<br>        Inclusion Criteria:<br><br>          -  male or female aged 18-50<br><br>          -  patients with grass pollen related allergic rhinoconjunctivitis for at least 2 pollen<br>             seasons<br><br>          -  Positive skin prick test and IgE value of at least Class 2+<br><br>          -  RTSS of greater or equal to 14 during pollen season prior tot the start of the study<br><br>          -  Patients must be in general good health<br><br>          -  Patients with normal spirometry<br><br>          -  Informed consent given and willing to comply with the protocol<br><br>          -  Female patients are eligible if they use an accepted contraceptive method<br><br>          -  Negative urine pregnancy test if female<br><br>        Exclusion Criteria:<br><br>          -  Pregnancy, breast feeding<br><br>          -  Asthma requiring treatment other than beta-2 inhaled agonists<br><br>          -  patients who have taken oral steroids within 12 weeks before screening visit<br><br>          -  patients who have received desensitisation treatment for grass pollen<br><br>          -  treatment by immunotherapy with any other allergen within the previous 5 years<br><br>          -  patients who have suffered a lower respiratory tract infection within 4 weeks or an<br>             upper respiratory tract infection within 2 weeks of the screening visit<br><br>          -  patients at risk of non-compliance<br><br>          -  participation in any other clinical study within the previous 3 months<br><br>          -  patients with a past or current disease, which may affect participation in or outcome<br>             of this study.<br><br>          -  patients treated with beta-blockers or under continuous corticotherapy<br><br>          -  allergic sensitivity to epithelial allergens the patients is exposed to<br><br>          -  positive skin prick test for environmental allergens and suffering from serious<br>             allergic symptoms due to exposure to these allergens during study period<br><br>          -  intention to subject the patient to surgery of the nasal cavity during current study<br><br>          -  Usual contraindications of immunotherapy<br><br>          -  a clinical history of symptomatic seasonal allergic rhinitis and/or asthma due to<br>             tree pollen or weed pollen adjacent to the start of, and potentially overlapping the<br>             grass pollen season<br>