Synthesis and biological evaluation of 3-(phthalimidoethyl)-4-substituted cinnamoyl substituted benzanilides

university Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar-751 004,
Orissa. India

E-mail : tuku_kh@yahoo.com Fax : 91-0674-2581850

Department of Chemistry. Berhampur University, Berhampur-760 007, Orissa, India

Manuscript received 6 December 2004, revised 14 November 2005, accepted 10 May 2006

3-Phthalimidoethyl substituted benzoic acids (2) were prepared by refluxing N-hydroxyethyl phthalimide (1) with substituted benzoic acids.The corresponding acid chlorides(3)were condensed with 4 aminoacetophenone in anhydrous potassium carbonate to give 3-phthalimidoethyl-4-acetyl substituted benzanilides (4).The substituted benzanilide derivatives (4) were condensed with diverse aryl aldehydes to afford the title compounds (5). Compounds (5) were screened for their possible hypoglycemic and \(in\) \(vitro\) antibacterial activities.