<br>        Inclusion Criteria:<br><br>          -  Main Inclusion at Screening:<br><br>               1. Subject has symptoms of OAB (urinary frequency and urgency with urgency<br>                  incontinence) for >= 3 months prior to the screening visit<br><br>               2. Subject is willing and able to complete the micturition diary and questionnaires<br>                  correctly, including collection and measurement of urine output for 3 days prior<br>                  to each visit;<br><br>               3. Subject has symptoms of wet OAB (urinary frequency and urgency with<br>                  incontinence or mixed incontinence with predominant urgency incontinence), and<br>                  reports an average of at least 2 incontinence episodes per day.<br><br>          -  Main Inclusion at Run-in (Visit 2):<br><br>               1. Subject experiences on average at least 1 episode of urgency (grade 3 or 4) with<br>                  or without incontinence per 24-hour period during the 3-day micturition diary<br>                  period.<br><br>               2. Subject experiences on average at least 2 incontinence episodes per 24-hour<br>                  period during the 3-day micturition diary period.<br><br>               3. Subject experiences on average at least 8 micturitions (excluding incontinence<br>                  episodes) per 24-hour period during the 3-day micturition diary period.<br><br>          -  Main Inclusion at Randomization (Visit 3):<br><br>               1. Subject experiences at least 1 incontinence episode during the 3-day micturition<br>                  diary period and wishes to increase their treatment for OAB symptoms.<br><br>        Exclusion Criteria:<br><br>          -  Main Exclusion at Screening:<br><br>               1. Subject in the opinion of the investigator has clinically significant Bladder<br>                  Outlet Obstruction (BOO).<br><br>               2. Subject has significant Post-void residual (PVR) volume (PVR > 150 ml).<br><br>               3. Subject has significant stress incontinence or mixed stress/urgency incontinence<br>                  where stress is the predominant factor as determined by the investigator<br><br>               4. Subject has an indwelling catheter or practices intermittent self<br>                  catheterization.<br><br>               5. Subject has evidence of a UTI.<br><br>               6. Subject has chronic inflammation such as interstitial cystitis, bladder stones,<br>                  previous pelvic radiation therapy, or previous or current malignant disease of<br>                  the pelvic organs<br><br>               7. Subject has moderate to severe hepatic impairment<br><br>               8. Subject has severe renal impairment or End Stage Renal disease<br><br>               9. Subject has a clinically significant abnormal Electrocardiogram (ECG)<br><br>              10. Subject has a concurrent malignancy or history of cancer (except noninvasive skin<br>                  cancer) within the last 5 years prior to screening.<br><br>              11. Subject has a QTcF interval > 450 ms for males or > 470 ms for females or is at<br>                  risk of QT prolongation (e.g., family history of long QT syndrome, hypokalaemia).<br><br>              12. Subject has received intravesical treatment in the past 12 months with e.g.,<br>                  botulinum toxin, resiniferatoxin, capsaicin.<br><br>              13. Subject has severe uncontrolled hypertension, which is defined as a sitting<br>                  average systolic blood pressure = 180 mmHg and/or average diastolic blood<br>                  pressure = 110 mmHg.<br><br>          -  Main Exclusion at Randomization (visit 3):<br><br>               1. Subject has achieved 100% continence from Visit 2 to Visit 3 (no incontinence<br>                  episodes are recorded in the 3 day diary administered for 3 days prior to Visit<br>                  3).<br><br>               2. Subject does not desire an increase in study medication.<br><br>               3. Subject has an average total daily urine volume > 3000ml as recorded in the<br>                  micturition diary.<br><br>               4. Subject has severe uncontrolled hypertension, which is defined as a sitting<br>                  average systolic blood pressure = 180 mmHg and/or average diastolic blood<br>                  pressure = 110 mmHg.<br><br>               5. Subject has a clinically significant abnormal ECG<br>