Genes polymorphism of surfactant protein B and respiratory morbidity in preschoolers

Mazulov O., Yablon O. Genes polymorphism of surfactant protein B and respiratory morbidity in preschoolers. Journal of Education, Health and Sport. 2017;7(6):635-643. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.834739

http://ojs.ukw.edu.pl/index.php/johs/article/view/4651

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 03.06.2017. Revised: 20.06.2017. Accepted: 30.06.2017.

Genes polymorphism of surfactant protein B and respiratory morbidity in preschoolers

O. Mazulov, O. Yablon

Vinnytsya Pirogov Medical University,

Ukraine, Vinnitsa

Abstract

There was a prospective single-center study of 50 prematurely born children (25 males and 25 females, mean gestational age 31.6 ± 2.6 weeks, mean body weight at birth 1743.4 ± 454.3 g) conducted in Vinnytsya Children’s Regional Hospital during 2010-2015. At the age of 5.2 ± 0.7 years children were divided on a several groups: children diagnosed with asthma - 9 (18%), children diagnosed with recurrent episodes of obstructive bronchitis (recurrent wheezing) - 18 (36%), children diagnosed with bronchopulmonary dysplasia - 8 (16%) and 15 children without respiratory diseases (30%). As a result of Single nucleotide polymorphism (SNP) investigation in surfactant protein B C1580T locus a several sequences were evaluated and explored: CC in 17 (34%) of patients, a TT sequence of nucleotides in 12 (24%) of patients, and CT nucleotide sequence was observed in 21 (42%) children. Odds ratio found that the nucleotide sequence CC might be a predictive value of recurrent bronchial obstructions, nucleotide sequence TT more often observed in patients with asthma, and the presence of CT nucleotide sequence in polymorphic locus of gene of surfactant protein B C1580T might have a positive prognostic value regarding the absence of chronic bronchopulmonary diseases in children.

Keywords: polymorphism; surfactant protein B; respiratory morbidity; preschoolers.