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Published June 1, 2022 | Version 1
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Supplementary Data for "Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance"

  • 1. Memorial Sloan Kettering Cancer Center


We performed functional genomic profiling of diverse leukemias using label tracing techniques. We identified AML stem cell quiescence is defined by distinct promoter-centered chromatin and gene expression dynamics, and controlled by a novel transcription factor network, which is associated with disease persistence and chemotherapy resistance in multiple patients.


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