### single cell data for manuscript: 

Multiomics approach identifies novel age-, time- and treatment-related immunopathological signatures in MIS-C and pediatric COVID-19

### Files:
1. misc_SeuratObj_submission.rds -- Seurat object contains all count data used for the manuscript
- raw sequencing data are not provided due to privacy issue
- metadata is included in the Seurat object

2. MIS-C_cohort_citeseq.xlsx -- sample meta data

3. immcant_bcr_ighl_filtered.csv -- single cell BCR data

4. TCR_filtered_contig_annotations.csv -- single cell TCR data


### SessionInfo for major packages used when creating the Seurat object
> sessionInfo()

R version 3.6.1 (2019-07-05)
Platform: x86_64-conda_cos6-linux-gnu (64-bit)
Running under: Red Hat Enterprise Linux Server 7.9 (Maipo)

Matrix products: default

locale:
[1] en_US.UTF-8

attached base packages:
[1] parallel  stats4    stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] openxlsx_4.2.3         RColorBrewer_1.1-2     reshape2_1.4.4         org.Hs.eg.db_3.10.0   
 [5] AnnotationDbi_1.48.0   IRanges_2.20.2         S4Vectors_0.24.4       Biobase_2.46.0        
 [9] BiocGenerics_0.32.0    clusterProfiler_3.14.3 viridis_0.5.1          viridisLite_0.3.0     
[13] pheatmap_1.0.12        parallelDist_0.2.4     genefilter_1.68.0      forcats_0.5.1         
[17] stringr_1.4.0          dplyr_1.0.4            purrr_0.3.4            readr_1.4.0           
[21] tidyr_1.1.2            tibble_3.1.0           ggplot2_3.3.3          tidyverse_1.2.1       
[25] plyr_1.8.6             matrixStats_0.58.0     Seurat_3.1.0          

loaded via a namespace (and not attached):
  [1] utf8_1.1.4          reticulate_1.18     R.utils_2.9.2       tidyselect_1.1.0   
  [5] RSQLite_2.2.0       htmlwidgets_1.5.3   grid_3.6.1          BiocParallel_1.20.1
  [9] Rtsne_0.15          munsell_0.5.0       codetools_0.2-18    mutoss_0.1-12      
 [13] ica_1.0-2           future_1.21.0       withr_2.4.1         colorspace_2.0-0   
 [17] GOSemSim_2.12.1     rstudioapi_0.13     ROCR_1.0-11         DOSE_3.12.0        
 [21] listenv_0.8.0       Rdpack_2.1.1        labeling_0.4.2      urltools_1.7.3     
 [25] mnormt_2.0.2        polyclip_1.10-0     bit64_4.0.5         farver_2.1.0       
 [29] parallelly_1.23.0   vctrs_0.3.6         generics_0.1.0      TH.data_1.0-10     
 [33] R6_2.5.0            graphlayouts_0.7.1  rsvd_1.0.3          bitops_1.0-6       
 [37] cachem_1.0.3        fgsea_1.12.0        gridGraphics_0.5-1  assertthat_0.2.1   
 [41] SDMTools_1.1-221.1  scales_1.1.1        multcomp_1.4-13     ggraph_2.0.0       
 [45] enrichplot_1.4.0    debugme_1.1.0       gtable_0.3.0        globals_0.14.0     
 [49] tidygraph_1.1.2     sandwich_3.0-0      rlang_0.4.10        splines_3.6.1      
 [53] lazyeval_0.2.2      broom_0.7.5         europepmc_0.4       BiocManager_1.30.10
 [57] yaml_2.2.0          modelr_0.1.8        backports_1.2.1     qvalue_2.16.0      
 [61] tools_3.6.1         ggplotify_0.0.5     ellipsis_0.3.1      ggridges_0.5.3     
 [65] TFisher_0.2.0       Rcpp_1.0.6          progress_1.2.2      RCurl_1.98-1.2     
 [69] prettyunits_1.1.1   pbapply_1.4-3       cowplot_1.1.1       zoo_1.8-8          
 [73] haven_2.1.0         ggrepel_0.9.1       cluster_2.1.1       magrittr_2.0.1     
 [77] data.table_1.14.0   DO.db_2.9           lmtest_0.9-38       triebeard_0.3.0    
 [81] RANN_2.6.1          tmvnsim_1.0-2       mvtnorm_1.1-1       fitdistrplus_1.1-3 
 [85] hms_1.0.0           xtable_1.8-4        XML_3.99-0.3        readxl_1.3.1       
 [89] gridExtra_2.3       compiler_3.6.1      KernSmooth_2.23-18  crayon_1.4.1       
 [93] R.oo_1.24.0         htmltools_0.5.1.1   RcppParallel_5.0.3  lubridate_1.7.10   
 [97] DBI_1.1.1           tweenr_1.0.1        MASS_7.3-53.1       Matrix_1.3-2       
[101] cli_2.3.1           R.methodsS3_1.8.1   rbibutils_2.0       metap_1.4          
[105] igraph_1.2.6        pkgconfig_2.0.3     sn_1.6-2            rvcheck_0.1.8      
[109] numDeriv_2016.8-1.1 plotly_4.9.0        xml2_1.3.2          annotate_1.64.0    
[113] multtest_2.42.0     rvest_0.3.6         digest_0.6.27       sctransform_0.2.0  
[117] RcppAnnoy_0.0.18    tsne_0.1-3          cellranger_1.1.0    leiden_0.3.7       
[121] fastmatch_1.1-0     uwot_0.1.8          lifecycle_1.0.0     nlme_3.1-152       
[125] jsonlite_1.7.2      fansi_0.4.2         pillar_1.5.0        lattice_0.20-41    
[129] fastmap_1.1.0       httr_1.4.2          plotrix_3.8-1       survival_3.2-7     
[133] GO.db_3.10.0        glue_1.4.2          zip_2.1.1           UpSetR_1.4.0       
[137] png_0.1-7           bit_4.0.4           ggforce_0.3.2       stringi_1.5.3      
[141] blob_1.2.1          memoise_2.0.0       mathjaxr_1.4-0      irlba_2.3.3        
[145] future.apply_1.6.0  ape_5.4-1