Index Study_ID Authors Gene Locus Response Trait_class EAF_study EAF_1000genomes Male_d Male_d_Var Male_d_SE Female_d Female_d_Var Female_d_SE z-value P-value Genotype_A Genotype B Males_N_A Males_Mean_A Males_SD_A Males_N_B Males_Mean_B Males_SD_B Females_N_A Females_Mean_A Females_SD_A Females_N_B Females_Mean_B Females_SD_B Total_N N_AA N_AB N_BB Allele_age_generations Notes study_statistic M_p_study F_p_study 1 4 Lauritzen et al. 2017 FADS1/2 rs1535 Concentration performance score Sex-opposite complex traits 0.672 0.678 0.2275 0.0113 0.1065 -0.2394 0.0124 0.1116 3.027 0.002 AA AG or GG 765 317 28729 compute Cohen's d based on means and SD provided in Table 3 model estimate 0.001 0.029 2 4 Lauritzen et al. 2017 FADS1/2 rs174448 "Reading speed, sentences" Sex-opposite complex traits 0.642 0.596 0.5511 0.0114 0.1069 -0.6074 0.0127 0.1129 7.451 0 AA AG or GG 765 299 46161 compute Cohen's d based on means and SD provided in Table 3 model estimate <0.001 <0.001 3 4 Lauritzen et al. 2017 ELOVL5 rs2397142 "Reading speed, sentences" Sex-opposite complex traits 0.695 0.596 -0.1963 0.0109 0.1042 0.2364 0.012 0.1095 -2.863 0.004 CC CG or GG 765 338 30324 compute Cohen's d based on means and SD provided in Table 3 model estimate <0.001 0.03 4 4 Lauritzen et al. 2017 FADS1/2 rs174448 "Correct sentences, n" Sex-opposite complex traits 0.642 0.596 0.6599 0.0116 0.1077 -0.3451 0.0124 0.1112 6.49 0 AA AG or GG 765 299 46161 compute Cohen's d based on means and SD provided in Table 3 model estimate <0.001 0.002 5 8 Wu et al. 2016 OPRM1 rs1799971 Speed-dating success Sex-opposite complex traits 0.922 0.777 0.4697 0.0518 0.2275 -0.53 0.0816 0.2856 2.738 0.006 AA AG or GG 108 5.643 1.236684277 24 5.056 1.308027523 111 6.261 1.237939316 14 6.907 1.043922411 257 219 36 2 1882 compute Cohen's d based on means and SE provided in Figure 1 beta <0.05 <0.05 6 8 Wu et al. 2016 HTR2A rs6311 Speed-dating success Sex-opposite complex traits 0.418 -0.4826 0.0393 0.1982 0.4702 0.0386 0.1964 -3.415 0.001 AA AG or GG 39 5.18 1.127222139 79 5.726 1.133244788 38 6.7 1.106512314 88 6.201 1.041272299 244 77 130 37 20287 compute Cohen's d based on means and SE provided in Figure 1 beta <0.05 <0.05 7 12 Winkler et al. 2015 SIM1 rs17185536 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.76 0.837 -0.0166 0.0001 0.008 0.0264 0 0.0067 -4.117 0 C T 320485 18264 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 8 12 Winkler et al. 2015 NMU rs3805389 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.28 0.2 -0.0139 0 0.0067 0.0261 0 0.006 -4.44 0 A G 320485 3242 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 9 12 Winkler et al. 2015 GNPNAT1 rs4898764 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.53 0.534 0.0208 0 0.0066 -0.0165 0 0.0059 4.202 0 A G 320485 58564 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 10 12 Winkler et al. 2015 SGCZ rs17470444 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.71 0.736 0.0345 0.0001 0.0081 -0.0149 0 0.0068 4.678 0 A G 320485 45723 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 11 12 Winkler et al. 2015 IQGAP2 rs2069664 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.53 0.751 0.0244 0.0001 0.0078 -0.0183 0 0.0067 4.135 0 G A 320485 11728 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 12 12 Winkler et al. 2015 SLC2A3 rs741361 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.6 0.0272 0.0001 0.0079 -0.0196 0 0.0067 4.533 0 A G 320485 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 13 12 Winkler et al. 2015 IRS1 rs2673140 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.38 0.229 0.022 0 0.0066 -0.0209 0 0.0059 4.855 0 G A 320485 49243 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 14 12 Winkler et al. 2015 TTN rs2042995 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.23 0.478 0.0198 0 0.0066 -0.022 0.0001 0.0078 4.095 0 C T 320485 66603 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 15 12 Winkler et al. 2015 RXRA rs10881574 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.07 0.094 0.0268 0.0001 0.008 -0.0191 0 0.0067 4.399 0 C T 320485 18767 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 16 12 Winkler et al. 2015 PTPRD rs7042428 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.98 0.971 0.0244 0.0001 0.0071 -0.0166 0 0.0063 4.317 0 A G 320485 14879 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 17 12 Winkler et al. 2015 CECR2 rs17809093 Waist-hip-ratio (BMI adjusted) Sex-opposite complex traits 0.04 0.06 0.0294 0.0001 0.0091 -0.024 0.0001 0.0077 4.476 0 G C 320485 9315 "Table 2 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta <0.001 <0.001 18 17 Schneider et al. 2015 CHRNA5 rs3841324 Reaction time (RT) in the Stroop task Sex-opposite complex traits 0.406 -1.5421 0.1488 0.3857 0.9945 0.0634 0.2517 -5.507 0 SS L+ 10 386.839 13.48553308 40 449.361 44.50905807 20 440.905 28.46290929 106 396.041 47.50403747 176 30 83 63 compute Cohen's d based on means and SE provided in Figure 2 unknown post-hoc test <0.05 <0.05 19 17 Schneider et al. 2015 CHRNA5 rs3841324 Reaction time (RT) in the Stroop task Sex-opposite complex traits 0.406 -1.6215 0.1513 0.389 1.0215 0.0636 0.2521 -5.702 0 SS L+ 10 388.231 13.67526974 40 477.066 60.42163925 20 467.993 35.02129666 106 410.661 59.14324734 176 30 83 63 compute Cohen's d based on means and SE provided in Figure 2 unknown post-hoc test <0.05 <0.05 20 17 Schneider et al. 2015 CHRNA5 rs3841324 Reaction time (RT) in the Negative priming task Sex-opposite complex traits 0.406 -1.675 0.1531 0.3912 0.6299 0.061 0.247 -4.982 0 SS L+ 10 518.274 14.67296834 40 567.311 31.70499582 20 588.083 22.36962405 106 554.399 57.33121644 176 30 83 63 compute Cohen's d based on means and SE provided in Figure 2 unknown post-hoc test <0.05 <0.05 21 18 Cicchetti et al. 2014 OXTR rs53576 Borderline personality traits after maltreatment Sex-opposite complex traits 0.738 0.611 -0.3429 0.0078 0.0881 0.2066 0.0074 0.0857 -4.47 0 GG AG or AA 1070 576 390 79 "40,213" "compute F-value from P value and sanple sizes, then compute Cohen's d d from F-value and sample sizes using Fomula in Koricheva et al. 2013 p.200" F test 0.018 0.016 22 18 Cicchetti et al. 2014 FKBP5 CATT haplotype Borderline personality traits after maltreatment Sex-opposite complex traits 0.2041 0.0077 0.0877 -0.195 0.0073 0.0857 3.254 0.001 0 copies 1 or 2 copies 1070 397 "compute F-value from P value and sanple sizes, then compute Cohen's d d from F-value and sample sizes using Fomula in Koricheva et al. 2013 p.200" F test <0.001 0.003 23 27 Kiy et al. 2013 C16orf62 (OXTR) rs226849 fluid intelligence Sex-opposite complex traits 0.46 -0.3949 0.0349 0.1869 0.494 0.0329 0.1814 -3.413 0.001 CC or CT TT 250 54 122 74 66527 "compute Cohen's d based on the reported R2: first square root R2 to get r and then use formula in Koricheva et al. 2013, p. 200 to compute Cohen's d (or Cohen's d first)" beta 0.003 0.017 24 27 Kiy et al. 2013 C16orf62 (OXTR) rs226849 face perception Sex-opposite complex traits 0.46 -0.5819 0.0365 0.1909 0.3498 0.032 0.1788 -3.562 0 CC or CT TT 250 54 122 74 66527 "compute Cohen's d based on the reported R2: first square root R2 to get r and then use formula in Koricheva et al. 2013, p. 200 to compute Cohen's d (or Cohen's d first)" beta 0.001 0.025 25 27 Kiy et al. 2013 C16orf62 (OXTR) rs226849 face memory Sex-opposite complex traits 0.46 -0.3679 0.0348 0.1864 0.3562 0.032 0.1789 -2.803 0.005 CC or CT TT 250 54 122 74 66527 "compute Cohen's d based on the reported R2: first square root R2 to get r and then use formula in Koricheva et al. 2013, p. 200 to compute Cohen's d (or Cohen's d first)" beta 0.024 0.023 26 29 Price et al. 2013 SLC6A4 rs25531 Hippocampal volume Sex-opposite complex traits 0.39 GG AG or AA 51 17 27 6 53709 compute Cohen's d based on means and SE provided in Figure B1 z score <0.05 <0.05 27 43 Herman et al. 2010 SLC6A4 rs25531 Sociopathy (in alcoholics) Sex-opposite complex traits 0.51 GG AG or AA 862 208 428 226 53709 compute Cohen's d either based on means and SD or F-values provided in Table 4 F test 0.01 0.009 28 44 Padmanabhan et al. 2010 PON1 rs3917542 systolic blood pressure S_NIGHT Sex-opposite complex traits -0.1047 0.0041 0.0637 0.1129 0.0042 0.0645 -2.402 0.016 1956 42594 "Table 6 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta 0.05 0.04 29 44 Padmanabhan et al. 2010 PON3 rs17884563 systolic blood pressure S_NIGHT Sex-opposite complex traits -0.1482 0.0041 0.0637 0.1061 0.0042 0.0645 -2.804 0.005 1956 1374 "Table 6 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta 0.01 0.05 30 44 Padmanabhan et al. 2010 EDNRB rs1335803 systolic blood pressure S_CLIN Sex-opposite complex traits -0.1308 0.0041 0.0637 0.1129 0.0042 0.0645 -2.688 0.007 1956 5085 "Table 6 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta 0.04 0.01 31 44 Padmanabhan et al. 2010 DRD1 rs265974 diastolic blood pressure D_NIGHT Sex-opposite complex traits -0.1482 0.0041 0.0637 0.1502 0.0042 0.0646 -3.288 0.001 1956 39123 "Table 7 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta 0.04 0.01 32 44 Padmanabhan et al. 2010 SLC4A2 rs2303933 diastolic blood pressure D_HOME Sex-opposite complex traits -0.1482 0.0041 0.0637 0.1325 0.0042 0.0646 -3.094 0.002 1956 43995 "Table 7 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta 0.01 0.02 33 44 Padmanabhan et al. 2010 LPL rs17410577 diastolic blood pressure D_CLIN Sex-opposite complex traits -0.1047 0.0041 0.0637 0.1775 0.0042 0.0647 -3.11 0.002 1956 15925 "Table 7 reports slopes (beta) with p-values; compute SE of slope using the p-value, then compute t-value as slope divided by SE, and compute Cohen's d using t-value" beta 0.05 0.003 34 48 Shalev et al. 2009 BDNF rs6265 Psychological Stress Sex-opposite complex traits 0.149 GG AG or AA 97 68 29 0 1983 "compute F-value from P value and sanple sizes, then compute Cohen's d d from F-value and sample sizes using Fomula in Koricheva et al. 2013 p.200" F test 0.007 0.016 35 57 Krner et al. 2007 FAS rs2228305 BMI standard deviation score (children) Sex-opposite complex traits 0.0312 0.051 -0.552 0.051 0.2259 0.4427 0.0431 0.2075 -3.243 0.001 CT or TT CC 738 0 15 190 1766 compute Cohen's d based on means and SE provided in Figure 1a t test <0.05 <0.05 36 61 Fillingim et al. 2005 OPRM1 rs1799971 Pain sensitivity Sex-opposite complex traits 0.8817 0.777 AA AG or GG 167 131 36 2 1882 Cohen's d provided in Table 2; compute Variance of Cohen's d using sample sizes and d according to formula in Borenstein 2009 Cohen's D <0.05 <0.05 37 19 Liu et al. 2014 PRR3 rs2074503 Graves opthalmopathy in GD Disease risk/severity 0.3586 0.4397 0.0283 0.1682 -0.2185 0.0072 0.0851 3.492 0 AA or AG GG 467 57 226 191 41490 Convert Odds Ratio to Cohen's d using formula provided in Borenstein 2009 p47 Chi square 0.008 0.01 38 28 Ljungberg et al. 2013 REN rs6693954 Central DBP Sex-opposite complex traits 0.22 0.3 -0.4444 0.0454 0.2132 1.1052 0.1539 0.3923 -3.471 0.001 AA AT or TT 761 31 256 432 35461 use p-value and sample size to compute t-value and then Cohen's d t test 0.018 0.013 39 35 Sainz et al. 2012 LTA rs1041981 Colorectal cancer Disease risk/severity 0.32 0.39 -0.0722 0.0014 0.0368 0.1027 0.0021 0.0453 -2.998 0.003 A AA or CA 3620 371 1489 1627 31651 Convert Odds Ratio to Cohen's d using formula provided in Borenstein 2009 p47 likelihood ratio test 0.05 0.02 41 37 Ovadia and Shifman 2011 RELN rs7341475 Schizophrenia risk Disease risk/severity 0.851 1.2396 0.0795 0.2819 -0.762 0.1341 0.3662 4.332 0 GG AG or AA 94 46 94 14298 extract data from Figure 1 permutation test 0.02 0.02 42 38 Press et al. 2011 ESR2 (CA)n repeats Colon cancer survival Disease risk/severity 0.2272 0.0092 0.0962 -0.2046 0.0145 0.1205 2.801 0.005 SS or SL LL 318 91 37462 compute from risk ratio risk ratio 0.014 0.083 43 42 Kim et al. 2010 DAO rs2070586 Schizophrenia risk Disease risk/severity 0.2729 0.304 0.1982 0.0079 0.0888 -0.2537 0.0082 0.0908 3.559 0 AA or AG GG 794 61 306 418 40448 Convert Odds Ratio to Cohen's d using formula provided in Borenstein 2009 p47 Chi square 0.025 0.005 44 47 McCarthy et al. 2009 SCARB1 rs9919713 "T2DM, fasting glucose" Disease risk/severity 0.04 0.265 0.1865 0.0073 0.0853 -0.2515 0.0049 0.0697 3.976 0 TT or TN NN 1382 37840 compute Cohen's d based on means and SE provided in Figure 5 t test 0.01 0.002 45 58 Sjoberg et al. 2006 SLC6A4 rs25531 Depression Disease risk/severity 0.4586 0.5404 0.0518 0.2277 -0.3996 0.0346 0.1859 3.198 0.001 SS or SL LL 200 46 90 62 53709 "assuming that non-parametric test-statistic showed F-distribution, compute F value from P-value and then Cohen's d" non-parametric rank test 0.032 0.018 46 59 Morea et al. 2005 CFTR rs213950 Infertility in cystic fibrosis Disease risk/severity 0.417931 22386 52167 cannot compute effect size Chi square <0.01 <0.01 47 60 Wong et al. 2005 APOE rs429358 Bone mineral density Disease risk/severity 0.0798 737 3 97 592 35562 cannot compute effect size t test 0.031 0.02 48 67 Dauvilliers et al. 2001 COMT Long allele Narcolepsy severity Disease risk/severity 0.4588 1.3596 0.1504 0.3878 -2.2152 0.2372 0.4871 5.741 0 L HH 34 4.3 1.0684358 10 5.6 0.284604989 19 5.95 1.627177274 10 3 0.158113883 218 40 112 66 25899 compute Cohen's d based on means and SD provided in Table 2 Chi square <0.03 <0.03 49 1 Carlson et al. 2018 IPMK rs11142081 Nonsyndromic cleft lip Disease risk/severity 0.863 0.839 1.2156 0.0088 0.0937 -1.1161 0.0061 0.0783 19.098 0 TT G 3842 647 42923 compute Cohen's d based on means and SD extracted from figure 2 likelihood ratio test <0.0001 <0.0001 50 1 Carlson et al. 2018 IPMK rs72804706 Nonsyndromic cleft lip Disease risk/severity 0.898 0.87 -0.816 0.0082 0.0906 2.0665 0.0082 0.0908 -22.473 0 CC T 3842 1670 compute Cohen's d based on means and SD extracted from figure 2 likelihood ratio test <0.0001 <0.0001 51 1 Carlson et al. 2018 IPMK rs77590619 Nonsyndromic cleft lip Disease risk/severity 0.744 0.682 -0.8577 0.0082 0.0904 1.2291 0.0065 0.0804 -17.247 0 GG A 3842 48750 compute Cohen's d based on means and SD extracted from figure 2 likelihood ratio test <0.0001 <0.0001 52 56 Gloria-Bottini et al 2007 ACP1 A* allele (CG haplotype) Allergy Disease risk/severity 48 cannot compute effect size Odds ratio <0.05 <0.05 53 25 Youssef et al. 2012 IL-12B rs3212227 Hepatitis C susceptability Disease risk/severity 0.3463 0.359 CC AA or CA 238 29 93 116 4260 "Compute Odds ration based on information in Table 3, and then transfrom to Cohen's d" Chi square 0.045 0.004 54 41 Schuurof et al. 2010 IL-9 rs2069885 RSV severity Disease risk/severity 0.15 0.1888 0.0087 0.0933 -0.2794 0.0092 0.0957 3.504 0 TT or CT CC 470 23867 "Odds ratio provided in Table 2, convert to Cohen's d" Odds ratio 95% (CI) 95% (CI) 56 55 Peng et al. 2008 NR3C1 GCAG haplotype Bone mineral density Disease risk/severity 0.6854 0.1351 0.3676 -0.9029 0.1858 0.4311 2.804 0.005 800 Table 3 provides all information to compute Cohen's d Chi square 0.001 <0.001 57 49 Lang et al. 2008 NGF rs6330 Anxiety Disease risk/severity 0.451 0.4562 0.0324 0.18 -0.4674 0.033 0.1817 3.612 0 CC CT 337 98 174 65 29977 combute Cohen's d from t-values and then Cohen's d Ancova <0.05 <0.05 58 3 Sangalli et al. 2017 "RNASEL, miR-146a" AG/AA and C haplotype Melanoma risk Disease risk/severity 0.4525 0.0245 0.1564 -0.3553 0.0303 0.174 3.452 0.001 616 combute Cohen's d from OR data provided in Table 3 logistic regression 0.0036 0.04