BLSA Study Numbers

Study Population

- Timeframe for current analysis: 
- n: 3023
  - Sex (Female): 46.64%
  - Strain (NW): 22.36%
  - Sex_Strain
    - Female_NW: 12.64%
    - Female_W: 34.01%
    - Male_NW: 9.73%
    - Male_W#: 43.63%
  - Diabetes: 15.15%

Measurement Frequencies (mean (SD)

- Fasting blood glucose: 5.83 (4.53)
- Body weight: 6.12 (4.76)
- Body fat: 5.77 (4.50)

Death and Life Expectancy (median (IQR))

- Deaths (1193)
- Median Life expectancy: 86.00 (79.00, 91.00)
  - Midlife or 50% MLE: 43.00 
  - Late Life or 75% MLE: 64.50 
  - Oldest in Life or 90% MLE: 77.40

Rate of Change Increment (5% MLE)

- All: 4 years
- Female: 4 years
- Male: 4 years
- NW: 4 years
- W: 4 years
- Female_NW: 4 years
- Female_W: 4 years
- Male_NW: 4 years
- Male_W: 4 years

Rate of Percent Change in Metabolic Indices During Pre- and Post-Peak Phases by Sex
Metabolic
Index 		Group Peak Age \(^†\)
(years) 		Pre-Peak\(^‡\)\(^§\)Rate
(per 4 years) 		Post-Peak\(^‡\)\(^§\)Rate
(per 4 years)
Glucose Male 69.00
(63.00, 75.00) 		0.70 %
(0.69, 0.70)* 		-0.64 %
(-0.64, -0.63)*
Female 69.00
(61.00, 76.00) 		0.65 %
(0.65, 0.66)* 		-0.58 %
(-0.58, -0.57)*
Male 67.00
(58.00, 75.00) 		0.75 %
(0.74, 0.76)* 		-0.57 %
(-0.58, -0.57)*
Body Weight Male 60.00
(52.00, 66.00) 		0.81 %
(0.80, 0.82)* 		-1.35 %
(-1.36, -1.34)*
Female 61.00
(54.00, 67.00) 		1.03 %
(1.02, 1.03)* 		-1.22 %
(-1.22, -1.21)*
Male 52.00
(44.00, 59.00) 		0.96 %
(0.94, 0.98)* 		-1.42 %
(-1.43, -1.41)*
Waist Circumference Male 73.00
(65.00, 80.00) 		0.88 %
(0.87, 0.88)* 		-0.55 %
(-0.56, -0.54)*
Female 69.00
(61.00, 78.00) 		1.00 %
(0.99, 1.01)* 		-0.28 %
(-0.28, -0.28)*
Male 68.00
(57.00, 78.00) 		1.01 %
(0.99, 1.03)* 		-0.36 %
(-0.36, -0.35)*
Note:
Entire population and sex-race-specific values are both listed.
The numbers in parentheses are 95% CI.
One sample Student’s t-test was used to test whether the means are significantly different from zero.
* p-value < 0.05 was considered statistically significant.
† Mean (range of ages at similar values) of age at peak index value
‡ Mean (95% confidence interval) rate of percent change
§ Pre-peak is defined as 25% life expectancy to age at peak value; post-peak is defined as peak to 125% life expectancy

Test of Statistical Interaction of Mortality Hazard Ratio Comparing Highest and Lowest Metabolic Index Quartiles at Varying Timepoints by Sex and Strain
Metabolic
Index 		Time Point Sex Strain
Glucose Midlife 0.22 0.13
Late Life 0.96 0.73
Oldest in Life 0.91 0.38
Body Weight Midlife 0.35 0.27
Late Life 0.33 0.85
Oldest in Life 0.28 0.36
Body Fat Midlife 0.71 0.81
Late Life 0.22 1.00
Oldest in Life 1.00 0.63
Note:
P-values are calculated from a likelihood ratio test comparing the base model of age,
sex, and strain, with a model additionally adjusting for the interaction term.
Mortality Hazard Ratios of Highest and Lowest Glucose Quartiles at Varying Timepoints Stratified by Sex
All
Female
Male
Timepoint\(^‡\) Model 1 Model 2 Model 1 Model 2 Model 1 Model 2
Midlife 1.60 (0.75, 3.42) 1.42 (0.64, 3.15) 1.11 (0.38, 3.26) 0.99 (0.33, 3.00) 1.84 (0.62, 5.42) 1.56 (0.50, 4.87)
Late Life 1.40 (1.05, 1.86)* 1.36 (1.00, 1.83)* 1.24 (0.76, 2.02) 1.45 (0.86, 2.42) 1.39 (0.98, 1.97) 1.26 (0.87, 1.82)
Oldest in Life 1.32 (1.06, 1.65)* 1.09 (0.76, 1.58) 1.40 (0.95, 2.05) 1.40 (0.95, 2.08) 1.29 (0.98, 1.70) 1.28 (0.96, 1.71)
* p-value < 0.05
† Hazard ratios (95% confidence intervals) are adjusted for: Model 1) age and sex; Model 2) additionally adjusted for body fat
‡ Timepoint is percent of median life expectancy
Mortality Hazard Ratios of Highest and Lowest Body Weight and Waist Circumference Quartiles at Varying Timepoints Stratified by Sex
Metabolic Index Timepoint\(^‡\) All Female Male
Body Weight Midlife 1.46 (0.68, 3.12) 1.55 (0.52, 4.65) 1.42 (0.49, 4.13)
Late Life 0.97 (0.72, 1.30) 0.63 (0.37, 1.09) 1.12 (0.79, 1.59)
Oldest in Life 0.91 (0.72, 1.14) 0.79 (0.54, 1.16) 0.96 (0.72, 1.27)
Waist Circumference Midlife 1.33 (0.67, 2.61) 1.83 (0.63, 5.30) 1.15 (0.47, 2.80)
Late Life 1.27 (0.94, 1.72) 0.70 (0.40, 1.25) 1.54 (1.07, 2.21)*
Oldest in Life 1.06 (0.85, 1.31) 1.04 (0.72, 1.50) 1.05 (0.80, 1.38)
* p-value < 0.05
† Hazard ratios are adjusted for age and sex
‡ Midlife: 50% median life expectancy, Late Life: 75% median life expectancy, Older in Life: 90% median life expectancy