Proteomics reveals mechanisms of metabolic disruptive effects of emerging di-(2-ethylhexyl) phthalate substitutes

The obesity pandemic and associated cardiovascular complications are presumed to be accelerated by endocrine disruptors such as the phthalate plasticizer di-(2-ethylhexyl)-phthalate (DEHP). However, the mode of action underlying their metabolic disruptve effects is insufficiently understood, and poorly studied emerging plasticizer alternatives require further investigation.