1. Intravesical BCG (Bacillus Calmette-Guérin) instillation ≤ 6 months<br/>2. Intravesical Mitomycin instillation ≤ 3 months<br/>3. Patients at high risk of suffering extensive bladder inflammation<br/>4. Recent bladder surgery (resection) ≤ 3 months<br/>5. Patients with symptoms and signs of urinary tract infection, e.g.<br/>moderate or severe leukocyturia, dysuria, alguria, urgency, frequency,<br/>polyuria, offensive urine, cloudy urine, significant bacteriuria (≥ 100000<br/>CFU/mL), positive urine culture, asymptomatic bacteriuria, suprapubic<br/>tenderness, pain or pressure, flank or back pain, fever ≥ 38°C,<br/>costovertebral angle tenderness<br/>6. Macroscopic hematuria<br/>7. Bladder stones<br/>8. Bladder capacity ≤ 50 mL<br/>9. Administration of any other photosensitiser < 6 months<br/>10. Oral intake of any drug or substance containing Hypericum extract,<br/>Hypericin, Pseudohypericin or parts of Hypericum plants (capsules,<br/>tablets, powder, drops, teas, etc.) within 14 days prior to PDD, during the study and until<br/>Visit 4 for patients included in the PK subgroup<br/>11. All anticoagulation therapy except low dose heparin and aspirin<br/>12. Known allergy to Hypericin, polyvinylpyrrolidone (PVP, povidone) or<br/>any similar compounds<br/>13. Pregnant or breast-feeding women<br/>14. Participation in other clinical studies with investigational drugs<br/>either concurrently or within the last 30 days<br/>15. Previous participation in this clinical study<br/>16. Conditions associated with a risk of poor protocol compliance<br/>17. Patients with mental health problems<br/>18. Patients who have difficulties in understanding the language in<br/>which the patient information is given<br/>19. Legal incapacity and/or other circumstances rendering the patient<br/>unable to understand the nature, scope and possible impact of the study<br/>20. Patients in custody by juridical or official order<br/>21. Staff of the study centre, staff of the sponsor or CRO, the<br/>investigator him-/herself or close relatives of the investigator