Formulation and Development of Boswellia serrata Extract-Loaded Microspheres for Targeted Delivery of Anti-Inflammatory Agents

Abstract: This study aimed to develop and optimize Boswellia serrata extract-loaded microspheres for targeted delivery of anti-inflammatory agents. Five formulations of microspheres were prepared using the solvent evaporation technique, with varying ratios of PLGA to B. serrata extract. The resulting microspheres were characterized for particle size, percentage yield, encapsulation efficiency, drug loading, and in vitro drug release. The particle size ranged from 4.68 to 8.64 µm, with all formulations showing high encapsulation efficiency (over 80%) and drug loading (around 10%). In vitro release studies showed sustained release of the drug over 24 hours, with F3 showing the highest release percentage (69.12%). These results suggest that Boswellia serrata extract-loaded microspheres have potential as a targeted delivery system for anti-inflammatory agents, with sustained release properties. Further studies, including in vivo testing, are needed to evaluate the efficacy and safety of these microspheres.