Published January 17, 2023 | Version v1
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Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Description

Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphism in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in Catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.

Notes

This data includes mean amplitudes, connectivity matrices, and detrended fluctuation analysis scaling exponents derived from 82 subjects' magnetoencephalographic resting-state recordings. The results of polymorphism analysis can be found, along with parcellation information, in the "settings" subfolder. This data can be used for replicating the main results from "Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations" with the python code in the associated code repository https://github.com/palvalab/RS-Gen.

Funding provided by: Academy of Finland
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002341
Award Number: SA 1266402

Funding provided by: Academy of Finland
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002341
Award Number: SA 1267030

Funding provided by: Academy of Finland
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002341
Award Number: SA 1266745

Funding provided by: Academy of Finland
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002341
Award Number: SA 1296304

Funding provided by: Academy of Finland
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002341
Award Number: SA 1294761

Funding provided by: Jane and Aatos Erkko Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100004012
Award Number:

Funding provided by: Jane ja Aatos Erkon Säätiö

Funding provided by: Academy of Finland
Award Number: 1267030

Funding provided by: Academy of Finland
Award Number: 1296304

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