Formulation and Characterization Of Qurecetin Perio Dontal Films For Local Delivery Of Antimicrobials

ABSTRACT

A novel periodontal film for the treatment of periodontitis was developed by using herbal drug Quercetin, it is a plant flavanol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds and grains; capers and red onions. It has a bitter flavour and is used as an antimicrobial agent and effective against infecting microorganisms in the periodontal pocket. Calibration curves for Quercetin was developed in phosphate buffer P^H 6.6, FT-IR studies was performed, which revealed that no interaction between the selected drug and polymers. Differential scanning calorimetry was performed to the identification of various physical properties and thermal transitions of drug and the polymeric materials. Periodontal films were prepared by solvent casting technique using Eutragit  and HPMC as polymers Dibutyl phthalate as plasticizers and PEG as surface active agent. The formulated periodontal films were evaluated for their folding endurance, percent moisture loss, surface pH, viscosity, thickness, uniformity of weight, content uniformity, and in-vitro release. Scanning electron microscopy was done to study the surface characteristics of the patch on placebo and optimized formulation F3 before dissolution and after dissolution. SEM analysis revealed that the drug was uniformly distributed in patch and drug was released by diffusion. Data of In-vitro release from the formulated periodontal films were fit to different equations and kinetic models to explain release kinetics. Kinetic models used were zero first-order equations and Higuchi models. The release mechanism was understood by fitting the data to Korsemeyer-Peppas model.

Keywords: Quercetin periodontal film, Periodontitis, Controlled release and Gingivitis.