TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

This study was supported by the Research Council of Finland (338537 to G.J.; 325464 to J.I.; and 332402 to G.F.), the Sigrid Juselius Foundation (to G.J. and to J.I.), the Cancer Society of Finland (Syöpäjärjestöt; to G.J. and to J.I.), and the Solutions for Health strategic funding to Åbo Akademi University (to G.J.). This research was supported by the InFLAMES Flagship Programme of the Academy of Finland (decision numbers: 337530, 337531, 357910, and 357911). This work was also supported by the Finnish Cancer Institute (K. Albin Johansson Professorship, J.I.), the Centre of Excellence program (# 346131, J.I.), and the Jane and Aatos Erkko Foundation (J.I.). B.T.G. was supported by the Biotechnology and Biological Sciences Research Council grant (BB/S007245/1) and the Cancer Research UK Program Grant (CRUK-A21671). The Cell Imaging and Cytometry Core facility, the Zebrafish Core (both at Turku Bioscience, University of Turku, Åbo Akademi University, and supported by Biocenter Finland), Turku Bioimaging and the Genome Biology Unit (Research Programs Unit, HiLIFE Helsinki Institute of Life Science, Faculty of Medicine, University of Helsinki, Biocenter Finland) are acknowledged for services, instrumentation, and expertise. Mass spectrometry was performed at the Turku Proteomics Facility, University of Turku and Åbo Akademi University. The facility is supported by Biocenter Finland.