<br>        Inclusion Criteria:<br><br>          -  Patients with stable or unstable angina or documented ischemia due to a significant<br>             lesion in a native coronary artery<br><br>          -  Patients eligible for coronary revascularization by means of PCI<br><br>          -  Intention to treat one lesion with one stent<br><br>          -  Patients suitable for coronary revascularization of any sort (balloon angioplasty,<br>             device-assisted balloon-angioplasty, or coronary artery bypass grafting)<br><br>          -  Patients must be = 18 years of age<br><br>          -  Women of childbearing potential may not be pregnant nor have the desire to becoming<br>             pregnant during the first year following the study procedure. Hence, patients will be<br>             advised to use an adequate birth control method up to and including 9 months<br>             follow-up<br><br>          -  Patients who are mentally and linguistically able to understand the aim of the study<br>             and to show sufficient compliance in following the study protocol<br><br>          -  Patients must agree to undergo the 9 months angiographic follow-up<br><br>          -  Patients must agree to undergo the 1 and 3 year clinical follow-up<br><br>          -  Patient is able to verbally acknowledge an understanding of the associated risks,<br>             benefits, and treatment alternatives to therapeutic options of this trial, e.g.<br>             balloon angioplasty by means of the Paclitaxel-eluting PTCA-balloon catheter in<br>             combination with the Coroflex BlueTM stent or the Sirolimus-eluting CypherTM stent.<br>             The patients, by providing informed consent, agree to these risks and benefits as<br>             stated in the patient informed consent document.<br><br>          -  Significant stenoses in native coronary arteries with nominal stent diameters between<br>             = 2.5 mm and = 3.5 mm and < 24 mm in length<br><br>        Exclusion Criteria:<br><br>          -  Unprotected left main<br><br>          -  In stent restenosis<br><br>          -  Indication for more than one lesion to treat, even as staged procedure<br><br>          -  Intended bifurcational stenting<br><br>          -  Patients requiring chronic anticoagulation<br><br>          -  SVG and AG<br><br>          -  Acute MI (STEMI, NSTEMI)<br><br>          -  Cardiogenic shock<br><br>          -  Chronic total occlusions<br><br>          -  Pregnancy<br><br>          -  Patients with stand alone balloon angioplasty, or stent deployment 6 months prior to<br>             enrolment into this study<br>