Characterization of vaccine-breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community in France
Creators
- 1. LBM BIOESTEREL–Biogroup–Plateau technique de Mouans-Sartoux, Mouans-Sartoux, France
- 2. BPO-BIOEPINE–Biogroup–Plateau technique Chocolaterie, Levallois-Perret, France
- 3. BIOLITTORAL – Biogroup – Plateau technique la Bastide, Sanary sur Mer, France
- 4. BPO-BIOEPINE–Biogroup–Plateau technique Chocolaterie, Levallois-Perret, France; UMR1173 INSERM, UniversitéParis-Saclay–UVSQ, Montigny-le-Bretonneux, France
- 5. DYOMEDEA-NEOLAB-Biogroup – Plateau technique de la Sauvegarde, Lyon 9 France
- 6. Institute of Ecology and Environmental Sciences of Paris (iEES-Paris, UMR 7618), CNRS, Sorbonne Université, UPEC, IRD, INRAE, 75252 Paris, France
Description
Abstract :
We compare test results of SARS-CoV-2 positive patients, depending on their vaccine status, the presence of symptoms and whether they are infected by the Delta variant or not, using a large number of PCR tests done in the community in France from 14 June 2021 to 30 July 2021. In asymptomatic individuals, Ct values at the first positive test were higher in fully vaccinated individuals (> 2 weeks after final dose) than non fully vaccinated individuals (1.7 [1, 2.3], p < 1e-6). In symptomatic individuals however, Ct values at the time of symptoms were not significantly different in vaccinated compared to unvaccinated individuals (p = 0.26). This was true both for infections by Delta and non-Delta (essentially Alpha in France at the time) variants. These results imply that some infected vaccinated individuals, especially if symptomatic, may transmit the virus as much as unvaccinated individuals.
Files
Blanquart-etal_2021_breakthroughInfections_v2.pdf
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Additional details
Related works
- Is identical to
- Preprint: https://hal.sorbonne-universite.fr/hal-03318483 (URL)