Exclusion criteria: 1. Intravesical BCG (Bacillus Calmette-Guérin) instillation = 6 months<br>2. Intravesical Mitomycin instillation = 3 months<br>3. Patients at high risk of suffering extensive bladder inflammation<br>4. Recent bladder surgery (resection) = 3 months<br>5. Patients with symptoms and signs of urinary tract infection, e.g.<br>moderate or severe leukocyturia, dysuria, alguria, urgency, frequency,<br>polyuria, offensive urine, cloudy urine, significant bacteriuria (= 100000<br>CFU/mL), positive urine culture, asymptomatic bacteriuria, suprapubic<br>tenderness, pain or pressure, flank or back pain, fever = 38°C,<br>costovertebral angle tenderness<br>6. Macroscopic hematuria<br>7. Bladder stones<br>8. Bladder capacity = 50 mL<br>9. Administration of any other photosensitiser < 6 months<br>10. Oral intake of any drug or substance containing Hypericum extract,<br>Hypericin, Pseudohypericin or parts of Hypericum plants (capsules,<br>tablets, powder, drops, teas, etc.) within 14 days prior to PDD, during the study and until<br>Visit 4 for patients included in the PK subgroup<br>11. All anticoagulation therapy except low dose heparin and aspirin<br>12. Known allergy to Hypericin, polyvinylpyrrolidone (PVP, povidone) or<br>any similar compounds<br>13. Pregnant or breast-feeding women<br>14. Participation in other clinical studies with investigational drugs<br>either concurrently or within the last 30 days<br>15. Previous participation in this clinical study<br>16. Conditions associated with a risk of poor protocol compliance<br>17. Patients with mental health problems<br>18. Patients who have difficulties in understanding the language in<br>which the patient information is given<br>19. Legal incapacity and/or other circumstances rendering the patient<br>unable to understand the nature, scope and possible impact of the study<br>20. Patients in custody by juridical or official order<br>21. Staff of the study centre, staff of the sponsor or CRO, the<br>investigator him-/herself or close relatives of the investigator