Ready file of the study “HIV protease and integrase empirical substitution models of evolution: Protein-specific models outperform generalist models” The folder “Substitution models” includes the four empirical substitution models developed in this study: HIVpr, HIVin, VIRpr and VIRin. The folder "Method data" includes the method datasets (10 or 1 partitioned method datasets) used to infer every empirical substitution model. The folder “Test data" includes the 4 datasets belonging to evaluate the developed empirical substitution models. For any questions or further information please contact rdelamparo@uvigo.es or marenas@uvigo.es.