// C++ script derived from the original O'Hara-Rudy dynamic model
// including a Markov model for hERG gating similar with that described in
// Li et al. 2017 https://doi.org/10.1161/CIRCEP.116.004628
// but with simplified pharmacodynamic component including only blocking/unblocking rates
// used to compute several proarrhythmogenic risk predictors, particularly Qnet
// as described in Dutta et al. 2017 https://doi.org/10.3389/fphys.2017.00616
// pharmacology data for a 12-compounds set (CiPA training set)
// and a supplementary 16-compounds set (CiPA validation set)
// and for chloroquine and hydroxychloroquine using experimental data from:
// Thomet U, Amuzescu B, Knott T, Mann SA, Mubagwa K, Radu BM (2021)
// Assessment of Proarrhythmogenic Risk for Chloroquine and Hydroxychloroquine Using the CiPA Concept
// European Journal of Pharmacology (in review)



// Copyright (c) 2011-2015 by Thomas O'Hara, Yoram Rudy,
//                            Washington University in St. Louis.
// All rights reserved.
//
// Redistribution and use in source and binary forms, with or without
// modification, are permitted provided that the following conditions are
// met:
//
// 1. Redistributions of source code must retain the above copyright notice,
// this list of conditions and the following disclaimer.
//
// 2. Redistributions in binary form must reproduce the above copyright
// notice, this list of conditions and the following disclaimer in the
// documentation and/or other materials provided with the distribution.
//
// 3. Neither the names of the copyright holders nor the names of its
// contributors may be used to endorse or promote products derived from
// this software without specific prior written permission.
//
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS
// IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED
// TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A
// PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT
// HOLDERS OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,
// SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT
// LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF
// USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND
// ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
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// THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH
// DAMAGE.
//

// C++ Implementation of the O'Hara-Rudy dynamic (ORd) model for the
// undiseased human ventricular action potential and calcium transient
//
// The ORd model is described in the article "Simulation of the Undiseased
// Human Cardiac Ventricular Action Potential: Model Formulation and
// Experimental Validation"
// by Thomas O'Hara, Laszlo Virag, Andras Varro, and Yoram Rudy
//
// The article and supplemental materails are freely available in the
// Open Access jounal PLoS Computational Biology
// Link to Article:
// http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002061
//
// Email: tom.ohara@gmail.com / rudy@wustl.edu
// Web: http://rudylab.wustl.edu
//