Change in Mean Cell Volume (fL);Time to first subsequent anticancer therapy or death (TFST);Time to pain progression (TTPP);Overall survival (OS);Time to opiate use;Time to a Symptomatic Skeletal-Related Event (SSRE);Circulating Tumour Cells (CTC) conversion;Time to second progression or death (PFS2);Brief Pain Inventory-Short Form (BPI-SF);Functional Assessment of Cancer Therapy- Prostate Cancer (FACT-P);Homologous Recombination Repair (HRR) gene status;Maximum plasma concentration at steady state [Cmax,ss];Time to maximum plasma concentration at steady state (Cmax,ss) [tmax,ss];Minimum plasma concentration at steady state [Cmin,ss];Partial area under the concentration-time curve in 0-8 h [AUC0-8]);Maximum plasma concentration at steady state [Cmax,ss];Time to maximum plasma concentration at steady state (Cmax,ss) [tmax,ss];Minimum plasma concentration at steady state [Cmin,ss];Partial area under the concentration-time curve [AUC0-8]);Number of adverse events;Vital signs-blood pressure;Vital signs-pulse rate;Vital signs-body temperature;ECG;Change in Albumin (g/L);Change in Alkaline phosphatase (U/L);Change in Aspartate aminotransferase (U/L);Change in Amylase (U/L);Change in Alanine aminotransferase (U/L);Change in Total bilirubin (μmol/L);Change in Direct bilirubin;Change in Calcium (mmol/L);Change in Chloride (mmol/L);Change in Creatinine (μmol/L);Change in Gamma glutamyltransferase (U/L);Change in Fasting gucose (mmol/L);Change in Lactate dehydrogenase (U/L);Change in Magnesium (mmol/L);Change in Potassium (mmol/L);Change in Phosphorus ((mmol/L);Change in Sodium (mmol/L);Change in Carbon dioxide (mEq/L );Change in Total protein (g/L);Change in Urea or blood urea nitrogen, depending on the local practice (mmol/L);Change in absolute neutrophil count (/L);Change in absolute lymphocyte count (/L);Change in haemoglobin (g/L);Change in platelet count with differential (/L);Change in total white blood cell count with differential(/L);Change in red blood cell count (/l);Change in Haematocrit (%);Urinalysis:change in blood;Urinalysis: Change in protein;Urinalysis: change in glucose