ID big.annotion left right this_pathway_gene rich.factor LogP Description R194315 Reactome Gene Sets 0 707 14 6.64070407 -7.636810213 Signaling by Rho GTPases R9716542 Reactome Gene Sets 0 723 14 6.493745197 -7.516073823 "Signaling by Rho GTPases, Miro GTPases and RHOBTB3" R9012999 Reactome Gene Sets 0 449 11 8.215837664 -6.994600497 RHO GTPase cycle hsa04650 KEGG Pathway 0 131 7 17.91976251 -6.864125489 Natural killer cell mediated cytotoxicity M5950 Hallmark Gene Sets 0 200 8 13.41422222 -6.803169996 HALLMARK ALLOGRAFT REJECTION hsa04015 KEGG Pathway 0 210 8 12.77544974 -6.64118721 Rap1 signaling pathway hsa04810 KEGG Pathway 0 229 8 11.71547792 -6.355288844 Regulation of actin cytoskeleton R1280218 Reactome Gene Sets 0 769 13 5.669209652 -6.331384536 Adaptive Immune System R9658195 Reactome Gene Sets 0 164 7 14.31395664 -6.201162783 Leishmania infection R9013149 Reactome Gene Sets 0 185 7 12.68912913 -5.850331159 RAC1 GTPase cycle hsa05130 KEGG Pathway 0 197 7 11.91618725 -5.668730139 Pathogenic Escherichia coli infection R109582 Reactome Gene Sets 0 621 11 5.940275541 -5.610996006 Hemostasis R983695 Reactome Gene Sets 0 32 4 41.91944444 -5.6031807 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R195258 Reactome Gene Sets 0 327 8 8.204417261 -5.204238409 RHO GTPase Effectors R9013148 Reactome Gene Sets 0 155 6 12.98150538 -5.138924882 CDC42 GTPase cycle R6798695 Reactome Gene Sets 0 482 9 6.261825726 -4.850818049 Neutrophil degranulation R76002 Reactome Gene Sets 0 263 7 8.925813266 -4.847354949 "Platelet activation, signaling and aggregation" hsa04670 KEGG Pathway 0 114 5 14.708577 -4.620730843 Leukocyte transendothelial migration R9664407 Reactome Gene Sets 0 59 4 22.73596987 -4.52755654 Parasite infection R9664417 Reactome Gene Sets 0 59 4 22.73596987 -4.52755654 Leishmania phagocytosis R9664422 Reactome Gene Sets 0 59 4 22.73596987 -4.52755654 FCGR3A-mediated phagocytosis M5924 Hallmark Gene Sets 0 200 6 10.06066667 -4.511574894 HALLMARK MTORC1 SIGNALING hsa05416 KEGG Pathway 0 60 4 22.35703704 -4.498580778 Viral myocarditis R2029482 Reactome Gene Sets 0 61 4 21.99052823 -4.470113188 Regulation of actin dynamics for phagocytic cup formation R198933 Reactome Gene Sets 0 134 5 12.513267 -4.284214968 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R1280215 Reactome Gene Sets 0 730 10 4.59391172 -4.189854959 Cytokine Signaling in Immune system R354192 Reactome Gene Sets 0 27 3 37.2617284 -4.14748912 Integrin signaling R449147 Reactome Gene Sets 0 473 8 5.67197557 -4.063236742 Signaling by Interleukins R5218920 Reactome Gene Sets 0 29 3 34.69195402 -4.052720969 VEGFR2 mediated vascular permeability hsa04662 KEGG Pathway 0 82 4 16.35880759 -3.965577173 B cell receptor signaling pathway hsa04514 KEGG Pathway 0 157 5 10.68011323 -3.958728551 Cell adhesion molecules R2871796 Reactome Gene Sets 0 32 3 31.43958333 -3.922818771 FCERI mediated MAPK activation R2029480 Reactome Gene Sets 0 86 4 15.59793282 -3.885261248 Fcgamma receptor (FCGR) dependent phagocytosis R2871809 Reactome Gene Sets 0 33 3 30.48686869 -3.882362838 FCERI mediated Ca+2 mobilization R114604 Reactome Gene Sets 0 35 3 28.7447619 -3.805200712 GPVI-mediated activation cascade hsa04666 KEGG Pathway 0 97 4 13.82909507 -3.683478559 Fc gamma R-mediated phagocytosis hsa05152 KEGG Pathway 0 180 5 9.315432099 -3.681577453 Tuberculosis R76009 Reactome Gene Sets 0 39 3 25.7965812 -3.66395665 Platelet Aggregation (Plug Formation) R4420097 Reactome Gene Sets 0 99 4 13.54971942 -3.649438167 VEGFA-VEGFR2 Pathway hsa04621 KEGG Pathway 0 186 5 9.014934289 -3.615661337 NOD-like receptor signaling pathway hsa04613 KEGG Pathway 0 190 5 8.825146199 -3.573009147 Neutrophil extracellular trap formation R9656223 Reactome Gene Sets 0 43 3 23.39689922 -3.537248116 Signaling by RAF1 mutants R194138 Reactome Gene Sets 0 108 4 12.42057613 -3.50489849 Signaling by VEGF hsa04510 KEGG Pathway 0 201 5 8.342177999 -3.460661738 Focal adhesion hsa05169 KEGG Pathway 0 202 5 8.300880088 -3.45078861 Epstein-Barr virus infection R983705 Reactome Gene Sets 0 112 4 11.97698413 -3.444776339 Signaling by the B Cell Receptor (BCR) R6802946 Reactome Gene Sets 0 47 3 21.40567376 -3.42242283 Signaling by moderate kinase activity BRAF mutants R6802949 Reactome Gene Sets 0 47 3 21.40567376 -3.42242283 Signaling by RAS mutants R6802955 Reactome Gene Sets 0 47 3 21.40567376 -3.42242283 Paradoxical activation of RAF signaling by kinase inactive BRAF R9649948 Reactome Gene Sets 0 47 3 21.40567376 -3.42242283 Signaling downstream of RAS mutants hsa05170 KEGG Pathway 0 212 5 7.90932914 -3.354954565 Human immunodeficiency virus 1 infection R1483249 Reactome Gene Sets 0 50 3 20.12133333 -3.342888495 Inositol phosphate metabolism hsa05417 KEGG Pathway 0 215 5 7.798966408 -3.327185949 Lipid and atherosclerosis hsa04611 KEGG Pathway 0 124 4 10.81792115 -3.277463466 Platelet activation R2454202 Reactome Gene Sets 0 134 4 10.0106136 -3.15095809 Fc epsilon receptor (FCERI) signaling R202733 Reactome Gene Sets 0 137 4 9.791403082 -3.115007546 Cell surface interactions at the vascular wall R5621481 Reactome Gene Sets 0 142 4 9.446635368 -3.056963515 C-type lectin receptors (CLRs) R9006934 Reactome Gene Sets 0 524 7 4.479940628 -3.005980736 Signaling by Receptor Tyrosine Kinases R8980692 Reactome Gene Sets 0 147 4 9.12532124 -3.00111946 RHOA GTPase cycle hsa05200 KEGG Pathway 0 531 7 4.42088303 -2.972676429 Pathways in cancer R6802952 Reactome Gene Sets 0 67 3 15.0159204 -2.970637912 Signaling by BRAF and RAF1 fusions hsa04664 KEGG Pathway 0 68 3 14.79509804 -2.95197509 Fc epsilon RI signaling pathway R388841 Reactome Gene Sets 0 69 3 14.58067633 -2.933602552 Costimulation by the CD28 family hsa04971 KEGG Pathway 0 76 3 13.2377193 -2.812453844 Gastric acid secretion R2219530 Reactome Gene Sets 0 78 3 12.8982906 -2.780024751 Constitutive Signaling by Aberrant PI3K in Cancer hsa04530 KEGG Pathway 0 169 4 7.937409599 -2.778064923 Tight junction R9662851 Reactome Gene Sets 0 79 3 12.7350211 -2.764142703 Anti-inflammatory response favouring Leishmania parasite infection R9664433 Reactome Gene Sets 0 79 3 12.7350211 -2.764142703 Leishmania parasite growth and survival R5663202 Reactome Gene Sets 0 433 6 4.646959199 -2.72086349 Diseases of signal transduction by growth factor receptors and second messengers R6802957 Reactome Gene Sets 0 84 3 11.97698413 -2.687839382 Oncogenic MAPK signaling R1474244 Reactome Gene Sets 0 300 5 5.589259259 -2.683764277 Extracellular matrix organization R216083 Reactome Gene Sets 0 85 3 11.83607843 -2.673165055 Integrin cell surface interactions R9013404 Reactome Gene Sets 0 88 3 11.43257576 -2.630232514 RAC2 GTPase cycle R9006925 Reactome Gene Sets 0 309 5 5.4264653 -2.628213651 Intracellular signaling by second messengers hsa04062 KEGG Pathway 0 192 4 6.986574074 -2.57704119 Chemokine signaling pathway hsa05167 KEGG Pathway 0 194 4 6.914547537 -2.560852626 Kaposi sarcoma-associated herpesvirus infection M5947 Hallmark Gene Sets 0 199 4 6.740815187 -2.521191997 HALLMARK IL2 STAT5 SIGNALING hsa05165 KEGG Pathway 0 331 5 5.065793891 -2.500054832 Human papillomavirus infection hsa04750 KEGG Pathway 0 98 3 10.26598639 -2.49776127 Inflammatory mediator regulation of TRP channels hsa05415 KEGG Pathway 0 203 4 6.607991242 -2.490266721 Diabetic cardiomyopathy R9679191 Reactome Gene Sets 0 99 3 10.16228956 -2.485326398 Potential therapeutics for SARS hsa05146 KEGG Pathway 0 102 3 9.863398693 -2.448824415 Amoebiasis R2219528 Reactome Gene Sets 0 104 3 9.673717949 -2.425132334 PI3K/AKT Signaling in Cancer hsa04625 KEGG Pathway 0 104 3 9.673717949 -2.425132334 C-type lectin receptor signaling pathway R6811558 Reactome Gene Sets 0 106 3 9.491194969 -2.401931199 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" R6785807 Reactome Gene Sets 0 108 3 9.315432099 -2.379202458 Interleukin-4 and Interleukin-13 signaling hsa04151 KEGG Pathway 0 354 5 4.736660389 -2.376428191 PI3K-Akt signaling pathway hsa04024 KEGG Pathway 0 225 4 5.961876543 -2.33172099 cAMP signaling pathway hsa05163 KEGG Pathway 0 225 4 5.961876543 -2.33172099 Human cytomegalovirus infection R199418 Reactome Gene Sets 0 113 3 8.903244838 -2.324334703 Negative regulation of the PI3K/AKT network R162906 Reactome Gene Sets 0 231 4 5.807022607 -2.291547717 HIV Infection hsa04071 KEGG Pathway 0 119 3 8.454341737 -2.261901304 Sphingolipid signaling pathway hsa04014 KEGG Pathway 0 236 4 5.683992467 -2.258977743 Ras signaling pathway R202403 Reactome Gene Sets 0 120 3 8.383888889 -2.251832497 TCR signaling hsa05132 KEGG Pathway 0 249 4 5.38723784 -2.177902743 Salmonella infection R162909 Reactome Gene Sets 0 130 3 7.738974359 -2.155958795 Host Interactions of HIV factors R9679506 Reactome Gene Sets 0 414 5 4.050187869 -2.094797771 SARS-CoV Infections hsa05135 KEGG Pathway 0 137 3 7.343552311 -2.093582741 Yersinia infection R1257604 Reactome Gene Sets 0 267 4 5.024053267 -2.073444524 PIP3 activates AKT signaling R3858494 Reactome Gene Sets 0 146 3 6.89086758 -2.018407761 Beta-catenin independent WNT signaling