Outlier,CHROM,Approx Pos,Pink Salmon Gene,Gene Like,GeneId,Info
1,1,26990871,LOC124003056,uncharacterized LOC124003056,,Blast returns zinc finger 345  after 10s of other hits
1,1,26990871,LOC124035667, leucine-rich repeat-containing protein 4C-like,LRC4C,May promote neurite outgrowth of developing thalamic neurons.
2,1,60247803,nap1l4a,,nap1l4a,"Predicted to enable chromatin binding activity and histone binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; mesoderm; nervous system; and pectoral fin. Orthologous to human NAP1L4 (nucleosome assembly protein 1 like 4)."
3,2,32191947,plin1,,plin1,"The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. "
3,2,32208882,gnrhr4,,gnrhr4,"Enables gonadotropin-releasing hormone receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gonad; heart; intestine; male organism; and nervous system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to several human genes including GNRHR2 (gonadotropin releasing hormone receptor 2 (pseudogene))."
4,2,92069251,lig3,,lig3,"This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized."
4,2,92117994,tmem132e,,tmem132e,Involved in posterior lateral line neuromast hair cell development. Predicted to be located in cell body. Implicated in autosomal recessive nonsyndromic deafness 99
5,5,70698462,LOC124035343,uncharacterized LOC124035343 ,,Blast reurns alpha-amylase after 10s of other hits
5,5,70698462,mrpl40,,mrpl40,"Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome."
5,5,70705310,LOC124036441,ubiquitin recognition factor in ER-associated degradation protein 1-like,UFD1,"Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I"
5,5,70712561,cdc45,,cdc45,"The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]"
5,5,70738288,LOC124036442, claudin-4-like,,"The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems."
5,5,70741727,zgc:63587,,zgc:63587,"Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cellular protein localization; cytoskeleton-dependent cytokinesis; and regulation of exocytosis. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including ciliary membrane; cleavage furrow; and midbody. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and synaptic vesicle."
6,6,28182361,LOC124037791,neuroligin-1-like,NLGN1,"redicted to enable neurexin family protein binding activity and signaling receptor activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in excitatory synapse and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface and synapse. Predicted to be integral component of postsynaptic specialization membrane. Is expressed in several structures, including brain; cardiovascular system; eye; gonad; and swim bladder. Orthologous to human NLGN1 (neuroligin 1)."
7,6,34635231,LOC124037889,BMP/retinoic acid-inducible neural-specific protein 3-like,BRIN3P,"This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene."
7,6,34635231,LOC124037108,uncharacterized LOC12403710,,
8,8,34869567,LOC124040638,G-protein coupled receptor 35-like,GPR35,"Enables C-X-C chemokine receptor activity. Involved in several processes, including chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Is integral component of plasma membrane. "
8,8,34903057,LOC124040842,semaphorin-6B-like,SEMA6B,"This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. "
9,8,43752511,LOC124040874, transcription factor MafB-like,MAFB,The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.
9,8,43752511,LOC124041687,nuclear receptor coactivator 6-like,NCOA6,"The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene."
10,8,61290205,LOC124040955,glypican-5-like,GPC5,Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
11,9,28035042,umad1,,umad1,
11,9,28052540,LOC124043343,replication protein A 14 kDa subunit-like,RFA3,"As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage "
11,9,28060150,LOC124043346,collagen alpha-2(V) chain-like,COL5A2,"This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II"
11,9,28074535,LOC124043344,glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-like,C1GALT1,"The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis."
11,9,28138413,LOC124042755,glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-like,C1GALT1,"The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis."
11,9,28138413,sdhaf3,,sdhaf3,Predicted to be involved in mitochondrial respiratory chain complex II assembly; regulation of gluconeogenesis; and succinate metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrial intermembrane space.
12,9,69062320,LOC124044004, ras-related protein Ral-B,RALB,This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.
12,9,69156185,lrp1bb,,lrp1bb,Predicted to enable calcium ion binding activity. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B).
13,11,34125167,LOC124047762,phospholipid phosphatase 4-like,PLPP4,Enables diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import.
13,11,34180725,LOC123989586, uncharacterized LOC123989586 ,,
13,11,34189729,LOC124047763,uncharacterized LOC124047763,,
14,12,34576382,LOC123991669,potassium channel subfamily K member 10-like,KCNK10,"The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene"
14,12,34592030,LOC123991721,B2 bradykinin receptor-like,BDKRB2,"This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system."
15,13,39253315,LOC123992852,schwannomin-interacting protein 1,SCHIP1,"Enables identical protein binding activity. Predicted to be involved in positive regulation of hippo signaling. Predicted to act upstream of or within several processes, including animal organ development; face morphogenesis; and fibroblast migration. Located in several cellular components, including cell junction; cytosol; and nuclear body."
15,13,39253315,LOC123992308,P2Y purinoceptor 3-like,P2RX3,Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception
16,13,56046821,LOC123994021,C-terminal-binding protein 1-like,CTBP1,"This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants."
16,13,56068584,LOC123992341,spondin 2-like,SPON2,"Predicted to enable antigen binding activity; lipopolysaccharide binding activity; and metal ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including defense response to other organism; opsonization; and positive regulation of cytokine production. Located in extracellular exosome."
17,14,52090382,LOC123995073,afadin-like,AFDN,"This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized"
18,15,53197706,LOC123998229,uncharacterized LOC123998229,,
18,15,53197706,LOC123997615,alpha-N-acetylgalactosaminidase-like,NAGAB,"Nagalase catalyzes the deglycosylation of the Gc protein also known as vitamin D3 binding protein (VDBP) rendering it incapable of being converted to the regulatory protein, Gc Macrophage Activating Factor (GcMAF). GcMAF is a protein involved in the activation of macrophages - in cases when many types of incompatible cells happen to be around, thus nagalase diminishes the body’s macrophage activating capacity, and elevated nagalase has been reported in systemic disorders including systemic lupus erythematosus (SLE)."
19,15,79115241,LOC123997340,"glutamate receptor ionotropic, NMDA 2D-like",GRIN2D,"N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). "
20,16,73302621,LOC123999818,piggyBac transposable element-derived protein 4-like,PGBD4,"The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families."
20,16,73302621,LOC124000439,amyloid protein-binding protein 2-like,APPBP2,"The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants."
21,16,79958276,LOC123999144,exportin-7,XPO7,The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.
21,16,79958276,LOC124000725,protein PBDC1-like,PBDC1,
21,16,80022104,LOC123999349,ras-specific guanine nucleotide-releasing factor 2-like,RASGRF2,"RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways."
22,16,80378895,LOC124000523,CAP-Gly domain-containing linker protein 1,CLIP1,The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene.
22,16,80382246,LOC124000748,B-cell CLL/lymphoma 7 protein family member A-like,BCL7A,
22,16,80395193,LOC124000231,translation initiation factor eIF-2B subunit alpha-like,EI2BA,Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
22,16,80401888,ddx55,,ddx55,"This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. "
22,16,80406995,LOC123999167,transmembrane emp24 domain-containing protein 2 ,TMED2,"Involved in several processes, including Golgi organization; negative regulation of GTPase activity; and protein localization to plasma membrane. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment."
23,16,83501812,cntnap3,,cntnap3,The protein encoded by this gene belongs to the NCP family of cell-recognition molecules. This family represents a distinct subgroup of the neurexins. NCP proteins mediate neuron-glial interactions in vertebrates and glial-glial contact in invertebrates. The protein encoded by this gene may play a role in cell recognition within the nervous system. Alternatively spliced transcript variants encoding different isoforms have been described but their biological nature has not been determined. 
24,18,48859985,ccnd3,,ccnd3,"The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene."
24,18,48881306,dstyk,,dstyk,This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
24,18,48931093,celsr2,,celsr2,"The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. "
25,18,56315110,cadpsa,,cadpsa,Predicted to enable metal ion binding activity. Predicted to be involved in exocytosis and positive regulation of exocytosis. Predicted to act upstream of or within dense core granule exocytosis; protein transport; and synaptic vesicle exocytosis. Predicted to be located in cytoplasmic vesicle. Predicted to be active in glutamatergic synapse. Is expressed in olfactory placode and peripheral olfactory organ. Orthologous to human CADPS (calcium dependent secretion activator).
25,18,56360470,nampt2,,nampt2,Predicted to enable nicotinamide phosphoribosyltransferase activity. Predicted to be involved in NAD biosynthetic process. Predicted to act upstream of or within pyridine nucleotide biosynthetic process and rhythmic process. Predicted to be located in cytoplasm; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase).
25,18,56404621,synpra,,synpra,Predicted to be located in membrane and synaptic vesicle. Predicted to be integral component of membrane. Orthologous to human SYNPR (synaptoporin).
26,19,4353946,LOC124005935,potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3-like,HCN3,This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins.
26,19,4387289,LOC124006196,pyruvate kinase PKM-like,PKM,"This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported."
26,19,4436398,LOC124004644,"cytochrome P450 11B, mitochondrial-like",CP11B,"Has 11 beta-hydroxylation, 18-hydroxylation activities and aldosterone synthetic activity. Catalyzes the final steps of glucocorticoid and mineralocorticoid biosynthesis."
27,19,65851175,alkbh8,,alkbh8,Enables tRNA (uracil) methyltransferase activity; tRNA binding activity; and zinc ion binding activity. Involved in cellular response to DNA damage stimulus; tRNA methylation; and tRNA wobble uridine modification. Located in cytosol and nuclear body. Implicated in autosomal recessive non-syndromic intellectual disability.
27,19,65851175,LOC124004703,guanylate cyclase soluble subunit alpha-2-like,GUCY1A2,"Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene."
28,20,14786536,LOC124007477,uncharacterized LOC124007477,,
30,21,27441121,LOC124008534,equilibrative nucleoside transporter 2-like,S29A2,"Mediates equilibrative transport of purine and pyrimidine nucleosides, and the purine base hypoxanthine."
30,21,27447244,LOC124008535,serine/threonine-protein phosphatase PP1-beta catalytic subunit,PPP1CB,"The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. "
30,21,27481722,LOC124008159,transcription factor p65-like,TF65,"NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells"
30,21,27505934,LOC124008178,uncharacterized LOC124008178,,
30,21,27519525,LOC124008719, dr1-associated corepressor-like,NC2A, dr1-associated corepressor-like
30,21,27520613,LOC124007706,mitogen-activated protein kinase kinase kinase 11-like,MAP3K11,"The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42"
31,22,14698004,LOC124009266,uncharacterized LOC124009266,,
31,22,14719464,LOC124009961,period circadian protein homolog 2-like,PER2,"This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. "
31,22,14757533,LOC124009839,transcription cofactor HES-6-like,HES6,"This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.["
31,22,14762252,LOC124010088,integral membrane protein 2C-like,Itm2c,"Enables ATP binding activity. Involved in positive regulation of extrinsic apoptotic signaling pathway. Located in lysosome. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human ITM2C (integral membrane protein 2C)."
31,22,14764384,lpar5a,,lpar5a,Predicted to enable G protein-coupled receptor activity. Predicted to be involved in behavioral response to pain and positive regulation of CREB transcription factor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human LPAR5
31,22,14793820,LOC124009960,G-protein coupled receptor 55-like,GPR55,This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways.
32,24,2565881,LOC124013273,uncharacterized LOC124013273,,
32,24,2565881,LOC124013275,oxidized low-density lipoprotein receptor 1-like,B7ZAN8,
32,24,2604986,LOC124013183,CD209 antigen-like protein A,Cd209a,Enables carbohydrate derivative binding activity and mannose binding activity. Predicted to be involved in immune response. Predicted to act upstream of or within regulation of T cell proliferation. Located in cell surface. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CD209 (CD209 molecule).
33,24,33655673,LOC124012221,mucin-5AC-like,MUC5AC,"Predicted to be an extracellular matrix structural constituent. Involved in phosphatidylinositol-mediated signaling. Located in cytoplasm; extracellular space; and mucus layer. Implicated in dry eye syndrome. Biomarker of several diseases, including Sjogren's syndrome; biliary tract disease (multiple); cystic fibrosis; eye disease (multiple); and pancreatic cancer (multiple)."
33,24,33663451,LOC124012222,mucin-5AC-like,MUC5AC,"Predicted to be an extracellular matrix structural constituent. Involved in phosphatidylinositol-mediated signaling. Located in cytoplasm; extracellular space; and mucus layer. Implicated in dry eye syndrome. Biomarker of several diseases, including Sjogren's syndrome; biliary tract disease (multiple); cystic fibrosis; eye disease (multiple); and pancreatic cancer (multiple)."
34,25,19360272,LOC124014460,ankyrin repeat and BTB/POZ domain-containing protein BTBD11-A-like ,ABTB3,Predicted to enable protein heterodimerization activity. Predicted to be involved in SMAD protein signal transduction. Predicted to be integral component of membrane.
34,25,19405130,LOC124014035,cyclin-dependent kinase inhibitor 1B-like,CDKN1B,"This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4)."
34,25,19416552,LOC124014286,protein Wnt-7b-like,WNT7B,"This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein."