Cluster decorated functional DNA origami based biosensor: Towards Safe Nano-innovations

The poster, presented at BMT2022 in Innsbruck, Austria, gives an overview of the Safe-by-Design and Sustainability-by-Design actions taken within the EU H2020-funded project DeDNAed. The project aims to develop a sensitive, versatile and ultrafast cutting-edge bioanalytical platform by assembling and integrating sensing elements using DNA origami.

DeDNAed will foster a safer nano-enabled biosensor considering the Safe-by-Design approach and sustainability aspects. Several nanocomponents are in the development stage such as atomic nanocluster-decorated aptamers and antibodies as well as DNA origami and gold NPs. Unique and novel properties and materials attributes need to be checked for unanticipated hazard or exposure behaviours. DeDNAed will define a preliminary hazard/risk assessment and control plans for the DNA origami biosensor nanocomponents.