A Bioresorbable Gene-eluting Stent Using Hyperbranched Polymers

In this work, a WE43 Mg-based surface were anodized. After anodization, the surface properties of WE43 Mg-based surface were enhanced. What’s more, HPAE polymer nanoparticles are synthesized by microfluidic chips, the size of polymer nanoparticles were from 217 nm to 380 nm. With the increase of total flow rate, the size of polymer nanoparticles increased. HPAE polymer nanoparticles were used to test transfection efficacy. There were no significant difference between the groups.

For next step, we are preparing to add PCL layer to WE43 Mg-based surface. And then, we will add HPAE polymer nanoparticles to PCL layer. Cell viability, confocal microscopy technology will be used to test the efficacy results.