ID big.annotion left right this_pathway_gene rich.factor LogP Description R1280215 Reactome Gene Sets 0 730 17 8.269041096 -10.72027539 Cytokine Signaling in Immune system R9012999 Reactome Gene Sets 0 449 13 10.28078082 -9.385860078 RHO GTPase cycle M5950 Hallmark Gene Sets 0 200 9 15.97870588 -8.261006891 HALLMARK ALLOGRAFT REJECTION R449147 Reactome Gene Sets 0 473 12 9.008431787 -8.049039819 Signaling by Interleukins R194315 Reactome Gene Sets 0 707 14 7.031333722 -7.966384225 Signaling by Rho GTPases R9716542 Reactome Gene Sets 0 723 14 6.875730209 -7.844565262 "Signaling by Rho GTPases, Miro GTPases and RHOBTB3" R109582 Reactome Gene Sets 0 621 13 7.433285971 -7.700971735 Hemostasis R114604 Reactome Gene Sets 0 35 5 50.72605042 -7.320929933 GPVI-mediated activation cascade hsa04650 KEGG Pathway 0 131 7 18.97386619 -7.036360856 Natural killer cell mediated cytotoxicity M5947 Hallmark Gene Sets 0 199 8 14.27466745 -7.014661151 HALLMARK IL2 STAT5 SIGNALING hsa04015 KEGG Pathway 210 8 13.52694678 -6.83529884 Rap1 signaling pathway R9013148 Reactome Gene Sets 0 155 7 16.03597723 -6.537394311 CDC42 GTPase cycle R9658195 Reactome Gene Sets 0 164 7 15.15595409 -6.371329628 Leishmania infection R76002 Reactome Gene Sets 0 263 8 10.80098412 -6.09375071 "Platelet activation, signaling and aggregation" hsa04670 KEGG Pathway 114 6 18.68854489 -6.059359562 Leukocyte transendothelial migration R9013149 Reactome Gene Sets 0 185 7 13.43554849 -6.019183596 RAC1 GTPase cycle R388841 Reactome Gene Sets 69 5 25.73060529 -5.81421508 Costimulation by the CD28 family R1280218 Reactome Gene Sets 0 769 12 5.54094699 -5.78286493 Adaptive Immune System hsa04060 KEGG Pathway 295 8 9.629351944 -5.721268734 Cytokine-cytokine receptor interaction hsa05200 KEGG Pathway 531 10 6.687049961 -5.600728079 Pathways in cancer R2219530 Reactome Gene Sets 78 5 22.76168929 -5.549036537 Constitutive Signaling by Aberrant PI3K in Cancer R8980692 Reactome Gene Sets 0 147 6 14.49315726 -5.415796417 RHOA GTPase cycle R2029480 Reactome Gene Sets 0 86 5 20.64432285 -5.339302504 Fcgamma receptor (FCGR) dependent phagocytosis hsa04666 KEGG Pathway 0 97 5 18.30321407 -5.082546109 Fc gamma R-mediated phagocytosis hsa04064 KEGG Pathway 0 104 5 17.07126697 -4.934831481 NF-kappa B signaling pathway R2219528 Reactome Gene Sets 104 5 17.07126697 -4.934831481 PI3K/AKT Signaling in Cancer R6811558 Reactome Gene Sets 106 5 16.74916759 -4.894571675 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" R9006934 Reactome Gene Sets 524 9 6.098742703 -4.766920295 Signaling by Receptor Tyrosine Kinases R199418 Reactome Gene Sets 113 5 15.71160854 -4.759796721 Negative regulation of the PI3K/AKT network hsa04062 KEGG Pathway 192 6 11.09632353 -4.753032831 Chemokine signaling pathway R9664407 Reactome Gene Sets 0 59 4 24.07337986 -4.625441504 Parasite infection R9664417 Reactome Gene Sets 0 59 4 24.07337986 -4.625441504 Leishmania phagocytosis R9664422 Reactome Gene Sets 0 59 4 24.07337986 -4.625441504 FCGR3A-mediated phagocytosis R2029482 Reactome Gene Sets 0 61 4 23.28408872 -4.567883805 Regulation of actin dynamics for phagocytic cup formation hsa04611 KEGG Pathway 0 124 5 14.31783681 -4.565103481 Platelet activation hsa04664 KEGG Pathway 0 68 4 20.88719723 -4.381113734 Fc epsilon RI signaling pathway R449836 Reactome Gene Sets 24 3 44.38529412 -4.378797999 Other interleukin signaling R202733 Reactome Gene Sets 137 5 12.95920996 -4.357635507 Cell surface interactions at the vascular wall R354192 Reactome Gene Sets 27 3 39.45359477 -4.221533949 Integrin signaling R6798695 Reactome Gene Sets 482 8 5.893483036 -4.18358693 Neutrophil degranulation R2424491 Reactome Gene Sets 0 30 3 35.50823529 -4.081784209 DAP12 signaling hsa04662 KEGG Pathway 0 82 4 17.32109039 -4.06214948 B cell receptor signaling pathway R9680350 Reactome Gene Sets 31 3 34.36280835 -4.038463822 Signaling by CSF1 (M-CSF) in myeloid cells R2871796 Reactome Gene Sets 0 32 3 33.28897059 -3.996595019 FCERI mediated MAPK activation R983695 Reactome Gene Sets 0 32 3 33.28897059 -3.996595019 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R2871809 Reactome Gene Sets 0 33 3 32.2802139 -3.956085412 FCERI mediated Ca+2 mobilization R202433 Reactome Gene Sets 0 34 3 31.33079585 -3.916851168 Generation of second messenger molecules hsa05340 KEGG Pathway 38 3 28.03281734 -3.771237103 Primary immunodeficiency R9013407 Reactome Gene Sets 38 3 28.03281734 -3.771237103 RHOH GTPase cycle R9607240 Reactome Gene Sets 38 3 28.03281734 -3.771237103 FLT3 Signaling hsa04640 KEGG Pathway 99 4 14.34676173 -3.745043576 Hematopoietic cell lineage R76009 Reactome Gene Sets 39 3 27.31402715 -3.737357478 Platelet Aggregation (Plug Formation) hsa04613 KEGG Pathway 0 190 5 9.344272446 -3.68905962 Neutrophil extracellular trap formation hsa04660 KEGG Pathway 104 4 13.65701357 -3.662794145 T cell receptor signaling pathway R5663202 Reactome Gene Sets 433 7 5.740361364 -3.648432287 Diseases of signal transduction by growth factor receptors and second messengers R6785807 Reactome Gene Sets 108 4 13.15119826 -3.599993176 Interleukin-4 and Interleukin-13 signaling R2172127 Reactome Gene Sets 0 45 3 23.67215686 -3.551566553 DAP12 interactions R202403 Reactome Gene Sets 0 120 4 11.83607843 -3.425622578 TCR signaling hsa04380 KEGG Pathway 0 128 4 11.09632353 -3.319534495 Osteoclast differentiation hsa04810 KEGG Pathway 229 5 7.752889802 -3.316864132 Regulation of actin cytoskeleton hsa05135 KEGG Pathway 137 4 10.36736797 -3.208462141 Yersinia infection hsa04072 KEGG Pathway 0 148 4 9.59682035 -3.083036029 Phospholipase D signaling pathway R1257604 Reactome Gene Sets 267 5 6.649482265 -3.016902829 PIP3 activates AKT signaling hsa04514 KEGG Pathway 157 4 9.046684151 -2.987779016 Cell adhesion molecules hsa05214 KEGG Pathway 75 3 14.20329412 -2.900493968 Glioma R9662851 Reactome Gene Sets 0 79 3 13.48413999 -2.835411765 Anti-inflammatory response favouring Leishmania parasite infection R9664433 Reactome Gene Sets 0 79 3 13.48413999 -2.835411765 Leishmania parasite growth and survival hsa01521 KEGG Pathway 79 3 13.48413999 -2.835411765 EGFR tyrosine kinase inhibitor resistance hsa05152 KEGG Pathway 180 4 7.890718954 -2.769374194 Tuberculosis R9006925 Reactome Gene Sets 309 5 5.745669141 -2.73731514 Intracellular signaling by second messengers hsa04621 KEGG Pathway 186 4 7.636179633 -2.717473787 NOD-like receptor signaling pathway hsa05202 KEGG Pathway 193 4 7.35921975 -2.659235576 Transcriptional misregulation in cancer hsa04658 KEGG Pathway 0 92 3 11.57877238 -2.645962821 Th1 and Th2 cell differentiation hsa05165 KEGG Pathway 331 5 5.363781766 -2.607884133 Human papillomavirus infection M5939 Hallmark Gene Sets 200 4 7.101647059 -2.603316991 HALLMARK P53 PATHWAY hsa04510 KEGG Pathway 201 4 7.066315481 -2.595508373 Focal adhesion hsa05169 KEGG Pathway 202 4 7.031333722 -2.58774334 Epstein-Barr virus infection hsa05231 KEGG Pathway 98 3 10.86986795 -2.568025946 Choline metabolism in cancer hsa04750 KEGG Pathway 98 3 10.86986795 -2.568025946 Inflammatory mediator regulation of TRP channels R9679191 Reactome Gene Sets 0 99 3 10.7600713 -2.555538361 Potential therapeutics for SARS hsa04061 KEGG Pathway 100 3 10.65247059 -2.543186368 Viral protein interaction with cytokine and cytokine receptor hsa04933 KEGG Pathway 100 3 10.65247059 -2.543186368 AGE-RAGE signaling pathway in diabetic complications hsa05146 KEGG Pathway 102 3 10.44359862 -2.518878327 Amoebiasis hsa04659 KEGG Pathway 0 108 3 9.863398693 -2.448940674 Th17 cell differentiation hsa05166 KEGG Pathway 222 4 6.397880233 -2.440970347 Human T-cell leukemia virus 1 infection hsa05163 KEGG Pathway 225 4 6.312575163 -2.420252925 Human cytomegalovirus infection R983705 Reactome Gene Sets 0 112 3 9.511134454 -2.404621097 Signaling by the B Cell Receptor (BCR) hsa04014 KEGG Pathway 236 4 6.018344965 -2.346900304 Ras signaling pathway hsa04722 KEGG Pathway 119 3 8.951655957 -2.331062159 Neurotrophin signaling pathway hsa04071 KEGG Pathway 119 3 8.951655957 -2.331062159 Sphingolipid signaling pathway R2454202 Reactome Gene Sets 0 134 3 7.949604917 -2.188248223 Fc epsilon receptor (FCERI) signaling R198933 Reactome Gene Sets 134 3 7.949604917 -2.188248223 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R3858494 Reactome Gene Sets 146 3 7.296212732 -2.086159305 Beta-catenin independent WNT signaling hsa04010 KEGG Pathway 294 4 4.831052421 -2.016130304 MAPK signaling pathway