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This is the accepted manuscript version of the work published in its final form as Raggi, Alberto; Monasta, Lorenzo; Beghi, Ettore; Caso, Valeria; Castelpietra, Giulio; Mondello, Stefania; Giussani, Giorgia; Logroscino, Giancarlo; Magnani, Francesca Giulia; Piccininni, Marco; Pupillo, Elisabetta; Ricci, Stefano; Ronfani, Luca; Santalucia, Paola; Sattin, Davide; Schiavolin, Silvia; Toppo, Claudia; Traini, Eugenio; Steinmetz, Jaimie; Nichols, Emma; Ma, Rui; Vos, Theo; Feigin, Valery; Leonardi, Matilde. Journal of Neurology; Volume: 269; Pages: 2080–2098; https://doi.org/10.1007/s00415-021-10774-5

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