp_metc13 import spleen C13-methacetin
Asp_blood_metc13 ⇆ Asp_metc13 Vp_metc13 Vsp_tissue Kp_metc13 Csp_blood_metc13 Csp_metc13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:139355; CHEBI:139357
Flow_ar_sp_metc13 meta_Flow_ar_sp_metc13 inflow spleen C13-methacetin
Aar_metc13 ➞ Asp_blood_metc13 Qsp Car_metc13 10 3 mole 3600 s
Flow_sp_li_metc13 meta_Flow_sp_li_metc13 outflow spleen C13-methacetin
Asp_blood_metc13 ➞ Ali_blood_metc13 Qsp Csp_blood_metc13 BP_metc13 0.001 mole 3600 s
import_re_metc13 meta_import_re_metc13 import rest C13-methacetin
Are_blood_metc13 ⇆ Are_metc13 Vp_metc13 Vre_tissue Kp_metc13 Cre_blood_metc13 Cre_metc13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:139355; CHEBI:139357
Flow_ar_re_metc13 meta_Flow_ar_re_metc13 inflow rest C13-methacetin
Aar_metc13 ➞ Are_blood_metc13 Qre Car_metc13 10 3 mole 3600 s
Flow_re_ve_metc13 meta_Flow_re_ve_metc13 outflow rest C13-methacetin
Are_blood_metc13 ➞ Ave_metc13 Qre Cre_blood_metc13 BP_metc13 0.001 mole 3600 s
Injection_co2c13 meta_Injection_co2c13 injection C13-CO2
➞ Ave_co2c13 Ki_co2c13 IVDOSE_co2c13 Mr_co2c13 mole 3600000 s
Infusion_co2c13 meta_Infusion_co2c13 infusion C13-CO2
➞ Ave_co2c13 Ri_co2c13 Mr_co2c13 60 mole 3599999.99999999 s
BQB_HAS_PROPERTY
CHEBI:17544; CHEBI:139357
Absorption_co2c13 meta_Absorption_co2c13 absorption C13-CO2
➞ Agu_blood_co2c13 Ka_co2c13 PODOSE_co2c13 Mr_co2c13 F_co2c13 mole 3600000 s
RenalClearance_co2c13 meta_RenalClearance_co2c13 clearance C13-CO2 (kidney)
Aki_co2c13 ➞ Aurine_co2c13 CLrenal_co2c13 Cki_co2c13 10 3 mole 3600 s
import_gu_co2c13 meta_import_gu_co2c13 import gut C13-CO2
Agu_blood_co2c13 ⇆ Agu_co2c13 Vp_co2c13 Vgu_tissue Kp_co2c13 Cgu_blood_co2c13 Cgu_co2c13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:17544; CHEBI:139357
Flow_ar_gu_co2c13 meta_Flow_ar_gu_co2c13 inflow gut C13-CO2
Aar_co2c13 ➞ Agu_blood_co2c13 Qgu Car_co2c13 10 3 mole 3600 s
Flow_gu_li_co2c13 meta_Flow_gu_li_co2c13 outflow gut C13-CO2
Agu_blood_co2c13 ➞ Ali_blood_co2c13 Qgu Cgu_blood_co2c13 BP_co2c13 0.001 mole 3600 s
import_he_co2c13 meta_import_he_co2c13 import heart C13-CO2
Ahe_blood_co2c13 ⇆ Ahe_co2c13 Vp_co2c13 Vhe_tissue Kp_co2c13 Che_blood_co2c13 Che_co2c13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:17544; CHEBI:139357
Flow_ar_he_co2c13 meta_Flow_ar_he_co2c13 inflow heart C13-CO2
Aar_co2c13 ➞ Ahe_blood_co2c13 Qhe Car_co2c13 10 3 mole 3600 s
Flow_he_ve_co2c13 meta_Flow_he_ve_co2c13 outflow heart C13-CO2
Ahe_blood_co2c13 ➞ Ave_co2c13 Qhe Che_blood_co2c13 BP_co2c13 0.001 mole 3600 s
import_ki_co2c13 meta_import_ki_co2c13 import kidney C13-CO2
Aki_blood_co2c13 ⇆ Aki_co2c13 Vp_co2c13 Vki_tissue Kp_co2c13 Cki_blood_co2c13 Cki_co2c13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:17544; CHEBI:139357
Flow_ar_ki_co2c13 meta_Flow_ar_ki_co2c13 inflow kidney C13-CO2
Aar_co2c13 ➞ Aki_blood_co2c13 Qki Car_co2c13 10 3 mole 3600 s
Flow_ki_ve_co2c13 meta_Flow_ki_ve_co2c13 outflow kidney C13-CO2
Aki_blood_co2c13 ➞ Ave_co2c13 Qki Cki_blood_co2c13 BP_co2c13 0.001 mole 3600 s
import_li_co2c13 meta_import_li_co2c13 import liver C13-CO2
Ali_blood_co2c13 ⇆ Ali_co2c13 Vp_co2c13 Vli_tissue Kp_co2c13 Cli_blood_co2c13 Cli_co2c13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:17544; CHEBI:139357
Flow_ar_li_co2c13 meta_Flow_ar_li_co2c13 inflow liver C13-CO2
Aar_co2c13 ➞ Ali_blood_co2c13 Qha Car_co2c13 10 3 mole 3600 s
Flow_li_ve_co2c13 meta_Flow_li_ve_co2c13 outflow liver C13-CO2
Ali_blood_co2c13 ➞ Ave_co2c13 Qh Cli_blood_co2c13 BP_co2c13 0.001 mole 3600 s
import_lu_co2c13 meta_import_lu_co2c13 import lung C13-CO2
Alu_blood_co2c13 ⇆ Alu_co2c13 Vp_co2c13 Vlu_tissue Kp_co2c13 Clu_blood_co2c13 Clu_co2c13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:17544; CHEBI:139357
Flow_ve_lu_co2c13 meta_Flow_ve_lu_co2c13 inflow lung C13-CO2
Ave_co2c13 ➞ Alu_blood_co2c13 Qlu Cve_co2c13 10 3 mole 3600 s
Flow_lu_ar_co2c13 meta_Flow_lu_ar_co2c13 outflow lung C13-CO2
Alu_blood_co2c13 ➞ Aar_co2c13 Qlu Clu_blood_co2c13 BP_co2c13 0.001 mole 3600 s
import_sp_co2c13 meta_import_sp_co2c13 import spleen C13-CO2
Asp_blood_co2c13 ⇆ Asp_co2c13 Vp_co2c13 Vsp_tissue Kp_co2c13 Csp_blood_co2c13 Csp_co2c13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:17544; CHEBI:139357
Flow_ar_sp_co2c13 meta_Flow_ar_sp_co2c13 inflow spleen C13-CO2
Aar_co2c13 ➞ Asp_blood_co2c13 Qsp Car_co2c13 10 3 mole 3600 s
Flow_sp_li_co2c13 meta_Flow_sp_li_co2c13 outflow spleen C13-CO2
Asp_blood_co2c13 ➞ Ali_blood_co2c13 Qsp Csp_blood_co2c13 BP_co2c13 0.001 mole 3600 s
import_re_co2c13 meta_import_re_co2c13 import rest C13-CO2
Are_blood_co2c13 ⇆ Are_co2c13 Vp_co2c13 Vre_tissue Kp_co2c13 Cre_blood_co2c13 Cre_co2c13 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:17544; CHEBI:139357
Flow_ar_re_co2c13 meta_Flow_ar_re_co2c13 inflow rest C13-CO2
Aar_co2c13 ➞ Are_blood_co2c13 Qre Car_co2c13 10 3 mole 3600 s
Flow_re_ve_co2c13 meta_Flow_re_ve_co2c13 outflow rest C13-CO2
Are_blood_co2c13 ➞ Ave_co2c13 Qre Cre_blood_co2c13 BP_co2c13 0.001 mole 3600 s
Injection_apap meta_Injection_apap injection paracetamol
➞ Ave_apap Ki_apap IVDOSE_apap Mr_apap mole 3600000 s
BQB_IS
SBO:0000375; OBI:0000426
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Infusion_apap meta_Infusion_apap infusion paracetamol
➞ Ave_apap Ri_apap Mr_apap 60 mole 3599999.99999999 s
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Absorption_apap meta_Absorption_apap absorption paracetamol
➞ Agu_blood_apap Ka_apap PODOSE_apap Mr_apap F_apap mole 3600000 s
BQB_IS
SBO:0000375; 0001059
BQB_HAS_PROPERTY
CHEBI:46195; C06804
RenalClearance_apap meta_RenalClearance_apap clearance paracetamol (kidney)
Aki_apap ➞ Aurine_apap CLrenal_apap Cki_apap 10 3 mole 3600 s
BQB_IS
SBO:0000375; C75913; MI:2123
BQB_HAS_PROPERTY
CHEBI:46195; C06804
import_gu_apap meta_import_gu_apap import gut paracetamol
Agu_blood_apap ⇆ Agu_apap Vp_apap Vgu_tissue Kp_apap Cgu_blood_apap Cgu_apap 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_ar_gu_apap meta_Flow_ar_gu_apap inflow gut paracetamol
Aar_apap ➞ Agu_blood_apap Qgu Car_apap 10 3 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_gu_li_apap meta_Flow_gu_li_apap outflow gut paracetamol
Agu_blood_apap ➞ Ali_blood_apap Qgu Cgu_blood_apap BP_apap 0.001 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
import_he_apap meta_import_he_apap import heart paracetamol
Ahe_blood_apap ⇆ Ahe_apap Vp_apap Vhe_tissue Kp_apap Che_blood_apap Che_apap 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_ar_he_apap meta_Flow_ar_he_apap inflow heart paracetamol
Aar_apap ➞ Ahe_blood_apap Qhe Car_apap 10 3 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_he_ve_apap meta_Flow_he_ve_apap outflow heart paracetamol
Ahe_blood_apap ➞ Ave_apap Qhe Che_blood_apap BP_apap 0.001 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
import_ki_apap meta_import_ki_apap import kidney paracetamol
Aki_blood_apap ⇆ Aki_apap Vp_apap Vki_tissue Kp_apap Cki_blood_apap Cki_apap 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_ar_ki_apap meta_Flow_ar_ki_apap inflow kidney paracetamol
Aar_apap ➞ Aki_blood_apap Qki Car_apap 10 3 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_ki_ve_apap meta_Flow_ki_ve_apap outflow kidney paracetamol
Aki_blood_apap ➞ Ave_apap Qki Cki_blood_apap BP_apap 0.001 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
import_li_apap meta_import_li_apap import liver paracetamol
Ali_blood_apap ⇆ Ali_apap Vp_apap Vli_tissue Kp_apap Cli_blood_apap Cli_apap 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_ar_li_apap meta_Flow_ar_li_apap inflow liver paracetamol
Aar_apap ➞ Ali_blood_apap Qha Car_apap 10 3 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_li_ve_apap meta_Flow_li_ve_apap outflow liver paracetamol
Ali_blood_apap ➞ Ave_apap Qh Cli_blood_apap BP_apap 0.001 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
import_lu_apap meta_import_lu_apap import lung paracetamol
Alu_blood_apap ⇆ Alu_apap Vp_apap Vlu_tissue Kp_apap Clu_blood_apap Clu_apap 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_ve_lu_apap meta_Flow_ve_lu_apap inflow lung paracetamol
Ave_apap ➞ Alu_blood_apap Qlu Cve_apap 10 3 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_lu_ar_apap meta_Flow_lu_ar_apap outflow lung paracetamol
Alu_blood_apap ➞ Aar_apap Qlu Clu_blood_apap BP_apap 0.001 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
import_sp_apap meta_import_sp_apap import spleen paracetamol
Asp_blood_apap ⇆ Asp_apap Vp_apap Vsp_tissue Kp_apap Csp_blood_apap Csp_apap 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_ar_sp_apap meta_Flow_ar_sp_apap inflow spleen paracetamol
Aar_apap ➞ Asp_blood_apap Qsp Car_apap 10 3 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_sp_li_apap meta_Flow_sp_li_apap outflow spleen paracetamol
Asp_blood_apap ➞ Ali_blood_apap Qsp Csp_blood_apap BP_apap 0.001 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
import_re_apap meta_import_re_apap import rest paracetamol
Are_blood_apap ⇆ Are_apap Vp_apap Vre_tissue Kp_apap Cre_blood_apap Cre_apap 0.001 mole 3600 s
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_ar_re_apap meta_Flow_ar_re_apap inflow rest paracetamol
Aar_apap ➞ Are_blood_apap Qre Car_apap 10 3 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804
Flow_re_ve_apap meta_Flow_re_ve_apap outflow rest paracetamol
Are_blood_apap ➞ Ave_apap Qre Cre_blood_apap BP_apap 0.001 mole 3600 s
BQB_IS
SBO:0000375; C16353
BQB_HAS_PROPERTY
CHEBI:46195; C06804