Published December 1, 2021 | Version v1
Conference paper Open

Development of a physiologically relevant 3D in vitro model for osteosarcoma cell cultivation comprising alginate composite scaffolds and a perfusion bioreactor system

  • 1. Faculty of Technology and Metallurgy, University of Belgrade, Serbia
  • 2. Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia

Description

The aim of this work was to develop a 3D microenvironment for osteosarcoma tumor engineering based on macroporous alginate scaffolds with incorporated hydroxyapatite/β-tricalcium phosphate powder as a matrix for cell immobilization followed by cultivation in a biomimetic perfusion bioreactor.

Notes

Premurosa

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Funding

PREMUROSA – Precision medicine for muscoloskeletal regeneration, prosthetics and active ageing 860462
European Commission