Koenig Human Glucose Metabolism
Description
This is a metabolism model of Human glucose metabolism in SBML format.
This model is described in the article:
Abstract:
Despite the crucial role of the liver in glucose homeostasis, a detailed mathematical model of human hepatic glucose metabolism is lacking so far. Here we present a detailed kinetic model of glycolysis, gluconeogenesis and glycogen metabolism in human hepatocytes integrated with the hormonal control of these pathways by insulin, glucagon and epinephrine. Model simulations are in good agreement with experimental data on (i) the quantitative contributions of glycolysis, gluconeogenesis, and glycogen metabolism to hepatic glucose production and hepatic glucose utilization under varying physiological states. (ii) the time courses of postprandial glycogen storage as well as glycogen depletion in overnight fasting and short term fasting (iii) the switch from net hepatic glucose production under hypoglycemia to net hepatic glucose utilization under hyperglycemia essential for glucose homeostasis (iv) hormone perturbations of hepatic glucose metabolism. Response analysis reveals an extra high capacity of the liver to counteract changes of plasma glucose level below 5 mM (hypoglycemia) and above 7.5 mM (hyperglycemia). Our model may serve as an important module of a whole-body model of human glucose metabolism and as a valuable tool for understanding the role of the liver in glucose homeostasis under normal conditions and in diseases like diabetes or glycogen storage diseases.
Terms of use
Redistribution and use of any part of this model, with or without modification, are permitted provided that the following conditions are met:
- Redistributions of this SBML file must retain the above copyright notice, this list of conditions and the following disclaimer.
- Redistributions in a different form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.
Model : Hepatic_glucose_3
CreatorMatthias, Koenig, Humboldt-University Berlin, Institute for Theoretical Biology, konigmatt@googlemail.com
Created: 2016-10-05 14:32
Modified: 2016-10-05 14:32
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![]() BQB_HAS_TAXON
9606 BQB_IS BTO:0000759; UBERON:0002107; FMA:7197; BTO:0000575; FMA:14515 BQB_IS_VERSION_OF PW:0000685; map00010; GO:0006006; R-HSA-70326 BQM_IS_DESCRIBED_BY 22761565 |
type | FunctionDefinitions [2] | name | math | sbo | cvterm |
---|---|---|---|---|---|
FunctionDefinition | max
|
minimum of arguments | |||
FunctionDefinition | min
|
maximum of arguments |
type | UnitDefinitions [16] | name | units | sbo | cvterm |
---|---|---|---|---|---|
UnitDefinition | s
|
||||
UnitDefinition | kg
|
||||
UnitDefinition | m
|
||||
UnitDefinition | m2
|
||||
UnitDefinition | m3
|
||||
UnitDefinition | per_s
|
||||
UnitDefinition | min
|
||||
UnitDefinition | s_per_min
|
||||
UnitDefinition | mM
|
||||
UnitDefinition | per_mM
|
||||
UnitDefinition | mM2
|
||||
UnitDefinition | mole_per_s
|
||||
UnitDefinition | pmol
|
||||
UnitDefinition | pM
|
||||
UnitDefinition | mumol_per_min_kg
|
||||
UnitDefinition | s_per_min_kg
|
type | Compartments [5] | name | size | constant | spatial dimensions | units | derived units | sbo | cvterm |
---|---|---|---|---|---|---|---|---|---|
Compartment | ext meta_f08012973f5e42f7a9d796778cf458ea
|
blood | F | 3 | m3 | ||||
Compartment | cyto meta_1edcfec978da48eea4f18b973b9ad6e6
|
cytosol | F | 3 | m3 | ||||
Compartment | mito meta_ad8abb25ec2f494c80de21a0ab8b8180
|
mitochondrion | F | 3 | m3 | ||||
Compartment | pm meta_e76b305621064b4fa8844e665a4cd3ed
|
plasma membrane | T | 2 | m2 | ||||
Compartment | mm meta_0de218213b3946e9899fd492fe6d8c55
|
mitochondrial membrane | T | 2 | m2 |
type | Species [49] | name | compartment | boundary condition | constant | initial amount | initial concentration | conversion factor | units | substance units | derived units | sbo | cvterm |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Species | atp meta_30adac61de9a4e01853cad35fc995a73
|
ATPC10H12N5O13P3 (-4) |
cyto | T | F | 2.8 | mole | mole | |||||
Species | adp meta_2d6c1b8f2d6d4f7ea18fb363a22ccefe
|
ADPC10H12N5O10P2 (-3) |
cyto | T | F | 0.8 | mole | mole | |||||
Species | amp meta_7a9f9064bb7542a5ba0388db3f9fbdbc
|
AMPC10H12N5O7P (-2) |
cyto | T | F | 0.16 | mole | mole | |||||
Species | utp meta_caf82aad1d5e4390b53b7e9591946408
|
UTPC9H11N2O15P3 (-4) |
cyto | F | F | 0.27 | mole | mole | |||||
Species | udp meta_f301e59aadb148bcb9a4f535adc5b608
|
UDPC9H11N2O12P2 (-3) |
cyto | F | F | 0.09 | mole | mole | |||||
Species | gtp meta_e0da1dea14ca40b58c9cbdf28b8701ef
|
GTPC10H12N5O14P3 (-4) |
cyto | F | F | 0.29 | mole | mole | |||||
Species | gdp meta_3b19085ef4504bf09031cc03fe07b71e
|
GDPC10H12N5O11P2 (-3) |
cyto | F | F | 0.1 | mole | mole | |||||
Species | nad meta_e21b1c11f99a4c3d9a3b01c18cd15b8e
|
NAD+C21H26N7O14P2 (-1) |
cyto | T | F | 1.22 | mole | mole | |||||
Species | nadh meta_a124633781394749b0ce1b20a9dd8ef5
|
NADHC21H27N7O14P2 (-2) |
cyto | T | F | 0.00056 | mole | mole | |||||
Species | phos meta_f98a1e1c4be04a06a6b9048b3eb5d864
|
phosphateHO4P (-2) |
cyto | T | F | 5.0 | mole | mole | |||||
Species | pp meta_14f6468ca05841e5a886f9c160dd2e4c
|
pyrophosphateHO7P2 (-3) |
cyto | F | F | 0.008 | mole | mole | |||||
Species | co2 meta_a7c4ea2a645b4d849b9047ed1dbb9b5a
|
CO2CO2 |
cyto | T | F | 5.0 | mole | mole | |||||
Species | h2o meta_dd9b514cd81f4b5f92e1f807ca8a955a
|
H2OH2O |
cyto | T | F | 0.0 | mole | mole | |||||
Species | h meta_92325fd074b8446fb2d48e70584d7a60
|
H+H (1) |
cyto | T | F | 0.0 | mole | mole | |||||
Species | glc1p meta_14bdf79e0806430e9c81f1d68e0861a7
|
glucose-1 phosphateC6H11O9P (-2) |
cyto | F | F | 0.012 | mole | mole | |||||
Species | udpglc meta_bc19915a517e4b2a9f7b636a425df34c
|
UDP-glucoseC15H22N2O17P2 (-2) |
cyto | F | F | 0.38 | mole | mole | |||||
Species | glyglc meta_7c9ff0cd3bdb4652b1743bdfad72ac8d
|
glycogenC6H12O6 |
cyto | F | F | 250.0 | mole | mole | |||||
Species | glc meta_3fb11a55bd44461d9661f7345f7cdea3
|
glucoseC6H12O6 |
cyto | F | F | 5.0 | mole | mole | |||||
Species | glc6p meta_61aa80f6510047f694a139fd16c0dc3e
|
glucose-6 phosphateC6H11O9P (-2) |
cyto | F | F | 0.12 | mole | mole | |||||
Species | fru6p meta_3360f52a781c40d8ac4cd6313195233d
|
fructose-6 phosphateC6H11O9P (-2) |
cyto | F | F | 0.05 | mole | mole | |||||
Species | fru16bp meta_9386761d87fd49c2b0c74b651091d106
|
fructose-16 bisphosphateC6H10O12P2 (-4) |
cyto | F | F | 0.02 | mole | mole | |||||
Species | fru26bp meta_59a115e45529430bae69d647f93fded3
|
fructose-26 bisphosphateC6H10O12P2 (-4) |
cyto | F | F | 0.004 | mole | mole | |||||
Species | grap meta_4a9b5f8ee45c45809f6918fbc0428548
|
glyceraldehyde 3-phosphateC3H5O6P (-2) |
cyto | F | F | 0.1 | mole | mole | |||||
Species | dhap meta_04fd18bf0446443db060503d4c9eb294
|
dihydroxyacetone phosphateC3H5O6P (-2) |
cyto | F | F | 0.03 | mole | mole | |||||
Species | bpg13 meta_cdde408ba42b45bd95251b9b8ecfc03b
|
13-bisphospho-glycerateC3H4O10P2 (-4) |
cyto | F | F | 0.3 | mole | mole | |||||
Species | pg3 meta_910a6794848a40fdbf2d1017eea5876b
|
3-phosphoglycerateC3H4O7P (-3) |
cyto | F | F | 0.27 | mole | mole | |||||
Species | pg2 meta_9c39119e54ae4c89a4d0e6d4d7c2a018
|
2-phosphoglycerateC3H4O7P (-3) |
cyto | F | F | 0.03 | mole | mole | |||||
Species | pep meta_aca24ba0a29247048aef9667ae412071
|
phosphoenolpyruvateC3H2O6P (-3) |
cyto | F | F | 0.15 | mole | mole | |||||
Species | pyr meta_9f33414948f0464f8d341fdabcfed96d
|
pyruvateC3H3O3 (-1) |
cyto | F | F | 0.1 | mole | mole | |||||
Species | oaa meta_67ebd001558d4bc2b5aa76cbf80ee251
|
oxaloacetateC4H2O5 (-2) |
cyto | F | F | 0.01 | mole | mole | |||||
Species | lac meta_2a077c9bc6164d2e920d4b7567b1e138
|
lactateC3H5O3 (-1) |
cyto | F | F | 0.5 | mole | mole | |||||
Species | glc_ext meta_51edb78d31b546f3bc9c6954386b7a09
|
glucoseC6H12O6 |
ext | T | F | 3.0 | mole | mole | |||||
Species | lac_ext meta_40c5ebc9558145e9b2e0f6ff73b12107
|
lactateC3H5O3 (-1) |
ext | T | F | 1.2 | mole | mole | |||||
Species | co2_mito meta_e1321f8dc319432eb371407c2ac685f6
|
CO2CO2 |
mito | T | F | 5.0 | mole | mole | |||||
Species | phos_mito meta_de6dc26cda7b46d4b0503887b7c460b3
|
phosphateHO4P (-2) |
mito | T | F | 5.0 | mole | mole | |||||
Species | oaa_mito meta_d1c59ba0e463477fb109b37a0001cf0d
|
oxaloacetateC4H2O5 (-2) |
mito | F | F | 0.01 | mole | mole | |||||
Species | pep_mito meta_a155df7c52c94bf2b4147d75a25bd46e
|
phosphoenolpyruvateC3H2O6P (-3) |
mito | F | F | 0.15 | mole | mole | |||||
Species | acoa_mito meta_1ede72cdc7a94215ad7896b194b7e4e8
|
acetyl-coenzyme AC23H34N7O17P3S (-4) |
mito | T | F | 0.04 | mole | mole | |||||
Species | pyr_mito meta_981b13ae77674f1e9e5b2d7eb8803ff8
|
pyruvateC3H3O3 (-1) |
mito | F | F | 0.1 | mole | mole | |||||
Species | cit_mito meta_af684a37c2fa4ec9a44c932e655cb99a
|
citrateC6H5O7 (-3) |
mito | T | F | 0.32 | mole | mole | |||||
Species | atp_mito meta_f96ddf3c29ac45de9e660a73d7eeba63
|
ATPC10H12N5O13P3 (-4) |
mito | T | F | 2.8 | mole | mole | |||||
Species | adp_mito meta_9a15984b9e4a40e78148fa7b85c7f67b
|
ADPC10H12N5O10P2 (-3) |
mito | T | F | 0.8 | mole | mole | |||||
Species | gtp_mito meta_b010d94455dc44b8b6067dbd73d29171
|
GTPC10H12N5O14P3 (-4) |
mito | F | F | 0.29 | mole | mole | |||||
Species | gdp_mito meta_16f8bcf3cd3f4233bb1155846dc6ac1b
|
GDPC10H12N5O11P2 (-3) |
mito | F | F | 0.1 | mole | mole | |||||
Species | coa_mito meta_94506773d69a46539e1867822e74dafc
|
coenzyme AC21H32N7O16P3S (-4) |
mito | T | F | 0.055 | mole | mole | |||||
Species | nadh_mito meta_4e2d61c5181b4ad3a52e8458ce577bcb
|
NADHC21H27N7O14P2 (-2) |
mito | T | F | 0.24 | mole | mole | |||||
Species | nad_mito meta_d8b0749a261141f795d43d7482c7f25d
|
NAD+C21H26N7O14P2 (-1) |
mito | T | F | 0.98 | mole | mole | |||||
Species | h2o_mito meta_3b8fab25d61248d7a5d67dc12dd72f37
|
H20H2O |
mito | T | F | 0.0 | mole | mole | |||||
Species | h_mito meta_c777da6ef46a48738842666fc8443026
|
H+H (1) |
mito | T | F | 0.0 | mole | mole |
type | Parameters [258] | name | constant | value | unit | derived unit | sbo | cvterm |
---|---|---|---|---|---|---|---|---|
Parameter | V_cyto
|
cytosolic volume | T | 0.001 | m3 | |||
Parameter | f_ext
|
external volume factor | T | 10.0 | dimensionless | None | ||
Parameter | f_mito
|
mitochondrial volume factor | T | 0.2 | dimensionless | None | ||
Parameter | Vliver
|
liver volume | T | 0.0015 | m3 | |||
Parameter | fliver
|
parenchymal fraction liver | T | 0.583333333333334 | dimensionless | None | ||
Parameter | bodyweight
|
bodyweight | T | 70.0 | kg | |||
Parameter | sec_per_min
|
time conversion | T | 60.0 | s_per_min | |||
Parameter | x_ins1
|
T | 818.9 | pM | ||||
Parameter | x_ins2
|
T | 0.0 | pM | ||||
Parameter | x_ins3
|
T | 8.6 | mM | ||||
Parameter | x_ins4
|
T | 4.2 | dimensionless | None | |||
Parameter | x_glu1
|
T | 190.0 | pM | ||||
Parameter | x_glu2
|
T | 37.9 | pM | ||||
Parameter | x_glu3
|
T | 3.01 | mM | ||||
Parameter | x_glu4
|
T | 6.4 | dimensionless | None | |||
Parameter | x_epi1
|
T | 6090.0 | pM | ||||
Parameter | x_epi2
|
T | 100.0 | pM | ||||
Parameter | x_epi3
|
T | 3.1 | mM | ||||
Parameter | x_epi4
|
T | 8.4 | dimensionless | None | |||
Parameter | K_val
|
T | 0.1 | dimensionless | None | |||
Parameter | epi_f
|
T | 0.8 | dimensionless | None | |||
Parameter | V_ext
|
external volume | T | m3 | ||||
Parameter | V_mito
|
mitochondrial volume | T | m3 | ||||
Parameter | conversion_factor
|
T | s_per_min_kg | |||||
Parameter | scale
|
scaling factor rates | T | dimensionless | None | |||
Parameter | f_gly
|
scaling factor glycolysis | T | dimensionless | None | |||
Parameter | f_glyglc
|
scaling factor glycogen metabolism | T | dimensionless | None | |||
Parameter | ins meta_1d72dbddbe7a40fc960fc456a795b8a3
|
insulin | F | pM | ||||
Parameter | ins_norm
|
insulin normalized | F | pM | ||||
Parameter | glu meta_0fc7b3a91c584a93b6ce70771c37bd91
|
glucagon | F | pM | ||||
Parameter | glu_norm
|
glucagon normalized | F | pM | ||||
Parameter | epi meta_8ef1ad13f19049f6878a62743255146a
|
epinephrine | F | pM | ||||
Parameter | epi_norm
|
epinephrine normalized | F | pM | ||||
Parameter | K_ins
|
F | pM | |||||
Parameter | K_glu
|
F | pM | |||||
Parameter | K_epi
|
F | pM | |||||
Parameter | gamma
|
phosphorylation state | F | dimensionless | None | |||
Parameter | nadh_tot
|
NADH balance | F | mM | ||||
Parameter | atp_tot
|
ATP balance | F | mM | ||||
Parameter | utp_tot
|
UTP balance | F | mM | ||||
Parameter | gtp_tot
|
GTP balance | F | mM | ||||
Parameter | nadh_mito_tot
|
NADH mito balance | F | mM | ||||
Parameter | atp_mito_tot
|
ATP mito balance | F | mM | ||||
Parameter | gtp_mito_tot
|
GTP mito balance | F | mM | ||||
Parameter | HGP
|
hepatic glucose production/utilization | F | mumol_per_min_kg | ||||
Parameter | GNG
|
gluconeogenesis/glycolysis | F | mumol_per_min_kg | ||||
Parameter | GLY
|
glycogenolysis/glycogen synthesis | F | mumol_per_min_kg | ||||
Parameter | GLUT2_keq meta_e097144762f34f8ea29a95f13ed89721
|
T | 1.0 | dimensionless | None | |||
Parameter | GLUT2_k_glc meta_6a52d394cd7e4661b221bf08ccdda225
|
T | 42.0 | mM | ||||
Parameter | GLUT2_Vmax meta_925228a7c16e4b9ca7182d1009268f20
|
T | 420.0 | mole_per_s | ||||
Parameter | GK_n_gkrp
|
T | 2.0 | dimensionless | None | |||
Parameter | GK_k_glc1 meta_dcc8f8df175e4211959569220aa560e3
|
T | 15.0 | mM | ||||
Parameter | GK_k_fru6p meta_edad1888770f46ad8fcd97c10fef4719
|
T | 0.01 | mM | ||||
Parameter | GK_b
|
T | 0.7 | dimensionless | None | |||
Parameter | GK_n
|
T | 1.6 | dimensionless | None | |||
Parameter | GK_k_glc meta_bf4bedd63a5e463ab493fd2e74c93799
|
T | 7.5 | mM | ||||
Parameter | GK_k_atp meta_c0c8a90ab8e243ac99467628154e3d4e
|
T | 0.26 | mM | ||||
Parameter | GK_Vmax meta_5ed3e72a140e4bbeb00f97c972942b66
|
T | 25.2 | mole_per_s | ||||
Parameter | GK_gc_free
|
F | dimensionless | None | ||||
Parameter | G6PASE_k_glc6p meta_d9be195083014de3ad08f2a4f077c882
|
T | 2.0 | mM | ||||
Parameter | G6PASE_Vmax meta_a0ee26db60e545c68dc5543e166a142f
|
T | 18.9 | mole_per_s | ||||
Parameter | GPI_keq meta_1aa6e6b75aa14f1aa136ea2ffd2c8908
|
T | 0.517060817492925 | dimensionless | None | |||
Parameter | GPI_k_glc6p meta_3fb8683155cf4abba3731a70c71c839a
|
T | 0.182 | mM | ||||
Parameter | GPI_k_fru6p meta_4597e08ecba44615b3f7c318388b903c
|
T | 0.071 | mM | ||||
Parameter | GPI_Vmax meta_d8770bbb21904cf9a4951810a5ff64b0
|
T | 420.0 | mole_per_s | ||||
Parameter | G16PI_keq meta_7fa1f847e95c4f6fbfad85d4d46d4ab1
|
T | 15.7175540821514 | dimensionless | None | |||
Parameter | G16PI_k_glc6p meta_dd8277d68e424e8da0e9d2de01db1183
|
T | 0.67 | mM | ||||
Parameter | G16PI_k_glc1p meta_3b5b9f7ba0bf40c7a5af1c8804edca35
|
T | 0.045 | mM | ||||
Parameter | G16PI_Vmax meta_e1b0a6dc995845088c2e7111e911253b
|
T | 100.0 | mole_per_s | ||||
Parameter | UPGASE_keq meta_ac94cc28ab74443c85cd8d44df006558
|
T | 0.312237619153088 | dimensionless | None | |||
Parameter | UPGASE_k_utp meta_ff565a1cd2e84dc6a682ae16933aca5f
|
T | 0.563 | mM | ||||
Parameter | UPGASE_k_glc1p meta_3004fb83c3d0454899070bfadc50d2c7
|
T | 0.172 | mM | ||||
Parameter | UPGASE_k_udpglc meta_27c418510b734f0c86745145037600a2
|
T | 0.049 | mM | ||||
Parameter | UPGASE_k_pp meta_c4ce382d509246f99a82e1562a913a2b
|
T | 0.166 | mM | ||||
Parameter | UPGASE_Vmax meta_2d087e18328c4edbbb2d1308c54563c4
|
T | 80.0 | mole_per_s | ||||
Parameter | PPASE_k_pp meta_233961cb25bf4bf59c3ca0836ce4e5ad
|
T | 0.005 | mM | ||||
Parameter | PPASE_Vmax meta_729d054ae6bd48f08603e016a2529cf5
|
T | 2.4 | mole_per_s | ||||
Parameter | GS_C
|
T | 500.0 | mM | ||||
Parameter | GS_k1_max
|
T | 0.2 | dimensionless | None | |||
Parameter | GSn_k1
|
T | 0.224 | mM2 | ||||
Parameter | GSp_k1
|
T | 3.003 | mM2 | ||||
Parameter | GSn_k2
|
T | 0.1504 | mM | ||||
Parameter | GSp_k2
|
T | 0.09029 | mM | ||||
Parameter | GS_Vmax meta_319da5956f1548ec8c1570860f335c3f
|
T | 13.2 | mole_per_s | ||||
Parameter | GS_fs
|
F | dimensionless | None | ||||
Parameter | GSn_k_udpglc meta_205751e7d3014a8d8a99d5ff2d5e48b7
|
F | mM | |||||
Parameter | GSp_k_udpglc meta_deaf8ca255c348baa79b88c2cf490ccf
|
F | mM | |||||
Parameter | GSn
|
F | mole_per_s | |||||
Parameter | GSp
|
F | mole_per_s | |||||
Parameter | GP_keq meta_777eecf3aa5b4fff8710b41676946f03
|
T | 0.211826505793075 | per_mM | ||||
Parameter | GPn_k_glyglc meta_1da097271bb44ca3b32a7da88d7855f5
|
T | 4.8 | mM | ||||
Parameter | GPp_k_glyglc meta_fd4481106d92410fb9033688b59c8de2
|
T | 2.7 | mM | ||||
Parameter | GPn_k_glc1p meta_dbf0cadd8a69478495c154ebe24cb283
|
T | 120.0 | mM | ||||
Parameter | GPp_k_glc1p meta_12ba58e229be4c34b53ca19141194d0a
|
T | 2.0 | mM | ||||
Parameter | GPn_k_phos meta_2bf86f0e3a934c6694eb4a93cf2e3770
|
T | 300.0 | mM | ||||
Parameter | GPp_k_phos meta_05ff2dc33ba349c0a185dd5e89dc5b93
|
T | 5.0 | mM | ||||
Parameter | GPp_ki_glc meta_e37c1a6eb81044169b20f999c9480d94
|
T | 5.0 | mM | ||||
Parameter | GPn_ka_amp
|
T | 1.0 | mM | ||||
Parameter | GPn_base_amp
|
T | 0.03 | dimensionless | None | |||
Parameter | GPn_max_amp
|
T | 0.3 | dimensionless | None | |||
Parameter | GP_Vmax meta_dc6945c2c541486680e2e5f2f756550d
|
T | 6.8 | mole_per_s | ||||
Parameter | GP_fmax
|
F | dimensionless | None | ||||
Parameter | GPn_Vmax meta_c122f15108cd48c4bfeba307a1368d48
|
F | mole_per_s | |||||
Parameter | GPn
|
F | mole_per_s | |||||
Parameter | GPp_Vmax meta_74cf94e419614a4fab6ee19e17f1dfc3
|
F | mole_per_s | |||||
Parameter | GPp
|
F | mole_per_s | |||||
Parameter | NDKGTP_keq meta_470603abbc46432d922b02dc409ee610
|
T | 1.0 | dimensionless | None | |||
Parameter | NDKGTP_k_atp meta_361c37419643433b891ef0d8f24670ea
|
T | 1.33 | mM | ||||
Parameter | NDKGTP_k_adp meta_332b23de498c4b219563dc251f34d7ae
|
T | 0.042 | mM | ||||
Parameter | NDKGTP_k_gtp meta_398196b284694e4f8612010e7403fa40
|
T | 0.15 | mM | ||||
Parameter | NDKGTP_k_gdp meta_45502aa3795546b785bfbe7699d0bfe3
|
T | 0.031 | mM | ||||
Parameter | NDKGTP_Vmax meta_13d872a692994167b9d60ceaa8d0b6d5
|
T | 0.0 | mole_per_s | ||||
Parameter | NDKUTP_keq meta_af758987c2f94cb9a7cd5c67f9fccbe8
|
T | 1.0 | dimensionless | None | |||
Parameter | NDKUTP_k_atp meta_f9be88d4a1c54e44b48e721e3900504b
|
T | 1.33 | mM | ||||
Parameter | NDKUTP_k_adp meta_5756f1208db24a94919908433ab893c0
|
T | 0.042 | mM | ||||
Parameter | NDKUTP_k_utp meta_cd33fc5e507b4d04afd73488b11baf1c
|
T | 16.0 | mM | ||||
Parameter | NDKUTP_k_udp meta_a1c1080d2e6d44939b45de10fc539d22
|
T | 0.19 | mM | ||||
Parameter | NDKUTP_Vmax meta_eef7d5668ee54be0afd1a85de449a9c9
|
T | 2940.0 | mole_per_s | ||||
Parameter | AK_keq meta_4101431556254b2b9745558bf02385da
|
T | 0.247390074904985 | dimensionless | None | |||
Parameter | AK_k_atp meta_0ad947be373a4833a808ae8ec6b06096
|
T | 0.09 | mM | ||||
Parameter | AK_k_amp meta_7a7f59affe514305b6341c871e5ab76d
|
T | 0.08 | mM | ||||
Parameter | AK_k_adp meta_6666b2c7851b4584a2427c7c8d97f19e
|
T | 0.11 | mM | ||||
Parameter | AK_Vmax meta_2fd8311454964443b4ab7c9ea09182fd
|
T | 0.0 | mole_per_s | ||||
Parameter | PFK2n_n
|
T | 1.3 | dimensionless | None | |||
Parameter | PFK2p_n
|
T | 2.1 | dimensionless | None | |||
Parameter | PFK2n_k_fru6p meta_a08a9fe2357d47b0adb6130ade6062bb
|
T | 0.016 | mM | ||||
Parameter | PFK2p_k_fru6p meta_6ba7004b142742c4b4ed248f75c4d9bc
|
T | 0.05 | mM | ||||
Parameter | PFK2n_k_atp meta_8f8ba21a8d8c40769e5eafdff18e5e43
|
T | 0.28 | mM | ||||
Parameter | PFK2p_k_atp meta_0f0570a67a3b47928e8544cea50df6c1
|
T | 0.65 | mM | ||||
Parameter | PFK2_Vmax meta_461be80580b447a0a04b9ae4ffa781bf
|
T | 0.0042 | mole_per_s | ||||
Parameter | PFK2n
|
F | mole_per_s | |||||
Parameter | PFK2p
|
F | mole_per_s | |||||
Parameter | FBP2n_k_fru26bp meta_aaacab41ebe949008c4538c8c743f1fa
|
T | 0.01 | mM | ||||
Parameter | FBP2p_k_fru26bp meta_721d5893840741288238f807faa96b1e
|
T | 0.0005 | mM | ||||
Parameter | FBP2n_ki_fru6p meta_c1810032476147838bbb4b9150f735e1
|
T | 0.0035 | mM | ||||
Parameter | FBP2p_ki_fru6p meta_62e329609e1f4d19b38f1af9831d4bef
|
T | 0.01 | mM | ||||
Parameter | FBP2_Vmax meta_7e09a45c77df4099ab84c6534fefff11
|
T | 0.126 | mole_per_s | ||||
Parameter | FBP2n
|
F | mole_per_s | |||||
Parameter | FBP2p
|
F | mole_per_s | |||||
Parameter | PFK1_k_atp meta_3e3588576d7f41659d2a87996348e799
|
T | 0.111 | mM | ||||
Parameter | PFK1_k_fru6p meta_a6d1dfe661c54aa38e4f0a4a249474c2
|
T | 0.077 | mM | ||||
Parameter | PFK1_ki_fru6p meta_b76ffbb55ef242ef9bb4d8482f617964
|
T | 0.012 | mM | ||||
Parameter | PFK1_ka_fru26bp
|
T | 0.001 | mM | ||||
Parameter | PFK1_Vmax meta_25249c2375914ae0b846294e3e3ccb01
|
T | 7.182 | mole_per_s | ||||
Parameter | FBP1_ki_fru26bp meta_3f8c4a2660374ee2935254b3f9f1ab6a
|
T | 0.001 | mM | ||||
Parameter | FBP1_k_fru16bp meta_3b407e6d73c4443eb644c28015dea3c1
|
T | 0.0013 | mM | ||||
Parameter | FBP1_Vmax meta_5d192b459d1e4e42a4826559b878af38
|
T | 4.326 | mole_per_s | ||||
Parameter | ALD_keq meta_f44258397b8d476ca2eb21b1105136d4
|
T | 9.76298897362969e-05 | mM | ||||
Parameter | ALD_k_fru16bp meta_28d5e02b9bcd40c9b695c5b650add794
|
T | 0.0071 | mM | ||||
Parameter | ALD_k_dhap meta_079eb7f2b01f4d1abef33c31ebe9aaab
|
T | 0.0364 | mM | ||||
Parameter | ALD_k_grap meta_91b6605836184f9fb4810cfd11d5e295
|
T | 0.0071 | mM | ||||
Parameter | ALD_ki1_grap
|
T | 0.0572 | mM | ||||
Parameter | ALD_ki2_grap
|
T | 0.176 | mM | ||||
Parameter | ALD_Vmax meta_d8c8e0f6264a4777be470c3fdfbf7e6a
|
T | 420.0 | mole_per_s | ||||
Parameter | TPI_keq meta_abdda832f5484f3c8d56443915350a0b
|
T | 0.054476985386756 | dimensionless | None | |||
Parameter | TPI_k_dhap meta_f7524d8d112048ac8d62f3a8ffcc682d
|
T | 0.59 | mM | ||||
Parameter | TPI_k_grap meta_fc799262b4fd4dae95e28b1ddf963a7a
|
T | 0.42 | mM | ||||
Parameter | TPI_Vmax meta_a3334fb52db542a29f995cb7adec9ba8
|
T | 420.0 | mole_per_s | ||||
Parameter | GAPDH_keq meta_3c6932eb3e564ec8975b9b1296c19492
|
T | 0.086779866194594 | per_mM | ||||
Parameter | GAPDH_k_nad meta_fd12b8c72ce64d7eabf9e4886b4eddd3
|
T | 0.05 | mM | ||||
Parameter | GAPDH_k_grap meta_79163de6a15e4fb8b7de8b197c76a18a
|
T | 0.005 | mM | ||||
Parameter | GAPDH_k_phos meta_08aa3f078e9847dbbf80240eb7945bfa
|
T | 3.9 | mM | ||||
Parameter | GAPDH_k_nadh meta_3dad61c2c72e4f9a8d01e3afe1c2e820
|
T | 0.0083 | mM | ||||
Parameter | GAPDH_k_bpg13 meta_81738e0fc3d844dc93073d16caef6d0d
|
T | 0.0035 | mM | ||||
Parameter | GAPDH_Vmax meta_d60055615d7f4ef7acc7cfe54123d166
|
T | 420.0 | mole_per_s | ||||
Parameter | PGK_keq meta_3ccec785469c4c5d82c50718d1fa1ee2
|
T | 6.95864405248854 | dimensionless | None | |||
Parameter | PGK_k_adp meta_853bf9f7c8314c21b423e2f0ca784da7
|
T | 0.35 | mM | ||||
Parameter | PGK_k_atp meta_73318af6f5f34686a08b152a66e5ec2f
|
T | 0.48 | mM | ||||
Parameter | PGK_k_bpg13 meta_64cef802898d4d8b82ddd9b78ea6c752
|
T | 0.002 | mM | ||||
Parameter | PGK_k_pg3 meta_4049ea8395b24930a0f1f72f148950de
|
T | 1.2 | mM | ||||
Parameter | PGK_Vmax meta_021572b467d342da844f43bc58414c9f
|
T | 420.0 | mole_per_s | ||||
Parameter | PGM_keq meta_6e90ed894cf14a7793e059b8bfb116c1
|
T | 0.181375378837397 | dimensionless | None | |||
Parameter | PGM_k_pg3 meta_4068d25696cd46d4bc12de17e3b18e4a
|
T | 5.0 | mM | ||||
Parameter | PGM_k_pg2 meta_48235180384740e6986488f13912a188
|
T | 1.0 | mM | ||||
Parameter | PGM_Vmax meta_46d79518e89f478eb6e0f261d3eafe79
|
T | 420.0 | mole_per_s | ||||
Parameter | EN_keq meta_8f7596f8411e4bfe93f444665a86bc95
|
T | 0.054476985386756 | dimensionless | None | |||
Parameter | EN_k_pep meta_794dd0e9e3fb4734bc64a4e0ebf93536
|
T | 1.0 | mM | ||||
Parameter | EN_k_pg2 meta_86582b79ba4a4a3387630498cb7adcb4
|
T | 1.0 | mM | ||||
Parameter | EN_Vmax meta_7f2bd8bbb66148d88d279589db1067b6
|
T | 35.994 | mole_per_s | ||||
Parameter | PKn_n
|
T | 3.5 | dimensionless | None | |||
Parameter | PKp_n
|
T | 3.5 | dimensionless | None | |||
Parameter | PKn_n_fbp
|
T | 1.8 | dimensionless | None | |||
Parameter | PKp_n_fbp
|
T | 1.8 | dimensionless | None | |||
Parameter | PKn_alpha
|
T | 1.0 | dimensionless | None | |||
Parameter | PKp_alpha
|
T | 1.1 | dimensionless | None | |||
Parameter | PKn_k_fbp meta_d6faa8876ccd49a4a9c8b40d9782bfe1
|
T | 0.00016 | mM | ||||
Parameter | PKp_k_fbp meta_e415762a6a714d269ea66d6f0e1711b3
|
T | 0.00035 | mM | ||||
Parameter | PKn_k_pep meta_1b3109d7ff454b0489ec4d938eb8618f
|
T | 0.58 | mM | ||||
Parameter | PKp_k_pep meta_84c455f1d7ec46348bf47a15923c4bf9
|
T | 1.1 | mM | ||||
Parameter | PKn_ba
|
T | 0.08 | dimensionless | None | |||
Parameter | PKp_ba
|
T | 0.04 | dimensionless | None | |||
Parameter | PK_ae
|
T | 1.0 | dimensionless | None | |||
Parameter | PKn_k_pep_end meta_c8abaea00a024fb3829a462e88013631
|
T | 0.08 | mM | ||||
Parameter | PK_k_adp meta_66aab064f6174f4b8f6f1d39d2c81a26
|
T | 2.3 | mM | ||||
Parameter | PK_Vmax meta_3936104345264b6e931c9607085d5134
|
T | 46.2 | mole_per_s | ||||
Parameter | PKn_f
|
F | dimensionless | None | ||||
Parameter | PKp_f
|
F | dimensionless | None | ||||
Parameter | PKn_alpha_inp
|
F | dimensionless | None | ||||
Parameter | PKp_alpha_inp
|
F | dimensionless | None | ||||
Parameter | PKn_pep_inp
|
F | mM | |||||
Parameter | PKp_pep_inp
|
F | mM | |||||
Parameter | PKn
|
F | mole_per_s | |||||
Parameter | PKp
|
F | mole_per_s | |||||
Parameter | PEPCK_keq meta_2d8cf38db76440ed8a6d34ddb6606f51
|
T | 336.956521586429 | mM | ||||
Parameter | PEPCK_k_pep meta_0c20385efa214b889f31bbeab6e15c1d
|
T | 0.237 | mM | ||||
Parameter | PEPCK_k_gdp meta_5faf2f2cbf3e4548b163d31c5b9f8831
|
T | 0.0921 | mM | ||||
Parameter | PEPCK_k_co2 meta_4640e904f73c461dbfcd590416c34c1e
|
T | 25.5 | mM | ||||
Parameter | PEPCK_k_oaa meta_9b2dbce4e495453ea950792803016b79
|
T | 0.0055 | mM | ||||
Parameter | PEPCK_k_gtp meta_bca48e58ac0c41efbe4e44c6c8518aa5
|
T | 0.0222 | mM | ||||
Parameter | PEPCK_Vmax meta_4e31140df28844a6bc96cfeac421f332
|
T | 0.0 | mole_per_s | ||||
Parameter | PEPCKM_Vmax meta_1235e785a8804ce9b13e68be38a7eb32
|
T | 546.0 | mole_per_s | ||||
Parameter | PC_k_atp meta_453a2d6018894b8ebee58f48826818e6
|
T | 0.22 | mM | ||||
Parameter | PC_k_pyr meta_24caa50209f04367830b7f9baa6846d4
|
T | 0.22 | mM | ||||
Parameter | PC_k_co2 meta_7e4a6f640a794a4781f5405771fed956
|
T | 3.2 | mM | ||||
Parameter | PC_k_acoa meta_7e8deccfd18247da922780f9f441db31
|
T | 0.015 | mM | ||||
Parameter | PC_n
|
T | 2.5 | dimensionless | None | |||
Parameter | PC_Vmax meta_8fec9d2a7b4a44d89289d21dcb4d7e3c
|
T | 168.0 | mole_per_s | ||||
Parameter | LDH_keq meta_ed5cc99aa0ba4490a4c74b8aa8cf6878
|
T | 0.000278321076004752 | dimensionless | None | |||
Parameter | LDH_k_pyr meta_222dfa46cf9740bcb2587b2cea691df1
|
T | 0.495 | mM | ||||
Parameter | LDH_k_lac meta_42b26d793f3d47b4b5a47c45e9a56b42
|
T | 31.98 | mM | ||||
Parameter | LDH_k_nad meta_630cebc045854c93b2b4a7628942c223
|
T | 0.984 | mM | ||||
Parameter | LDH_k_nadh meta_8aaa9fd43d22424aa0523d8354445625
|
T | 0.027 | mM | ||||
Parameter | LDH_Vmax meta_a2248cc8404943ed947f6d255baabf2f
|
T | 12.6 | mole_per_s | ||||
Parameter | LACT_keq meta_0d11576865934290a95a861a78eaea56
|
T | 1.0 | dimensionless | None | |||
Parameter | LACT_k_lac meta_061ed12ee480486d8cd4717a97927b48
|
T | 0.8 | mM | ||||
Parameter | LACT_Vmax meta_aca590d031784b8bb3e8e8cf09f48245
|
T | 5.418 | mole_per_s | ||||
Parameter | PYRTM_keq meta_b609795b4649458cabc8da67cbdf5f4f
|
T | 1.0 | dimensionless | None | |||
Parameter | PYRTM_k_pyr meta_604d50771b8e48569df79514cf51489c
|
T | 0.1 | mM | ||||
Parameter | PYRTM_Vmax meta_1ab6cbfa23304682af19714b4a68595f
|
T | 42.0 | mole_per_s | ||||
Parameter | PEPTM_keq meta_5549c86f206a4d7b8d2afdc39fa96104
|
T | 1.0 | dimensionless | None | |||
Parameter | PEPTM_k_pep meta_294089eb99b84f60a6860d7a2626c429
|
T | 0.1 | mM | ||||
Parameter | PEPTM_Vmax meta_f7b4c943bfda48a2b9c90f332ee73d93
|
T | 33.6 | mole_per_s | ||||
Parameter | PDH_k_pyr meta_003c65134a674ad0a6335dc3d6767888
|
T | 0.025 | mM | ||||
Parameter | PDH_k_coa meta_006b987f483645c498b20776429b8a90
|
T | 0.013 | mM | ||||
Parameter | PDH_k_nad meta_251f1c303c934fda824cc63161ce5dc3
|
T | 0.05 | mM | ||||
Parameter | PDH_ki_acoa meta_3b56b468e84d4a39a57105a446594b43
|
T | 0.035 | mM | ||||
Parameter | PDH_ki_nadh meta_c8bd71024dd342bca868fb3e9842c44f
|
T | 0.036 | mM | ||||
Parameter | PDHn_alpha
|
T | 5.0 | dimensionless | None | |||
Parameter | PDHp_alpha
|
T | 1.0 | dimensionless | None | |||
Parameter | PDH_Vmax meta_2e6bff1b10164bf886a97e81826372bf
|
T | 13.44 | mole_per_s | ||||
Parameter | PDH_base
|
F | mole_per_s | |||||
Parameter | PDHn
|
F | mole_per_s | |||||
Parameter | PDHp
|
F | mole_per_s | |||||
Parameter | CS_keq meta_21c5e753574141f9ab57c86e82b88069
|
T | 266599.030842759 | dimensionless | None | |||
Parameter | CS_k_oaa meta_9fe6f533444d405e95b16bafbe0e6fa0
|
T | 0.002 | mM | ||||
Parameter | CS_k_acoa meta_7bd6dd90fe8a461e984e37c11e03b16f
|
T | 0.016 | mM | ||||
Parameter | CS_k_cit meta_082a66e64b7e46b0a52d175563f54f6e
|
T | 0.42 | mM | ||||
Parameter | CS_k_coa meta_eccab28f2b384535a314d1092245c9bf
|
T | 0.07 | mM | ||||
Parameter | CS_Vmax meta_c978d887e2eb4fd191152fe164b54836
|
T | 4.2 | mole_per_s | ||||
Parameter | NDKGTPM_keq meta_4c03222af0084efd87b73d5b4dd61b27
|
T | 1.0 | dimensionless | None | |||
Parameter | NDKGTPM_k_atp meta_fd7856783cd64f10b54b1fe70a3c19ad
|
T | 1.33 | mM | ||||
Parameter | NDKGTPM_k_adp meta_9592bfb8c1c84945bb4e1d21a6032a3f
|
T | 0.042 | mM | ||||
Parameter | NDKGTPM_k_gtp meta_e6377382d30d432c81e92595416a6959
|
T | 0.15 | mM | ||||
Parameter | NDKGTPM_k_gdp meta_79a26e19d3444a02af89d57c8e1656c1
|
T | 0.031 | mM | ||||
Parameter | NDKGTPM_Vmax meta_5fee90f9ce1b437497796397b290bf2a
|
T | 420.0 | mole_per_s | ||||
Parameter | OAAFLX_Vmax meta_820f800730f9494e8dfc32830bbb0bec
|
T | 0.0 | mole_per_s | ||||
Parameter | ACOAFLX_Vmax meta_94dc473ae9294fa3a75e1be33298757e
|
T | 0.0 | mole_per_s | ||||
Parameter | CITFLX_Vmax meta_c392c70ea4404aa789d82d0b5e914c28
|
T | 0.0 | mole_per_s |
type | InitialAssignments [8] | name | assignment | derived units | sbo | cvterm | |
---|---|---|---|---|---|---|---|
InitialAssignment | pm | = | |||||
InitialAssignment | mm | = | |||||
InitialAssignment | V_ext | = | |||||
InitialAssignment | V_mito | = | |||||
InitialAssignment | conversion_factor | = | |||||
InitialAssignment | scale | = | None | ||||
InitialAssignment | f_gly | = | None | ||||
InitialAssignment | f_glyglc | = | None |
type | Rules [49] | assignment | name | derived units | sbo | cvterm | |
---|---|---|---|---|---|---|---|
Rule | ext
|
= | |||||
Rule | cyto
|
= | |||||
Rule | mito
|
= | |||||
Rule | ins
|
= | |||||
Rule | ins_norm
|
= | |||||
Rule | glu
|
= | |||||
Rule | glu_norm
|
= | |||||
Rule | epi
|
= | |||||
Rule | epi_norm
|
= | |||||
Rule | K_ins
|
= | |||||
Rule | K_glu
|
= | |||||
Rule | K_epi
|
= | |||||
Rule | gamma
|
= | None | ||||
Rule | nadh_tot meta_4fd016d1f69c4059984c438a25d93779
|
= | |||||
Rule | atp_tot meta_c0c4a3f29ad1462e9069418e568abc23
|
= | |||||
Rule | utp_tot meta_fc2021dcbf604c40b5eb191564eca230
|
= | |||||
Rule | gtp_tot meta_09e3a68118fa4f5c99348c24d5da773e
|
= | |||||
Rule | nadh_mito_tot meta_4f58fd6e7cfc45408135e98374016eed
|
= | |||||
Rule | atp_mito_tot meta_c6299ae28c4746b8b22a7a393be83f05
|
= | |||||
Rule | gtp_mito_tot meta_99a80cd7754e41e59ed392270e5d7ddf
|
= | |||||
Rule | HGP
|
= | |||||
Rule | GNG
|
= | |||||
Rule | GLY
|
= | |||||
Rule | GK_gc_free
|
= | None | ||||
Rule | GS_fs
|
= | None | ||||
Rule | GSn_k_udpglc
|
= | |||||
Rule | GSp_k_udpglc
|
= | |||||
Rule | GSn
|
= | |||||
Rule | GSp
|
= | |||||
Rule | GP_fmax
|
= | None | ||||
Rule | GPn_Vmax
|
= | |||||
Rule | GPn
|
= | |||||
Rule | GPp_Vmax
|
= | |||||
Rule | GPp
|
= | |||||
Rule | PFK2n
|
= | |||||
Rule | PFK2p
|
= | |||||
Rule | FBP2n
|
= | |||||
Rule | FBP2p
|
= | |||||
Rule | PKn_f
|
= | None | ||||
Rule | PKp_f
|
= | None | ||||
Rule | PKn_alpha_inp
|
= | None | ||||
Rule | PKp_alpha_inp
|
= | None | ||||
Rule | PKn_pep_inp
|
= | |||||
Rule | PKp_pep_inp
|
= | |||||
Rule | PKn
|
= | |||||
Rule | PKp
|
= | |||||
Rule | PDH_base
|
= | |||||
Rule | PDHn
|
= | |||||
Rule | PDHp
|
= |
type | Reactions [36] | name | equation | modifiers | kinetic law | derived units | sbo | cvterm | |
---|---|---|---|---|---|---|---|---|---|
Reaction | GLUT2 meta_22ca43bd7a2545028a6085b60b551ba7
|
GLUT2 glucose transporter |
⇆ | glc_ext ⇆ glc | |||||
Reaction | GK meta_560cdcc124cf45c1b3b3f455e7561b0e
|
Glucokinase |
➞ | glc + atp ➞ glc6p + adp + h | glc1p fru6p |
||||
Reaction | G6PASE meta_61a6571784ec450a917238d3b42a3ccd
|
D-Glucose-6-phosphate Phosphatase |
➞ | glc6p + h2o ➞ glc + phos | |||||
Reaction | GPI meta_1f8257e0d9334adbb540b363007b4d4a
|
D-Glucose-6-phosphate Isomerase |
⇆ | glc6p ⇆ fru6p | |||||
Reaction | G16PI meta_4f230843c6b548939ac75b5ea0f30c70
|
Glucose 1-phosphate 1,6-phosphomutase |
⇆ | glc1p ⇆ glc6p | |||||
Reaction | UPGASE meta_9fd0ef886b77400cb02cce15b64b5c5e
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UTP:Glucose-1-phosphate uridylyltransferase |
⇆ | glc1p + h + utp ⇆ pp + udpglc | |||||
Reaction | PPASE meta_136770feabb54ae3933a16385e60902a
|
Pyrophosphate phosphohydrolase |
➞ | pp + h2o ➞ h + 2.0 phos | |||||
Reaction | GS meta_6e1c8137d18f44c6a45019b1efb17f7f
|
Glycogen synthase |
➞ | udpglc + h2o ➞ udp + h + glyglc | glc6p | ||||
Reaction | GP meta_e11b9bd9c2e94442abf904add157ee64
|
Glycogen-Phosphorylase |
⇆ | glyglc + phos ⇆ glc1p + h2o | phos amp glc |
||||
Reaction | NDKGTP meta_e28964a7b1084d37893ae35835ef29a3
|
Nucleoside-diphosphate kinase (ATP, GTP) |
⇆ | atp + gdp ⇆ adp + gtp | |||||
Reaction | NDKUTP meta_5a8b50018e9f4afb9640ad61140ebc14
|
Nucleoside-diphosphate kinase (ATP, UTP) |
⇆ | atp + udp ⇆ adp + utp | |||||
Reaction | AK meta_356ebf930a0943aa88e0df5944ecdbd5
|
ATP:AMP phosphotransferase (Adenylatkinase) |
⇆ | amp + atp ⇆ 2.0 adp | |||||
Reaction | PFK2 meta_86d1e4ff2822414b9b8bc5a851c006cc
|
ATP:D-fructose-6-phosphate 2-phosphotransferase |
➞ | fru6p + atp ➞ fru26bp + adp + h | |||||
Reaction | FBP2 meta_a9a3ebe5b3f64cbc848fc835dc99bc85
|
D-Fructose-2,6-bisphosphate 2-phosphohydrolase |
➞ | fru26bp + h2o ➞ fru6p + phos | |||||
Reaction | PFK1 meta_528d7c511dff4400a4aeb63532249d1b
|
ATP:D-fructose-6-phosphate 1-phosphotransferase |
➞ | fru6p + atp ➞ fru16bp + adp + h | fru26bp | ||||
Reaction | FBP1 meta_b1b91f1555614a24bf9805ea59d49b68
|
D-Fructose-1,6-bisphosphate 1-phosphohydrolase |
➞ | fru16bp + h2o ➞ fru6p + phos | fru26bp | ||||
Reaction | ALD meta_14268c7ae34f42b9900233354364cf10
|
Aldolase |
⇆ | fru16bp ⇆ grap + dhap | |||||
Reaction | TPI meta_6340c27ac1ce4919804c18b11df6c027
|
Triosephosphate Isomerase |
⇆ | dhap ⇆ grap | |||||
Reaction | GAPDH meta_7067d7523d994e07a8a3faa87edadd6d
|
D-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase |
⇆ | grap + nad + phos ⇆ bpg13 + nadh + h | |||||
Reaction | PGK meta_1fc282a4548c4963b4f84e0f597c5972
|
Phosphoglycerate Kinase |
⇆ | adp + bpg13 ⇆ atp + pg3 | |||||
Reaction | PGM meta_11be42c3881c485c8713fec7c9f58235
|
2-Phospho-D-glycerate 2,3-phosphomutase |
⇆ | pg3 ⇆ pg2 | |||||
Reaction | EN meta_b15bd3db5c164bae99e51b039e7e1551
|
2-Phospho-D-glucerate hydro-lyase (enolase) |
⇆ | pg2 ⇆ h2o + pep | |||||
Reaction | PK meta_7b1853d5e1184d629fe981f440ff195f
|
Pyruvatkinase |
➞ | pep + adp + h ➞ pyr + atp | fru16bp | ||||
Reaction | PEPCK meta_162e1bf01c724d0b9a2f4ce0a225295a
|
PEPCK cyto |
⇆ | gtp + oaa ⇆ co2 + gdp + pep | |||||
Reaction | PEPCKM meta_13135b3bc29e4ae18039ba6cc29b64ec
|
PEPCK mito |
⇆ | gtp_mito + oaa_mito ⇆ co2_mito + gdp_mito + pep_mito | |||||
Reaction | PC meta_d6597e7449ab48e2a3b627edc0e92411
|
Pyruvate Carboxylase |
➞ | atp_mito + pyr_mito + co2_mito + h2o_mito ➞ adp_mito + oaa_mito + phos_mito + 2.0 h | acoa_mito | ||||
Reaction | LDH meta_551d79dffaf74569881915ae14274a09
|
Lactate Dehydrogenase |
⇆ | pyr + nadh + h ⇆ lac + nad | |||||
Reaction | LACT meta_96b62460d8ed4288a467107d28357deb
|
Lactate transport (import) |
⇆ | lac_ext ⇆ lac | |||||
Reaction | PYRTM meta_02f8c3be7c5e4a3bbb2aeb318ec86639
|
Pyruvate transport (mito) |
⇆ | pyr ⇆ pyr_mito | |||||
Reaction | PEPTM meta_b2615383c9d84753afa383a5a7a2d1d6
|
PEP Transport (export mito) |
⇆ | pep_mito ⇆ pep | |||||
Reaction | PDH meta_c98332bcc65546c59f745d63ce5ac1e2
|
Pyruvate Dehydrogenase |
➞ | pyr_mito + coa_mito + nad_mito ➞ acoa_mito + co2_mito + nadh_mito | |||||
Reaction | CS meta_27329c61aea3449b85566f3b081fa742
|
Citrate Synthase |
⇆ | acoa_mito + oaa_mito + h2o_mito ⇆ cit_mito + coa_mito + h_mito | |||||
Reaction | NDKGTPM meta_8a94238f3219471eb74c0f9d9b2e5fd9
|
Nucleoside-diphosphate kinase (ATP, GTP) mito |
⇆ | atp_mito + gdp_mito ⇆ adp_mito + gtp_mito | |||||
Reaction | OAAFLX
|
oxalacetate influx |
➞ | ➞ oaa_mito | |||||
Reaction | ACOAFLX
|
acetyl-coa efflux |
➞ | acoa_mito ➞ | |||||
Reaction | CITFLX
|
citrate efflux |
➞ | cit_mito ➞ |