<br>        Inclusion Criteria:<br><br>          -  Male, non-smoking volunteers without regular medication or regular alcohol<br>             consumption will be included.<br><br>          -  Before inclusion blood will be drawn and the following blood count, liver, pancreas,<br>             kidney, thyroid and coagulation parameters will be examined:<br><br>               -  Creatinine (0.5 – 1.3 mg/dl),<br><br>               -  Alc. Phosphatase (38 - 126 U/l),<br><br>               -  GGT (0 - 85 U/l),<br><br>               -  ALAT (0 - 50 U/l),<br><br>               -  ASAT (0 - 37 U/l),<br><br>               -  LDH (0 - 248 U/l),<br><br>               -  Cholinesterase (>7000 U/l),<br><br>               -  Amylase (25 - 130 U/l),<br><br>               -  Lipase (114 - 300 U/l),<br><br>               -  Leucocytes (3,5 – 11.0 10E9/L),<br><br>               -  Erythrocytes (4.0 – 5.9 10E12/L),<br><br>               -  Hb (12.0 – 17.5 g/dl),<br><br>               -  Ht (33 – 50%),<br><br>               -  Platelets (145 – 440 10E9/L),<br><br>               -  CrP (< 10 mg/l),<br><br>               -  TSH (0.4 - 5.0 mE/l),<br><br>               -  fT4 (6 - 23 pmol/l),<br><br>               -  INR (0.75 – 1.30),<br><br>               -  PTT (15.0 – 33.0 sec.)<br><br>        The results have to be within the physiological range (as given in parenthesis).<br><br>        Moreover, volunteers have mentally to be able to understand the explanations concerning<br>        the study and follow to the instructions of the investigator.<br><br>        Exclusion Criteria:<br><br>          -  Any acute or chronic disease,<br><br>          -  Heartburn more than once weekly,<br><br>          -  Alcohol consumption of more than 50 g ethanol-equivalent per week,<br><br>          -  Smoking,<br><br>          -  Known hypersensitivity against esomeprazole,<br><br>          -  Benzimidazole or other ingredients of the medication,<br><br>          -  Fructose-intolerance,<br><br>          -  Glucose-galactose-malabsorption or saccharase-isomaltase-deficiency.<br>