<br>        Inclusion Criteria:<br><br>          -  Subjects must have voluntarily signed the informed consent form before any study<br>             related action<br><br>          -  Males and females must be at least 18 years of age and not more than 80 year old.<br><br>          -  Have at least one missing tooth in the posterior mandible or maxilla in quadrant 1,<br>             2, 3, 4 (FDI positions 4-7), requiring one or more dental implants.<br><br>          -  Partially edentulous patients and patients in need of a fixed dental prosthesis<br><br>          -  The tooth at the implant site(s) must have been extracted or lost at least 6 weeks<br>             before the date of implantation.<br><br>          -  Bone defect(s) must be present with a vertical dimension greater than or equal to 3<br>             mm at the foreseen GBR site measured after dental implant placement.<br><br>          -  Full mouth bleeding on Probing (FMBoP) and full mouth plaque score (FMPI) are both<br>             lower or equal than 25%<br><br>          -  Patients must be committed to the study.<br><br>        Exclusion Criteria:<br><br>          -  Presence of conditions requiring chronic routine prophylactic use of antibiotics<br>             (e.g., history of rheumatic heart disease, bacterial endocarditis, cardiac valvular<br>             anomalies, prosthetic joint replacements)<br><br>          -  Major systemic diseases<br><br>          -  Medical conditions requiring prolonged use of steroids<br><br>          -  Use of Bisphosphonate intravenously<br><br>          -  Current pregnancy or breastfeeding women<br><br>          -  Physical or mental handicaps that would interfere with the ability to perform<br>             adequate oral hygiene<br><br>          -  Alcoholism or chronically drug abuse<br><br>          -  Immunocompromised patients<br><br>          -  Patients who smoke more than 10 cigarettes per day or cigar equivalents, or who chew<br>             tobacco<br><br>          -  Conditions or circumstances, in the opinion of the investigator, which would prevent<br>             completion of study participation or interfere with analysis of study results, such<br>             as history of non-compliance, or unreliability.<br><br>        Local exclusion criteria<br><br>          -  Local inflammation, including untreated periodontitis<br><br>          -  Regenerative treatment necessary adjacent to the planned study site of interest<br><br>          -  Mucosal diseases or oral lesions<br><br>          -  History of local irradiation therapy<br><br>          -  Severe bruxing or clenching habits<br><br>          -  Persistent intraoral infection<br><br>          -  Patients with inadequate oral hygiene or unmotivated for adequate home care<br><br>          -  Previous GBR or GTR treatment at the implant site<br><br>          -  Lack of primary stability of the dental implant at site of interest. In this instance<br>             the patient must be withdrawn and the patient treated accordingly (exclusion criteria<br>             at surgery)<br>