GO id GO term Pathway Enrichment score (ES) Normalized enrichment score (NES) P value FDR Size Leading edge GO:0044281 small molecule metabolic process GO_SMALL_MOLECULE_METABOLIC_PROCESS -0.332619758456919 -1.69000468634115 1.34321942832581e-05 0.0269718461207823 332 NAMPT,PGM2,TALDO1,GCDH,GBAS,APOBEC2,HPRT1,ERLIN2,ALDH6A1,MSRA,COQ7,CYGB,PPA1,ALDH2,ECI2,PCCB,DCXR,NT5C,ABHD10,PAM,QDPR,ACO2,MPST,ENO1,SDHA,APOC1,PAFAH1B1,ADA,IVD,ALDH4A1,VCAN,BCAT2,CBR1,BGN,MCCC2,AKR7A2,AHCY,NDUFB8,ME3,MTAP,NDUFV1,GPI,OLA1,PEPD,NDUFC2,FH,BDH1,GLUD1,OXCT1,C3,NDUFB9,ACAD10,LHPP,BRP44,SDHB,ACSBG2,AK4,COQ9,OGDH,ETFA,MCCC1,NDUFS3,ACO1,NDUFA10,COX5A,AKR1A1,SUCLG1,CA3,IDH2,NDUFS8,PRELP,ATP5D,ADK,GSS,ECHS1,NDUFA5,GSTO1,GPD1L,NDUFA9,ME2,CA1,ATP5J2,HIBADH,ACADVL,CYB5R3,ATP5F1,NDUFB2,COQ3,PGM5,NDUFB3,CRAT,GOT1,OGN,FMOD,NDUFS7,COQ5,AQP1,COX4I1,ATP5A1,CS,MCEE,COX6C,SDHD,ALDH1A1,P4HB,UQCRFS1,STOML2,PTGES2,CYC1,NDUFB11,PTGR2,PRKAR2B,PDXK,ENO3,PCCA,HSD17B10,DLAT,DDAH2,HSD17B4,PDHA1,DBT,WARS,PCYOX1,NME1,ESD,IDH3A,ALDH1A2,CKM,NDUFA7,UQCRC2,SUCLA2,ETFB,SLC25A11,ATP1B1,PGK1,ECH1,NDUFB10,GLRX,NDUFS4,MTHFD1,ACAT1,PRDX4,PDE5A,NDUFA3,CAT,ALDH5A1,TPI1,PGM1,UQCR10,ALDH7A1,ADI1,SLC25A12 GO:0043062 extracellular structure organization GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION 0.419021982141105 1.83376133783162 0.000242600679281902 0.144165066878931 68 CD36,COL3A1,COL5A3,COL8A1,LAMC1,COL4A2,COL1A1,LAMB2,VTN,MFAP5,COL1A2,FBN1,LAMA2,NID1,ENG,COL4A1,HSPG2,ERO1L,COL14A1,POSTN,LAMA5,LAMB1,FN1,ANXA2,FKBP1A,COL18A1,FBLN5,MYH11,NID2,ITGB1 GO:0015908 fatty acid transport GO_FATTY_ACID_TRANSPORT 0.771594872324678 2.108005495502 0.000253117952966082 0.144165066878931 11 CD36,APOE,SLC25A20,PRKAG2,FABP3,PRKAA2,CPT1B GO:0016054 organic acid catabolic process GO_ORGANIC_ACID_CATABOLIC_PROCESS -0.464269870240851 -1.84473787477698 0.000337181483919654 0.144165066878931 59 GCDH,ALDH6A1,ECI2,PCCB,DCXR,ABHD10,QDPR,IVD,ALDH4A1,BCAT2,MCCC2,AHCY,GLUD1,ACAD10,OGDH,ETFA,MCCC1,AKR1A1,ECHS1,HIBADH,ACADVL,CRAT,GOT1,MCEE,PCCA,HSD17B10,DDAH2,HSD17B4,DBT,PCYOX1,ETFB,ECH1,ACAT1,ALDH5A1,ALDH7A1 GO:0045333 cellular respiration GO_CELLULAR_RESPIRATION -0.416319898518291 -1.77174339240574 0.000358976760156701 0.144165066878931 86 ACO2,SDHA,NDUFB8,ME3,NDUFV1,NDUFC2,FH,NDUFB9,SDHB,COQ9,OGDH,ETFA,NDUFS3,ACO1,NDUFA10,COX5A,SUCLG1,IDH2,NDUFS8,NDUFA5,NDUFA9,NDUFB2,NDUFB3,NDUFS7,COX4I1,CS,COX6C,SDHD,UQCRFS1,CYC1,NDUFB11,DLAT,PDHA1,IDH3A,NDUFA7,UQCRC2,SUCLA2,ETFB,NDUFB10,NDUFS4,NDUFA3,CAT,ALDH5A1,UQCR10,SLC25A12,NDUFS5,SIRT3,PDHB,NDUFS1,UQCRC1,NDUFAF2 GO:0015909 long chain fatty acid transport GO_LONG_CHAIN_FATTY_ACID_TRANSPORT 0.778867252653563 2.06568833482872 0.000456881781838949 0.152903102988768 10 CD36,APOE,SLC25A20,PRKAG2,FABP3,PRKAA2,CPT1B GO:1901565 organonitrogen compound catabolic process GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS -0.448846208059757 -1.81247788058041 0.000543018223052721 0.155768655984266 64 BLVRA,GCDH,APOBEC2,HPRT1,ALDH6A1,NT5C,QDPR,MPST,ADA,IVD,ALDH4A1,VCAN,BCAT2,BGN,MCCC2,AHCY,MTAP,GLUD1,OGDH,MCCC1,PRELP,NPEPPS,HIBADH,GOT1,OGN,FMOD,TPP1,HSD17B10,DDAH2,DBT,AGRN,PCYOX1,MAOB,MAOA GO:0040017 positive regulation of locomotion GO_POSITIVE_REGULATION_OF_LOCOMOTION 0.491355570013527 1.91996957959811 0.00065912893576028 0.16544136287583 40 MYO1C,GLIPR2,COL1A1,FAM83H,VTN,C1QBP,PFN1,RETN,CDH13,SDCBP,POSTN,LAMB1,FN1,LGALS1,HSPA5,COL18A1,RRAS2,MYADM,ITGB1,RDX GO:0006520 cellular amino acid metabolic process GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS -0.457260611409915 -1.76223922066707 0.00156395093103954 0.262352319795402 51 GCDH,ALDH6A1,MSRA,PPA1,QDPR,MPST,IVD,ALDH4A1,BCAT2,MCCC2,AHCY,MTAP,PEPD,GLUD1,OGDH,MCCC1,GSS,HIBADH,GOT1,P4HB,HSD17B10,DDAH2,DBT,WARS,PCYOX1,CKM,MTHFD1,ACAT1,PRDX4,ALDH5A1,ALDH7A1,ADI1 GO:0044282 small molecule catabolic process GO_SMALL_MOLECULE_CATABOLIC_PROCESS -0.390245190950491 -1.66999916460425 0.00165093604959038 0.262352319795402 89 PGM2,GCDH,ALDH6A1,ALDH2,ECI2,PCCB,DCXR,ABHD10,QDPR,ENO1,IVD,ALDH4A1,BCAT2,MCCC2,AHCY,GPI,BDH1,GLUD1,OXCT1,ACAD10,OGDH,ETFA,MCCC1,AKR1A1,ECHS1,HIBADH,ACADVL,PGM5,CRAT,GOT1,MCEE,ALDH1A1,ENO3,PCCA,HSD17B10,DDAH2,HSD17B4,DBT,PCYOX1,ESD,ETFB,PGK1,ECH1,ACAT1,ALDH5A1,TPI1,PGM1,ALDH7A1 GO:0060306 regulation of membrane repolarization GO_REGULATION_OF_MEMBRANE_REPOLARIZATION 0.752072310950433 1.92778082876389 0.00206036180859012 0.262352319795402 9 GJA1,CACNA2D1,NPPA,ANK2 GO:0099623 regulation of cardiac muscle cell membrane repolarization GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION 0.827741494665071 1.85400003408413 0.00214934633281631 0.262352319795402 6 GJA1,CACNA2D1,NPPA,ANK2 GO:0044248 cellular catabolic process GO_CELLULAR_CATABOLIC_PROCESS -0.300301910088452 -1.48422136967206 0.00216064010705623 0.262352319795402 251 PGM2,RPL39,PCBP2,BLVRA,RPL13A,GCDH,APOBEC2,HPRT1,ERLIN2,ALDH6A1,PSMD2,RPS2,NEDD8,ECI2,PCCB,DCXR,RPL10A,NT5C,ABHD10,QDPR,PSME2,UBA1,MPST,EIF4B,ADA,PSMB6,IVD,PPP2R1A,PRDX3,ALDH4A1,VCAN,BCAT2,BGN,MCCC2,AHCY,RPS3,MTAP,GPI,BDH1,GLUD1,OXCT1,ACAD10,PSMA2,RPL10,PSMA1,RANBP1,CRYZ,OGDH,ETFA,MCCC1,RNH1,AKR1A1,RPSA,STBD1,PRELP,NPEPPS,LONP1,ECHS1,GSTO1,GSTM3,DROSHA,UBE2L3,HIBADH,ACADVL,GSTM2,PSMC2,CRAT,UBR4,GOT1,OGN,FMOD,CAPN1,PRDX2,RPL21,MCEE,PABPC4,AIFM1,TPP1,HBA2,HBA1,PCCA,PSMC3,HSD17B10,HNRNPD,USP5,DDAH2,HSD17B4,DBT,CTSB,RPL22,HMGB1,HBB,GPX3,PCYOX1,MAOB,MAOA,ESD GO:0006082 organic acid metabolic process GO_ORGANIC_ACID_METABOLIC_PROCESS -0.321726509608109 -1.53106426264628 0.00224585603338356 0.262352319795402 182 GCDH,ALDH6A1,MSRA,CYGB,PPA1,ECI2,PCCB,DCXR,ABHD10,PAM,QDPR,ACO2,MPST,ENO1,SDHA,IVD,ALDH4A1,VCAN,BCAT2,CBR1,BGN,MCCC2,AHCY,ME3,MTAP,GPI,PEPD,FH,GLUD1,C3,ACAD10,BRP44,SDHB,ACSBG2,OGDH,ETFA,MCCC1,ACO1,AKR1A1,SUCLG1,IDH2,PRELP,GSS,ECHS1,GSTO1,ME2,HIBADH,ACADVL,CYB5R3,CRAT,GOT1,OGN,FMOD,CS,MCEE,SDHD,P4HB,PTGES2,PTGR2,PRKAR2B,ENO3,PCCA,HSD17B10,DLAT,DDAH2,HSD17B4,PDHA1,DBT,WARS,PCYOX1,IDH3A,ALDH1A2,CKM,SUCLA2,ETFB,PGK1,ECH1,MTHFD1,ACAT1,PRDX4,ALDH5A1,TPI1,PGM1,ALDH7A1,ADI1 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY -0.76856962497232 -1.81324777412564 0.00226753288822503 0.262352319795402 8 YWHAH,YWHAZ,YWHAB,YWHAG,YWHAQ,DYNLL2 GO:0019068 virion assembly GO_VIRION_ASSEMBLY 0.856926771565466 1.80591514475647 0.00274791180511635 0.262352319795402 5 UBC,APOE,PDCD6IP GO:1901606 alpha amino acid catabolic process GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS -0.578240676612965 -1.80596958354023 0.00331808960561153 0.262352319795402 21 GCDH,ALDH6A1,QDPR,IVD,ALDH4A1,MCCC2,AHCY,GLUD1,OGDH,MCCC1,HIBADH,GOT1 GO:0044272 sulfur compound biosynthetic process GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS -0.469941169786891 -1.73055419912403 0.0033604586037624 0.262352319795402 41 GCDH,MPST,VCAN,BGN,GSTK1,AHCY,ACOT9,MTAP,BRP44,ACSBG2,AKR1A1,PRELP,GSS,GSTO1,GSTM3,GSTM2,OGN,FMOD GO:0001890 placenta development GO_PLACENTA_DEVELOPMENT -0.651383811861529 -1.82149649407984 0.00348042044878185 0.262352319795402 14 KRT8,KRT19,TRIM28,ADA,HSP90AB1,PRDX3,DAZAP1 GO:1901564 organonitrogen compound metabolic process GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS -0.274788138325966 -1.40495427117745 0.00350153108773798 0.262352319795402 358 NAMPT,PGM2,RPL39,PCBP2,BLVRA,CLIC4,TALDO1,RPL13A,GCDH,GBAS,EEF1A1P5,APOBEC2,HPRT1,EIF3F,ALDH6A1,EEF2,MSRA,EIF4H,RPS2,PPA1,PCCB,DCXR,RPL10A,NT5C,CLIC1,PAM,QDPR,TUFM,MPST,ENO1,EIF4B,PAFAH1B1,ADA,IVD,PPP2R1A,ALDH4A1,VCAN,BCAT2,VAPA,AEBP1,BGN,GSTK1,MCCC2,AHCY,RPS3,NDUFB8,MTAP,NDUFV1,GPI,OLA1,PEPD,NDUFC2,GLUD1,NDUFB9,BRP44,RPL10,AK4,COQ9,OGDH,MCCC1,NDUFS3,NDUFA10,COX5A,AKR1A1,RPSA,NDUFS8,PRELP,NPEPPS,ATP5D,ADK,GSS,NDUFA5,GSTO1,HPX,GSTM3,AGT,GPD1L,NDUFA9,PCBD2,MRPS23,ATP5J2,HIBADH,GSTM2,ATP5F1,NDUFB2,ITIH1,NDUFB3,CRAT,GOT1,OGN,FMOD,NDUFS7,AQP1,COX4I1,EEF1A2,RPL21,ASAH1,ATP5A1,MCEE,COX6C,ALAD,P4HB,UQCRFS1,STOML2,CYC1,NDUFB11,PABPC4,PDXK,ENO3,TPP1 GO:0072350 tricarboxylic acid metabolic process GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS -0.539776058426785 -1.78139982375211 0.00351986940774371 0.262352319795402 26 ACO2,SDHA,FH,GLUD1,SDHB,OGDH,ACO1,SUCLG1,IDH2,CS,SDHD,DLAT,PDHA1,IDH3A,SUCLA2 GO:0000003 reproduction GO_REPRODUCTION -0.385360759576956 -1.62932186181098 0.00360524170794407 0.262352319795402 83 NAMPT,CLIC4,KRT8,RAN,EIF4H,ARID4A,KRT19,TRIM28,ACTR3,PAM,SERPINF1,PAFAH1B1,ADA,PPP2R1A,HSP90AB1,PRDX3 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY -0.779600122742637 -1.76381719995388 0.00368976993199248 0.262352319795402 7 YWHAH,YWHAZ,YWHAB,YWHAG,YWHAQ,DYNLL2 GO:0034723 dna replication dependent nucleosome organization GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION 0.623796423658872 1.8750771370023 0.00377694888216389 0.262352319795402 15 HIST1H3A,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H NA chromatin silencing at rdna GO_CHROMATIN_SILENCING_AT_RDNA 0.623796423658872 1.8750771370023 0.00377694888216389 0.262352319795402 15 HIST1H3A,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0006790 sulfur compound metabolic process GO_SULFUR_COMPOUND_METABOLIC_PROCESS -0.400116534054962 -1.64722189340191 0.00380883143155166 0.262352319795402 71 CLIC4,GCDH,MSRA,PCCB,CLIC1,MPST,VCAN,BGN,GSTK1,MCCC2,AHCY,ACOT9,MTAP,BRP44,ACSBG2,OGDH,MCCC1,AKR1A1,SUCLG1,PRELP,GSS,GSTO1,GSTM3,GSTM2,OGN,FMOD,MCEE,PCCA,DLAT,HSD17B4,PDHA1,PCYOX1,ESD GO:0010876 lipid localization GO_LIPID_LOCALIZATION 0.478082623569341 1.76741350934018 0.00389220814636686 0.262352319795402 32 CD36,ESYT1,APOE,SLC25A20,PRKAG2,FABP3,APOC2,CLU,APOA4,PRKAA2,CPT1B,SLC10A4,APOH,PSAP,FITM2,APOC3,RBP4,CAV1,SCP2 GO:0007492 endoderm development GO_ENDODERM_DEVELOPMENT 0.727937436978997 1.86591610290001 0.00405279960151244 0.262352319795402 9 COL8A1,LAMC1,COL4A2,VTN,LAMB1,FN1 GO:0001944 vasculature development GO_VASCULATURE_DEVELOPMENT 0.41592620547703 1.69251957262079 0.00449380165289256 0.262352319795402 48 COL3A1,GJA1,COL8A1,COL4A2,COL1A1,APOE,COL1A2,ENG,COL4A1,HSPG2,CDH13,LAMA5,MYH10,FN1,GPX1,ANXA2,COL18A1,TNNI3,ITGB1,DLL1 GO:0003006 developmental process involved in reproduction GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION -0.48292715123324 -1.72620107324059 0.00453099232063434 0.262352319795402 36 KRT8,RAN,ARID4A,KRT19,TRIM28,PAFAH1B1,ADA,HSP90AB1,PRDX3,DAZAP1 GO:0009063 cellular amino acid catabolic process GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS -0.513222722186628 -1.74015832726436 0.00461117492061347 0.262352319795402 29 GCDH,ALDH6A1,QDPR,IVD,ALDH4A1,BCAT2,MCCC2,AHCY,GLUD1,OGDH,MCCC1,HIBADH,GOT1,HSD17B10,DDAH2,DBT,PCYOX1,ACAT1,ALDH5A1,ALDH7A1 GO:1901136 carbohydrate derivative catabolic process GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS -0.537243781421725 -1.75583933093895 0.00465108354913452 0.262352319795402 25 PGM2,APOBEC2,HPRT1,NT5C,ABHD10,ADA,VCAN,BGN,AHCY,MTAP,PRELP,GPD1L,OGN,FMOD NA cofactor metabolic process GO_COFACTOR_METABOLIC_PROCESS -0.36808495223076 -1.5809775747213 0.00470694235160704 0.262352319795402 91 NAMPT,PGM2,BLVRA,TALDO1,GCDH,COQ7,PCCB,DCXR,QDPR,ENO1,CBR1,MCCC2,AKR7A2,AHCY,ACOT9,GPI,BRP44,ACSBG2,COQ9,OGDH,MCCC1,SUCLG1,HPX,GPD1L,NDUFA9,PCBD2,COQ3,COQ5,MCEE,ALAD,PDXK,ENO3,PCCA,DLAT,HSD17B4,PDHA1 GO:0060840 artery development GO_ARTERY_DEVELOPMENT 0.80438662504031 1.80168910203661 0.0047861732771992 0.262352319795402 6 COL3A1,APOE,ENG,MYH10 GO:0015850 organic hydroxy compound transport GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT 0.538107493677476 1.80509179018759 0.00510693392154982 0.262352319795402 22 CD36,APOE,SLC25A20,PRKAG2,APOC2,PARK7,CLU,APOA4,PRKAA2,CPT1B,MECP2,SLC10A4 NA multicellular organismal macromolecule metabolic process GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS 0.567279245359047 1.82662354508231 0.00516383885015349 0.262352319795402 19 COL3A1,COL5A3,COL8A1,COL4A2,COL1A1,COL1A2,COL4A1 GO:0051896 regulation of protein kinase b signaling GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING 0.672863611495106 1.83827062831771 0.00522343412030006 0.262352319795402 11 PRKCDBP,HCLS1,C1QBP,RRAS,PARK7,GPX1,DAG1 GO:0022610 biological adhesion GO_BIOLOGICAL_ADHESION 0.315148567948349 1.51766141855667 0.00527128170777878 0.262352319795402 115 AOC3,CD36,BCL11B,COL3A1,COL5A3,COL8A1,LAMC1,EPDR1,LAMB2,VTN,EMILIN1,MYL9,SPON1,NCAM1,BMP10,LGALS3BP,LAMA2,NID1,ENG,BCAM,GNAS,FNDC3A,AMBP,CDH13,SSPN,COL14A1,POSTN,LAMA5,APOA4,MYH10,LAMB1,FN1,NME2,FKBP1A,COL18A1,SGCE,FBLN5,PCDH15,COL6A6,TINAGL1,NID2 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION 0.623367697594502 1.83580027055625 0.00548744892002335 0.262352319795402 14 HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0045652 regulation of megakaryocyte differentiation GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION 0.623367697594502 1.83580027055625 0.00548744892002335 0.262352319795402 14 HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:1901532 regulation of hematopoietic progenitor cell differentiation GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION 0.623367697594502 1.83580027055625 0.00548744892002335 0.262352319795402 14 HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0045653 negative regulation of megakaryocyte differentiation GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION 0.623367697594502 1.83580027055625 0.00548744892002335 0.262352319795402 14 HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0055114 oxidation reduction process GO_OXIDATION_REDUCTION_PROCESS -0.289742105722918 -1.42398132512481 0.0060122492554925 0.280758058256487 240 PGM2,BLVRA,GCDH,ALDH6A1,MSRA,COQ7,CYGB,ALDH2,ECI2,DCXR,PAM,QDPR,ACO2,ENO1,SDHA,IVD,PRDX3,ALDH4A1,CBR1,GSTK1,AKR7A2,SCCPDH,NDUFB8,ME3,NDUFV1,GPI,NDUFC2,FH,BDH1,GLUD1,NDUFB9,ACAD10,GDI2,SDHB,COQ9,CRYZ,OGDH,ETFA,NDUFS3,ACO1,NDUFA10,COX5A,AKR1A1,SUCLG1,STBD1,IDH2,NDUFS8,ECHS1,NDUFA5,GSTO1,GPD1L,HIGD1A,NDUFA9,ME2,PCBD2,HIBADH,ACADVL,CYB5R3,NDUFB2,PGM5,NDUFB3,CRAT,NDUFS7,PRDX2,COX4I1,CS,COX6C,SDHD,ALDH1A1,UQCRFS1,PTGES2,CYC1,NDUFB11,PTGR2,AIFM1,ENO3,HSD17B10,DLAT,GDI1,HSD17B4,PDHA1,GPX3,PCYOX1,MAOB,MAOA,IDH3A,ALDH1A2,NDUFA7,UQCRC2,SUCLA2,ETFB,PGK1,ECH1,NDUFB10,GLRX,NDUFS4,MTHFD1,PRDX4,NDUFA3,CAT,ALDH5A1,TPI1,PGM1,UQCR10,CP,ALDH7A1,ADI1,SLC25A12,TXNL1,NDUFS5,COQ6,SIRT3,GRHPR,PDHB,NDUFS1,UQCRC1,DECR1,NDUFAF2,HK1,PGD,NDUFB4,BCKDHA,VAT1,PRDX6,ADH5,FTH1,COX5B,NNT,TXN,BLVRB,SH3BGRL3,IDH3B,GBE1,SUOX,DLD GO:0061383 trabecula morphogenesis GO_TRABECULA_MORPHOGENESIS 0.759474867931868 1.79029877258222 0.00673091974328585 0.290258042398162 7 COL1A1,BMP10,FHL2,NACA,RHOA,FKBP1A GO:0043902 positive regulation of multi organism process GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS 0.601174802953069 1.80707853653167 0.00692049639899594 0.290258042398162 15 RAB7A,APOE,CFL1,STOM,MIF,C1QBP,PFN1,LGALS1,VAPB GO:0009060 aerobic respiration GO_AEROBIC_RESPIRATION -0.473415903018327 -1.6811390644592 0.00704413433932029 0.290258042398162 35 ACO2,SDHA,ME3,NDUFV1,FH,SDHB,OGDH,ACO1,SUCLG1,IDH2,CS,SDHD,DLAT,PDHA1,IDH3A,UQCRC2,SUCLA2,CAT,UQCR10,SIRT3,PDHB,UQCRC1,NNT,IDH3B,DLD GO:0048598 embryonic morphogenesis GO_EMBRYONIC_MORPHOGENESIS 0.441750394977308 1.68362653192754 0.00708013309649496 0.290258042398162 36 GJA1,COL8A1,COL4A2,VTN,FBN1,ENG,GNAS,PFN1,LAMA5,SOD1,PRKACB,LAMB1,FN1,TXNRD1,RALA,ITGB1,DLL1 GO:0033108 mitochondrial respiratory chain complex assembly GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY -0.446678923393556 -1.65303531535015 0.00730587596465536 0.290258042398162 42 NDUFB8,NDUFV1,NDUFC2,NDUFB9,NDUFS3,NDUFA10,NDUFS8,NDUFA5,NDUFA9,NDUFB2,NDUFB3,NDUFS7,NDUFB11,AIFM1,SAMM50,NUBPL,NDUFAF3,NDUFA7,NDUFB10,NDUFS4,NDUFA3,UQCR10,NDUFS5,NDUFS1,NDUFAF2,NDUFB4 GO:0072359 circulatory system development GO_CIRCULATORY_SYSTEM_DEVELOPMENT 0.310409118901336 1.48775377176765 0.00767374938232131 0.290258042398162 112 COL3A1,GJA1,COL8A1,NEXN,COL4A2,COL1A1,APOE,COL1A2,FBN1,NPPA,BMP10,WHSC1,ENG,COL4A1,FHL2,NACA,SGCD,NDUFS6,HSPG2,CDH13,ANK2,XIRP2,LAMA5,TPM1,MYH10,MYLK3,FN1,GPX1,ANXA2,SGCG,FKBP1A,COL18A1,MECP2,TNNI3,MYH11,SRI,ITGB1,DLL1,TNNC1,GNA11,COL15A1,PLN GO:0050856 regulation of t cell receptor signaling pathway GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY -0.820877716231214 -1.65982822986719 0.00779259149831961 0.290258042398162 5 EZR,ADA GO:0050854 regulation of antigen receptor mediated signaling pathway GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY -0.820877716231214 -1.65982822986719 0.00779259149831961 0.290258042398162 5 EZR,ADA NA multicellular organism metabolic process GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS 0.540720676833927 1.76731634199544 0.00786559574164726 0.290258042398162 20 COL3A1,COL5A3,COL8A1,COL4A2,COL1A1,COL1A2,COL4A1,APOA4,COL18A1,COL6A6 GO:0071230 cellular response to amino acid stimulus GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS 0.701947317785487 1.79929584207001 0.00787918581746553 0.290258042398162 9 COL3A1,COL1A1,COL1A2,COL4A1 GO:1901605 alpha amino acid metabolic process GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS -0.466182022605909 -1.66634637479542 0.00791257850110776 0.290258042398162 36 GCDH,ALDH6A1,MSRA,QDPR,MPST,IVD,ALDH4A1,MCCC2,AHCY,MTAP,GLUD1,OGDH,MCCC1 GO:0010562 positive regulation of phosphorus metabolic process GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS 0.328139238809235 1.51895270637341 0.00802716887928373 0.290258042398162 91 CD36,GLIPR2,EHD4,UBC,APOE,VTN,PRKCDBP,PRKAG2,BMP10,CRK,HCLS1,GNAI2,MIF,ENG,GNAS,FABP3,SDCBP,APOC2,PARK7,CLU,AKAP12,RHOA,SOD1,PRKACB,PHB2,IQGAP1,PRKAA2,ANXA2,HSPA5,PIN1,VAPB GO:1901658 glycosyl compound catabolic process GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS -0.705780690521477 -1.72746076642644 0.00809484580393281 0.290258042398162 9 APOBEC2,HPRT1,NT5C,ABHD10,ADA,AHCY,MTAP GO:0043588 skin development GO_SKIN_DEVELOPMENT 0.546597970541731 1.76003040980955 0.00859053375532447 0.302627925977044 19 BCL11B,COL3A1,COL5A3,COL1A1,KRT2,COL1A2,KRT9,GNAS,LAMA5 GO:1901385 regulation of voltage gated calcium channel activity GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY 0.747633115853408 1.76238438712136 0.00874348710838793 0.302705553683499 7 CACNA2D1,AHNAK,NPPA,S100A1,DMD,SRI GO:0051270 regulation of cellular component movement GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT 0.319244453154799 1.49702469546718 0.00909709233123618 0.306473340190451 98 MYO1C,COL3A1,GLIPR2,NEXN,COL1A1,APOE,FAM83H,VTN,ARHGDIB,BMP10,LAMA2,C1QBP,ENG,RRAS,PFN1,RETN,CDH13,SDCBP,ANK2,POSTN,RHOA,LAMA5,TPM1,LAMB1,FN1,HSPA5,COL18A1,PIN1,SRI,RRAS2,MYADM,PFN2,ITGB1,RDX,TNNC1,DAG1,ABL2,PLN,CD81,APOH GO:0097031 mitochondrial respiratory chain complex i biogenesis GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS -0.455442473943615 -1.64794666097308 0.00915756992600949 0.306473340190451 38 NDUFB8,NDUFV1,NDUFC2,NDUFB9,NDUFS3,NDUFA10,NDUFS8,NDUFA5,NDUFA9,NDUFB2,NDUFB3,NDUFS7,NDUFB11,AIFM1,NUBPL,NDUFAF3,NDUFA7,NDUFB10,NDUFS4,NDUFA3,NDUFS5,NDUFS1,NDUFAF2,NDUFB4 GO:0048514 blood vessel morphogenesis GO_BLOOD_VESSEL_MORPHOGENESIS 0.412830885608303 1.62236251996672 0.00987377850162866 0.322158437679804 41 COL3A1,GJA1,COL8A1,COL4A2,APOE,ENG,COL4A1,HSPG2,CDH13,LAMA5,FN1,GPX1,ANXA2,COL18A1,TNNI3,ITGB1,DLL1,COL15A1 GO:0006959 humoral immune response GO_HUMORAL_IMMUNE_RESPONSE -0.458880609169468 -1.64024780552266 0.0100114940614016 0.322158437679804 36 RPL39,GPI,C3,FGA,IGJ,C5,FGB,IGHG3,IGHG2,CFB,SERPING1,IGHA1,C8A,C1R,IFNA2,CFI,C8G,IGKC,LTF,C8B,CFH,C2 GO:0002224 toll like receptor signaling pathway GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.741718521064046 1.7484420010875 0.0101075605447349 0.322158437679804 7 CD36,UBC GO:0070848 response to growth factor GO_RESPONSE_TO_GROWTH_FACTOR 0.389826835134084 1.59451948139876 0.0104491859955107 0.327843210609149 49 MYO1C,COL3A1,EHD4,COL4A2,UBC,COL1A1,COL1A2,FBN1,BMP10,ENG,PFN1,PDCD5,CLU,POSTN,RHOA,FN1,IQGAP1 GO:0015718 monocarboxylic acid transport GO_MONOCARBOXYLIC_ACID_TRANSPORT 0.564570695653772 1.73145794710155 0.0111567821491486 0.344658747007543 16 CD36,APOE,SLC25A20,PRKAG2,FABP3,PRKAA2,CPT1B,SLC10A4 GO:1901661 quinone metabolic process GO_QUINONE_METABOLIC_PROCESS -0.654127401965887 -1.705216749612 0.0114243270965232 0.347576497118463 11 COQ7,CBR1,AKR7A2,COQ9,NDUFA9,COQ3,COQ5 GO:0035556 intracellular signal transduction GO_INTRACELLULAR_SIGNAL_TRANSDUCTION 0.284917269160603 1.41492237001637 0.012159430347283 0.364419942348421 139 CD36,RAB2A,PSMB3,RAB7A,ARL8B,UBC,APOE,CRYAB,CFL1,PSMB2,COL1A2,PRKAG2,DIABLO,NCAM1,HCLS1,GNAI2,MIF,SPTAN1,C1QBP,PSMA6,SPTBN1,BCAP31,RRAS,PSMB1,S100A1,CDH13,SDCBP,PARK7,ERO1L,ANK2,DMD,CLU,RHOA,RAPGEF4,PSMA4,TOLLIP,RGL2,PSMD14,KPNB1,PSMC6,IQGAP1,PRKAA2,TJP1,GPX1 GO:0051247 positive regulation of protein metabolic process GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS 0.274438489664229 1.39226113911181 0.0126617983514589 0.366990287087057 161 CD36,RPS4X,PSMB3,GLIPR2,GJA1,RAB7A,EHD4,UBC,APOE,VTN,PRKCDBP,PSMB2,PRKAG2,DIABLO,BMP10,CRK,HCLS1,GNAI2,MIF,C1QBP,PSMA6,ENG,BCAP31,PSMB1,PDCD5,SDCBP,PARK7,CLU,RHOA,SOD1,PSMA4,PRKACB,TOLLIP,PHB2,PSMD14,PSMC6,HSPE1,FN1,IQGAP1,ANXA2,PSMC1,FKBP1A,HSPA5,PIN1,PSMA5,PSMA3,VAPB GO:0015838 amino acid betaine transport GO_AMINO_ACID_BETAINE_TRANSPORT 0.802597895823012 1.69142071797873 0.0129762501908272 0.366990287087057 5 SLC25A20,PRKAG2,PRKAA2,CPT1B GO:0015697 quaternary ammonium group transport GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT 0.802597895823012 1.69142071797873 0.0129762501908272 0.366990287087057 5 SLC25A20,PRKAG2,PRKAA2,CPT1B GO:0032365 intracellular lipid transport GO_INTRACELLULAR_LIPID_TRANSPORT 0.802597895823012 1.69142071797873 0.0129762501908272 0.366990287087057 5 SLC25A20,PRKAG2,PRKAA2,CPT1B GO:0035987 endodermal cell differentiation GO_ENDODERMAL_CELL_DIFFERENTIATION 0.69982165084108 1.72601540536381 0.0133441346564954 0.367055101236203 8 COL8A1,COL4A2,VTN,LAMB1,FN1 GO:0001706 endoderm formation GO_ENDODERM_FORMATION 0.69982165084108 1.72601540536381 0.0133441346564954 0.367055101236203 8 COL8A1,COL4A2,VTN,LAMB1,FN1 GO:1904019 epithelial cell apoptotic process GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS -0.796225229733716 -1.60998049711008 0.013886324186579 0.374144589741852 5 KRT8,KRT18,MTCH2 GO:0050879 multicellular organismal movement GO_MULTICELLULAR_ORGANISMAL_MOVEMENT -0.683658761488253 -1.67331538529632 0.0142197070095634 0.374144589741852 9 HSP90AA1,EEF2 GO:0003009 skeletal muscle contraction GO_SKELETAL_MUSCLE_CONTRACTION -0.683658761488253 -1.67331538529632 0.0142197070095634 0.374144589741852 9 HSP90AA1,EEF2 GO:0009062 fatty acid catabolic process GO_FATTY_ACID_CATABOLIC_PROCESS -0.481910400221979 -1.61944873054347 0.014347177993089 0.374144589741852 28 GCDH,ECI2,PCCB,IVD,ACAD10,ETFA,ECHS1,ACADVL,CRAT,MCEE,PCCA,HSD17B4,ETFB,ECH1 GO:0070206 protein trimerization GO_PROTEIN_TRIMERIZATION 0.756216772357062 1.69379683241841 0.0154221138931974 0.39702057304539 6 COL1A1,COL1A2,MIF GO:0007033 vacuole organization GO_VACUOLE_ORGANIZATION 0.577661816414935 1.70119774084666 0.0158085230589609 0.400577927414438 14 MAP1LC3B,MAP1LC3B2,RAB7A GO:0022411 cellular component disassembly GO_CELLULAR_COMPONENT_DISASSEMBLY 0.357628320410727 1.52145520183498 0.0159592799766708 0.400577927414438 59 MAP1LC3B2,LAMC1,H1F0,CFL1,STOM,FBN1,CDC37,NID1,ENG,BCAP31,HSPG2,CFL2,SET,MRPS36,KPNB1,FN1,DSTN,MRPL50,NME2,MDH1,MYH11,PNPO GO:0002181 cytoplasmic translation GO_CYTOPLASMIC_TRANSLATION -0.606521741669472 -1.6610610308817 0.016352024703488 0.405368711167949 13 PCBP2,EIF3F,EIF4H,EIF4B GO:0006140 regulation of nucleotide metabolic process GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS 0.482953561795578 1.6387513687681 0.017530340974764 0.420173946067225 23 APOE,PRKAG2,GNAI2,ME1,GNAS,PARK7,PPIF,AKAP12,PRKAA2 GO:0072665 protein localization to vacuole GO_PROTEIN_LOCALIZATION_TO_VACUOLE 0.716142270861833 1.68815148815853 0.0175540597956126 0.420173946067225 7 RAB7A,PACSIN2,SCARB2,TOLLIP,VPS13A,CD81,HSPA8 GO:0006997 nucleus organization GO_NUCLEUS_ORGANIZATION -0.590544398947277 -1.6513682604529 0.017576997743848 0.420173946067225 14 TOR1AIP1,PAFAH1B1,RTN4,PPP2R1A GO:0006446 regulation of translational initiation GO_REGULATION_OF_TRANSLATIONAL_INITIATION -0.63307180779299 -1.65032782163138 0.0181091500725073 0.423291057361333 11 RPL13A,EIF3F,EIF4H,EIF4B GO:0007163 establishment or maintenance of cell polarity GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY -0.50977636191109 -1.61224715522291 0.0183209249665489 0.423291057361333 22 CLIC4,EZR,ACTR3,PAFAH1B1,PARD3,PARVA,ACTR2,AQP1,ARF4,CAP2,MSN,MAP4 GO:0048660 regulation of smooth muscle cell proliferation GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION -0.542551523333984 -1.62780467877073 0.0184594701735638 0.423291057361333 18 NAMPT,XRCC6,XRCC5,SERPINF2,MFN2,CAMK2D GO:0032869 cellular response to insulin stimulus GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS -0.587940060217345 -1.64408562035718 0.0187487975934379 0.423291057361333 14 NAMPT,PIK3R1,PTPN1,TBC1D4,YWHAG,GOT1 GO:0009888 tissue development GO_TISSUE_DEVELOPMENT 0.259205464085547 1.33875373203074 0.0190817512592019 0.423291057361333 183 BCL11B,COL3A1,GJA1,COL8A1,LAMC1,NEXN,COL4A2,COL1A1,FAM83H,LAMB2,VTN,KRT2,NPPA,BMP10,KRT5,PKM2,ENG,COL4A1,KRT9,FHL2,NACA,TAGLN,SGCD,GNAS,PTER,FNDC3A,FABP5,PFN1,XIRP2,ARHGAP12,POSTN,RHOA,LAMA5,SOD1,TMOD1,TPM1,PRKACB,TOLLIP,MYH10,LAMB1,PHB2,MYLK3,FN1,IQGAP1,TJP1,GPX1,ALDOC,SGCG,FKBP1A,COL18A1,TXNRD1,TNNI3,MYH11,RALA,MYADM,ITGB1,DLL1,RDX,COPS2,ANXA4,TNNC1,DAG1,TGM2,ASPN,PLN GO:0072329 monocarboxylic acid catabolic process GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS -0.445749204525039 -1.57229563319395 0.0192121353870828 0.423291057361333 34 GCDH,ECI2,PCCB,DCXR,IVD,ALDH4A1,ACAD10,ETFA,AKR1A1,ECHS1,ACADVL,CRAT,MCEE,PCCA,HSD17B4,ETFB,ECH1,ALDH5A1 GO:1901185 negative regulation of erbb signaling pathway GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY 0.745693929175754 1.67022745509162 0.0194992244626634 0.423291057361333 6 RAB7A,UBC,CLTA GO:0022900 electron transport chain GO_ELECTRON_TRANSPORT_CHAIN -0.376593701282542 -1.50693580763088 0.0198317981577893 0.423291057361333 61 SDHA,NDUFB8,NDUFV1,NDUFC2,NDUFB9,SDHB,COQ9,ETFA,NDUFS3,NDUFA10,COX5A,NDUFS8,NDUFA5,NDUFA9,NDUFB2,NDUFB3,NDUFS7,COX4I1,COX6C,UQCRFS1,CYC1,NDUFB11,NDUFA7,UQCRC2,ETFB,NDUFB10,NDUFS4,NDUFA3,ALDH5A1,UQCR10,SLC25A12,NDUFS5,NDUFS1,UQCRC1,NDUFAF2,NDUFB4 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY -0.645857307038893 -1.63435345519931 0.0199359772363507 0.423291057361333 10 YWHAH,YWHAZ,YWHAB,YWHAG,YWHAQ,DYNLL2 GO:0031668 cellular response to extracellular stimulus GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS 0.564881695896371 1.66356064672668 0.0199883245767659 0.423291057361333 14 MAP1LC3B,MAP1LC3B2,COL1A1,POSTN,PRKAA2,HSPA5,ITGB1,HSPA8,GSTP1,CAV1 GO:0008652 cellular amino acid biosynthetic process GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS -0.645575300349579 -1.6336398322333 0.0201138182464876 0.423291057361333 10 ALDH4A1,BCAT2,AHCY,MTAP,GLUD1 GO:0048524 positive regulation of viral process GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS 0.596016656013637 1.67432119669277 0.0202370226626932 0.423291057361333 12 RAB7A,APOE,CFL1,STOM,PFN1,LGALS1,VAPB GO:0009266 response to temperature stimulus GO_RESPONSE_TO_TEMPERATURE_STIMULUS -0.595660383378931 -1.63131538821241 0.0207032072426135 0.42786457324432 13 HSP90AA1,DNAJA3,LXN,DNAJA2 GO:0042181 ketone biosynthetic process GO_KETONE_BIOSYNTHETIC_PROCESS -0.666592601995729 -1.63154444801674 0.0208818367420037 0.42786457324432 9 COQ7,GPI,COQ9,NDUFA9,COQ3,COQ5 GO:0015849 organic acid transport GO_ORGANIC_ACID_TRANSPORT 0.506426266483046 1.63067862921826 0.0217737905432739 0.438036440679046 19 CD36,APOE,SLC25A20,PRKAG2,FABP3,PRKAA2,CPT1B,SLC10A4 GO:0043691 reverse cholesterol transport GO_REVERSE_CHOLESTEROL_TRANSPORT 0.70519608070127 1.66234819744231 0.021869898700776 0.438036440679046 7 APOE,APOC2,CLU,APOA4,APOC3 GO:0007512 adult heart development GO_ADULT_HEART_DEVELOPMENT 0.740333431278773 1.65822085236871 0.0221138931974296 0.438036440679046 6 GJA1,BMP10,MYH10 GO:1901135 carbohydrate derivative metabolic process GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS -0.289339984951365 -1.36973348202337 0.0222954068547447 0.438036440679046 175 PGM2,ERP44,TALDO1,GBAS,APOBEC2,HPRT1,DCXR,NT5C,ABHD10,ENO1,ADA,VCAN,RPN2,BGN,MCCC2,AKR7A2,AHCY,NDUFB8,MTAP,NDUFV1,GPI,OLA1,NDUFC2,NDUFB9,AK4,COQ9,OGDH,LMAN1,NDUFS3,NDUFA10,COX5A,AKR1A1,NDUFS8,PRELP,ATP5D,ADK,NDUFA5,GPD1L,NDUFA9,ATP5J2,ATP5F1,NDUFB2,ITIH1,NDUFB3,OGN,FMOD,NDUFS7,AQP1,COX4I1,ASAH1,ATP5A1,MCEE,COX6C,ALDH1A1,UQCRFS1,STOML2,CYC1,NDUFB11 GO:0010810 regulation of cell substrate adhesion GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION 0.407122248568594 1.54103670424597 0.0227216042300594 0.438036440679046 35 CD36,COL8A1,COL1A1,VTN,FAM21C,NID1,C1QBP,CDH13,POSTN,FN1,LGALS1,MYADM,ITGB1 GO:0000281 mitotic cytokinesis GO_MITOTIC_CYTOKINESIS 0.775139034256201 1.63355302658815 0.022855647394936 0.438036440679046 5 SPTBN1,RHOA,ANK3,MYH10 GO:0071496 cellular response to external stimulus GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS 0.456762026563118 1.58589307442736 0.0230469411964074 0.438036440679046 25 MAP1LC3B,MAP1LC3B2,GJA1,COL1A1,NPPA,POSTN,PRKAA2,HSPA5,ITGB1 GO:0030258 lipid modification GO_LIPID_MODIFICATION -0.46110868575252 -1.56345789965704 0.0231234376055672 0.438036440679046 29 GCDH,CYGB,ECI2,IVD,PIK3R1,ACAD10,ETFA,ECHS1,ACADVL,CRAT GO:0061458 reproductive system development GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT -0.455278051414579 -1.55768776488345 0.0236674420956812 0.444151623627363 30 KRT8,ARID4A,KRT19,TRIM28,ADA,HSP90AB1,PRDX3,DAZAP1 GO:0046461 neutral lipid catabolic process GO_NEUTRAL_LIPID_CATABOLIC_PROCESS 0.734928710888788 1.64611519878987 0.0246842455129626 0.445819956482954 6 APOE,FABP3,FABP5,APOC3 GO:0046503 glycerolipid catabolic process GO_GLYCEROLIPID_CATABOLIC_PROCESS 0.734928710888788 1.64611519878987 0.0246842455129626 0.445819956482954 6 APOE,FABP3,FABP5,APOC3 GO:0008154 actin polymerization or depolymerization GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION 0.697773438091434 1.64485091278575 0.0251123683445515 0.445819956482954 7 CFL1,HCLS1,CFL2,DSTN NA regulation of symbiosis encompassing mutualism through parasitism GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM 0.459175463512959 1.57842154593618 0.0252759673889517 0.445819956482954 24 CD36,RAB7A,APOE,CFL1,STOM NA positive regulation of glucose transport GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT -0.702899900832874 -1.59028571028609 0.025466647373752 0.445819956482954 7 ITLN1,PIK3R1,C3 GO:0050731 positive regulation of peptidyl tyrosine phosphorylation GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION 0.567870624764654 1.63401928462796 0.025785900297619 0.445819956482954 13 CD36,EHD4,VTN,HCLS1,MIF GO:0042246 tissue regeneration GO_TISSUE_REGENERATION 0.600997177135515 1.64193075618283 0.0258640526485342 0.445819956482954 11 GJA1,PKM2,NACA,POSTN,GPX1 GO:1903747 regulation of establishment of protein localization to mitochondrion GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION -0.559847077160998 -1.59690247508016 0.0260043572984749 0.445819956482954 15 YWHAH,YWHAZ,YWHAB,YWHAG,NPEPPS,YWHAQ,DYNLL2,UBE2L3,RUVBL1 GO:1901796 regulation of signal transduction by p53 class mediator GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR 0.619036373696612 1.64178967805254 0.0262021701884637 0.445819956482954 10 UBC,PRKAG2,MIF,PRKAA2,PIN1,RBBP7 GO:0046716 muscle cell cellular homeostasis GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS 0.69537176494727 1.63918948452302 0.0262975469040005 0.445819956482954 7 CFL2,DMD,SOD1,PFKM,LAMP2 GO:0051168 nuclear export GO_NUCLEAR_EXPORT -0.510574520040924 -1.57315259152218 0.0264502762430939 0.445819956482954 20 RAN,THOC4,SRSF7,RANBP1,HNRNPA2B1,RPSA,HSPA9 GO:0072507 divalent inorganic cation homeostasis GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS 0.386996208064733 1.50365886485743 0.0266633000883727 0.445819956482954 39 CD36,GJA1,CACNA2D1,APOE,ANXA6,BCAP31,ERO1L,ANK2,ANK3,VAPB,TNNI3,ITGB1,PYGM,TGM2,ABL2,PLN,NOL3,ANXA7 GO:0001837 epithelial to mesenchymal transition GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION -0.731308640110383 -1.57267923616912 0.0267325108879859 0.445819956482954 6 TRIM28,RTN4,LIMS1 GO:0002221 pattern recognition receptor signaling pathway GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY 0.617971990367218 1.63896675255423 0.0268646487721302 0.445819956482954 10 CD36,UBC,UBE2N,PGLYRP2,UBE2V1,HSPD1 GO:0002252 immune effector process GO_IMMUNE_EFFECTOR_PROCESS -0.370948488482872 -1.47393309400118 0.0272314188917969 0.448202369956788 59 PCBP2,HSP90AA1,SERPINB9,ARPC3,ACTR3,ADA,TUBB,HSP90AB1,PIK3R1,C3,C5,IGHG3,ACTR2,IGHG2,ACTG1,CFB,SERPING1,IGHA1,C8A,C1R,IFNA2,CFI,HMGB1,C8G,TUBB4B,IGKC,ARPC4,ANXA3,C8B,CFH,C2 GO:0070302 regulation of stress activated protein kinase signaling cascade GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE -0.532809809396551 -1.57286994787886 0.0289757061852989 0.468627889510516 17 EZR,SERPINF2,PAFAH1B1,RPS3,PTPN1,DBNL GO:0019433 triglyceride catabolic process GO_TRIGLYCERIDE_CATABOLIC_PROCESS 0.762374846449007 1.60665336510434 0.0291365886637734 0.468627889510516 5 APOE,FABP3,FABP5,APOC3 GO:0090092 regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY 0.512001793850432 1.59661970394638 0.0293388136914464 0.468627889510516 17 UBC,FBN1,BMP10,ENG,LTBP4,SDCBP,FKBP1A,HSPA5,PIN1,ASPN GO:0008286 insulin receptor signaling pathway GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY -0.726154081389132 -1.56159435759951 0.0294658964593546 0.468627889510516 6 NAMPT,PIK3R1,PTPN1 GO:0009408 response to heat GO_RESPONSE_TO_HEAT -0.647866187788523 -1.58570989023804 0.0296393137290018 0.468627889510516 9 HSP90AA1,DNAJA3,DNAJA2 GO:0031099 regeneration GO_REGENERATION 0.438899743781203 1.54004450504832 0.0305148933071153 0.4737791094232 26 GJA1,APOE,LAMB2,PKM2,NACA,CAST,POSTN,APOA4,GPX1 GO:0071559 response to transforming growth factor beta GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA 0.450351836857299 1.54809021612156 0.0309997354560977 0.4737791094232 24 COL3A1,COL4A2,UBC,COL1A1,COL1A2,FBN1,ENG,PDCD5,POSTN,RHOA,FN1,FKBP1A GO:0007606 sensory perception of chemical stimulus GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS 0.759652527508573 1.60091626227768 0.0310557651625848 0.4737791094232 5 CD36,GNAS,OR8J3,OR4K15 GO:0034440 lipid oxidation GO_LIPID_OXIDATION -0.465644079615202 -1.53674522685457 0.0311516944685337 0.4737791094232 26 GCDH,CYGB,ECI2,IVD,ACAD10,ETFA,ECHS1,ACADVL,CRAT GO:0044091 membrane biogenesis GO_MEMBRANE_BIOGENESIS 0.685821028038506 1.61667567493301 0.0313960508955925 0.4737791094232 7 PACSIN2,SPTBN1,ANK3,ANXA2,CDH2,CAV1 GO:0071709 membrane assembly GO_MEMBRANE_ASSEMBLY 0.685821028038506 1.61667567493301 0.0313960508955925 0.4737791094232 7 PACSIN2,SPTBN1,ANK3,ANXA2,CDH2,CAV1 GO:0071216 cellular response to biotic stimulus GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS 0.589272800008837 1.60989963168882 0.0316167333977634 0.4737791094232 11 CD36,FN1,HSPA5,B2M,GSTP1,NCL NA protein targeting to plasma membrane GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE 0.720243086357084 1.61322189990633 0.0321072457345446 0.47456176302617 6 SPTBN1,ANK2,ANK3,ANXA2,MYADM GO:0007338 single fertilization GO_SINGLE_FERTILIZATION 0.608703686237625 1.61438563470788 0.0321416333523701 0.47456176302617 10 CCT8,PARK7,CAST,SLIRP,TCP1 GO:0009081 branched chain amino acid metabolic process GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS -0.573406436909449 -1.57036924115091 0.0330724963155309 0.476675575856634 13 ALDH6A1,IVD,BCAT2,MCCC2,MCCC1,HIBADH,HSD17B10,DBT,ACAT1 GO:1901861 regulation of muscle tissue development GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT 0.586174562808523 1.6014352143127 0.033365548345529 0.476675575856634 11 GJA1,BMP10,NACA,PIN1,DLL1,KCNK2,RBP4,JPH2 GO:0048545 response to steroid hormone GO_RESPONSE_TO_STEROID_HORMONE -0.356125268786296 -1.43806310669552 0.0333796495935349 0.476675575856634 64 HSP90AA1,EEF2,SERPINB9,RAN,KRT19,PAM,SERPINF1,YWHAH,MTAP,BDH1,C3,FGA,GSTM3,UBE2L3,GOT1,AQP1,ALAD,AIFM1,HNRNPD,H2AFZ,HMGB1,MAOB,NME1,MSN,ALDH1A2,ATP1A3,ANXA3,PAQR8,CAT GO:0051897 positive regulation of protein kinase b signaling GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING 0.682879348879672 1.60974129855038 0.0334980656991435 0.476675575856634 7 HCLS1,C1QBP,PARK7,GPX1 GO:0006766 vitamin metabolic process GO_VITAMIN_METABOLIC_PROCESS -0.516751651562693 -1.55039792535693 0.0336441510539651 0.476675575856634 18 NAMPT,PCCB,CBR1,MCCC2,MCCC1,AKR1A1,GSTO1,CYB5R3,PDXK,PCCA,ALDH1A2,MTHFD1 GO:1901184 regulation of erbb signaling pathway GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY 0.653222191998198 1.61108414573822 0.0337091293683476 0.476675575856634 8 RAB7A,UBC,CDH13,CLTA GO:0031214 biomineral tissue development GO_BIOMINERAL_TISSUE_DEVELOPMENT 0.754437304542233 1.58992553302203 0.033956338734652 0.476813483770499 5 COL1A1,FAM83H,ASPN,GPNMB GO:0051480 regulation of cytosolic calcium ion concentration GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION 0.492499951433269 1.56066447858879 0.0342995974561132 0.478288831193578 18 CD36,GJA1,CACNA2D1,BCAP31,ERO1L,ABL2,PLN,NOL3,CAV1,JPH2,KNG1 GO:0010647 positive regulation of cell communication GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION 0.253146866155347 1.29315223394889 0.0359037514209928 0.49392817082415 169 CD36,MYO1C,PSMB3,COL3A1,GLIPR2,GJA1,UBC,COL1A1,VTN,PRKCDBP,S100A13,PSMB2,BMP10,CRK,HCLS1,GNAI2,LAMA2,MIF,C1QBP,PSMA6,ENG,BCAP31,GNAS,PSMB1,RETN,PDCD5,CDH13,SDCBP,PARK7,PPIF,CLU,AKAP12,RHOA,SOD1,PSMA4,ANK3,PHB2,PSMD14,PSMC6,PRKAA2,GPX1,LGALS1,PSMC1,PFKM,FKBP1A,MECP2,PIN1,PSMA5,PSMA3 GO:0031401 positive regulation of protein modification process GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS 0.27921423005031 1.33824040143804 0.036334040635991 0.49392817082415 112 CD36,PSMB3,GLIPR2,EHD4,UBC,VTN,PRKCDBP,PSMB2,PRKAG2,BMP10,CRK,HCLS1,GNAI2,MIF,PSMA6,ENG,PSMB1,SDCBP,PARK7,CLU,RHOA,SOD1,PSMA4,PRKACB,TOLLIP,PHB2,PSMD14,PSMC6,IQGAP1,ANXA2,PSMC1,FKBP1A,HSPA5,PIN1,PSMA5,PSMA3,VAPB NA fibril organization GO_FIBRIL_ORGANIZATION 0.600845355769393 1.59354400665874 0.0365505425471159 0.49392817082415 10 CD36,COL3A1,MFAP5 GO:0001937 negative regulation of endothelial cell proliferation GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION 0.648998926900718 1.60066803384681 0.036724498751097 0.49392817082415 8 GJA1,APOE,ENG,APOH,CAV1 GO:0030199 collagen fibril organization GO_COLLAGEN_FIBRIL_ORGANIZATION 0.564149516816297 1.58480049941406 0.0368008871023633 0.49392817082415 12 COL3A1,COL5A3,COL1A1,COL1A2,COL14A1,ANXA2 GO:1901607 alpha amino acid biosynthetic process GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS -0.635053168760215 -1.55434889103796 0.0371252552025502 0.49392817082415 9 ALDH4A1,AHCY,MTAP,GLUD1,GOT1,MTHFD1,ADI1 GO:0042180 cellular ketone metabolic process GO_CELLULAR_KETONE_METABOLIC_PROCESS -0.511822310428819 -1.53560853814506 0.0371430048777125 0.49392817082415 18 COQ7,CBR1,AKR7A2,GPI,OXCT1,COQ9,NDUFA9,COQ3,COQ5 GO:0001676 long chain fatty acid metabolic process GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS -0.596498915833668 -1.55498751366789 0.0375623386269586 0.494849636662178 11 PAM,CBR1,ACSBG2 GO:0032370 positive regulation of lipid transport GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT 0.675249438400858 1.59175542443932 0.0378586283235314 0.494849636662178 7 APOE,MIF,RETN,PON1,SCP2,LRP1 GO:0045981 positive regulation of nucleotide metabolic process GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS 0.579304373568627 1.5826657833687 0.0379676929449123 0.494849636662178 11 APOE,GNAS,PARK7,AKAP12,PRKAA2 GO:0042330 taxis GO_TAXIS 0.392344688350543 1.47410807339804 0.0384366281387007 0.494849636662178 34 BCL11B,KIF5A,LAMB2,NCAM1,LAMA2,MIF,SPTAN1,ENG,SPTBN1,RHOA,ANK3,MYH10,DPYSL2 GO:0055012 ventricular cardiac muscle cell differentiation GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION 0.709742760971705 1.58970295860901 0.0384444936849103 0.494849636662178 6 BMP10,FHL2,MYH10,RARB,RARA GO:0001816 cytokine production GO_CYTOKINE_PRODUCTION 0.671055197732981 1.58186840350332 0.0408774793711845 0.518256322343748 7 CD36,NFAT5,S100A13 GO:0014070 response to organic cyclic compound GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND -0.30575312462978 -1.35829721845918 0.0409152578545405 0.518256322343748 112 NAMPT,HSP90AA1,EEF2,SERPINB9,EZR,RAN,KRT19,NEDD8,PAM,SERPINF1,ADA,PPP5C,HSP90AB1,YWHAH,MTAP,BDH1,C3,FGA,HNRNPA2B1,GSTM3,DROSHA,UBE2L3,GSTM2,PEA15,NPM1,GOT1,AQP1,ALAD,PRKAR2B,AIFM1,HNRNPD,H2AFZ,IFNA2,CTSB,HMGB1,MAOB,NME1,MSN,ALDH1A2,JUP,NDUFS4,ATP1A3,ANXA3,ACAT1,DDX1,PAQR8,CAT GO:1903046 meiotic cell cycle process GO_MEIOTIC_CELL_CYCLE_PROCESS -0.706984201592745 -1.52036953095028 0.041037228711482 0.518256322343748 6 ACTR3,PPP2R1A,ACTR2 GO:0006289 nucleotide excision repair GO_NUCLEOTIDE_EXCISION_REPAIR 0.705314671265842 1.57978479150187 0.0413915355639264 0.519463771327277 6 UBC,SUMO3,UBE2N,COPS2 GO:0070208 protein heterotrimerization GO_PROTEIN_HETEROTRIMERIZATION 0.742863778048208 1.56553510963075 0.041676662377598 0.519793404063458 5 COL1A1,COL1A2 GO:0015671 oxygen transport GO_OXYGEN_TRANSPORT -0.70502970226063 -1.51616638012157 0.042440366638118 0.526050964255191 6 CYGB,HBD,HBA2,HBA1,HBB GO:0051924 regulation of calcium ion transport GO_REGULATION_OF_CALCIUM_ION_TRANSPORT 0.402996936673248 1.46728807507206 0.0434119960668633 0.526264708394468 30 GJA1,CACNA2D1,AHNAK,NPPA,GNAI2,S100A1,ANK2,DMD,GNAO1 GO:0006821 chloride transport GO_CHLORIDE_TRANSPORT -0.737957817974781 -1.49216283315544 0.0435794216493703 0.526264708394468 5 CLIC4,CLIC1 GO:0060343 trabecula formation GO_TRABECULA_FORMATION 0.740454004472096 1.56045667499557 0.0436176477002595 0.526264708394468 5 COL1A1,BMP10,FHL2,FKBP1A,RBP4 GO:0031589 cell substrate adhesion GO_CELL_SUBSTRATE_ADHESION 0.383159671857468 1.45033370196597 0.0443457873996109 0.526264708394468 35 COL3A1,COL5A3,LAMC1,EPDR1,VTN,NID1,BCAM,LAMA5,LAMB1,FN1,SGCE,FBLN5,NID2,ITGB1,DAG1 GO:0090287 regulation of cellular response to growth factor stimulus GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS 0.422553732092268 1.48268838707905 0.0446920593304688 0.526264708394468 26 MYO1C,UBC,VTN,FBN1,ENG,LTBP4,SDCBP,DMD,HSPA5,PIN1,DLL1,ASPN GO:0043506 regulation of jun kinase activity GO_REGULATION_OF_JUN_KINASE_ACTIVITY -0.701701793839926 -1.50900971303731 0.044882191081874 0.526264708394468 6 RPS3,PTPN1,DBNL GO:0015669 gas transport GO_GAS_TRANSPORT -0.646177850221305 -1.52449499763313 0.0452966688862094 0.526264708394468 8 CYGB,HBD,AQP1,HBA2,HBA1,HBB GO:0061041 regulation of wound healing GO_REGULATION_OF_WOUND_HEALING 0.432876242952837 1.48801763790538 0.0454294028522643 0.526264708394468 24 CD36,GJA1,APOE,VTN,SERPINC1 GO:0097485 neuron projection guidance GO_NEURON_PROJECTION_GUIDANCE 0.478614971144931 1.51666488943381 0.0454946049591501 0.526264708394468 18 BCL11B,KIF5A,LAMB2,NCAM1,LAMA2,SPTAN1,SPTBN1,ANK3,MYH10,DPYSL2 GO:0043603 cellular amide metabolic process GO_CELLULAR_AMIDE_METABOLIC_PROCESS -0.290830677916851 -1.32712064070589 0.045540455404554 0.526264708394468 134 NAMPT,RPL39,PCBP2,CLIC4,RPL13A,EEF1A1P5,EIF3F,EEF2,EIF4H,RPS2,PPA1,PCCB,RPL10A,CLIC1,PAM,TUFM,EIF4B,PPP2R1A,AEBP1,GSTK1,MCCC2,RPS3 GO:0016236 macroautophagy GO_MACROAUTOPHAGY 0.390739607188289 1.45574230109672 0.0455609221729821 0.526264708394468 33 MAP1LC3B,MAP1LC3B2,RAB7A,UBC,STOM,PRKAG2,CDC37,HIST1H3A,PRKAA2,NME2,MDH1,MYH11,PNPO GO:0015918 sterol transport GO_STEROL_TRANSPORT 0.567641395489217 1.55080240173263 0.045768328040867 0.526264708394468 11 CD36,APOE,APOC2,CLU,APOA4 GO:0015980 energy derivation by oxidation of organic compounds GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS -0.307149612877659 -1.35061403469671 0.0458980180401301 0.526264708394468 105 PGM2,ACO2,SDHA,NDUFB8,ME3,NDUFV1,NDUFC2,FH,NDUFB9,SDHB,COQ9,OGDH,ETFA,NDUFS3,ACO1,NDUFA10,COX5A,SUCLG1,STBD1,IDH2,NDUFS8,NDUFA5,NDUFA9,ACADVL,NDUFB2,PGM5,NDUFB3,NDUFS7,COX4I1,CS,COX6C,SDHD,UQCRFS1,CYC1,NDUFB11,DLAT,PDHA1,IDH3A,NDUFA7,UQCRC2,SUCLA2,ETFB,NDUFB10,NDUFS4,NDUFA3,CAT,ALDH5A1,PGM1,UQCR10,SLC25A12,NDUFS5,SIRT3,PDHB,NDUFS1,UQCRC1,NDUFAF2 GO:0006767 water soluble vitamin metabolic process GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS -0.530928856779608 -1.51441641846604 0.0466579520697168 0.526264708394468 15 NAMPT,PCCB,MCCC2,MCCC1,AKR1A1,GSTO1,CYB5R3,PDXK,PCCA GO:0030030 cell projection organization GO_CELL_PROJECTION_ORGANIZATION 0.298960095623678 1.35058240876166 0.0467950481430536 0.526264708394468 80 BCL11B,GJA1,KIF5A,APOE,LAMB2,ZMYND10,NCAM1,PACSIN2,LAMA2,SPTAN1,SPTBN1,MAP1B,CDH13,SDCBP,DMD,GNAO1,CLU,POSTN,LAMA5,SOD1,TPM1,APOA4,ANK3,MYH10,LAMB1,DPYSL2 GO:0009611 response to wounding GO_RESPONSE_TO_WOUNDING 0.281982185527335 1.32503532856365 0.0468404019758133 0.526264708394468 99 CD36,COL3A1,GJA1,COL1A1,LAMB2,MYL9,COL1A2,SERPINC1,EHD2,CD59,PKM2,C1QBP,ENG,NACA,GNAS,FABP5,DYSF,CLU,POSTN,RHOA,SOD1,TPM1,PRKACB,MYH10,HIST1H3A,FN1,GPX1,LGALS1 GO:0001654 eye development GO_EYE_DEVELOPMENT 0.415108412505281 1.47068644164344 0.0469130392443276 0.526264708394468 27 BCL11B,GJA1,COL8A1,CRYAB,LAMB2,FBN1,COL4A1,TMOD1,MYH10 NA regulation of cyclic nucleotide metabolic process GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS 0.607098755957813 1.55617129611227 0.0475694523060203 0.529801273486681 9 APOE,GNAI2,GNAS,AKAP12 GO:0071166 ribonucleoprotein complex localization GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION -0.529709993459758 -1.51093974433187 0.0477559912854031 0.529801273486681 15 RAN,THOC4,SRSF7,HNRNPA2B1,RPSA GO:0007188 adenylate cyclase modulating g protein coupled receptor signaling pathway GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY 0.695146958304853 1.55701084541154 0.0484156880124086 0.531670621965549 6 GNAI2,GNAS,GNAO1,PRKACB,PSAP,FLNA GO:0048260 positive regulation of receptor mediated endocytosis GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS 0.660251449249258 1.55640088842627 0.0485252353585724 0.531670621965549 7 VTN,ATAD1,TF,B2M,CD63 GO:0006743 ubiquinone metabolic process GO_UBIQUINONE_METABOLIC_PROCESS -0.696339235586021 -1.49747753147114 0.0487635985932176 0.531670621965549 6 COQ7,COQ9,NDUFA9,COQ3,COQ5 GO:0009056 catabolic process GO_CATABOLIC_PROCESS -0.246755364324872 -1.24680863266489 0.0491381528170826 0.531670621965549 313 PGM2,RPL39,PCBP2,BLVRA,RPL13A,GCDH,APOBEC2,HPRT1,ERLIN2,ALDH6A1,PSMD2,RPS2,NEDD8,ALDH2,ECI2,PCCB,DCXR,RPL10A,LYPLAL1,NT5C,ABHD10,QDPR,PSME2,UBA1,MPST,ENO1,EIF4B,PAFAH1B1,ADA,PSMB6,IVD,PPP2R1A,PRDX3,ALDH4A1,VCAN,BCAT2,YWHAH,BGN,MCCC2,AHCY,RPS3,MTAP,GPI,PEPD,BDH1,GLUD1,OXCT1,NDUFB9,ACAD10,PSMA2,CTSD,RPL10,PSMA1,RANBP1,CRYZ,OGDH,C5,ETFA,MCCC1,RNH1,AKR1A1,RPSA,STBD1,PRELP,NPEPPS,LONP1,ECHS1,GSTO1,GSTM3,GPD1L,DROSHA,UBE2L3,HIBADH,ACADVL,GSTM2,PGM5,PSMC2,CRAT,UBR4,GOT1,OGN,FMOD,CAPN1,PRDX2,RPL21,PAFAH1B2,MCEE,ALDH1A1,PABPC4,AIFM1,ENO3,TPP1,OBSCN,HBA2,HBA1,PCCA,PSMC3,HSD17B10,HNRNPD,USP5,DDAH2,HSD17B4,COL6A3,DBT,CTSB,RPL22,HMGB1,HBB,GPX3,AGRN,PCYOX1,MAOB,MAOA,ESD GO:1901863 positive regulation of muscle tissue development GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT 0.658332045977729 1.55187630773742 0.0496209664795724 0.531670621965549 7 GJA1,BMP10,NACA,PIN1,DLL1 GO:0050730 regulation of peptidyl tyrosine phosphorylation GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION 0.473006919181364 1.49889374556232 0.049686777981564 0.531670621965549 18 CD36,EHD4,VTN,HCLS1,MIF GO:0044770 cell cycle phase transition GO_CELL_CYCLE_PHASE_TRANSITION -0.417690861473126 -1.45260073680347 0.0497779267577307 0.531670621965549 32 HSP90AA1,PAFAH1B1,TUBB,PPP2R1A,DYNC1I2,CEP70,DYNC1H1,TUBA4A,CAMK2D,RANBP1,YWHAG,MAPRE1,UBE2L3 GO:0009262 deoxyribonucleotide metabolic process GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS -0.729757418953623 -1.47558149159584 0.0503933227462422 0.533526431118686 5 NT5C,ADA,ADK NA coenzyme metabolic process GO_COENZYME_METABOLIC_PROCESS -0.327864174376177 -1.36866824418135 0.0506141965114267 0.533526431118686 77 NAMPT,PGM2,TALDO1,GCDH,COQ7,DCXR,QDPR,ENO1,MCCC2,AHCY,ACOT9,GPI,BRP44,ACSBG2,COQ9,OGDH,SUCLG1,GPD1L,NDUFA9,PCBD2,COQ3,COQ5,MCEE,PDXK,ENO3,DLAT,HSD17B4,PDHA1 GO:0006957 complement activation alternative pathway GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY -0.616148721994312 -1.50807858279962 0.0509151473906659 0.533526431118686 9 C3,C5,CFB,C8A,C8G,C8B,CFH GO:0040011 locomotion GO_LOCOMOTION 0.286899537544882 1.32480158001341 0.0519072843969842 0.533526431118686 90 BCL11B,GJA1,LAMC1,KIF5A,COL1A1,LAMB2,SORD,DNAH6,KRT2,COL1A2,NCAM1,LAMA2,MIF,SPTAN1,ENG,SCARB2,SPTBN1,CDH13,SDCBP,RHOA,LAMA5,ANK3,MYH10,LAMB1,DPYSL2,FN1,GPX1 GO:1904951 positive regulation of establishment of protein localization GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION -0.337252459302229 -1.37745944590482 0.0523337148670991 0.533526431118686 68 HSP90AA1,EZR,TRIM28,HSP90AB1,ANP32B,YWHAH,ARF1,PIK3R1,GLUD1,OXCT1,FGA,BRP44,YWHAZ,C5,FGB,CCT6A,YWHAB,YWHAG,VAMP3,DPP10,NPEPPS,FGG,YWHAQ,DYNLL2,UBE2L3,RUVBL1 GO:1902749 regulation of cell cycle g2 m phase transition GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION -0.692114969239499 -1.48839324666053 0.0523534449769485 0.533526431118686 6 H2AFY,CAMK2D,NPM1,CDK5RAP3 GO:0061384 heart trabecula morphogenesis GO_HEART_TRABECULA_MORPHOGENESIS 0.729090159697533 1.53650814162958 0.0524502213595621 0.533526431118686 5 BMP10,FHL2,NACA,FKBP1A,RBP4 GO:0045824 negative regulation of innate immune response GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE -0.726862350933286 -1.46972761649054 0.0526461572552351 0.533526431118686 5 SERPINB9,DNAJA3 GO:0002088 lens development in camera type eye GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE 0.689017706539682 1.54328236489585 0.0527586970972745 0.533526431118686 6 GJA1,CRYAB,TMOD1 GO:0033539 fatty acid beta oxidation using acyl coa dehydrogenase GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE -0.594915620740797 -1.50544460783071 0.0528721323137115 0.533526431118686 10 GCDH,IVD,ACAD10,ETFA,ACADVL GO:0006119 oxidative phosphorylation GO_OXIDATIVE_PHOSPHORYLATION -0.350808064153375 -1.38899387482687 0.0534385496857974 0.533526431118686 58 GBAS,NDUFB8,NDUFV1,NDUFC2,NDUFB9,COQ9,NDUFS3,NDUFA10,COX5A,NDUFS8,ATP5D,NDUFA5,NDUFA9,NDUFB2,NDUFB3,NDUFS7,COX4I1,COX6C,UQCRFS1,CYC1,NDUFB11,NDUFA7,UQCRC2,NDUFB10,NDUFS4,NDUFA3,UQCR10,NDUFS5,NDUFS1,UQCRC1 GO:0006998 nuclear envelope organization GO_NUCLEAR_ENVELOPE_ORGANIZATION -0.577289172021911 -1.50491045405363 0.0536731156934177 0.533526431118686 11 TOR1AIP1,PAFAH1B1,PPP2R1A GO:1902533 positive regulation of intracellular signal transduction GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION 0.287825880610486 1.32294761549796 0.0539776702017517 0.533526431118686 88 CD36,COL3A1,GLIPR2,GJA1,UBC,PRKCDBP,S100A13,CRK,HCLS1,GNAI2,MIF,C1QBP,BCAP31,GNAS,CDH13,SDCBP,PARK7,CLU,AKAP12,RHOA,SOD1 GO:0046889 positive regulation of lipid biosynthetic process GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS 0.623327401027469 1.5373526890255 0.0539841130538491 0.533526431118686 8 APOE,FABP3,APOC2,APOA4,APOC3 GO:1901361 organic cyclic compound catabolic process GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS -0.315436491742437 -1.34816977591449 0.0541819030576519 0.533526431118686 88 RPL39,BLVRA,RPL13A,APOBEC2,HPRT1,ALDH6A1,RPS2,RPL10A,NT5C,QDPR,EIF4B,ADA,PPP2R1A,ALDH4A1,YWHAH,AHCY,RPS3,MTAP GO:0043620 regulation of dna templated transcription in response to stress GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS 0.726588874659676 1.53123685278542 0.054282162562973 0.533526431118686 5 UBC,TCEB1,HSPA5,CHD6 GO:0046165 alcohol biosynthetic process GO_ALCOHOL_BIOSYNTHETIC_PROCESS 0.4859808746558 1.49043415473016 0.0544685848502642 0.533526431118686 16 PRKAG2,FABP5,PARK7,CYB5R1,APOA4,PRKAA2,FDPS GO:0048863 stem cell differentiation GO_STEM_CELL_DIFFERENTIATION -0.575867646981776 -1.50120474121979 0.0549641000247586 0.535371826042858 11 XRCC5,TRIM28,RTN4,LIMS1 GO:0006091 generation of precursor metabolites and energy GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY -0.287009780606438 -1.30819347562851 0.0551902231030238 0.535371826042858 133 PGM2,GBAS,ACO2,ENO1,SDHA,NDUFB8,ME3,NDUFV1,GPI,NDUFC2,FH,NDUFB9,SDHB,COQ9,OGDH,ETFA,NDUFS3,ACO1,NDUFA10,COX5A,SUCLG1,STBD1,COX7A1,IDH2,NDUFS8,ATP5D,NDUFA5,NDUFA9,ACADVL,NDUFB2,PGM5,NDUFB3,NDUFS7,COX4I1,CS,COX6C,SDHD,UQCRFS1,CYC1,NDUFB11,ENO3,DLAT,PDHA1,IDH3A,NDUFA7,UQCRC2,SUCLA2,ETFB,PGK1,NDUFB10,NDUFS4,NDUFA3,CAT,ALDH5A1,TPI1,PGM1,UQCR10,SLC25A12,SLC25A3,NDUFS5,SIRT3,SCO1,PDHB,NDUFS1,UQCRC1,NDUFAF2,HK1,BPGM,NDUFB4 GO:0051248 negative regulation of protein metabolic process GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS -0.27573603592932 -1.28900968752391 0.0558876358175554 0.539530638084862 159 RPL13A,SERPINB9,DNAJA3,EZR,RAN,LXN,PSMD2,SERPINF2,PSME2,SERPINF1,H2AFY,PAFAH1B1,PSMB6,PPP5C,PPP2R1A,HSP90AB1,PRDX3,OTUB1,BGN,PARD3,RPS3,GPI,PRKAR2A,STRAP,C3,FGA,SERPINA3,PSMA2,PSMA1,CAPRIN2,HNRNPA2B1,C5,PTPN1,SERPINA7,SERPINA1,YWHAB,YWHAG,SYNCRIP,AGT,GPD1L,PURA,DROSHA,SERPINA4,SNX3,NPM1,ITIH1,PSMC2,AQP1,SERPING1,HHATL,AHSG GO:0008347 glial cell migration GO_GLIAL_CELL_MIGRATION -0.657779087059589 -1.48820149417636 0.0568658660107076 0.54524433845629 7 MATN2,PAFAH1B1,RTN4,VCAN GO:0032481 positive regulation of type i interferon production GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION -0.722318362618544 -1.46053959745694 0.0570225652768032 0.54524433845629 5 XRCC6,XRCC5 GO:0007160 cell matrix adhesion GO_CELL_MATRIX_ADHESION 0.394989680577092 1.42615337214729 0.0583361929506348 0.550746055561539 29 COL3A1,COL5A3,EPDR1,VTN,NID1,BCAM,LAMA5,FN1,SGCE,FBLN5,NID2,ITGB1,DAG1 GO:0021766 hippocampus development GO_HIPPOCAMPUS_DEVELOPMENT -0.588983148523817 -1.49043238088828 0.058420771829984 0.550746055561539 10 RAN,PAFAH1B1,OGDH,NME1,ANXA3 GO:0021761 limbic system development GO_LIMBIC_SYSTEM_DEVELOPMENT -0.588983148523817 -1.49043238088828 0.058420771829984 0.550746055561539 10 RAN,PAFAH1B1,OGDH,NME1,ANXA3 GO:0016137 glycoside metabolic process GO_GLYCOSIDE_METABOLIC_PROCESS -0.719691851919131 -1.45522874966715 0.0592384680725339 0.555845064904897 5 ABHD10,AKR7A2 GO:0006635 fatty acid beta oxidation GO_FATTY_ACID_BETA_OXIDATION -0.441492847577368 -1.44290270620382 0.0599018672481941 0.558730253341246 25 GCDH,ECI2,IVD,ACAD10,ETFA,ECHS1,ACADVL,CRAT,HSD17B4,ETFB,ECH1 GO:0001704 formation of primary germ layer GO_FORMATION_OF_PRIMARY_GERM_LAYER 0.533657132460363 1.49914174315327 0.0607341696121237 0.558730253341246 12 COL8A1,COL4A2,VTN,LAMB1,FN1,TXNRD1,ITGB1 GO:0042060 wound healing GO_WOUND_HEALING 0.287998862988532 1.31364356145359 0.0612680546699565 0.558730253341246 84 CD36,COL3A1,GJA1,COL1A1,MYL9,COL1A2,SERPINC1,EHD2,CD59,PKM2,C1QBP,ENG,NACA,GNAS,DYSF,POSTN,RHOA,TPM1,PRKACB,MYH10,HIST1H3A,FN1,GPX1 GO:0043403 skeletal muscle tissue regeneration GO_SKELETAL_MUSCLE_TISSUE_REGENERATION 0.643927698336552 1.51792115399801 0.0615845613721237 0.558730253341246 7 GJA1,PKM2,NACA,GPX1 GO:0051321 meiotic cell cycle GO_MEIOTIC_CELL_CYCLE -0.652076310871956 -1.47529916844064 0.0618579076834033 0.558730253341246 7 ACTR3,PPP2R1A,ACTR2 GO:0071383 cellular response to steroid hormone stimulus GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS -0.445879404827786 -1.4405438221831 0.0621865425103987 0.558730253341246 24 SERPINB9,RAN,SERPINF1,YWHAH,UBE2L3,AQP1,AIFM1,HNRNPD,H2AFZ,MSN,ATP1A3,PAQR8,CTNNB1 GO:0046470 phosphatidylcholine metabolic process GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS 0.643220424390256 1.51625390767901 0.0624119501777768 0.558730253341246 7 DBI,FABP5,APOA4,MECP2,PON1 GO:0044794 positive regulation by host of viral process GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS 0.676350366606142 1.51490967992125 0.0628406824728562 0.558730253341246 6 APOE,CFL1,STOM,VAPB GO:0008217 regulation of blood pressure GO_REGULATION_OF_BLOOD_PRESSURE 0.428956174130644 1.43894161923268 0.0628416610722164 0.558730253341246 22 GJA1,COL1A2,NPPA,ENG,POSTN,SOD1,TPM1,MECP2,TNNI3,DLL1,CTSG GO:0032411 positive regulation of transporter activity GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY 0.450347195600642 1.45010556560247 0.0628941294053257 0.558730253341246 19 CACNA2D1,NPPA,S100A1,PARK7,ANK2,DMD,ANK3 GO:2000026 regulation of multicellular organismal development GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT 0.240568312099295 1.23653958706477 0.0633508688028057 0.558730253341246 176 BCL11B,PSMB3,COL3A1,GLIPR2,GJA1,COL4A2,UBC,COL1A1,APOE,CFL1,ARHGDIB,PSMB2,BMP10,HCLS1,LAMA2,WHSC1,C1QBP,PSMA6,ENG,NACA,GNAS,MAP1B,RRAS,PSMB1,PFN1,RETN,SDCBP,DMD,RHOA,LAMA5,SOD1,PSMA4,PRKACB,DPYSL2,PHB2,PSMD14,PSMC6,FN1,GPX1,NME2,LGALS1,PSMC1,MECP2,PIN1,PSMA5,PSMA3,LRRC4B GO:0009267 cellular response to starvation GO_CELLULAR_RESPONSE_TO_STARVATION 0.612437065361528 1.5104931497323 0.0634352708206755 0.558730253341246 8 MAP1LC3B,MAP1LC3B2,PRKAA2,HSPA5,HSPA8,CAV1 GO:0048285 organelle fission GO_ORGANELLE_FISSION -0.411305655705622 -1.41842264623453 0.0634669716130768 0.558730253341246 31 RAN,ACTR3,PAFAH1B1,PPP5C,PPP2R1A,DYNC1LI1,RPS3,ACTR2,MAPRE1,RUVBL1,DCLRE1A GO:0055024 regulation of cardiac muscle tissue development GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT 0.641716792964426 1.51270941975749 0.063798385473736 0.558730253341246 7 GJA1,BMP10,PIN1,KCNK2,RBP4,JPH2 GO:0031110 regulation of microtubule polymerization or depolymerization GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION -0.476259868592528 -1.44892267464724 0.0643336380413598 0.558730253341246 19 EZR,RAN,TUBB,PPP2R1A,DYNC1H1,RPS3,RANBP1,MAPRE1 GO:0043123 positive regulation of i kappab kinase nf kappab signaling GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING 0.457909268478985 1.45105137097371 0.0644784793845128 0.558730253341246 18 CD36,GJA1,UBC,S100A13,RHOA,LGALS1,FKBP1A,UBE2N GO:0070542 response to fatty acid GO_RESPONSE_TO_FATTY_ACID 0.513219764377477 1.47676417069921 0.0648018973214286 0.558730253341246 13 CD36,GNAS,FABP3,FN1,PRKAA2,PON1,APOC3 GO:0032886 regulation of microtubule based process GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS -0.443574634621313 -1.43309758796251 0.0648225809212441 0.558730253341246 24 EZR,RAN,PAFAH1B1,TUBB,PPP2R1A,DYNC1H1,RPS3,RANBP1,MAPRE1,NPM1 NA cofactor biosynthetic process GO_COFACTOR_BIOSYNTHETIC_PROCESS -0.395049800347787 -1.40285454615529 0.0648327435400948 0.558730253341246 35 NAMPT,GCDH,COQ7,QDPR,ACOT9,BRP44,ACSBG2,COQ9,NDUFA9,PCBD2,COQ3,COQ5,ALAD,PDXK,DLAT,PDHA1 GO:0015711 organic anion transport GO_ORGANIC_ANION_TRANSPORT 0.361171165692944 1.3855737742213 0.0652550239594571 0.559966188506794 37 CD36,GJA1,APOE,SLC25A20,PRKAG2,FABP3,APOC2,CYB5R1,APOA4,PRKAA2,CPT1B GO:0000096 sulfur amino acid metabolic process GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS -0.62230765190188 -1.46817923577591 0.0657584537585258 0.561391397251203 8 MSRA,MPST,AHCY,MTAP GO:0048812 neuron projection morphogenesis GO_NEURON_PROJECTION_MORPHOGENESIS 0.357942745881217 1.38246864497367 0.0659802638203605 0.561391397251203 38 BCL11B,GJA1,KIF5A,LAMB2,NCAM1,LAMA2,SPTAN1,SPTBN1,MAP1B,CLU,POSTN,ANK3,MYH10,DPYSL2,IQGAP1 GO:0001525 angiogenesis GO_ANGIOGENESIS 0.370141164635835 1.39068552547637 0.0665603826225588 0.563937756565814 34 COL8A1,COL4A2,ENG,COL4A1,HSPG2,CDH13,LAMA5,FN1,GPX1,ANXA2,COL18A1,ITGB1,DLL1,COL15A1 GO:0007369 gastrulation GO_GASTRULATION 0.510900709154144 1.47009120542897 0.0671502976190476 0.564830846902309 13 COL8A1,COL4A2,VTN,LAMB1,FN1,TXNRD1,ITGB1 NA coenzyme biosynthetic process GO_COENZYME_BIOSYNTHETIC_PROCESS -0.403620390208257 -1.4036679522689 0.0674935054051789 0.564830846902309 32 NAMPT,GCDH,COQ7,QDPR,ACOT9,BRP44,ACSBG2,COQ9,NDUFA9,PCBD2,COQ3,COQ5,PDXK,DLAT,PDHA1 GO:0006953 acute phase response GO_ACUTE_PHASE_RESPONSE -0.52121676240906 -1.45750399088145 0.0675096629763716 0.564830846902309 14 SERPINF2,HP,FGA,SERPINA3,SERPINA1,AHSG,ITIH4,APCS,ORM1 GO:0016233 telomere capping GO_TELOMERE_CAPPING 0.472828729496467 1.45009839796335 0.0682560187903699 0.568705749921423 16 HIST3H3,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0009065 glutamine family amino acid catabolic process GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS -0.70951991504035 -1.43466092616556 0.0689884403737489 0.572433009382181 5 ALDH4A1,GLUD1,GOT1,DDAH2 GO:0045923 positive regulation of fatty acid metabolic process GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS 0.668497692527284 1.49732102681676 0.0701307334367383 0.579516513337327 6 MLYCD,APOC2,APOA4 GO:0001764 neuron migration GO_NEURON_MIGRATION -0.595669626144446 -1.4579541814273 0.0705791754719009 0.579914925684489 9 MARK1,HSP90AA1,MATN2,PAFAH1B1,TUBB2B GO:0046824 positive regulation of nucleocytoplasmic transport GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT -0.56014008252619 -1.4602052260494 0.0707565521875995 0.579914925684489 11 HSP90AA1,TRIM28,HSP90AB1,ANP32B,PIK3R1 GO:1903510 mucopolysaccharide metabolic process GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS -0.559602079293142 -1.45880272842955 0.0713578325611007 0.582465560092237 11 VCAN,BGN,PRELP,ITIH1,OGN,FMOD,ITIH4,ITIH2,DCN,LUM GO:0051339 regulation of lyase activity GO_REGULATION_OF_LYASE_ACTIVITY 0.578140699885638 1.48194334685608 0.0720673806235425 0.585871855495998 9 GNAI2,GNAS,PARK7,CALM1,CAP1 GO:0006352 dna templated transcription initiation GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION 0.435920238035881 1.42478176532534 0.0725725963594886 0.585871855495998 20 PTRF,NPPA,TFAM,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,RARB,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,RARA GO:0098813 nuclear chromosome segregation GO_NUCLEAR_CHROMOSOME_SEGREGATION -0.558289195789924 -1.45538022857211 0.07273724047678 0.585871855495998 11 ACTR3,PAFAH1B1,PPP2R1A,ACTR2,MAPRE1 GO:0055086 nucleobase containing small molecule metabolic process GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS -0.269116672880566 -1.26066239704784 0.0729422130846611 0.585871855495998 161 NAMPT,PGM2,TALDO1,GBAS,APOBEC2,HPRT1,ALDH6A1,DCXR,NT5C,ENO1,ADA,MCCC2,AHCY,NDUFB8,MTAP,NDUFV1,GPI,OLA1,NDUFC2,NDUFB9,LHPP,BRP44,AK4,COQ9,OGDH,NDUFS3,NDUFA10,COX5A,SUCLG1,NDUFS8,ATP5D,ADK,NDUFA5,GPD1L,NDUFA9,ATP5J2,ATP5F1,NDUFB2,NDUFB3,NDUFS7,AQP1,COX4I1,ATP5A1,MCEE,COX6C,UQCRFS1,STOML2,CYC1,NDUFB11 GO:0071774 response to fibroblast growth factor GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR 0.537075570447992 1.46729623875447 0.0733811956371669 0.586309351917807 11 UBC,COL1A1,POSTN,IQGAP1,HNRNPA1 GO:0031348 negative regulation of defense response GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE -0.468613928230823 -1.42566147400942 0.0737508408216768 0.586309351917807 19 PCBP2,SERPINB9,DNAJA3,SERPINF1,ADA GO:0031175 neuron projection development GO_NEURON_PROJECTION_DEVELOPMENT 0.318482892805753 1.33050371432775 0.0739271170512687 0.586309351917807 54 BCL11B,GJA1,KIF5A,APOE,LAMB2,NCAM1,LAMA2,SPTAN1,SPTBN1,MAP1B,GNAO1,CLU,POSTN,APOA4,ANK3,MYH10,LAMB1,DPYSL2,IQGAP1 GO:0034249 negative regulation of cellular amide metabolic process GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS -0.4849578537142 -1.43160959247129 0.0741646291768541 0.586309351917807 17 RPL13A,RAN,RPS3,CAPRIN2,HNRNPA2B1,SYNCRIP,PURA,DROSHA GO:0006508 proteolysis GO_PROTEOLYSIS -0.283643054417655 -1.27951918641461 0.0744981345256257 0.586636290695908 124 PCBP2,CAPNS1,EIF3F,ERLIN2,DNAJA3,PSMD2,NEDD8,PSME2,UBA1,PSMB6,OTUB1,ANP32B,AEBP1,PEPD,HP,C3,FGA,PSMA2,CTSD,PSMA1,RANBP1,FGB,IGHG3,DPP10,NPEPPS,LONP1,FGG,AGT,UBE2L3,IGHG2,CFB,PSMC2,UBR4,CAPN1,ERVK-7,ERVK-21,STOML2,AIFM1,TPP1,PSMC3,C1R,USP5,CFI,CTSB,PCYOX1,PSMD11,IGKC,UQCRC2,LTF GO:0061245 establishment or maintenance of bipolar cell polarity GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY -0.63915301669258 -1.44606068079975 0.0753689769931992 0.591175413290407 7 CLIC4,EZR GO:0007178 transmembrane receptor protein serine threonine kinase signaling pathway GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY 0.425830996621912 1.41035671658493 0.0757720623386557 0.591704507602525 21 COL3A1,UBC,COL1A2,BMP10,ENG,SPTBN1,LTBP4,RHOA GO:0043648 dicarboxylic acid metabolic process GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS -0.424687418628727 -1.40157771150491 0.0760257783672567 0.591704507602525 26 SDHA,ALDH4A1,ME3,FH,GLUD1,SDHB,OGDH,SUCLG1,IDH2,ME2,GOT1 GO:0070585 protein localization to mitochondrion GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION -0.483140090458644 -1.42624350283367 0.0766096169519152 0.593946373897474 17 HSP90AA1,TOMM40,MTX2,MFN2,MTCH2,HSPA4,SAMM50,TOMM22,DNM1L,FIS1,HK1,TOMM70A,TIMM50 GO:0090559 regulation of membrane permeability GO_REGULATION_OF_MEMBRANE_PERMEABILITY -0.502229292041429 -1.43255405312776 0.0771067538126362 0.595501390983744 15 YWHAH,YWHAZ,MTCH2,YWHAB,YWHAG,YWHAQ,DYNLL2 GO:0015698 inorganic anion transport GO_INORGANIC_ANION_TRANSPORT -0.665224995003566 -1.43056635685981 0.0776645953678226 0.596292521212086 6 CLIC4,CLIC1 GO:0010811 positive regulation of cell substrate adhesion GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION 0.390134551964846 1.38220662050312 0.078683416106729 0.596292521212086 27 CD36,COL8A1,VTN,NID1,C1QBP,CDH13,FN1,MYADM,ITGB1 GO:0007517 muscle organ development GO_MUSCLE_ORGAN_DEVELOPMENT 0.327354814034618 1.33209791220002 0.0788997933884298 0.596292521212086 48 COL3A1,CRYAB,BMP10,LAMA2,TAGLN,MURC,SGCD,XIRP2,DMD,LAMA5,TPM1,GPX1,SGCG,FKBP1A,SGCE,TNNI3,SRI,DLL1,COPS2,TNNC1 GO:0060350 endochondral bone morphogenesis GO_ENDOCHONDRAL_BONE_MORPHOGENESIS 0.699064370584502 1.47323082425341 0.0789697511613199 0.596292521212086 5 COL1A1,GNAS,RARB,SERPINH1,RARA GO:0009896 positive regulation of catabolic process GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS 0.308551303081931 1.31266725344295 0.0791866599506906 0.596292521212086 59 PSMB3,GJA1,RAB7A,UBC,APOE,PSMB2,PSMA6,BCAP31,PSMB1,APOC2,PARK7,CLU,PSMA4,APOA4,PSMD14,PSMC6,PRKAA2,PSMC1,PSMA5,PSMA3 GO:0043270 positive regulation of ion transport GO_POSITIVE_REGULATION_OF_ION_TRANSPORT 0.373062596776166 1.36962802517586 0.079357639745424 0.596292521212086 31 CACNA2D1,APOE,NPPA,MIF,S100A1,PARK7,ANK2,DMD,ANK3,DPYSL2 GO:0032388 positive regulation of intracellular transport GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT -0.355350922187905 -1.34746112824919 0.0793796067792178 0.596292521212086 47 HSP90AA1,EZR,TRIM28,HSP90AB1,ANP32B,YWHAH,ARF1,PIK3R1,YWHAZ,YWHAB,YWHAG,NPEPPS,YWHAQ,GSTO1,EHD1,DYNLL2,UBE2L3,GSTM2,RUVBL1 GO:1901617 organic hydroxy compound biosynthetic process GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS 0.410988220142702 1.39455956345446 0.0795848584087844 0.596292521212086 23 PRKAG2,DDT,FABP5,PARK7,CYB5R1,APOA4,PRKAA2,FDPS,ACADM,PNPO GO:0007049 cell cycle GO_CELL_CYCLE -0.286823659397744 -1.27737913186595 0.080192131747484 0.598608923973784 114 HSP90AA1,KRT18,EZR,RAN,PSMD2,ACTR3,ESCO2,PSME2,PAFAH1B1,SEPT11,PSMB6,TUBB,PPP5C,PPP2R1A,DYNC1LI1,DYNC1I2,CEP70,DYNC1H1,PARD3,RPS3,MFN2,TUBA4A,CAMK2D,PSMA2,PSMA1,RANBP1 NA positive regulation of cyclic nucleotide metabolic process GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS 0.621798915024932 1.4657573033239 0.0814642545674098 0.604379720597258 7 APOE,GNAS,AKAP12,CALM1,CAP1 GO:0043094 cellular metabolic compound salvage GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE -0.63305288376619 -1.43225934975362 0.0817175517291275 0.604379720597258 7 HPRT1,ADA,MTAP,ADK,PDXK GO:0002250 adaptive immune response GO_ADAPTIVE_IMMUNE_RESPONSE -0.388488647675852 -1.37031989756889 0.0818771091583414 0.604379720597258 34 OTUB1,C3,FGA,IGJ,C5,DBNL,FGB,IGHG3,IGHG2,SERPING1,IGHA1,C8A,C1R,CFI,HMGB1,C8G,IGKC,C8B,C2 GO:0071384 cellular response to corticosteroid stimulus GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS -0.585747693336733 -1.43366937187863 0.0823274472581396 0.604379720597258 9 RAN,SERPINF1,UBE2L3,AQP1,AIFM1 GO:0070911 global genome nucleotide excision repair GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR 0.695019733778307 1.46470702606467 0.083026192397444 0.604379720597258 5 UBC,SUMO3,UBE2N,CETN2 GO:0072488 ammonium transmembrane transport GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT 0.65469407459202 1.46640327255724 0.0830932860624862 0.604379720597258 6 SLC25A20,PRKAG2,PRKAA2,CPT1B GO:0042176 regulation of protein catabolic process GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS 0.303697201525321 1.3001272525488 0.0836682012933443 0.604379720597258 61 PSMB3,GJA1,RAB7A,UBC,APOE,PSMB2,PSMA6,BCAP31,PSMB1,SDCBP,PARK7,CLU,PSMA4,PSMD14,PSMC6,GPX1,ANXA2,PSMC1,PIN1,PSMA5,PSMA3 GO:2001257 regulation of cation channel activity GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY 0.427737448314187 1.39803675885927 0.0840977139869778 0.604379720597258 20 CACNA2D1,STOM,AHNAK,NPPA,S100A1,ANK2,DMD,ANK3,FKBP1A,SRI,PLN,CALM1,CAV1,JPH2 GO:0035239 tube morphogenesis GO_TUBE_MORPHOGENESIS 0.419927938762228 1.39080572718575 0.0841380629123243 0.604379720597258 21 GJA1,ENG,COL4A1,PFN1,RHOA,LAMA5,PRKACB,PHB2,RALA,DLL1,DAG1,TGM2 GO:0007005 mitochondrion organization GO_MITOCHONDRION_ORGANIZATION -0.285636142212023 -1.27069337361377 0.0849841521394612 0.604379720597258 113 HSP90AA1,DNAJA3,TOMM40,MTX2,TUFM,PRDX3,YWHAH,NDUFB8,MFN2,NDUFV1,NDUFC2,NDUFB9,YWHAZ,C5,NDUFS3,NDUFA10,MTCH2,YWHAB,YWHAG,NDUFS8,LONP1,NDUFA5,YWHAQ,DYNLL2,NDUFA9,MRPS23,NDUFB2,NDUFB3,NDUFS7,HSPA4,STOML2,NDUFB11,AIFM1,OBSCN,HSD17B10,SAMM50,NUBPL,NDUFAF3,NDUFA7,ATP1B1,NDUFB10,NDUFS4,OPA3,NDUFA3,TOMM22,UQCR10,DNM1L,FIS1,ACAA2,NDUFS5,HSPA1A,SIRT3,ANXA5,NDUFS1,NDUFAF2,IMMT,NDUFB4,TOMM70A,TIMM50 GO:1901657 glycosyl compound metabolic process GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS -0.278991557759763 -1.26112287863378 0.0859567272123326 0.604379720597258 126 GBAS,APOBEC2,HPRT1,NT5C,ABHD10,ENO1,ADA,MCCC2,AKR7A2,AHCY,NDUFB8,MTAP,NDUFV1,GPI,OLA1,NDUFC2,NDUFB9,AK4,COQ9,OGDH,NDUFS3,NDUFA10,COX5A,NDUFS8,ATP5D,ADK,NDUFA5,NDUFA9,ATP5J2,ATP5F1,NDUFB2,NDUFB3,NDUFS7,COX4I1,ATP5A1,MCEE,COX6C,UQCRFS1,STOML2,CYC1,NDUFB11,ENO3 GO:0006739 nadp metabolic process GO_NADP_METABOLIC_PROCESS -0.53200193928218 -1.42287091559841 0.0861822733924573 0.604379720597258 12 PGM2,TALDO1,DCXR GO:0071391 cellular response to estrogen stimulus GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS -0.692885259728285 -1.40102537980448 0.0866417993130701 0.604379720597258 5 SERPINB9,AIFM1,HNRNPD,H2AFZ GO:0071229 cellular response to acid chemical GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL 0.425755956746235 1.39156036063815 0.0867591844494083 0.604379720597258 20 COL3A1,COL1A1,COL1A2,COL4A1,GNAS,FN1,PRKAA2 GO:0030155 regulation of cell adhesion GO_REGULATION_OF_CELL_ADHESION 0.284309086459109 1.27404775917312 0.0868681876836065 0.604379720597258 77 CD36,COL8A1,COL1A1,VTN,FAM21C,ARHGDIB,CD59,LAMA2,NID1,C1QBP,ENG,HLA-DRA,CDH13,POSTN,LAMA5,SOD1,TPM1,ANK3,FN1,LGALS1,MYADM,ITGB1,DLL1,RDX,TGM2,ABL2 GO:1903651 positive regulation of cytoplasmic transport GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT -0.400082930396201 -1.36884324574959 0.0869829068473753 0.604379720597258 30 HSP90AA1,EZR,TRIM28,HSP90AB1,ANP32B,ARF1,PIK3R1,NPEPPS,GSTO1,UBE2L3,GSTM2,RUVBL1 GO:0030100 regulation of endocytosis GO_REGULATION_OF_ENDOCYTOSIS 0.343109533159299 1.33313887940157 0.0871354626941043 0.604379720597258 39 CD36,EHD4,VTN,PACSIN2,ATAD1,CDH13,SDCBP,APOC2,ANXA2,ITGB1,DLL1,C4B,ABL2,TF,LMAN2,B2M,CD63 GO:0070304 positive regulation of stress activated protein kinase signaling cascade GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE -0.562218609575203 -1.42270423686831 0.0873199359772363 0.604379720597258 10 SERPINF2,RPS3,PTPN1,DBNL GO:0034976 response to endoplasmic reticulum stress GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS -0.367961803287168 -1.3478561475541 0.0873226877157059 0.604379720597258 40 ERP44,ERLIN2,EEF2,PIK3R1,PTPN1,SSR1,ACADVL,PSMC2,TXNDC5,P4HB,AIFM1,TPP1,PSMC3,CDK5RAP3 NA regulation of organ morphogenesis GO_REGULATION_OF_ORGAN_MORPHOGENESIS 0.345870923589447 1.3358441051608 0.087377907562179 0.604379720597258 38 PSMB3,UBC,PSMB2,BMP10,PSMA6,NACA,PSMB1,PFN1,RHOA,PSMA4,PHB2,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0009066 aspartate family amino acid metabolic process GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS -0.50455740604561 -1.41091861578143 0.0884796334190321 0.604379720597258 14 GCDH,MSRA,AHCY,MTAP,OGDH GO:0051983 regulation of chromosome segregation GO_REGULATION_OF_CHROMOSOME_SEGREGATION -0.691034489484212 -1.39728309196139 0.088691509399121 0.604379720597258 5 H2AFY,DYNC1LI1 GO:0006633 fatty acid biosynthetic process GO_FATTY_ACID_BIOSYNTHETIC_PROCESS 0.479336835071182 1.41163344669115 0.089246935201401 0.604379720597258 14 PRKAG2,MLYCD,MIF,NDUFAB1,PRKAA2,HSD17B8,CBR4 GO:0042476 odontogenesis GO_ODONTOGENESIS 0.523066724397574 1.42902392057414 0.0894887017350085 0.604379720597258 11 BCL11B,COL1A1,COL1A2,LAMA5,LAMB1 GO:0006098 pentose phosphate shunt GO_PENTOSE_PHOSPHATE_SHUNT -0.65486757265605 -1.408292720022 0.0895274887475627 0.604379720597258 6 PGM2,TALDO1 GO:0044788 modulation by host of viral process GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS 0.585588468670427 1.44427471901421 0.0897409932716758 0.604379720597258 8 APOE,CFL1,STOM,VAPB GO:0071772 response to bmp GO_RESPONSE_TO_BMP 0.687720428150725 1.44932423372295 0.0902012954441367 0.604379720597258 5 BMP10,ENG,FN1,RYR2 GO:0001701 in utero embryonic development GO_IN_UTERO_EMBRYONIC_DEVELOPMENT -0.415465259790991 -1.37114221539187 0.0904623441990172 0.604379720597258 26 KRT8,KRT19,TRIM28,ENO1,ADA,MFN2,GPI,C5 GO:0034764 positive regulation of transmembrane transport GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT 0.396856810877192 1.36420037810317 0.0906904595849066 0.604379720597258 24 CACNA2D1,NPPA,S100A1,PDCD5,PARK7,ANK2,DMD,ANK3 GO:0050806 positive regulation of synaptic transmission GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION 0.68710171014936 1.44802032743122 0.0910736483981419 0.604379720597258 5 LAMA2,RETN,MECP2 GO:0006928 movement of cell or subcellular component GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT 0.243576661973819 1.21428464844532 0.0913498185809678 0.604379720597258 143 BCL11B,GJA1,CACNA2D1,LAMC1,KIF5A,COL1A1,LAMB2,SORD,TPM3,DNAH6,KRT2,ARHGDIB,COL1A2,NCAM1,TPM2,LAMA2,MIF,SPTAN1,ENG,SPTBN1,MAP1B,CDH13,SDCBP,ANK2,DMD,CLTA,RHOA,LAMA5,SOD1,TMOD1,TPM1,ANK3,MYH10,LAMB1,DPYSL2,KPNB1,FN1,GPX1 NA negative regulation of protein complex disassembly GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY -0.415028831956909 -1.36970189128973 0.0913635668009998 0.604379720597258 26 EZR,RAN,TUBB,PPP2R1A,DYNC1H1,SPTB,RPS3,RANBP1,CAPZB GO:0002718 regulation of cytokine production involved in immune response GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE 0.647546952392555 1.45039493555008 0.0914690892975848 0.604379720597258 6 CD36,MIF,B2M GO:0032479 regulation of type i interferon production GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION -0.600112968070821 -1.41581643122773 0.0915831338744219 0.604379720597258 8 PCBP2,XRCC6,XRCC5 GO:0010591 regulation of lamellipodium assembly GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY -0.652302750394914 -1.40277706972974 0.0922062066075041 0.604379720597258 6 HSP90AA1,CAPZB GO:0035023 regulation of rho protein signal transduction GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION 0.538572316881191 1.4283853232407 0.0922215876641919 0.604379720597258 10 COL3A1,APOE,ARHGDIB,ITGB1,CDH2,APOC3 NA clathrin mediated endocytosis GO_CLATHRIN_MEDIATED_ENDOCYTOSIS 0.685749321862236 1.44517026069232 0.0922949425337492 0.604379720597258 5 CLTA,CLTB,DLL1,CANX GO:1901566 organonitrogen compound biosynthetic process GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS -0.259862680264287 -1.22920670348454 0.0930249515115279 0.604379720597258 174 NAMPT,RPL39,PCBP2,RPL13A,GBAS,EEF1A1P5,HPRT1,EIF3F,EEF2,EIF4H,RPS2,PPA1,RPL10A,QDPR,TUFM,EIF4B,ADA,ALDH4A1,VCAN,BCAT2,VAPA,BGN,GSTK1,AHCY,RPS3,MTAP,GLUD1,RPL10,AK4,AKR1A1,RPSA,PRELP,ATP5D,ADK,GSS,GSTO1,GSTM3,PCBD2,MRPS23,ATP5J2,GSTM2,ATP5F1,GOT1,OGN,FMOD,AQP1,EEF1A2,RPL21,ATP5A1 GO:0007034 vacuolar transport GO_VACUOLAR_TRANSPORT 0.377358771559284 1.35021632995381 0.0931260069325782 0.604379720597258 28 RAB7A,EHD4,UBC,FAM21C,EHD2,SCARB2 GO:0048562 embryonic organ morphogenesis GO_EMBRYONIC_ORGAN_MORPHOGENESIS 0.464765411781212 1.3970439147259 0.0931569193234335 0.604379720597258 15 GJA1,FBN1,ENG,GNAS,SOD1 GO:0042730 fibrinolysis GO_FIBRINOLYSIS -0.577178760946014 -1.41269615071528 0.0933056341559511 0.604379720597258 9 SERPINF2,FGA,FGB,FGG,SERPING1 GO:0045087 innate immune response GO_INNATE_IMMUNE_RESPONSE -0.323694972875369 -1.30301917628395 0.0940205129846233 0.607052058112937 63 RPL39,PCBP2,RPL13A,DNAJA3,TRIM28,TUBB,CAMK2D,C3,FGA,IGJ,C5,FGB,IGHG3,SYNCRIP,IGHG2,CFB,SERPING1,IGHA1,C8A,C1R,IFNA2,CFI,HMGB1,C8G,TUBB4B,IGKC,LTF,C8B,CFH,C2 GO:0046620 regulation of organ growth GO_REGULATION_OF_ORGAN_GROWTH 0.5359244529688 1.42136273809874 0.0954197601370645 0.612082087785494 10 GJA1,BMP10,SOD1,PIN1,KCNK2,RBP4 GO:0006261 dna dependent dna replication GO_DNA_DEPENDENT_DNA_REPLICATION -0.686117363265197 -1.38734058195441 0.0955608080658862 0.612082087785494 5 DNAJA3,THOC4,PURA GO:0019835 cytolysis GO_CYTOLYSIS -0.555856169613343 -1.40660396886509 0.0957140316556998 0.612082087785494 10 HPRT1,C5,C8A,ALB,C8G,C8B GO:0031960 response to corticosteroid GO_RESPONSE_TO_CORTICOSTEROID -0.411791940826328 -1.35901931802716 0.0970769780135693 0.618827212226182 26 RAN,PAM,SERPINF1,BDH1,C3,UBE2L3,GOT1,AQP1,ALAD,AIFM1,HMGB1,MAOB GO:0043627 response to estrogen GO_RESPONSE_TO_ESTROGEN -0.386351234331393 -1.34361112348832 0.0976787061091092 0.619016944096085 32 HSP90AA1,EEF2,SERPINB9,KRT19,PAM,BDH1,C3,FGA GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS 0.473725384366299 1.39510788278723 0.097723292469352 0.619016944096085 14 UBC,FBN1,ENG,LTBP4,SDCBP,HSPA5,PIN1,ASPN GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY 0.53348865653288 1.4149025919486 0.098709308966305 0.619565784262489 10 UBC,FBN1,ENG,HSPA5,PIN1,ASPN,CAV1,CD109 GO:0090101 negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY 0.53348865653288 1.4149025919486 0.098709308966305 0.619565784262489 10 UBC,FBN1,ENG,HSPA5,PIN1,ASPN,CAV1,CD109 GO:0032755 positive regulation of interleukin 6 production GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION 0.680130800175331 1.43332960669222 0.0990992955749896 0.619565784262489 5 CD36,NCL,HSPD1 GO:0015748 organophosphate ester transport GO_ORGANOPHOSPHATE_ESTER_TRANSPORT 0.533153395259645 1.41401342206904 0.0991661907481439 0.619565784262489 10 GJA1,APOE,APOC2,APOA4 NA organ morphogenesis GO_ORGAN_MORPHOGENESIS 0.287395053931274 1.26412066798805 0.0995740293567029 0.619565784262489 70 BCL11B,COL3A1,GJA1,COL8A1,COL1A1,COL1A2,FBN1,BMP10,WHSC1,ENG,FHL2,GNAS,XIRP2,LAMA5,SOD1,TPM1,LAMB1,PHB2,FKBP1A,COL18A1,TNNI3,DLL1,TNNC1,DAG1,TGM2 NA single organism biosynthetic process GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS -0.258525300118257 -1.22181448459444 0.100179622354951 0.619565784262489 173 NAMPT,PGM2,TALDO1,GBAS,HPRT1,EEF2,COQ7,DCXR,TUFM,ENO1,ADA,ALDH4A1,VCAN,BCAT2,VAPA,CBR1,BGN,GSTK1,AHCY,MTAP,ARF1,GPI,PIK3R1,BDH1,GLUD1,LHPP,BRP44,AK4,COQ9,AKR1A1,SUCLG1,PRELP,ATP5D,ADK,GSTO1,GSTM3,GPD1L,NDUFA9,MRPS23,ATP5J2,GSTM2,CYB5R3,ATP5F1,COQ3,PGM5,GOT1,OGN,FMOD,COQ5,AQP1 GO:0038094 fc gamma receptor signaling pathway GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY -0.444469492324294 -1.36947361502972 0.100224447513812 0.619565784262489 20 HSP90AA1,ARPC3,ACTR3,HSP90AB1,PIK3R1,IGHG3,ACTR2,IGHG2,ACTG1 GO:0071867 response to monoamine GO_RESPONSE_TO_MONOAMINE 0.678928574006125 1.4307959964487 0.100407825005997 0.619565784262489 5 GNAS,RYR2,ATP2B4,DNM2 NA regulation of g protein coupled receptor protein signaling pathway GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY -0.552251753466777 -1.39748292940495 0.100586875333452 0.619565784262489 10 ADA,C3,YWHAB GO:0055092 sterol homeostasis GO_STEROL_HOMEOSTASIS 0.531302022173382 1.40910326597417 0.101313535122787 0.62213326766531 10 APOE,FABP3,APOC2,APOA4,APOC3,CAV1 GO:0071260 cellular response to mechanical stimulus GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS 0.469611058679027 1.38299130979348 0.103841214244016 0.635710848176783 14 GJA1,COL1A1,NPPA GO:0072376 protein activation cascade GO_PROTEIN_ACTIVATION_CASCADE -0.367678251296658 -1.3221962173414 0.104534193505479 0.635764331729209 37 C3,FGA,C5,FGB,IGHG3,FGG,IGHG2,CFB,SERPING1,IGHA1,C8A,C1R,CFI,C8G,IGKC,C8B,CFH,C2 GO:0010324 membrane invagination GO_MEMBRANE_INVAGINATION -0.532805402604594 -1.38894761796342 0.104658154422948 0.635764331729209 11 IGHG3,IGHG2,SNX3,IGHA1,IGKC,IGHM,IGHG1 GO:0003073 regulation of systemic arterial blood pressure GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE 0.481789140257633 1.38632412379415 0.105073474702381 0.635764331729209 13 GJA1,NPPA,ENG,POSTN,TPM1,MECP2,TNNI3 GO:0044703 multi organism reproductive process GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS -0.3275811655296 -1.29183705982125 0.105264006449013 0.635764331729209 57 NAMPT,CLIC4,RAN,EIF4H,ARID4A,TRIM28,PAM,PAFAH1B1,PRDX3,DAZAP1,ACSBG2 GO:0022409 positive regulation of cell cell adhesion GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION -0.441223420789904 -1.3594720077302 0.105438535911602 0.635764331729209 20 DNAJA3,SERPINF2,ADA,PIK3R1,FGA,FGB,ADK,FGG GO:0140014 mitotic nuclear division GO_MITOTIC_NUCLEAR_DIVISION -0.418092869318729 -1.35077129258419 0.1057496448195 0.635764331729209 24 RAN,PAFAH1B1,PPP5C,PPP2R1A,DYNC1LI1,RPS3,MAPRE1,RUVBL1,DCLRE1A GO:0007265 ras protein signal transduction GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION 0.428716610712714 1.3585438613205 0.106257294619251 0.636776543946742 18 CFL1,COL1A2,RRAS,CDH13,SDCBP,PARK7,RHOA,RGL2,KPNB1,RALA,RRAS2 GO:0007423 sensory organ development GO_SENSORY_ORGAN_DEVELOPMENT 0.342755732913138 1.30633192966918 0.106552250381527 0.636776543946742 36 BCL11B,GJA1,COL8A1,CRYAB,LAMB2,FBN1,COL4A1,SOD1,TMOD1,MYH10 GO:0072523 purine containing compound catabolic process GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS -0.566448054858635 -1.38643179691395 0.107973064937856 0.638657127004296 9 HPRT1,NT5C,ADA,AHCY GO:0051216 cartilage development GO_CARTILAGE_DEVELOPMENT 0.569143723011206 1.40371597906812 0.108688314318504 0.638657127004296 8 COL1A1,GNAS,RARB,SERPINH1,RARA GO:0007059 chromosome segregation GO_CHROMOSOME_SEGREGATION -0.470829152466648 -1.36720233939672 0.10874675675205 0.638657127004296 16 ACTR3,ESCO2,PAFAH1B1,PPP2R1A,RPS3,ACTR2,MAPRE1 GO:0010466 negative regulation of peptidase activity GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY -0.341749396808935 -1.29588527579265 0.10892836713681 0.638657127004296 47 SERPINB9,DNAJA3,LXN,SERPINF2,SERPINF1,PRDX3,GPI,C3,SERPINA3,C5,SERPINA7,SERPINA1,AGT,SERPINA4,ITIH1,AQP1,SERPING1,AHSG GO:0009612 response to mechanical stimulus GO_RESPONSE_TO_MECHANICAL_STIMULUS 0.365710545919641 1.32043785936663 0.109024952203539 0.638657127004296 29 COL3A1,GJA1,COL1A1,NPPA,RETN,DMD,POSTN GO:0006801 superoxide metabolic process GO_SUPEROXIDE_METABOLIC_PROCESS 0.631453992787549 1.41434944568579 0.109483713715932 0.638657127004296 6 SOD3,SOD1,APOA4 GO:0071450 cellular response to oxygen radical GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL 0.631453992787549 1.41434944568579 0.109483713715932 0.638657127004296 6 SOD3,SOD1,APOA4 GO:0000305 response to oxygen radical GO_RESPONSE_TO_OXYGEN_RADICAL 0.631453992787549 1.41434944568579 0.109483713715932 0.638657127004296 6 SOD3,SOD1,APOA4 GO:0006626 protein targeting to mitochondrion GO_PROTEIN_TARGETING_TO_MITOCHONDRION -0.490303396930095 -1.37105943113836 0.109729436661595 0.638657127004296 14 HSP90AA1,TOMM40,MTX2,MFN2 GO:0044839 cell cycle g2 m phase transition GO_CELL_CYCLE_G2_M_PHASE_TRANSITION -0.400105401368038 -1.33255094901416 0.11088295687885 0.643505715065697 27 HSP90AA1,PAFAH1B1,TUBB,PPP2R1A,DYNC1I2,CEP70,DYNC1H1,TUBA4A,YWHAG,MAPRE1 GO:0048002 antigen processing and presentation of peptide antigen GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN 0.316855743905132 1.27835545020571 0.111552967134464 0.644802781444175 46 CD36,PSMB3,RAB7A,KIF5A,PSMB2,DCTN2,PSMA6,BCAP31,HLA-DRA,PSMB1,CLTA,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0016126 sterol biosynthetic process GO_STEROL_BIOSYNTHETIC_PROCESS 0.566429579124421 1.39702191043602 0.111748689214429 0.644802781444175 8 PRKAG2,CYB5R1,APOA4,PRKAA2,FDPS GO:0008380 rna splicing GO_RNA_SPLICING -0.353312474795908 -1.30107006189356 0.112443580535697 0.646953322967561 41 PCBP2,C14orf166,THOC4,PPP2R1A,SRSF7,STRAP,HNRNPA2B1,FUS,SYNCRIP,HNRNPC,C22orf28,HNRNPD GO:0005976 polysaccharide metabolic process GO_POLYSACCHARIDE_METABOLIC_PROCESS 0.42450284428361 1.34519101617233 0.113236309934974 0.649652886712649 18 GYG1,UBC,PRKAG2,PYGB GO:0048661 positive regulation of smooth muscle cell proliferation GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION -0.607919297136987 -1.37539551520577 0.113641296483866 0.6498649862584 7 NAMPT,SERPINF2,CAMK2D GO:0001936 regulation of endothelial cell proliferation GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION 0.487716890891553 1.3700870943213 0.114145124402245 0.6498649862584 12 GJA1,APOE,ENG,CDH13 GO:0003279 cardiac septum development GO_CARDIAC_SEPTUM_DEVELOPMENT 0.564769385515851 1.39292726754974 0.114314003465425 0.6498649862584 8 WHSC1,ANK2,XIRP2,MYH10 GO:0044042 glucan metabolic process GO_GLUCAN_METABOLIC_PROCESS 0.431153590586503 1.34450372327941 0.114567831242766 0.6498649862584 17 GYG1,UBC,PRKAG2,PYGB GO:0010001 glial cell differentiation GO_GLIAL_CELL_DIFFERENTIATION 0.450422846447738 1.353931425903 0.11546672296901 0.651315822731148 15 LAMB2,VTN,LAMA2,CLU,SOD1,DLL1,DAG1,CDH2,GSTP1 GO:0008544 epidermis development GO_EPIDERMIS_DEVELOPMENT 0.408139978607464 1.33398348707161 0.115773965115726 0.651315822731148 20 BCL11B,KRT2,KRT5,KRT9,GNAS,FABP5,LAMA5,SOD1 GO:2001259 positive regulation of cation channel activity GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY 0.52067300173335 1.3809132971973 0.115796687607082 0.651315822731148 10 CACNA2D1,NPPA,S100A1,ANK2,ANK3 GO:0009582 detection of abiotic stimulus GO_DETECTION_OF_ABIOTIC_STIMULUS -0.606002509218724 -1.37105885157493 0.116318188395312 0.652421570664207 7 CSRP3,LXN GO:0009118 regulation of nucleoside metabolic process GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS 0.519757815480486 1.37848606770434 0.116893203883495 0.653820483002948 10 PRKAG2,PARK7,PPIF,PRKAA2,APOC3 GO:0045732 positive regulation of protein catabolic process GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS 0.312611007282177 1.26657278392341 0.118201726136803 0.656591737077036 47 PSMB3,GJA1,RAB7A,UBC,APOE,PSMB2,PSMA6,BCAP31,PSMB1,CLU,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:1901685 glutathione derivative metabolic process GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS -0.55913294203171 -1.36852741021111 0.118324438554389 0.656591737077036 9 GSTK1,AKR1A1,GSTO1,GSTM3,GSTM2,ESD GO:0045926 negative regulation of growth GO_NEGATIVE_REGULATION_OF_GROWTH 0.373359177692114 1.310070826336 0.118369625907314 0.656591737077036 26 CD36,GJA1,CRYAB,NPPA,BMP10,GNAS GO:0042158 lipoprotein biosynthetic process GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS 0.623431115369985 1.39637956607787 0.118967427431864 0.656733560023464 6 APOE,DBI,APOA4 GO:0032835 glomerulus development GO_GLOMERULUS_DEVELOPMENT 0.66277361113529 1.3967505061227 0.119512354698711 0.656733560023464 5 LAMB2,NID1,IQGAP1,CD34 GO:0072521 purine containing compound metabolic process GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS -0.271150897099997 -1.221859478222 0.119552734965246 0.656733560023464 123 GBAS,HPRT1,NT5C,ENO1,ADA,MCCC2,AHCY,NDUFB8,MTAP,NDUFV1,GPI,OLA1,NDUFC2,NDUFB9,AK4,COQ9,OGDH,NDUFS3,NDUFA10,COX5A,NDUFS8,ATP5D,ADK,NDUFA5,NDUFA9,ATP5J2,ATP5F1,NDUFB2,NDUFB3,NDUFS7,AQP1,COX4I1,ATP5A1,MCEE,COX6C,UQCRFS1,STOML2,CYC1,NDUFB11,ENO3,NME1,NDUFA7,UQCRC2,ATP1B1,PGK1,NDUFB10,NDUFS4,MTHFD1,PDE5A,NDUFA3,CAT,TPI1,PGM1,UQCR10 GO:0098732 macromolecule deacylation GO_MACROMOLECULE_DEACYLATION -0.558161878530746 -1.36615064626425 0.119703427773201 0.656733560023464 9 ARID4A,LYPLAL1 NA regulation of camp metabolic process GO_REGULATION_OF_CAMP_METABOLIC_PROCESS 0.588574905740299 1.38743884203695 0.120172633556207 0.657454969631498 7 GNAI2,GNAS,AKAP12,CALM1,CAP1 GO:0019882 antigen processing and presentation GO_ANTIGEN_PROCESSING_AND_PRESENTATION 0.311889263239612 1.26364857031615 0.120546180600283 0.657454969631498 47 CD36,PSMB3,RAB7A,KIF5A,PSMB2,DCTN2,PSMA6,BCAP31,HLA-DRA,PSMB1,CLTA,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0022402 cell cycle process GO_CELL_CYCLE_PROCESS -0.281236995649418 -1.23136574529595 0.121220036877689 0.657454969631498 102 HSP90AA1,EZR,RAN,PSMD2,ACTR3,PSME2,PAFAH1B1,PSMB6,TUBB,PPP5C,PPP2R1A,DYNC1LI1,DYNC1I2,CEP70,DYNC1H1,RPS3,MFN2,TUBA4A,CAMK2D,PSMA2,PSMA1,RANBP1,YWHAG,ACTR2,MAPRE1,UBE2L3,PEA15,RUVBL1,NPM1,PSMC2,DCLRE1A GO:0001501 skeletal system development GO_SKELETAL_SYSTEM_DEVELOPMENT 0.36005443191863 1.3000158421534 0.121378498946027 0.657454969631498 29 COL3A1,COL1A1,COL1A2,FBN1,WHSC1,GNAS,POSTN,RHOA GO:0050873 brown fat cell differentiation GO_BROWN_FAT_CELL_DIFFERENTIATION -0.630850750907784 -1.35664454466806 0.121854328771617 0.657454969631498 6 ALDH6A1,LRG1 NA extracellular fibril organization GO_EXTRACELLULAR_FIBRIL_ORGANIZATION 0.586615982503474 1.38282110152366 0.122364095798207 0.657454969631498 7 COL3A1,MFAP5,FKBP1A,LTBP2,ILK,TNXB GO:0050818 regulation of coagulation GO_REGULATION_OF_COAGULATION 0.419421790649752 1.32908985738624 0.122478145916204 0.657454969631498 18 CD36,APOE,VTN,SERPINC1 GO:0097306 cellular response to alcohol GO_CELLULAR_RESPONSE_TO_ALCOHOL -0.493357626126503 -1.35114221098051 0.122973542002948 0.657454969631498 13 SERPINF1,AQP1,AIFM1,HNRNPD,H2AFZ,MSN,JUP,CTNNB1,OSBPL7 GO:0006112 energy reserve metabolic process GO_ENERGY_RESERVE_METABOLIC_PROCESS 0.419152309945006 1.32823591016789 0.123049805873806 0.657454969631498 18 GYG1,UBC,PRKAG2,PYGB,GNAS GO:0002520 immune system development GO_IMMUNE_SYSTEM_DEVELOPMENT -0.347284366307968 -1.28520351400209 0.123179701512185 0.657454969631498 42 EEF2,DNAJA3,XRCC5,ARID4A,ESCO2,PAFAH1B1,ADA,PRDX3,PIK3R1,C3 GO:0097191 extrinsic apoptotic signaling pathway GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY -0.629568819360608 -1.35388775086602 0.12343969240301 0.657454969631498 6 KRT8,KRT18,PIK3R1 GO:0007006 mitochondrial membrane organization GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION -0.389841257035527 -1.31005250878348 0.123941323937936 0.657454969631498 28 HSP90AA1,YWHAH,MFN2,YWHAZ,MTCH2,YWHAB,YWHAG,YWHAQ,DYNLL2 GO:0045931 positive regulation of mitotic cell cycle GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE -0.55487674246416 -1.35810998470519 0.124395572907339 0.657454969631498 9 H2AFY,PAFAH1B1,DYNC1LI1,RANBP1 GO:0007264 small gtpase mediated signal transduction GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION 0.335358417942859 1.2781388235835 0.124540291711491 0.657454969631498 36 RAB2A,RAB7A,ARL8B,CFL1,COL1A2,RRAS,CDH13,SDCBP,PARK7,RHOA,RAPGEF4,RGL2,KPNB1,IQGAP1 GO:0032870 cellular response to hormone stimulus GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS -0.320360907886201 -1.26336351681361 0.124901249496171 0.657454969631498 57 NAMPT,SERPINB9,RAN,SERPINF1,YWHAH,PRKAR2A,PIK3R1,PTPN1,TBC1D4,FGB,YWHAG,AGT,UBE2L3,GOT1,AQP1,PRKAR2B,AIFM1,HNRNPD,H2AFZ,CTSB,MSN,ATP1A3,PAQR8,CTNNB1,PRKAR1A,ANXA5,ACTN2,GRB2,RAB10,SORBS1,SLC2A4,ANXA1,CA2 GO:0046660 female sex differentiation GO_FEMALE_SEX_DIFFERENTIATION 0.658444133095671 1.38762642432239 0.125073604780494 0.657454969631498 5 SOD1,RBP4,CTNNA1,IDH1,HNRNPK GO:0048646 anatomical structure formation involved in morphogenesis GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS 0.25715616606813 1.20587570869706 0.125573881992858 0.658361240317649 98 COL8A1,COL4A2,COL1A1,VTN,ZMYND10,BMP10,ENG,COL4A1,FHL2,GNAS,HSPG2,CFL2,PFN1,CDH13,ANK2,DMD,CAST,LAMA5,TMOD1,TPM1,PRKACB,MYH10,LAMB1,MYLK3,FN1,TJP1,GPX1,ANXA2,FKBP1A,COL18A1,TXNRD1,MYH11,RALA,ITGB1,DLL1,TGM2,TMOD3,COL15A1 GO:0050678 regulation of epithelial cell proliferation GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION 0.365506295666471 1.29495123967202 0.126643295354952 0.66223882044777 27 BCL11B,GJA1,LAMC1,APOE,ENG,CDH13,LAMB1,PHB2,GPX1,NME2 GO:0002449 lymphocyte mediated immunity GO_LYMPHOCYTE_MEDIATED_IMMUNITY -0.384343584326324 -1.30317435273818 0.127390041213432 0.66223882044777 29 TUBB,C3,C5,IGHG3,IGHG2,SERPING1,IGHA1,C8A,C1R,CFI,C8G,TUBB4B,IGKC,C8B,C2 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY -0.598003568915425 -1.3529615372252 0.127622630588916 0.66223882044777 7 PPP2R1A,AGT,PEA15 GO:0032787 monocarboxylic acid metabolic process GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS -0.272487954065115 -1.21527879676533 0.127632681032514 0.66223882044777 115 GCDH,CYGB,ECI2,PCCB,DCXR,ABHD10,PAM,ENO1,IVD,ALDH4A1,VCAN,CBR1,BGN,MCCC2,ME3,GPI,C3,ACAD10,BRP44,ACSBG2,OGDH,ETFA,MCCC1,AKR1A1,IDH2,ECHS1,ACADVL,CRAT,MCEE,P4HB,PTGES2,PTGR2,PRKAR2B,ENO3,PCCA,DLAT,HSD17B4,PDHA1,DBT,ALDH1A2,ETFB,PGK1,ECH1,PRDX4,ALDH5A1,TPI1,PGM1,ACAA2,GRHPR,BRP44L,PDHB,DECR1,HK1,PGD,BPGM,DCN,BCKDHA GO:0035567 non canonical wnt signaling pathway GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY 0.343294946828141 1.27898213197941 0.128441965841757 0.66365873071835 33 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PFN1,GNAO1,RHOA,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0033044 regulation of chromosome organization GO_REGULATION_OF_CHROMOSOME_ORGANIZATION -0.416532118347649 -1.31734770978278 0.128623872096614 0.66365873071835 22 XRCC5,TRIM28,H2AFY,DYNC1LI1,OTUB1,CAMK2D,CCT6A GO:0050853 b cell receptor signaling pathway GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY -0.596805817550947 -1.35025166790078 0.129539863984952 0.66365873071835 7 IGHG3,IGHG2,IGHA1,IGKC,IGHM,IGHG1 GO:0019682 glyceraldehyde 3 phosphate metabolic process GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS -0.596781334808014 -1.35019627657665 0.129612212414991 0.66365873071835 7 PGM2,TALDO1 GO:0001656 metanephros development GO_METANEPHROS_DEVELOPMENT 0.580973885041232 1.36952106937257 0.129832956908697 0.66365873071835 7 LAMB2,FBN1,CD34 GO:0071407 cellular response to organic cyclic compound GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND -0.327276499141186 -1.26129272541296 0.12988938305394 0.66365873071835 51 SERPINB9,EZR,RAN,SERPINF1,HSP90AB1,YWHAH,FGA,HNRNPA2B1,DROSHA,UBE2L3,GSTM2,NPM1,AQP1,AIFM1,HNRNPD,H2AFZ,MSN,JUP,ATP1A3,PAQR8 GO:0010874 regulation of cholesterol efflux GO_REGULATION_OF_CHOLESTEROL_EFFLUX 0.65370977838119 1.37764909234581 0.131441781344732 0.667516358363103 5 APOE,PON1,LRP1 GO:0014896 muscle hypertrophy GO_MUSCLE_HYPERTROPHY -0.550037955699116 -1.34626662542096 0.132006877037143 0.667516358363103 9 CSRP3,SORBS2,CAMK2D,AGT GO:0051156 glucose 6 phosphate metabolic process GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS -0.570662368787007 -1.34633510922003 0.132074792592726 0.667516358363103 8 PGM2,TALDO1,GPI GO:0090313 regulation of protein targeting to membrane GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE 0.652755665954018 1.37563836501273 0.132292325474887 0.667516358363103 5 MYO1C,STOM,ANK3 GO:0008219 cell death GO_CELL_DEATH -0.29598151201083 -1.23557414324021 0.132622406769531 0.667516358363103 77 CLIC4,KRT8,HSP90AA1,KRT18,SERPINB9,DNAJA3,RTN4,PPP2R1A,PRDX3,ANP32B,VAPA,RPS3,MFN2,GPI,PIK3R1 GO:0006974 cellular response to dna damage stimulus GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS -0.32464580349145 -1.25678176374461 0.132768361581921 0.667516358363103 52 XRCC6,XRCC5,TRIM28,ESCO2,UBA1,THOC4,PPP5C,OTUB1,RPS3,PIK3R1,PEA15,RUVBL1,ASCC3,NPM1,DCLRE1A,ZMAT3,CDK5RAP3,NDRG1,HMGB1 GO:0007623 circadian rhythm GO_CIRCADIAN_RHYTHM -0.514073988225762 -1.3401174948915 0.132971386128108 0.667516358363103 11 NAMPT,AHCY,ADK,SYNCRIP,HEBP1,HNRNPD GO:0008361 regulation of cell size GO_REGULATION_OF_CELL_SIZE -0.457058002845741 -1.32721342222953 0.133856896581747 0.66834900935779 16 HSP90AA1,EZR,PAFAH1B1,RTN4,HSP90AB1 GO:0006956 complement activation GO_COMPLEMENT_ACTIVATION -0.389312465658388 -1.29660507906747 0.134216912450999 0.66834900935779 27 C3,C5,IGHG3,IGHG2,CFB,SERPING1,IGHA1,C8A,C1R,CFI,C8G,IGKC,C8B,CFH,C2 GO:0006694 steroid biosynthetic process GO_STEROID_BIOSYNTHETIC_PROCESS 0.450428876604629 1.32650032513398 0.134781085814361 0.66834900935779 14 PRKAG2,CYB5R1,APOA4,PRKAA2,FDPS,HSD17B8 GO:0086001 cardiac muscle cell action potential GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL 0.475058396989244 1.33452704000907 0.135213805530529 0.66834900935779 12 GJA1,CACNA2D1,ANK2,DMD GO:0032675 regulation of interleukin 6 production GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION 0.61018043693657 1.36670030217057 0.135874141369377 0.66834900935779 6 CD36,NCL,HSPD1 GO:0046328 regulation of jnk cascade GO_REGULATION_OF_JNK_CASCADE -0.485786670423265 -1.33040788503439 0.13595690925679 0.66834900935779 13 SERPINF2,PAFAH1B1,RPS3,PTPN1,DBNL GO:0042454 ribonucleoside catabolic process GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS -0.620974615575816 -1.33540591556088 0.136286604588443 0.66834900935779 6 APOBEC2,HPRT1,ADA,AHCY GO:0046823 negative regulation of nucleocytoplasmic transport GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT 0.649749608365513 1.36930330219847 0.136414193182562 0.66834900935779 5 CD36,PARK7,SRI GO:0010939 regulation of necrotic cell death GO_REGULATION_OF_NECROTIC_CELL_DEATH 0.609695258120983 1.36561358422006 0.136472413029027 0.66834900935779 6 UBC,PPIF,HEBP2,NOL3,CAV1 NA de novo protein folding GO__DE_NOVO_PROTEIN_FOLDING 0.548143088369606 1.35192075542756 0.136524224217467 0.66834900935779 8 ERO1L,UGGT1,HSPE1,FKBP1A,HSPA8,HSPD1 GO:0046434 organophosphate catabolic process GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS -0.45490493125204 -1.32096129339601 0.13749629964999 0.66834900935779 16 PGM2,HPRT1,NT5C,ADA GO:0051653 spindle localization GO_SPINDLE_LOCALIZATION -0.567012373069121 -1.33772385736205 0.137617650763943 0.66834900935779 8 ACTR3,PAFAH1B1,DYNC1H1,ACTR2 GO:0006612 protein targeting to membrane GO_PROTEIN_TARGETING_TO_MEMBRANE 0.284699017492397 1.22310103406318 0.13770701315299 0.66834900935779 62 RPS4X,MYO1C,RPS8,RPS23,RPL14,SPTBN1,RPL18,RPL19,SDCBP,RPL35,RPL7A,ANK2,RPL24,ANK3,RPS21,RPL3,ANXA2,RPL23A,MYADM,RPS24,RPS14,RPL31,RPL7,RPL29,FAU GO:0032990 cell part morphogenesis GO_CELL_PART_MORPHOGENESIS 0.286108971746794 1.22483206792311 0.137797056710222 0.66834900935779 61 BCL11B,GJA1,KIF5A,LAMB2,ZMYND10,NCAM1,PACSIN2,LAMA2,SPTAN1,SPTBN1,MAP1B,NDUFS6,DMD,CLU,POSTN,LAMA5,ANK3,MYH10,DPYSL2,IQGAP1 GO:0002011 morphogenesis of an epithelial sheet GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET 0.648274821864529 1.36619528951199 0.138420604976774 0.669755601911714 5 ARHGAP12,RHOA,DAG1,FLNA,PDCD10 GO:0043650 dicarboxylic acid biosynthetic process GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS -0.655609291764587 -1.32565276010926 0.139269490711674 0.672243118627504 5 ALDH4A1,GLUD1,GOT1,MTHFD1 GO:0051153 regulation of striated muscle cell differentiation GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION 0.545883556792556 1.34634792654151 0.14007965975832 0.674532270490905 8 EHD2,BMP10,NACA,MYLK3,PIN1 GO:1902275 regulation of chromatin organization GO_REGULATION_OF_CHROMATIN_ORGANIZATION -0.564776423666941 -1.33244869406542 0.141720805514064 0.677341034682733 8 TRIM28,H2AFY,OTUB1,CAMK2D NA single organism catabolic process GO_SINGLE_ORGANISM_CATABOLIC_PROCESS -0.245656134416059 -1.175439605336 0.141820960950568 0.677341034682733 190 PGM2,BLVRA,GCDH,APOBEC2,HPRT1,ERLIN2,ALDH6A1,ALDH2,ECI2,PCCB,DCXR,NT5C,ABHD10,QDPR,MPST,ENO1,PAFAH1B1,ADA,IVD,PRDX3,ALDH4A1,VCAN,BCAT2,YWHAH,BGN,MCCC2,AHCY,MTAP,GPI,PEPD,BDH1,GLUD1,OXCT1,NDUFB9,ACAD10,CTSD,OGDH,C5,ETFA,MCCC1,AKR1A1,STBD1,PRELP,ECHS1,HIBADH,ACADVL,PGM5,PSMC2,CRAT,GOT1,OGN,FMOD,PRDX2,PAFAH1B2,MCEE,ALDH1A1,ENO3,OBSCN,HBA2,HBA1,PCCA,PSMC3,HSD17B10,DDAH2,HSD17B4,COL6A3,DBT,CTSB,HBB,GPX3,PCYOX1 GO:0060135 maternal process involved in female pregnancy GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY -0.543814781718836 -1.3310348557821 0.141910526881335 0.677341034682733 9 PAM,PRDX3,DAZAP1 GO:0051301 cell division GO_CELL_DIVISION -0.366839943030547 -1.27575683522442 0.142311237744071 0.677341034682733 32 RAN,ACTR3,PAFAH1B1,SEPT11,TUBB,DYNC1LI1,PARD3,RPS3,ACTR2,MAPRE1,RUVBL1,DCLRE1A GO:0030048 actin filament based movement GO_ACTIN_FILAMENT_BASED_MOVEMENT 0.334388514433215 1.25635652377476 0.142835791151853 0.677341034682733 34 GJA1,CACNA2D1,TPM3,TPM2,ANK2,DMD,TMOD1,TPM1,MYH10 GO:1902882 regulation of response to oxidative stress GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS 0.434216489556956 1.30521654372756 0.144274755436695 0.677341034682733 15 CD36,PARK7,SOD1,GPX1,FBLN5,HEBP2,NOL3,PSAP GO:0009123 nucleoside monophosphate metabolic process GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS -0.273051564307072 -1.20421620069503 0.144381833215937 0.677341034682733 107 GBAS,HPRT1,ENO1,ADA,NDUFB8,NDUFV1,GPI,OLA1,NDUFC2,NDUFB9,LHPP,AK4,COQ9,OGDH,NDUFS3,NDUFA10,COX5A,NDUFS8,ATP5D,ADK,NDUFA5,NDUFA9,ATP5J2,ATP5F1,NDUFB2,NDUFB3,NDUFS7,COX4I1,ATP5A1,COX6C,UQCRFS1,STOML2,CYC1,NDUFB11,ENO3,NDUFA7,UQCRC2,ATP1B1,PGK1,NDUFB10,NDUFS4,NDUFA3,TPI1,PGM1,UQCR10,NDUFS5,HSPA1A,NDUFS1,UQCRC1,VCP,HK1,BPGM,NDUFB4 GO:0050775 positive regulation of dendrite morphogenesis GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS -0.652090011871383 -1.31853671834075 0.14479078184437 0.677341034682733 5 PAFAH1B1,CAPRIN2 GO:0071806 protein transmembrane transport GO_PROTEIN_TRANSMEMBRANE_TRANSPORT -0.493865991363731 -1.32087404843445 0.145176931078865 0.677341034682733 12 HSP90AA1,TOMM40 GO:0019730 antimicrobial humoral response GO_ANTIMICROBIAL_HUMORAL_RESPONSE -0.541760718821495 -1.32600735486775 0.145295318600236 0.677341034682733 9 RPL39,FGA,IGJ,FGB,IGHA1 GO:0016071 mrna metabolic process GO_MRNA_METABOLIC_PROCESS -0.279729947782109 -1.21039099944254 0.145455108742797 0.677341034682733 95 RPL39,PCBP2,RPL13A,APOBEC2,RPS2,RPL10A,EIF4B,THOC4,PPP2R1A,SRSF7,RPS3,STRAP,RPL10,HNRNPA2B1,FUS,RNH1,RPSA GO:0048762 mesenchymal cell differentiation GO_MESENCHYMAL_CELL_DIFFERENTIATION -0.56215695904624 -1.32626872254617 0.145913941728004 0.677341034682733 8 TRIM28,RTN4,LIMS1 GO:0090303 positive regulation of wound healing GO_POSITIVE_REGULATION_OF_WOUND_HEALING 0.520193698248117 1.33340826955748 0.146534743134014 0.677341034682733 9 CD36,VTN,APOH,PLG NA positive regulation of transcription from rna polymerase ii promoter GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER -0.313449072731261 -1.23610625741015 0.146827891979041 0.677341034682733 57 NAMPT,XRCC6,CSRP3,ERLIN2,C14orf166,COQ7,ARID4A,TRIM28,SERPINF2 GO:0030836 positive regulation of actin filament depolymerization GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION 0.642427039094871 1.35387148330428 0.146947855102174 0.677341034682733 5 FAM21C,CFL2,DSTN GO:0090130 tissue migration GO_TISSUE_MIGRATION 0.519988320542398 1.33288182655728 0.146964928566577 0.677341034682733 9 KRT2,CDH13,RHOA,GPX1,ITGB1 GO:0006413 translational initiation GO_TRANSLATIONAL_INITIATION -0.313383615321601 -1.23584812197217 0.147053607416364 0.677341034682733 57 RPL39,PCBP2,RPL13A,EIF3F,EIF4H,RPS2,RPL10A,EIF4B GO:0060429 epithelium development GO_EPITHELIUM_DEVELOPMENT 0.255584857365664 1.18742292569337 0.147177362532059 0.677341034682733 93 BCL11B,GJA1,LAMB2,KRT2,KRT5,ENG,COL4A1,KRT9,TAGLN,GNAS,PTER,FNDC3A,FABP5,PFN1,ARHGAP12,RHOA,LAMA5,SOD1,TMOD1,PRKACB,TOLLIP,PHB2,IQGAP1,TJP1,GPX1,ALDOC,COL18A1,RALA,MYADM,DLL1,RDX,ANXA4,DAG1,TGM2 GO:0072006 nephron development GO_NEPHRON_DEVELOPMENT 0.499643804603372 1.3251402921644 0.147344374643061 0.677341034682733 10 LAMB2,NID1,LAMA5,IQGAP1,DLL1 GO:0002702 positive regulation of production of molecular mediator of immune response GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE 0.567516732185615 1.33779872376623 0.147409378563921 0.677341034682733 7 CD36,MIF,WHSC1 GO:0016311 dephosphorylation GO_DEPHOSPHORYLATION -0.388087309928601 -1.28078793920982 0.14807257392576 0.678834996445035 26 NT5C,PPP5C,PPP2R1A,LHPP,PTPN1,CA3,HDHD2,PPP1R12A,PDP1,BPGM,TIMM50,MYH6,PPP2CA,HDHD1,ATP1A1,IMPA1,PPA2,PGAM1,DUSP3 GO:0009991 response to extracellular stimulus GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS 0.295659050064634 1.2207172804765 0.149486004298402 0.680953560703456 51 MAP1LC3B,MAP1LC3B2,COL1A1,APOE,SORD,SERPINC1,GNAI2,PKM2,POSTN,SOD1,PRKAA2,SIRT5,HSPA5 GO:0090322 regulation of superoxide metabolic process GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS 0.599370077961842 1.34248693841294 0.150254819410592 0.680953560703456 6 CD36,PARK7,SOD1,FBLN5,GSTP1 GO:0060828 regulation of canonical wnt signaling pathway GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY 0.326215221430173 1.2432917053683 0.151284681394011 0.680953560703456 36 PSMB3,UBC,COL1A1,APOE,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PIN1,PSMA5,PSMA3,PFDN5 NA regulation of establishment of protein localization to plasma membrane GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE -0.647624178909491 -1.30950673071476 0.151420024374931 0.680953560703456 5 EZR,PIK3R1,DPP10 GO:0006911 phagocytosis engulfment GO_PHAGOCYTOSIS_ENGULFMENT -0.519835648398826 -1.31545339634167 0.152196336475191 0.680953560703456 10 IGHG3,IGHG2,IGHA1,IGKC,IGHM,IGHG1 GO:0090175 regulation of establishment of planar polarity GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY 0.344224216471114 1.25330006760972 0.152605703048181 0.680953560703456 30 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PFN1,RHOA,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:1901890 positive regulation of cell junction assembly GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY -0.646607951859501 -1.30745190292229 0.15326661003804 0.680953560703456 5 LIMS1,AGT GO:0050673 epithelial cell proliferation GO_EPITHELIAL_CELL_PROLIFERATION 0.563138916835407 1.32747896497104 0.153558889957289 0.680953560703456 7 COL8A1,KRT2,CDH13 NA macromolecular complex disassembly GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY 0.452690980342042 1.30259562583043 0.153599330357143 0.680953560703456 13 CFL1,CFL2,SET,MRPS36,DSTN,MRPL50,MRPL12,HSPA8,CAV1 GO:0045815 positive regulation of gene expression epigenetic GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC 0.403496459753595 1.27862467831957 0.15441964604721 0.680953560703456 18 MYO1C,HIST1H3A,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0042475 odontogenesis of dentin containing tooth GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH 0.596537676823636 1.33614284204877 0.154487037447374 0.680953560703456 6 BCL11B,LAMA5 GO:0048666 neuron development GO_NEURON_DEVELOPMENT 0.281579486754037 1.20544134963688 0.154855363653299 0.680953560703456 61 BCL11B,GJA1,KIF5A,APOE,LAMB2,NCAM1,LAMA2,SPTAN1,SPTBN1,MAP1B,GNAO1,CLU,POSTN,SOD1,APOA4,ANK3,MYH10,LAMB1,DPYSL2,IQGAP1 GO:0008033 trna processing GO_TRNA_PROCESSING -0.645332226373593 -1.30487236502864 0.155390183550615 0.680953560703456 5 C14orf166,C22orf28,HSD17B10,DDX1 GO:0032368 regulation of lipid transport GO_REGULATION_OF_LIPID_TRANSPORT 0.418937414172564 1.28482140623201 0.155537287140341 0.680953560703456 16 APOE,MIF,RETN,APOC2,APOA4,PON1,APOC3,SCP2,LRP1 GO:0060271 cilium morphogenesis GO_CILIUM_MORPHOGENESIS -0.454798139017413 -1.29726188362309 0.155590413943355 0.680953560703456 15 ABLIM1,ACTR3,IFT52,PARVA,ACTR2,IFT81,EHD1 GO:0043122 regulation of i kappab kinase nf kappab signaling GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING 0.371626111212527 1.26099659800681 0.156015218647659 0.680953560703456 23 CD36,GJA1,UBC,S100A13 GO:0070252 actin mediated cell contraction GO_ACTIN_MEDIATED_CELL_CONTRACTION 0.339631529924221 1.24689225249956 0.156273126449257 0.680953560703456 31 GJA1,CACNA2D1,TPM3,TPM2,ANK2,DMD,TMOD1,TPM1 GO:0061008 hepaticobiliary system development GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT -0.40396648813031 -1.27760694680283 0.156345421484201 0.680953560703456 22 QDPR,MPST,ADA,BDH1,FGA,AK4 GO:0010896 regulation of triglyceride catabolic process GO_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS 0.635748491634852 1.3397968967664 0.156500119948531 0.680953560703456 5 APOC2,APOA4,APOH,APOC3 GO:0090208 positive regulation of triglyceride metabolic process GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS 0.635748491634852 1.3397968967664 0.156500119948531 0.680953560703456 5 APOC2,APOA4,APOH,APOC3 GO:0055081 anion homeostasis GO_ANION_HOMEOSTASIS 0.595121614011174 1.33297110241811 0.156702858409041 0.680953560703456 6 APOE,FABP3,PRKAA2 GO:0060348 bone development GO_BONE_DEVELOPMENT 0.462986161879834 1.30061389524842 0.157229653244623 0.680953560703456 12 COL1A1,WHSC1,GNAS,RHOA,ANXA2 GO:0035383 thioester metabolic process GO_THIOESTER_METABOLIC_PROCESS -0.398967000306377 -1.27608174499315 0.157351985497828 0.680953560703456 23 GCDH,ACOT9,BRP44,ACSBG2,OGDH,SUCLG1,MCEE,DLAT,HSD17B4,PDHA1,SUCLA2 GO:0071826 ribonucleoprotein complex subunit organization GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION -0.379654362433659 -1.26443876845585 0.15850119639554 0.680953560703456 27 EIF3F,EIF4H,EIF4B,DYNC1H1,STRAP,RPL10,RPSA GO:0001893 maternal placenta development GO_MATERNAL_PLACENTA_DEVELOPMENT -0.643091021170108 -1.30034061128248 0.159009491450308 0.680953560703456 5 PRDX3,DAZAP1,CTSB GO:0006536 glutamate metabolic process GO_GLUTAMATE_METABOLIC_PROCESS -0.642517543988045 -1.29918103099769 0.16022823798796 0.680953560703456 5 ALDH4A1,GLUD1,GOT1,ALDH5A1 GO:0002700 regulation of production of molecular mediator of immune response GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE 0.492519375194542 1.30624509446288 0.160434037692747 0.680953560703456 10 CD36,MIF,WHSC1 GO:0060420 regulation of heart growth GO_REGULATION_OF_HEART_GROWTH 0.532427109662366 1.31315942055537 0.160827201332163 0.680953560703456 8 GJA1,BMP10,PIN1,KCNK2,RBP4 GO:0051702 interaction with symbiont GO_INTERACTION_WITH_SYMBIONT 0.461056595822683 1.29519338674869 0.160879709843602 0.680953560703456 12 APOE,CFL1,STOM,GPX1,VAPB,CTSG GO:0055090 acylglycerol homeostasis GO_ACYLGLYCEROL_HOMEOSTASIS 0.632719142796663 1.33341274922058 0.160905502366257 0.680953560703456 5 APOC2,APOA4,FITM2,APOC3 GO:0044419 interspecies interaction between organisms GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS -0.253873947153987 -1.17194985316843 0.161098881485007 0.680953560703456 145 RPL39,PCBP2,XRCC6,RPL13A,KRT8,KRT18,EIF3F,SERPINB9,C14orf166,RAN,EIF4H,XRCC5,KRT19,RPS2,RPL10A,THOC4,PSMB6,HSP90AB1,DYNC1LI1,DYNC1I2,VAPA GO:0034381 plasma lipoprotein particle clearance GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE 0.510986421283882 1.30980733151159 0.161681798627935 0.680953560703456 9 CD36,APOE,APOC2 GO:2000351 regulation of endothelial cell apoptotic process GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS -0.641659634056803 -1.2974463230206 0.161816301658234 0.680953560703456 5 FGA,FGB,FGG GO:0002526 acute inflammatory response GO_ACUTE_INFLAMMATORY_RESPONSE -0.442450668936308 -1.28479637776935 0.162937294304073 0.680953560703456 16 SERPINF2,HP,FGA,SERPINA3,SERPINA1,AHSG,ITIH4,APCS,ORM1 GO:0060349 bone morphogenesis GO_BONE_MORPHOGENESIS 0.590666402378739 1.32299218681267 0.163217372036339 0.680953560703456 6 COL1A1,GNAS,RARB,SERPINH1,RARA GO:0048667 cell morphogenesis involved in neuron differentiation GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION 0.333969261761468 1.23464387919963 0.163299204204576 0.680953560703456 32 BCL11B,KIF5A,LAMB2,NCAM1,LAMA2,SPTAN1,SPTBN1,MAP1B,SOD1,ANK3,MYH10,DPYSL2 GO:0030834 regulation of actin filament depolymerization GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION 0.399477403614796 1.2658888432499 0.16351856703904 0.680953560703456 18 FAM21C,SPTAN1,SPTBN1,CFL2,TMOD1,DSTN,RDX,TMOD3 GO:0045428 regulation of nitric oxide biosynthetic process GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS -0.496952047367909 -1.29548303951029 0.163672054610406 0.680953560703456 11 HSP90AA1,HSP90AB1,AGT,DDAH2,HBB GO:0006575 cellular modified amino acid metabolic process GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS -0.347071563412604 -1.2405914716623 0.163782045942929 0.680953560703456 36 CLIC4,CLIC1,MPST,ALDH4A1,GSTK1,AHCY,GSS,GSTO1,GSTM3,GSTM2,P4HB,DDAH2,PCYOX1,CKM,MTHFD1,PRDX4,ALDH5A1,ALDH7A1 GO:0042273 ribosomal large subunit biogenesis GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 0.47461608771264 1.2966562596996 0.163928390630034 0.680953560703456 11 RPL14,RPL35,RPL24,RPL3,RPL23A,RPL7 GO:0007266 rho protein signal transduction GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION 0.590027147967472 1.32156036575753 0.164148016840239 0.680953560703456 6 CFL1,COL1A2,CDH13,RHOA,TAX1BP3 GO:0033043 regulation of organelle organization GO_REGULATION_OF_ORGANELLE_ORGANIZATION -0.250383511856747 -1.16655402314161 0.164564812900558 0.680953560703456 155 CLIC4,EZR,RAN,XRCC5,ARPC3,TRIM28,ARHGDIA,SERPINF2,ACTR3,PAM,H2AFY,PAFAH1B1,TUBB,PPP2R1A,DYNC1LI1,OTUB1,YWHAH,DYNC1H1,SPTB,RPS3,ARF1,PIK3R1,CAMK2D,TMED9,YWHAZ,RANBP1,CAPZB,LMAN1,TBC1D4,VDAC3,CCT6A,YWHAB,YWHAG,ACTR2,NPEPPS,MAPRE1,YWHAQ,DYNLL2,UBE2L3,RUVBL1,NPM1,HNRNPC GO:0031579 membrane raft organization GO_MEMBRANE_RAFT_ORGANIZATION 0.589712903024202 1.32085651058138 0.164613339242189 0.680953560703456 6 PACSIN2,ANXA2,MYADM,CAV1 GO:0090201 negative regulation of release of cytochrome c from mitochondria GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA 0.589610529757831 1.32062721189264 0.164701972080656 0.680953560703456 6 PPIF,GPX1,NOL3,OPA1 GO:0022617 extracellular matrix disassembly GO_EXTRACELLULAR_MATRIX_DISASSEMBLY 0.41483746508958 1.27224744609363 0.165002935995302 0.680953560703456 16 LAMC1,FBN1,NID1,ENG,HSPG2,FN1 GO:0014072 response to isoquinoline alkaloid GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID -0.639244421908264 -1.29256272437247 0.165583336410976 0.680953560703456 5 ADA,PPP5C,FGA,PEA15 GO:2001233 regulation of apoptotic signaling pathway GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY -0.309517196340914 -1.21601152401111 0.165600361897376 0.680953560703456 56 PPP2R1A,YWHAH,RPS3,ERP29,FGA,YWHAZ,NDUFS3,PTPN1,FGB,YWHAB,YWHAG,FGG,YWHAQ,AGT,DYNLL2,PEA15 GO:0051962 positive regulation of nervous system development GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT -0.3584035113048 -1.24641751260292 0.165742059834074 0.680953560703456 32 DPYSL3,XRCC5,ARHGDIA,SERPINF1,PAFAH1B1,PARD3,ARF1,CAPRIN2 GO:1902531 regulation of intracellular signal transduction GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION 0.225802587567567 1.14090121538293 0.166005332010664 0.680953560703456 156 CD36,COL3A1,GLIPR2,GJA1,NFAT5,UBC,APOE,PRKCDBP,S100A13,ARHGDIB,PRKAG2,BMP10,CRK,HCLS1,GNAI2,MIF,C1QBP,BCAP31,GNAS,RRAS,AMBP,CDH13,SDCBP,PARK7,PPIF,DMD,ARHGAP12,CLU,AKAP12,RHOA,SOD1 GO:0006631 fatty acid metabolic process GO_FATTY_ACID_METABOLIC_PROCESS -0.306637129470414 -1.21410291880487 0.166021118271966 0.680953560703456 58 GCDH,CYGB,ECI2,PCCB,PAM,IVD,CBR1,C3,ACAD10,ACSBG2,ETFA,ECHS1,ACADVL,CRAT,MCEE,PTGES2,PTGR2,PRKAR2B,PCCA,HSD17B4 GO:0046578 regulation of ras protein signal transduction GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION 0.423104480709567 1.27181482331741 0.166959908039505 0.680953560703456 15 COL3A1,APOE,ARHGDIB,CRK GO:0009127 purine nucleoside monophosphate biosynthetic process GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS -0.384727741032604 -1.25738095584967 0.167013084366907 0.680953560703456 25 GBAS,HPRT1,ADA,LHPP,AK4,ATP5D,ADK,ATP5J2,ATP5F1,ATP5A1,STOML2 GO:0045861 negative regulation of proteolysis GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS -0.313041154987548 -1.21608155555087 0.16722972972973 0.680953560703456 53 SERPINB9,DNAJA3,LXN,SERPINF2,SERPINF1,HSP90AB1,PRDX3,GPI,C3,SERPINA3,C5,SERPINA7,SERPINA1,AGT,SERPINA4,ITIH1,AQP1,SERPING1,AHSG GO:0048511 rhythmic process GO_RHYTHMIC_PROCESS -0.411226017453293 -1.2670457487893 0.167403314917127 0.680953560703456 20 NAMPT,PAM,SERPINF1,AHCY,ADK,SYNCRIP GO:0002218 activation of innate immune response GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE 0.318184435632575 1.22066225450764 0.167716199603603 0.680953560703456 37 CD36,PSMB3,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PRKACB,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0007062 sister chromatid cohesion GO_SISTER_CHROMATID_COHESION -0.637657274743286 -1.28935348672685 0.168371680762271 0.680953560703456 5 PAFAH1B1,PPP2R1A,MAPRE1 GO:0046459 short chain fatty acid metabolic process GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS -0.637632195987323 -1.28930277707023 0.168427078332164 0.680953560703456 5 PCCB,MCEE,PCCA,ALDH5A1 GO:0051385 response to mineralocorticoid GO_RESPONSE_TO_MINERALOCORTICOID -0.637443287021525 -1.28892080003746 0.168888724747941 0.680953560703456 5 RAN,BDH1,AIFM1,MAOB GO:0043279 response to alkaloid GO_RESPONSE_TO_ALKALOID -0.469275019052473 -1.28518797161129 0.169099585935855 0.680953560703456 13 ADA,PPP5C,FGA,GSTM2,PEA15 GO:0045807 positive regulation of endocytosis GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS 0.371408509513393 1.24589688715666 0.169967392346792 0.680953560703456 22 CD36,VTN,ATAD1,ITGB1,DLL1,C4B,TF,LMAN2,B2M,CD63 GO:0034109 homotypic cell cell adhesion GO_HOMOTYPIC_CELL_CELL_ADHESION -0.404034820296201 -1.26188735185518 0.170013409895815 0.680953560703456 21 CLIC1,PKP2,CSRP1,FGA,FGB,FGG,ACTG1,HBB,DSP,HSPB1,JUP,ACTN1 NA oxidoreduction coenzyme metabolic process GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS -0.313595364685832 -1.21400286494809 0.17005974413923 0.680953560703456 52 NAMPT,PGM2,TALDO1,COQ7,DCXR,ENO1,GPI,BRP44,COQ9,OGDH GO:0051899 membrane depolarization GO_MEMBRANE_DEPOLARIZATION 0.526609741297933 1.29881166866227 0.170683408717568 0.680953560703456 8 CACNA2D1,PARK7,ANK2 GO:0010629 negative regulation of gene expression GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION -0.259134199566647 -1.17030065232139 0.170890374775482 0.680953560703456 125 XRCC6,RPL13A,DNAJA3,EZR,RAN,XRCC5,COQ7,ARID4A,TRIM28,SERPINF2,SERPINF1,H2AFY,ENO1,LIMS1,AEBP1,SRSF7,RPS3,ERP29,STRAP,CAPRIN2,HNRNPA2B1,CNPY2,YWHAB,SYNCRIP,YWHAQ,AGT,PURA,DROSHA GO:0032465 regulation of cytokinesis GO_REGULATION_OF_CYTOKINESIS 0.62568306010929 1.31858468140135 0.171286502518919 0.680953560703456 5 RHOA,PIN1,CALM1,CDC42,CETN2 NA regulation of transcription from rna polymerase ii promoter GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER -0.269207658016684 -1.18057769277933 0.171419800460476 0.680953560703456 103 NAMPT,XRCC6,CSRP3,ERLIN2,DNAJA3,EZR,C14orf166,COQ7,ARID4A,TRIM28,NEDD8,SERPINF2,PAM,H2AFY,ENO1,AEBP1,PIK3R1,STRAP,CAMK2D,CAPRIN2,HNRNPA2B1 GO:0034114 regulation of heterotypic cell cell adhesion GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION -0.57152234684902 -1.29304872603656 0.171465779192592 0.680953560703456 7 FGA,FGB,FGG GO:0007507 heart development GO_HEART_DEVELOPMENT 0.262296166813027 1.17540331802198 0.171594871372484 0.680953560703456 77 COL3A1,GJA1,NEXN,FBN1,NPPA,BMP10,WHSC1,ENG,FHL2,NACA,SGCD,ANK2,XIRP2,TPM1,MYH10,MYLK3,SGCG,FKBP1A,MECP2,TNNI3,MYH11,SRI,ITGB1,DLL1,TNNC1,GNA11,PLN GO:0043624 cellular protein complex disassembly GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY 0.485665872917933 1.28806844156435 0.17197030268418 0.681097372366537 10 CFL1,CFL2,MRPS36,DSTN,MRPL50,MRPL12,HSPA8 GO:0014910 regulation of smooth muscle cell migration GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION 0.503756242506524 1.29127427314395 0.173591142708357 0.682797934786567 9 VTN,RETN,POSTN,TPM1 GO:0044706 multi multicellular organism process GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS -0.408434266317144 -1.25844396714465 0.173808701657459 0.682797934786567 20 NAMPT,TRIM28,PAM,PRDX3,DAZAP1 GO:0030837 negative regulation of actin filament polymerization GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION 0.43033483286378 1.26732393361037 0.174197314652656 0.682797934786567 14 SPTAN1,SPTBN1,PFN1,TMOD1,MYADM,PFN2,RDX,TMOD3 GO:0071277 cellular response to calcium ion GO_CELLULAR_RESPONSE_TO_CALCIUM_ION -0.545847916071989 -1.28779161531956 0.174294095416344 0.682797934786567 8 CLIC4,CAMK2D,FUS GO:1902743 regulation of lamellipodium organization GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION -0.5699410230929 -1.28947103799063 0.174558674576762 0.682797934786567 7 HSP90AA1,CAPZB,CORO1B GO:0009068 aspartate family amino acid catabolic process GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS -0.545564561142403 -1.28712311024381 0.175013947126892 0.682797934786567 8 GCDH,OGDH,GOT1 GO:0070727 cellular macromolecule localization GO_CELLULAR_MACROMOLECULE_LOCALIZATION -0.238738151951698 -1.14793558771738 0.176105597288252 0.682797934786567 198 RPL39,RPL13A,HSP90AA1,KRT18,CSRP3,DNAJA3,EZR,TOR1AIP1,TOMM40,FERMT2,RAN,MTX2,RPS2,RPL10A,ESCO2,PKP2,H2AFY,VAPA,YWHAH,PARD3,RPS3,MFN2,ERP29,PIK3R1,TMED9,RPL10,YWHAZ,RANBP1,LMAN1,TBC1D4,RPSA,MTCH2,YWHAB,YWHAG,VAMP3,DPP10,SSR1,TOM1,IFT81,HSPA9,MAPRE1,YWHAQ,AGT,RAB11B,EHD1 GO:0046888 negative regulation of hormone secretion GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION 0.622530519987603 1.31194091656739 0.176193487885198 0.682797934786567 5 PFKL,HADH GO:0007389 pattern specification process GO_PATTERN_SPECIFICATION_PROCESS 0.467557428624388 1.27737192710148 0.176262138156381 0.682797934786567 11 GJA1,ENG,COL4A1,DLL1 GO:0006518 peptide metabolic process GO_PEPTIDE_METABOLIC_PROCESS -0.260370836029942 -1.16755769667396 0.177360206091832 0.682797934786567 119 RPL39,PCBP2,CLIC4,RPL13A,EEF1A1P5,EIF3F,EEF2,EIF4H,RPS2,PPA1,RPL10A,CLIC1,PAM,TUFM,EIF4B,AEBP1,GSTK1,RPS3 GO:0050714 positive regulation of protein secretion GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION -0.376999872165966 -1.24419654289301 0.177574860990665 0.682797934786567 26 EZR,ARF1,GLUD1,OXCT1,FGA,BRP44,C5,FGB,VAMP3,FGG GO:0006553 lysine metabolic process GO_LYSINE_METABOLIC_PROCESS -0.596135822128464 -1.28199009006174 0.177797620132296 0.682797934786567 6 GCDH,OGDH GO:0032373 positive regulation of sterol transport GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT 0.621486464760637 1.30974064087418 0.17806904673631 0.682797934786567 5 APOE,PON1,SCP2,LRP1 GO:0000375 rna splicing via transesterification reactions GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS -0.347981704859344 -1.22743935250478 0.178505797053025 0.682797934786567 34 PCBP2,THOC4,SRSF7,STRAP,HNRNPA2B1,FUS,SYNCRIP,HNRNPC GO:0045665 negative regulation of neuron differentiation GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION -0.419968015596038 -1.26002024014309 0.178613902342336 0.682797934786567 18 DPYSL3,ARHGDIA,PAFAH1B1,RTN4,YWHAH GO:0002474 antigen processing and presentation of peptide antigen via mhc class i GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I 0.329291973962729 1.2173525131574 0.178719289981902 0.682797934786567 32 CD36,PSMB3,PSMB2,PSMA6,BCAP31,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0043331 response to dsrna GO_RESPONSE_TO_DSRNA -0.595435178486789 -1.28048335590495 0.179000309783698 0.682797934786567 6 HNRNPA2B1,DROSHA,NPM1,IFNA2,DDX1 GO:0043467 regulation of generation of precursor metabolites and energy GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY 0.439708492750841 1.26523916793079 0.179268973214286 0.682797934786567 13 PRKCDBP,PRKAG2,PARK7,PPIF,PRKAA2 GO:1901888 regulation of cell junction assembly GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY 0.481443766020874 1.27687069645959 0.179348943460879 0.682797934786567 10 MYO1C,GJA1 GO:0090083 regulation of inclusion body assembly GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY 0.620597575704627 1.30786736737926 0.179421193815018 0.682797934786567 5 APOE,CLU,PSMC5 NA negative regulation of protein complex assembly GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY 0.373591128996195 1.2373377283856 0.179749498039966 0.682797934786567 21 SPTAN1,SPTBN1,PFN1,PARK7,CLU,TMOD1,HIST3H3,MYADM,PFN2,RDX,TMOD3 GO:0009067 aspartate family amino acid biosynthetic process GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS -0.630867558166742 -1.27562456824885 0.180023636296488 0.682797934786567 5 MTAP,GOT1,MTHFD1,ADI1 GO:0090090 negative regulation of canonical wnt signaling pathway GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY 0.334694339359005 1.21860234717806 0.180899705014749 0.682797934786567 30 PSMB3,UBC,APOE,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3,PFDN5 GO:0022603 regulation of anatomical structure morphogenesis GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS 0.230445342471109 1.13818463842672 0.180915526757859 0.682797934786567 134 CD36,PSMB3,GLIPR2,COL4A2,UBC,COL1A1,APOE,CFL1,FAM21C,S100A13,PSMB2,EHD2,BMP10,C1QBP,PSMA6,ENG,NACA,MAP1B,RRAS,PSMB1,PFN1,SDCBP,POSTN,RHOA,TPM1,PSMA4,MYH10,DPYSL2,PHB2,PSMD14,MYLK3,PSMC6,FN1 GO:0035966 response to topologically incorrect protein GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN -0.339255811319635 -1.21998717317655 0.181351113180254 0.682797934786567 37 ERP44,HSP90AA1,HSPB3,HSP90AB1,MFN2,HSPB2,PTPN1,SSR1,ACADVL,HSPA4,TPP1,CDK5RAP3 GO:0006914 autophagy GO_AUTOPHAGY 0.297238309082878 1.19296843984299 0.181727268065029 0.682797934786567 45 MAP1LC3B,MAP1LC3B2,RAB7A,UBC,STOM,PRKAG2,CDC37,PARK7,TOLLIP,HIST1H3A,PRKAA2,NME2,MDH1,LAMP2,MYH11,PNPO GO:0015696 ammonium transport GO_AMMONIUM_TRANSPORT 0.519927674596014 1.2823312553265 0.181844775985058 0.682797934786567 8 SLC25A20,PRKAG2,PARK7,PRKAA2,CPT1B GO:1902106 negative regulation of leukocyte differentiation GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION -0.475054076918562 -1.27056046129438 0.181920764497417 0.682797934786567 12 PIK3R1,IFNA2,HMGB1,NME1,LTF,CTNNB1,APCS,ANXA1,C1QC GO:0046688 response to copper ion GO_RESPONSE_TO_COPPER_ION 0.498648954412775 1.27818280317392 0.182534471437951 0.683823169118296 9 SOD3,SORD,S100A13,PARK7,SOD1 GO:0048638 regulation of developmental growth GO_REGULATION_OF_DEVELOPMENTAL_GROWTH 0.340479586879247 1.21826000312825 0.18359127080994 0.686016404167592 28 GJA1,APOE,BMP10,NACA,GNAS,MAP1B,SOD1,DPYSL2,FN1,PIN1,DLL1 GO:0050954 sensory perception of mechanical stimulus GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS 0.415532383041087 1.24905376429428 0.184014826283811 0.686016404167592 15 COL1A1,TIMM13,SOD1,TJP1,GPX1,PCDH15 GO:0071479 cellular response to ionizing radiation GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION -0.564645438045564 -1.2774899675446 0.184144841556938 0.686016404167592 7 XRCC6,XRCC5 GO:0051053 negative regulation of dna metabolic process GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS -0.473769869909192 -1.26712577305677 0.18467126258441 0.686703509758326 12 XRCC5,TRIM28,OTUB1,RPS3,S100A11,HNRNPC GO:1901998 toxin transport GO_TOXIN_TRANSPORT 0.517605848576286 1.27660478562695 0.185850266657666 0.68880311655454 8 CCT8,HSPA5,TCP1 GO:0010717 regulation of epithelial to mesenchymal transition GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 0.542320796405811 1.27840472034979 0.186587356604575 0.68880311655454 7 GLIPR2,COL1A1,SDCBP,DAG1 GO:2000736 regulation of stem cell differentiation GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION 0.542320796405811 1.27840472034979 0.186587356604575 0.68880311655454 7 GLIPR2,COL1A1,SDCBP,DAG1 GO:0042326 negative regulation of phosphorylation GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION -0.312185552551139 -1.19920335327969 0.186608015640274 0.68880311655454 50 DNAJA3,EZR,H2AFY,PAFAH1B1,PPP5C,PPP2R1A,PRDX3,BGN,PARD3,PRKAR2A,STRAP,PTPN1,YWHAG,GPD1L,NPM1,AHSG,PRKAR2B,CDK5RAP3,NDRG2 GO:0006414 translational elongation GO_TRANSLATIONAL_ELONGATION -0.450017782768482 -1.2584067928305 0.186998268534551 0.688977106820876 14 EEF1A1P5,EEF2,TUFM GO:1901016 regulation of potassium ion transmembrane transporter activity GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 0.476279457455037 1.26317407238719 0.188121073672187 0.690402650366884 10 NPPA,ANK2,ANK3,CAV1,YWHAE GO:1902656 calcium ion import into cytosol GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL 0.614575492303925 1.2951762343943 0.188668135127473 0.690402650366884 5 ERO1L,NOL3,JPH2,RYR2,ATP2B4 GO:0051493 regulation of cytoskeleton organization GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION -0.280777926124139 -1.17719984614586 0.188859741442956 0.690402650366884 79 CLIC4,EZR,RAN,ARPC3,ARHGDIA,SERPINF2,ACTR3,PAM,PAFAH1B1,TUBB,PPP2R1A,DYNC1H1,SPTB,RPS3,ARF1,PIK3R1,RANBP1,CAPZB GO:0043900 regulation of multi organism process GO_REGULATION_OF_MULTI_ORGANISM_PROCESS 0.295605728729839 1.18641606493986 0.189035335145392 0.690402650366884 45 CD36,RAB7A,APOE,CFL1,STOM,ARHGDIB,MIF,C1QBP,PFN1 GO:0009218 pyrimidine ribonucleotide metabolic process GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS 0.614286427302422 1.29456704947751 0.189104311604475 0.690402650366884 5 CMPK1,ENTPD4,NME2 GO:0042440 pigment metabolic process GO_PIGMENT_METABOLIC_PROCESS -0.499592379766312 -1.26422744337419 0.190236528543482 0.69164622270185 10 BLVRA,HPRT1,ADA NA modulation of synaptic transmission GO_MODULATION_OF_SYNAPTIC_TRANSMISSION 0.369619419608491 1.2241833853347 0.190434075915479 0.69164622270185 21 APOE,NCAM1,ATAD1,GNAI2,LAMA2,RETN,SNCG,MECP2,PFN2 GO:0050996 positive regulation of lipid catabolic process GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS 0.613443369716697 1.29279036270276 0.190478267507033 0.69164622270185 5 APOC2,APOA4,APOH,APOA2 GO:0002443 leukocyte mediated immunity GO_LEUKOCYTE_MEDIATED_IMMUNITY -0.343977627692648 -1.21331573101481 0.191152393999131 0.692841168141256 34 SERPINB9,TUBB,C3,C5,IGHG3,IGHG2,SERPING1,IGHA1,C8A,C1R,CFI,C8G,TUBB4B,IGKC,ANXA3,C8B,C2 GO:0051260 protein homooligomerization GO_PROTEIN_HOMOOLIGOMERIZATION 0.300975333488809 1.18899652102938 0.191516480154987 0.692910075948134 42 EHD4,PFKL,CRYAB,PCBD1,STOM,ANXA6,ATL3,MIF GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS 0.612018674487816 1.28978791398034 0.192702767539747 0.693195309075573 5 MYO1C,DLL1,CD63 GO:0006259 dna metabolic process GO_DNA_METABOLIC_PROCESS -0.290503227211614 -1.17976172932086 0.19272750450149 0.693195309075573 66 XRCC6,APOBEC2,DNAJA3,RAN,XRCC5,TRIM28,ESCO2,THOC4,PPP5C,OTUB1,RPS3 GO:0010927 cellular component assembly involved in morphogenesis GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS -0.332631979680158 -1.20357628374082 0.194515411924749 0.693195309075573 38 KRT8,CSRP3,KRT19,ABLIM1,MYOZ1,PAFAH1B1,MYL2,LDB3,NEBL,ACTR2,IFT81,EHD1,ACTG1 GO:0031102 neuron projection regeneration GO_NEURON_PROJECTION_REGENERATION 0.537402656635851 1.26681126286314 0.194816520941882 0.693195309075573 7 APOE,LAMB2,APOA4 GO:0006403 rna localization GO_RNA_LOCALIZATION -0.366888844935756 -1.22192321530829 0.194834286490064 0.693195309075573 27 C14orf166,RAN,THOC4,SRSF7,RANBP1,HNRNPA2B1,RPSA GO:1903829 positive regulation of cellular protein localization GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION -0.310023888452779 -1.1908997184246 0.19504724666015 0.693195309075573 50 HSP90AA1,EZR,TRIM28,HSP90AB1,ANP32B,YWHAH,PIK3R1,YWHAZ,CCT6A,YWHAB,YWHAG,DPP10,NPEPPS,YWHAQ,GPD1L,DYNLL2,UBE2L3,RUVBL1 GO:0061077 chaperone mediated protein folding GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING 0.444263012514943 1.2480171002861 0.195070113428974 0.693195309075573 12 ERO1L,CLU,HSPE1,FKBP1A,HSPA8,CANX GO:0006397 mrna processing GO_MRNA_PROCESSING -0.326219096958489 -1.20129893776272 0.195170164398906 0.693195309075573 41 PCBP2,APOBEC2,THOC4,SRSF7,STRAP,HNRNPA2B1,FUS GO:0034248 regulation of cellular amide metabolic process GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS -0.312980315225797 -1.19223914583142 0.195473385333377 0.693195309075573 48 RPL13A,EIF3F,EEF2,RAN,EIF4H,EIF4B,RPS3,CAPRIN2,HNRNPA2B1,ACO1,SYNCRIP,PURA,DROSHA GO:0032409 regulation of transporter activity GO_REGULATION_OF_TRANSPORTER_ACTIVITY 0.315387846822918 1.19380419452889 0.195764952361949 0.693195309075573 35 CACNA2D1,STOM,AHNAK,NPPA,S100A1,PARK7,PPIF,ANK2,DMD,ANK3 GO:0045823 positive regulation of heart contraction GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION -0.534687954047031 -1.26146247656156 0.195799665268955 0.693195309075573 8 HSP90AA1,ADA,HRC GO:0043537 negative regulation of blood vessel endothelial cell migration GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION 0.609772337744652 1.28505391140356 0.195952282293416 0.693195309075573 5 APOE,RHOA,PDCD10,HRG GO:0071398 cellular response to fatty acid GO_CELLULAR_RESPONSE_TO_FATTY_ACID 0.609706810986454 1.28491581819776 0.196083135236517 0.693195309075573 5 GNAS,FN1,PRKAA2 GO:0045596 negative regulation of cell differentiation GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION -0.300059118315353 -1.18330212468225 0.197323659814591 0.696354848695428 57 CSRP3,DPYSL3,ARHGDIA,PKP2,PAFAH1B1,RTN4,ANP32B,YWHAH,PIK3R1,STRAP GO:2001235 positive regulation of apoptotic signaling pathway GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY -0.365757050448094 -1.21815377402241 0.197973764148862 0.697423365633185 27 PPP2R1A,YWHAH,RPS3,YWHAZ,YWHAB,YWHAG,YWHAQ,AGT,DYNLL2,PEA15 GO:0021782 glial cell development GO_GLIAL_CELL_DEVELOPMENT 0.442407800654354 1.24280546649835 0.19892808464435 0.698904191599696 12 LAMB2,LAMA2,CLU,SOD1,DLL1,DAG1,GSTP1,VIM,ILK GO:0031349 positive regulation of defense response GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE 0.299140146738244 1.18174665561161 0.199520762701063 0.698904191599696 42 CD36,PSMB3,GJA1,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PRKACB,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0042026 protein refolding GO_PROTEIN_REFOLDING -0.532536346938447 -1.25638629780863 0.199794842262494 0.698904191599696 8 HSP90AA1,DNAJA2 GO:0006839 mitochondrial transport GO_MITOCHONDRIAL_TRANSPORT -0.3056892246653 -1.18339630083251 0.20004545749724 0.698904191599696 52 HSP90AA1,TOMM40,MTX2,YWHAH,MFN2,BRP44,YWHAZ,MTCH2,YWHAB,YWHAG,ATP5D,YWHAQ,DYNLL2,ATP5J2,ATP5F1,ATP5A1,HSPA4,STOML2 GO:0051640 organelle localization GO_ORGANELLE_LOCALIZATION -0.31697707303655 -1.19079325556335 0.200134417415251 0.698904191599696 45 EZR,RAN,ACTR3,PAFAH1B1,DYNC1H1,MFN2,ARF1,TMED9,YWHAZ,LMAN1,SERPINA1,ACTR2,RAB11B GO:0043200 response to amino acid GO_RESPONSE_TO_AMINO_ACID 0.399608049390163 1.22554099631601 0.201150910158544 0.699594039370169 16 COL3A1,COL1A1,COL1A2,COL4A1 GO:0090317 negative regulation of intracellular protein transport GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT 0.533927484155929 1.25861929063599 0.201167289071759 0.699594039370169 7 CD36,PARK7,SRI GO:0007187 g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER 0.509440109842494 1.2564650959878 0.201377168703166 0.699594039370169 8 GNAI2,GNAS,GNAO1,PRKACB,PSAP,FLNA GO:0090199 regulation of release of cytochrome c from mitochondria GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA 0.487809218668895 1.25039739683512 0.202753186768402 0.703157856702851 9 PDCD5,PPIF,GPX1,NOL3,OPA1 GO:1901019 regulation of calcium ion transmembrane transporter activity GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 0.376950800211553 1.21377119405847 0.203460009994527 0.703476031728328 19 CACNA2D1,AHNAK,NPPA,S100A1,ANK2,DMD,FKBP1A,SRI,PLN GO:0010035 response to inorganic substance GO_RESPONSE_TO_INORGANIC_SUBSTANCE -0.265993750068963 -1.15491581535375 0.20358920456302 0.703476031728328 97 CLIC4,KRT8,EEF2,PAM,QDPR,SERPINF1,ADA,PPP5C,PRDX3,RPS3,HP,CAMK2D,BDH1,C3,FGA,FUS,ACO1,FGB,ATP5D,LONP1,GSS,FGG,PRDX2,AQP1,EEF1A2,ALAD,AIFM1,HBA2,HBA1,HNRNPD,GDI1,ALB,NDRG1,HBB,MAOB NA cellular protein complex assembly GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY -0.27334681614358 -1.160736827942 0.203895941467075 0.703476031728328 85 HSP90AA1,EIF4H,EIF4B,RTN4,NDUFB8,NDUFV1,NDUFC2,NDUFB9,FGA,NDUFS3,NDUFA10,FGB,VAMP3,NDUFS8,LONP1,FGG,NDUFA5,NDUFA9,NDUFB2,NDUFB3,FMOD,CAND1,NDUFS7,HSPA4,NDUFB11,AIFM1,SAMM50,TPPP,NUBPL,NDUFAF3,PSMD11,NDUFA7,ARPC4,NDUFB10,NDUFS4,NDUFA3,UQCR10,DNM1L,APCS,NDUFS5,SCO1,NDUFS1,NDUFAF2,NDUFB4,CCT2,HDGFRP3 GO:0044068 modulation by symbiont of host cellular process GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS -0.618220442278154 -1.25005189212035 0.20463862318573 0.704447698686415 5 SERPINB9,VAPA GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS -0.363478488325794 -1.21056502338801 0.20527092843688 0.704447698686415 27 C3,C5,IGHG3,IGHG2,SERPING1,IGHA1,C8A,C1R,CFI,HMGB1,C8G,IGKC,C8B,C2 GO:0061061 muscle structure development GO_MUSCLE_STRUCTURE_DEVELOPMENT 0.245996996246646 1.13871722432379 0.205478683095231 0.704447698686415 91 COL3A1,NEXN,CRYAB,NPPA,BMP10,LAMA2,FHL2,TAGLN,MURC,SGCD,CFL2,ANK2,XIRP2,DMD,CAST,LAMA5,TMOD1,TPM1,MYH10,MYLK3,GPX1,LGALS1,SGCG,FKBP1A,SGCE,TNNI3,MYH11,SRI,ITGB1,DLL1,COPS2,TNNC1,TMOD3 GO:0051100 negative regulation of binding GO_NEGATIVE_REGULATION_OF_BINDING 0.416513758060719 1.22662125851067 0.205580852305896 0.704447698686415 14 PARK7,ANXA2,HSPA5,PIN1,SRI,PLN,B2M,CAV1,LRPAP1 GO:0000278 mitotic cell cycle GO_MITOTIC_CELL_CYCLE -0.274379523102183 -1.16008842185807 0.206360900369929 0.705915993088276 83 HSP90AA1,RAN,PSMD2,PSME2,PAFAH1B1,PSMB6,TUBB,PPP5C,PPP2R1A,DYNC1LI1,DYNC1I2,CEP70,DYNC1H1,RPS3,TUBA4A,CAMK2D,PSMA2,PSMA1,RANBP1 GO:0018212 peptidyl tyrosine modification GO_PEPTIDYL_TYROSINE_MODIFICATION -0.552659281664768 -1.25037172042144 0.206807987266676 0.706242242230418 7 HSP90AA1,ERLIN2 GO:0044262 cellular carbohydrate metabolic process GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS 0.32661043351463 1.18916932283954 0.207300884955752 0.706372057319577 30 GYG1,UBC,SORD,PRKAG2,PYGB GO:0006984 er nucleus signaling pathway GO_ER_NUCLEUS_SIGNALING_PATHWAY -0.552298375324064 -1.24955518282385 0.207549558674577 0.706372057319577 7 ERLIN2 GO:0071478 cellular response to radiation GO_CELLULAR_RESPONSE_TO_RADIATION -0.490243834668964 -1.24057078297193 0.20837631157745 0.706702333258506 10 XRCC6,XRCC5,PIK3R1,MFAP4,AQP1 GO:1903169 regulation of calcium ion transmembrane transport GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT 0.362769772492478 1.20149728241372 0.208934888612678 0.706702333258506 21 CACNA2D1,AHNAK,NPPA,S100A1,ANK2,DMD,FKBP1A,SRI,PLN GO:0044093 positive regulation of molecular function GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION 0.211663059338916 1.10210923788106 0.209069165492612 0.706702333258506 194 PSMB3,CACNA2D1,UBC,APOE,VTN,ARHGDIB,PSMB2,PRKAG2,DIABLO,NCAM1,NPPA,CRK,GNAI2,MIF,SPTAN1,PSMA6,SPTBN1,BCAP31,GNAS,PSMB1,S100A1,PFN1,PDCD5,PPP1R12B,APOC2,PARK7,ANK2,DMD,GNAO1,ARHGAP12,CLU,RHOA,SOD1,RAPGEF4,TPM1,PSMA4,PRKACB,APOA4,ANK3,RGL2,PHB2,PSMD14,PSMC6,HSPE1,FN1,IQGAP1,DNAJC1,ANXA2,PSMC1,FKBP1A,HSPA5,PIN1,PSMA5,PSMA3,VAPB GO:0030178 negative regulation of wnt signaling pathway GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY 0.320028604347304 1.18310695853323 0.210352777846642 0.706702333258506 32 PSMB3,UBC,APOE,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3,PFDN5 NA de novo posttranslational protein folding GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING 0.560470164727919 1.2553577550551 0.210502991358298 0.706702333258506 6 ERO1L,UGGT1,HSPE1,HSPA8 NA membrane budding GO_MEMBRANE_BUDDING -0.40071840211878 -1.21910330319069 0.21054174787423 0.706702333258506 19 VAPA,ARF1,TMED9,LMAN1,SERPINA1,SNX3,TFG,SEC22B,NAPA GO:0021885 forebrain cell migration GO_FOREBRAIN_CELL_MIGRATION -0.614594678953314 -1.24272053910347 0.211729512132068 0.706702333258506 5 PAFAH1B1,RTN4,OGDH GO:0003205 cardiac chamber development GO_CARDIAC_CHAMBER_DEVELOPMENT 0.335493829209819 1.18862015562656 0.211997273346967 0.706702333258506 27 BMP10,WHSC1,FHL2,NACA,ANK2,XIRP2,TPM1,MYH10,FKBP1A,TNNI3,TNNC1,KCNK2 GO:0002376 immune system process GO_IMMUNE_SYSTEM_PROCESS -0.233742425034585 -1.12332477893274 0.212004539773299 0.706702333258506 197 RPL39,PCBP2,RPL13A,HSP90AA1,HPRT1,EEF2,SERPINB9,DNAJA3,XRCC5,PSMD2,ARPC3,ARID4A,TRIM28,ACTR3,ESCO2,PSME2,PAFAH1B1,ADA,PSMB6,TUBB,HSP90AB1,DYNC1I2,PRDX3,OTUB1,DYNC1H1,AHCY,ARF1,GPI,HP,PIK3R1,CAMK2D,C3,FGA,PSMA2,CTSD,PSMA1,IGJ GO:0006470 protein dephosphorylation GO_PROTEIN_DEPHOSPHORYLATION -0.421227829245682 -1.22316910613238 0.212008288784021 0.706702333258506 16 PPP5C,PPP2R1A,LHPP,PTPN1 GO:0051049 regulation of transport GO_REGULATION_OF_TRANSPORT 0.20879868162727 1.09701626363203 0.212232026034153 0.706702333258506 209 CD36,MYO1C,GJA1,RAB7A,CACNA2D1,EHD4,PFKL,APOE,CRYAB,VTN,STOM,AHNAK,PRKAG2,NPPA,PACSIN2,EHD2,ATAD1,HCLS1,GNAI2,MIF,SPTBN1,BCAP31,GNAS,MAP1B,S100A1,RETN,PDCD5,CDH13,SDCBP,APOC2,PARK7,CYB5R1,PPIF,ANK2,DMD,GNAO1,SSC5D,POSTN,RHOA,RAPGEF4 GO:0098792 xenophagy GO_XENOPHAGY 0.464275494399938 1.23133752210194 0.212632781267847 0.706702333258506 10 STOM,HIST1H3A,MDH1,PNPO,CD93,SNRPD1 GO:0050691 regulation of defense response to virus by host GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST 0.464275494399938 1.23133752210194 0.212632781267847 0.706702333258506 10 STOM,HIST1H3A,MDH1,PNPO,CD93,SNRPD1 GO:0051129 negative regulation of cellular component organization GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION -0.262269235571383 -1.14642544872551 0.212809821991784 0.706702333258506 101 RPL13A,EZR,DPYSL3,RAN,XRCC5,ARHGDIA,H2AFY,APOC1,PAFAH1B1,RTN4,TUBB,PPP2R1A,OTUB1,YWHAH,DYNC1H1,SPTB,RPS3,STRAP,RANBP1,CAPZB,TBC1D4 GO:1990138 neuron projection extension GO_NEURON_PROJECTION_EXTENSION 0.482522651749278 1.23684638291102 0.213190843842688 0.706702333258506 9 LAMB2,MAP1B,POSTN,IQGAP1,ITGB1 GO:0006399 trna metabolic process GO_TRNA_METABOLIC_PROCESS -0.505908499371061 -1.2382558715505 0.213277696192557 0.706702333258506 9 C14orf166,PPA1,C22orf28,HSD17B10,WARS,DDX1 GO:0044273 sulfur compound catabolic process GO_SULFUR_COMPOUND_CATABOLIC_PROCESS -0.487434409850715 -1.23346148327247 0.214013871598791 0.707973400610167 10 VCAN,BGN,AHCY,PRELP,OGN,FMOD GO:0060401 cytosolic calcium ion transport GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT 0.502387990643179 1.23907199824089 0.214991336438714 0.710037176922594 8 CACNA2D1,ERO1L,NOL3,JPH2,RYR2 GO:0010565 regulation of cellular ketone metabolic process GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS 0.283085956097973 1.15791431278289 0.215433834722258 0.710330279346953 49 PSMB3,PSMB2,PRKAG2,MLYCD,PSMA6,FABP3,PSMB1,APOC2,PARK7,PSMA4,APOA4,PSMD14,PSMC6,PRKAA2,SIRT5,PSMC1,PSMA5,PSMA3 GO:0042594 response to starvation GO_RESPONSE_TO_STARVATION 0.433993889495197 1.21916923140538 0.217732806616305 0.713557556218825 12 MAP1LC3B,MAP1LC3B2,PRKAA2,HSPA5 GO:0048525 negative regulation of viral process GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS -0.48560121154558 -1.22882254220699 0.218157567134981 0.713557556218825 10 TRIM28,VAPA,SNX3,IFNA2,LTF,APCS GO:0070303 negative regulation of stress activated protein kinase signaling cascade GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE -0.61139200161348 -1.23624467289989 0.218488015659046 0.713557556218825 5 EZR,PAFAH1B1 GO:2001236 regulation of extrinsic apoptotic signaling pathway GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY -0.410602889405384 -1.21211159004262 0.218644332310253 0.713557556218825 17 PPP2R1A,FGA,FGB,FGG,AGT,PEA15 GO:0000271 polysaccharide biosynthetic process GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS 0.461756740051785 1.22465735746856 0.218892061679041 0.713557556218825 10 GYG1,UBC GO:0009141 nucleoside triphosphate metabolic process GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS -0.258150980242622 -1.14028986721309 0.21900858047445 0.713557556218825 108 GBAS,ENO1,ADA,NDUFB8,NDUFV1,GPI,OLA1,NDUFC2,NDUFB9,AK4,COQ9,OGDH,NDUFS3,NDUFA10,COX5A,SUCLG1,NDUFS8,ATP5D,ADK,NDUFA5,NDUFA9,ATP5J2,ATP5F1,NDUFB2,NDUFB3,NDUFS7,COX4I1,ATP5A1,COX6C,UQCRFS1,STOML2,CYC1,NDUFB11,ENO3,NME1,NDUFA7,UQCRC2,ATP1B1,PGK1,NDUFB10,NDUFS4,NDUFA3,TPI1,PGM1,UQCR10,NDUFS5,HSPA1A,NDUFS1,UQCRC1,VCP,HK1,BPGM,NDUFB4 GO:0006730 one carbon metabolic process GO_ONE_CARBON_METABOLIC_PROCESS -0.573980972064498 -1.23434608482918 0.219144632541866 0.713557556218825 6 AHCY,CA3,CA1 GO:1901881 positive regulation of protein depolymerization GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION 0.554990643502409 1.24308456033871 0.21925548415688 0.713557556218825 6 FAM21C,CFL2,DSTN GO:0032989 cellular component morphogenesis GO_CELLULAR_COMPONENT_MORPHOGENESIS -0.257938637115424 -1.13935191719605 0.220109817836986 0.715178825593315 108 CLIC4,KRT8,HPRT1,CSRP3,EZR,FERMT2,KRT19,TRIM28,ABLIM1,ACTR3,MYOZ1,MATN2,PAFAH1B1,RTN4,LIMS1,PARD3,SPTB,PALLD,MYL2,LDB3,DBNL,IFT52,PARVA,NEBL,VAMP3,ACTR2,PRELP,IFT81,EHD1 GO:0043604 amide biosynthetic process GO_AMIDE_BIOSYNTHETIC_PROCESS -0.264677922165433 -1.14362485629217 0.220651753231674 0.715781454748307 94 RPL39,PCBP2,RPL13A,EEF1A1P5,EIF3F,EEF2,EIF4H,RPS2,PPA1,RPL10A,TUFM,EIF4B GO:0071320 cellular response to camp GO_CELLULAR_RESPONSE_TO_CAMP -0.609734900085593 -1.23289398638306 0.221276360010341 0.71588752649994 5 EZR,AQP1 GO:0030177 positive regulation of wnt signaling pathway GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY 0.313978899102273 1.16976205295386 0.221879201314545 0.71588752649994 33 PSMB3,UBC,COL1A1,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PIN1,PSMA5,PSMA3 GO:0042311 vasodilation GO_VASODILATION 0.553001949978288 1.23863022539807 0.222401949922446 0.71588752649994 6 APOE,SOD1,GPX1,KNG1 GO:0051592 response to calcium ion GO_RESPONSE_TO_CALCIUM_ION -0.370568724777951 -1.19723064441455 0.22255695725852 0.71588752649994 24 CLIC4,CAMK2D,FGA,FUS,FGB,FGG GO:1900026 positive regulation of substrate adhesion dependent cell spreading GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING -0.444960343343647 -1.2185981735485 0.222577022948979 0.71588752649994 13 LIMS1,FGA,FGB,FGG GO:0031345 negative regulation of cell projection organization GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION -0.402092539784643 -1.20638886706679 0.222823557800031 0.71588752649994 18 DPYSL3,ARHGDIA,PAFAH1B1,RTN4,YWHAH,CAPZB NA negative regulation of transcription from rna polymerase ii promoter GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER 0.295116462269045 1.15976276025226 0.223305171009772 0.716288791354029 41 CD36,UBC,HIST1H1D,HCLS1,WHSC1,C1QBP,ENG,FHL2,NACA,S100A1 GO:0006081 cellular aldehyde metabolic process GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS -0.331764326800827 -1.17812259035431 0.224477532216065 0.716941932094417 35 PGM2,TALDO1,AKR7A2,GPI,OGDH,AKR1A1,IDH2,ALDH1A1,PDXK,DLAT,PDHA1,DBT,ESD,ALDH1A2,TPI1,ALDH7A1,GRHPR,PDHB,PGD,BCKDHA,ADH5 GO:0032504 multicellular organism reproduction GO_MULTICELLULAR_ORGANISM_REPRODUCTION -0.316341452168618 -1.17069233571861 0.224606321886364 0.716941932094417 42 RAN,ARID4A,PAM,SERPINF1,PAFAH1B1,PRDX3,DAZAP1,ACSBG2 GO:0099536 synaptic signaling GO_SYNAPTIC_SIGNALING 0.362747057873605 1.18561917614201 0.224656622784088 0.716941932094417 20 KIF5A,APOE,GNAI2,SDCBP,PARK7,SNCG,MECP2,GNA11,DTNA,HSPA8 GO:0002026 regulation of the force of heart contraction GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION -0.424876548498228 -1.21191382357654 0.224976034858388 0.716941932094417 15 CSRP3,MYL2,CAMK2D GO:0002793 positive regulation of peptide secretion GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION -0.454840607507731 -1.21649833180888 0.225294003561542 0.716941932094417 12 GLUD1,OXCT1,FGA,BRP44,FGB,FGG GO:0045761 regulation of adenylate cyclase activity GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY 0.551228842756918 1.23465876707438 0.225703523155329 0.717108662177058 6 GNAI2,GNAS,CALM1,CAP1 GO:0010639 negative regulation of organelle organization GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION -0.297057802023018 -1.15856568048194 0.226456381495769 0.718360808389754 54 EZR,RAN,XRCC5,H2AFY,TUBB,PPP2R1A,OTUB1,DYNC1H1,SPTB,RPS3,RANBP1,CAPZB,TBC1D4 GO:1904591 positive regulation of protein import GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT -0.466899826254764 -1.21714118951108 0.227619990803947 0.718360808389754 11 HSP90AA1,TRIM28,HSP90AB1,PIK3R1 GO:0050982 detection of mechanical stimulus GO_DETECTION_OF_MECHANICAL_STIMULUS -0.606442601697494 -1.22623690494734 0.227813273257746 0.718360808389754 5 CSRP3,PIEZO2,JUP GO:0090263 positive regulation of canonical wnt signaling pathway GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY 0.315055744301202 1.16472289771981 0.228921337729628 0.718360808389754 32 PSMB3,UBC,COL1A1,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PIN1,PSMA5,PSMA3 GO:0010563 negative regulation of phosphorus metabolic process GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS -0.291309370932481 -1.15341399828249 0.22931164719307 0.718360808389754 58 DNAJA3,EZR,H2AFY,APOC1,PAFAH1B1,PPP5C,PPP2R1A,PRDX3,BGN,PARD3,PRKAR2A,STRAP,PTPN1,YWHAB,YWHAG GO:1903362 regulation of cellular protein catabolic process GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS 0.280035290471761 1.1454360908294 0.229624087308754 0.718360808389754 49 PSMB3,UBC,APOE,PSMB2,PSMA6,BCAP31,PSMB1,SDCBP,PARK7,CLU,PSMA4,PSMD14,PSMC6,GPX1,ANXA2,PSMC1,PSMA5,PSMA3 NA single organism membrane budding GO_SINGLE_ORGANISM_MEMBRANE_BUDDING -0.432457596486795 -1.20930238285741 0.229672770519615 0.718360808389754 14 VAPA,TMED9,LMAN1,SERPINA1,SNX3,TFG,SEC22B,NAPA GO:0007030 golgi organization GO_GOLGI_ORGANIZATION 0.441928340400959 1.2073529822413 0.230268305030144 0.718360808389754 11 RAB2A,ATL3,NSFL1C GO:0007010 cytoskeleton organization GO_CYTOSKELETON_ORGANIZATION -0.245250409139623 -1.1228798886233 0.230317906962821 0.718360808389754 137 MARK1,KRT8,KRT18,CSRP3,EZR,DPYSL3,RAN,ARPC3,KRT19,SORBS2,ABLIM1,ACTR3,MYOZ1,PKP2,PAFAH1B1,TUBB,PPP2R1A,DYNC1H1,RPS3,PALLD,ARF1,MYL2,RANBP1,CAPZB,PTPN1,LDB3,PARVA,NEBL,ACTR2 GO:0045010 actin nucleation GO_ACTIN_NUCLEATION -0.517625251853748 -1.22120729893383 0.230388539960768 0.718360808389754 8 ARPC3,ACTR3,ACTR2 GO:0008610 lipid biosynthetic process GO_LIPID_BIOSYNTHETIC_PROCESS 0.295429319938727 1.15438867862656 0.230416265274046 0.718360808389754 40 CDIPT,PRKAG2,MLYCD,MIF,FABP5,CYB5R1,NDUFAB1,APOA4,PRKAA2,FDPS,VAPB,HSD17B8 GO:0009790 embryo development GO_EMBRYO_DEVELOPMENT 0.262624346855943 1.13555451741299 0.230816550322287 0.718360808389754 64 GJA1,COL8A1,COL4A2,COL1A1,VTN,FBN1,ENG,GNAS,PFN1,LAMA5,SOD1,TPM1,PRKACB,MYH10,LAMB1,FN1,TJP1,TXNRD1,RALA,ITGB1,DLL1 GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION -0.465298529656402 -1.21296683789026 0.231139249460616 0.718360808389754 11 ARHGDIA,RTN4,YWHAH,STRAP GO:0048259 regulation of receptor mediated endocytosis GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS 0.405568052482576 1.1943864646012 0.231663747810858 0.718360808389754 14 VTN,ATAD1,SDCBP,APOC2,ANXA2,TF,B2M,CD63,APOC3 GO:0055003 cardiac myofibril assembly GO_CARDIAC_MYOFIBRIL_ASSEMBLY -0.540509977589317 -1.22288435751497 0.231894805382723 0.718360808389754 7 CSRP3,MYL2,NEBL GO:0045089 positive regulation of innate immune response GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE 0.297259282769348 1.15498949700956 0.231965660901401 0.718360808389754 39 CD36,PSMB3,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PRKACB,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0002455 humoral immune response mediated by circulating immunoglobulin GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN -0.362758797529285 -1.1855812693829 0.232179364863023 0.718360808389754 25 C3,C5,IGHG3,IGHG2,SERPING1,IGHA1,C8A,C1R,CFI,C8G,IGKC,C8B,C2,IGHM GO:0042590 antigen processing and presentation of exogenous peptide antigen via mhc class i GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I 0.332817847902118 1.16781635238133 0.233801859539242 0.721017106389362 26 CD36,PSMB3,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0009250 glucan biosynthetic process GO_GLUCAN_BIOSYNTHETIC_PROCESS 0.472232522084471 1.21046977735797 0.233885027282813 0.721017106389362 9 GYG1,UBC GO:1903524 positive regulation of blood circulation GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION -0.430661968201144 -1.20428117943261 0.23411511621806 0.721017106389362 14 HSP90AA1,ADA,HRC,FGA,FGB,FGG,AGT GO:0006281 dna repair GO_DNA_REPAIR -0.313694971766006 -1.16089844275034 0.235236042321426 0.723359836112439 42 XRCC6,XRCC5,TRIM28,ESCO2,PPP5C,OTUB1,RPS3 GO:0072527 pyrimidine containing compound metabolic process GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS -0.462632518728265 -1.20601692801698 0.236762989424539 0.72694202257565 11 APOBEC2,ALDH6A1,NT5C GO:0001954 positive regulation of cell matrix adhesion GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION 0.514400911650595 1.21258959266293 0.237796015116617 0.728999081456744 7 CD36,CDH13 GO:0002762 negative regulation of myeloid leukocyte differentiation GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION -0.513308238579774 -1.21102238600523 0.239728615905124 0.733803446246171 8 PIK3R1,NME1,LTF,CTNNB1,APCS,C1QC GO:0051649 establishment of localization in cell GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL 0.199549126955646 1.07686438588334 0.240930796094362 0.735078463991401 259 RAB2A,RPS4X,MYO1C,RAB7A,CACNA2D1,EHD4,UBC,KIF5A,APOE,ATP5I,FAM21C,RPS8,S100A13,SLC25A20,PRKAG2,RPS23,ATL3,CDC37,EHD2,CD59,DCTN2,RPL14,SPTAN1,SCARB2,SPTBN1,BCAP31,TIMM13,GNAS,MAP1B,RRAS,RPL18,SET,RPL19,SDCBP,RPL35,PARK7,RPL7A,ERO1L,PPIF,ANK2,CLTA,AKAP12,SOD1,STX7,RPL24,ANK3,MYH10,RPS21,CLTB,DPYSL2,VPS13A,RPL3,PHB2,KPNB1 GO:0006022 aminoglycan metabolic process GO_AMINOGLYCAN_METABOLIC_PROCESS -0.427736083691554 -1.19609938510605 0.241338300365532 0.735078463991401 14 VCAN,BGN,PRELP,ITIH1,OGN,FMOD,AGRN,ITIH4,ITIH2,DCN,LUM GO:2001022 positive regulation of response to dna damage stimulus GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS -0.599358131255255 -1.21191198930988 0.241736529157588 0.735078463991401 5 TRIM28,RPS3 GO:0002699 positive regulation of immune effector process GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS 0.37772701434261 1.17789898601102 0.241844423971842 0.735078463991401 17 CD36,MIF,WHSC1,STX7 GO:0010648 negative regulation of cell communication GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION 0.223363213316949 1.09915241989755 0.241975530228245 0.735078463991401 131 PSMB3,RAB7A,UBC,PFKL,APOE,PRKCDBP,PSMB2,FBN1,ATAD1,GNAI2,MIF,C1QBP,PSMA6,ENG,AMBP,PSMB1,PARK7,PPIF,CLTA,CLU,PSMA4,PRKACB,PHB2,PSMD14,PSMC6,PRKAA2,GPX1,PSMC1,FKBP1A,HSPA5,PIN1,PSMA5,PSMA3,LRRC4B,TXNDC12,PFDN5,SRI,MYADM,ITGB1 GO:0033032 regulation of myeloid cell apoptotic process GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS 0.580770733259142 1.2239349937778 0.242601356508843 0.735866350256432 5 MIF,TCP1,APOH GO:0030518 intracellular steroid hormone receptor signaling pathway GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY -0.562277933106751 -1.20917869946074 0.243380651274669 0.737116663287383 6 RAN,YWHAH GO:1904036 negative regulation of epithelial cell apoptotic process GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS -0.598352197743173 -1.20987797522019 0.243767773387007 0.737177242411312 5 FGA,FGB,FGG GO:0050921 positive regulation of chemotaxis GO_POSITIVE_REGULATION_OF_CHEMOTAXIS 0.511221337627662 1.20509443026725 0.244482211140678 0.738225984918019 7 C1QBP,CDH13,FN1 GO:1904064 positive regulation of cation transmembrane transport GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT 0.356124775415248 1.16397460342381 0.245948386483532 0.739733173799097 20 CACNA2D1,NPPA,S100A1,ANK2,DMD,ANK3 GO:0048706 embryonic skeletal system development GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT 0.578709180753223 1.21959041146845 0.246025341853314 0.739733173799097 5 COL1A1,GNAS,RBP4 GO:2001251 negative regulation of chromosome organization GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION -0.510148546644948 -1.20356788327498 0.246333255349398 0.739733173799097 8 XRCC5,H2AFY,OTUB1 GO:0042762 regulation of sulfur metabolic process GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS -0.533515731874145 -1.20706012848622 0.246454926928086 0.739733173799097 7 DLAT,PDHA1,PDP1,CTNNB1,PDHB,DLD,PDHX GO:0006955 immune response GO_IMMUNE_RESPONSE -0.26738069523796 -1.12807180964789 0.24699919978661 0.74026028831569 82 RPL39,PCBP2,RPL13A,SERPINB9,DNAJA3,TRIM28,ADA,TUBB,OTUB1,AHCY,GPI,CAMK2D,C3,FGA,IGJ,C5,DBNL,FGB,IGHG3,SYNCRIP,IGHG2,CFB,SERPING1,IGHA1,C8A,C1R,IFNA2,CFI,HMGB1,C8G,TUBB4B,IGKC,LTF,ANXA3,C8B,CFH,C2 GO:1902117 positive regulation of organelle assembly GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY 0.509208161034723 1.20034879912721 0.248417898432434 0.743402593222544 7 BMP10,SDCBP,MYLK3,FSCN1,PDCD6IP GO:0006611 protein export from nucleus GO_PROTEIN_EXPORT_FROM_NUCLEUS -0.595584632327724 -1.20428191247694 0.249122871810023 0.744402866956141 5 RAN,HSPA9 GO:0043277 apoptotic cell clearance GO_APOPTOTIC_CELL_CLEARANCE 0.484041721905604 1.19382340892683 0.250388172551137 0.745517880385436 8 CD36,TGM2 GO:1903825 organic acid transmembrane transport GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT 0.484037789364781 1.19381370984702 0.250388172551137 0.745517880385436 8 SLC25A20,PRKAG2,PRKAA2,CPT1B GO:0060393 regulation of pathway restricted smad protein phosphorylation GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION 0.575861336844488 1.21358877327095 0.251194033105795 0.745517880385436 5 BMP10,ENG,SDCBP,PIN1 GO:0060761 negative regulation of response to cytokine stimulus GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS -0.558744452704947 -1.20157994982955 0.251453249995444 0.745517880385436 6 DNAJA3 GO:0001101 response to acid chemical GO_RESPONSE_TO_ACID_CHEMICAL 0.292860254069568 1.13789724038445 0.251862138618861 0.745517880385436 39 CD36,COL3A1,COL1A1,COL1A2,COL4A1,GNAS,FABP3 GO:0010656 negative regulation of muscle cell apoptotic process GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS 0.507197251655772 1.19560851245688 0.25226413828574 0.745517880385436 7 NACA,SIRT5,APOH,NOL3,CAV1,ILK GO:0034637 cellular carbohydrate biosynthetic process GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS 0.408969080119804 1.17678804746991 0.253162202380952 0.745517880385436 13 GYG1,UBC GO:0050808 synapse organization GO_SYNAPSE_ORGANIZATION 0.408926537450299 1.17666563306889 0.253255208333333 0.745517880385436 13 APOE,LAMB2,COL4A1,ANK3,SNCG,MECP2,PIN1 GO:2000479 regulation of camp dependent protein kinase activity GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY -0.593456367894818 -1.19997852682459 0.253351552978543 0.745517880385436 5 PRKAR2A,PRKAR2B,PRKAR1A GO:0071897 dna biosynthetic process GO_DNA_BIOSYNTHETIC_PROCESS 0.574396565260475 1.21050186634383 0.253898327263211 0.745517880385436 5 UBC,PHB GO:0022613 ribonucleoprotein complex biogenesis GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS -0.275861326161318 -1.12671614097916 0.253942515579295 0.745517880385436 68 RPL39,RPL13A,EIF3F,RAN,EIF4H,RPS2,RPL10A,EIF4B,DYNC1H1,RPS3,STRAP,RPL10 GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL 0.292238478030492 1.13548135352657 0.254488069688171 0.745517880385436 39 PSMB3,UBC,PSMB2,PSMA6,PSMB1,CLU,PSMA4,TOLLIP,PSMD14,PSMC6,PSMC1,FKBP1A,HSPA5,PIN1,PSMA5,PSMA3 GO:0042451 purine nucleoside biosynthetic process GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS -0.348547009964106 -1.16083573807214 0.254603153053778 0.745517880385436 27 GBAS,HPRT1,ADA,MTAP,AK4,ATP5D,ADK,ATP5J2,ATP5F1,ATP5A1,STOML2 NA regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS 0.317321425750898 1.14572365720553 0.254693857542036 0.745517880385436 29 PSMB3,UBC,PSMB2,PSMA6,PSMB1,CLU,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:1901031 regulation of response to reactive oxygen species GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES 0.505216208531671 1.19093862906341 0.256490529752454 0.746511969607222 7 CD36,PARK7,FBLN5,HEBP2,PSAP GO:0050878 regulation of body fluid levels GO_REGULATION_OF_BODY_FLUID_LEVELS 0.246288123483655 1.10657571081244 0.256959138248468 0.746511969607222 78 CD36,COL3A1,GJA1,COL1A1,APOE,VTN,MYL9,COL1A2,SERPINC1,EHD2,CD59,C1QBP,GNAS GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES 0.57266937615962 1.20686193226943 0.25708241554533 0.746511969607222 5 CDH13,PCDH15,ITGB1,CDH2 GO:0098742 cell cell adhesion via plasma membrane adhesion molecules GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES 0.57266937615962 1.20686193226943 0.25708241554533 0.746511969607222 5 CDH13,PCDH15,ITGB1,CDH2 GO:0006721 terpenoid metabolic process GO_TERPENOID_METABOLIC_PROCESS 0.379105023324136 1.16266113433426 0.257803875513799 0.746511969607222 16 APOE,HSPG2,APOC2,APOA4,FDPS,TTR,APOC3,RBP4 GO:0006720 isoprenoid metabolic process GO_ISOPRENOID_METABOLIC_PROCESS 0.379105023324136 1.16266113433426 0.257803875513799 0.746511969607222 16 APOE,HSPG2,APOC2,APOA4,FDPS,TTR,APOC3,RBP4 GO:0034314 arp2 3 complex mediated actin nucleation GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION -0.527961414975208 -1.19449368654432 0.258157285486905 0.746511969607222 7 ARPC3,ACTR3,ACTR2 GO:0046164 alcohol catabolic process GO_ALCOHOL_CATABOLIC_PROCESS 0.503880705852104 1.18779046852649 0.259129229186699 0.746511969607222 7 APOE,SORD GO:2000117 negative regulation of cysteine type endopeptidase activity GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY -0.441291928762359 -1.18026158245119 0.259446021475043 0.746511969607222 12 SERPINB9,DNAJA3,PRDX3,GPI GO:0051495 positive regulation of cytoskeleton organization GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION 0.313335509650621 1.1408361080912 0.259660766961652 0.746511969607222 30 FAM21C,BMP10,HCLS1,ARPC5L,CFL2,PFN1,PFDN2,RHOA,TPM1,MYLK3,DSTN GO:0070588 calcium ion transmembrane transport GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT 0.443655106192822 1.17664874781601 0.25982866933181 0.746511969607222 10 CACNA2D1,ERO1L,FKBP1A,NOL3,JPH2 GO:0051783 regulation of nuclear division GO_REGULATION_OF_NUCLEAR_DIVISION -0.441137256361547 -1.17984790189044 0.259851543628894 0.746511969607222 12 H2AFY,DYNC1LI1,RANBP1 GO:0070646 protein modification by small protein removal GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL -0.504016515693325 -1.18910089015864 0.259866467507693 0.746511969607222 8 EIF3F,OTUB1 GO:0042698 ovulation cycle GO_OVULATION_CYCLE -0.526535874921791 -1.19126845351512 0.26087035161337 0.747902454324473 7 PAM,SERPINF1 GO:0006023 aminoglycan biosynthetic process GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS -0.484395220921121 -1.18560021664441 0.261452774096493 0.747902454324473 9 VCAN,BGN,PRELP,OGN,FMOD,AGRN GO:0044033 multi organism metabolic process GO_MULTI_ORGANISM_METABOLIC_PROCESS -0.289415025532764 -1.12875781654132 0.261467889908257 0.747902454324473 54 RPL39,PCBP2,RPL13A,EIF3F,RPS2,RPL10A GO:0048515 spermatid differentiation GO_SPERMATID_DIFFERENTIATION -0.553657405310248 -1.19064025436821 0.262532572844725 0.748968360014058 6 RAN,PAFAH1B1 GO:1902745 positive regulation of lamellipodium organization GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION -0.588694820085628 -1.19035059891855 0.263193854562913 0.748968360014058 5 HSP90AA1 GO:0031098 stress activated protein kinase signaling cascade GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE 0.477784935826439 1.17839189270019 0.263282252075879 0.748968360014058 8 UBC,CRYAB GO:0051050 positive regulation of transport GO_POSITIVE_REGULATION_OF_TRANSPORT 0.222614622712905 1.08722311739929 0.263711517378293 0.748968360014058 125 CD36,MYO1C,GJA1,RAB7A,CACNA2D1,APOE,VTN,STOM,NPPA,EHD2,ATAD1,HCLS1,MIF,SPTBN1,BCAP31,S100A1,RETN,PDCD5,SDCBP,PARK7,CYB5R1,ANK2,DMD,POSTN,RHOA GO:0019724 b cell mediated immunity GO_B_CELL_MEDIATED_IMMUNITY -0.349646476516246 -1.15392330192813 0.263905184580591 0.748968360014058 26 C3,C5,IGHG3,IGHG2,SERPING1,IGHA1,C8A,C1R,CFI,C8G,IGKC,C8B,C2,IGHM GO:0070374 positive regulation of erk1 and erk2 cascade GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE 0.385521926735924 1.15884497444782 0.264925985877495 0.748968360014058 15 CD36,GLIPR2,PRKCDBP,MIF NA single organism cellular localization GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION -0.236563624529301 -1.09814852572157 0.265269833743295 0.748968360014058 151 RPL39,RPL13A,HSP90AA1,KRT18,DNAJA3,EZR,TOMM40,FERMT2,RAN,MTX2,RPS2,RPL10A,ACTR3,PKP2,PAFAH1B1,VAPA,DYNC1H1,PARD3,RPS3,MFN2,ARF1,PIK3R1,RPL10,RANBP1,LMAN1,RPSA,SERPINA1,VAMP3,DPP10,ACTR2,SSR1,AGT,RAB11B GO:0002698 negative regulation of immune effector process GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS -0.418206450962686 -1.16945120581542 0.265368942057121 0.748968360014058 14 PCBP2,SERPINB9 GO:0008543 fibroblast growth factor receptor signaling pathway GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 0.528934561052243 1.18472337141432 0.265632616884556 0.748968360014058 6 UBC,IQGAP1,HNRNPA1 GO:0002220 innate immune response activating cell surface receptor signaling pathway GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY 0.311750628460326 1.13506564916383 0.265683382497542 0.748968360014058 30 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PRKACB,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0030010 establishment of cell polarity GO_ESTABLISHMENT_OF_CELL_POLARITY -0.465059976682583 -1.17684258036941 0.265943446558776 0.748968360014058 10 EZR,PAFAH1B1,PARD3 GO:0000302 response to reactive oxygen species GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES 0.271334989998204 1.11501397349532 0.266350784526954 0.749064951442749 50 COL1A1,APOE,CRYAB,SOD3,GSR,PARK7,ERO1L,PPIF,GNAO1,SOD1,TPM1,APOA4,FN1,GPX1,TXNRD1 GO:0042157 lipoprotein metabolic process GO_LIPOPROTEIN_METABOLIC_PROCESS 0.384518831780682 1.15582975931436 0.267975696155019 0.749951303237749 15 APOE,DBI,HSPG2,APOC2,PRKACB,APOA4 GO:0034599 cellular response to oxidative stress GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS 0.300183037156317 1.12784052316241 0.26820944599442 0.749951303237749 34 CD36,SOD3,DIABLO,PARK7,PPIF,SOD1,TPM1,APOA4,GPX1 GO:0033120 positive regulation of rna splicing GO_POSITIVE_REGULATION_OF_RNA_SPLICING -0.523106215878209 -1.18350897345018 0.268430762552453 0.749951303237749 7 PIK3R1,DAZAP1,HSPA1A,U2AF2 GO:0000904 cell morphogenesis involved in differentiation GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION -0.289371663309856 -1.12413188120325 0.268711018711019 0.749951303237749 53 CLIC4,HPRT1,EZR,FERMT2,TRIM28,MATN2,PAFAH1B1,RTN4,LIMS1,PARD3,SPTB,PALLD GO:1903319 positive regulation of protein maturation GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION -0.550752661791332 -1.18439360340849 0.269147365927438 0.749951303237749 6 C3 GO:1901293 nucleoside phosphate biosynthetic process GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS -0.318141108574336 -1.13718088051283 0.269260881877697 0.749951303237749 36 NAMPT,GBAS,HPRT1,ADA,LHPP,AK4,SUCLG1,ATP5D,ADK,ATP5J2,ATP5F1,AQP1,ATP5A1,STOML2 GO:0001578 microtubule bundle formation GO_MICROTUBULE_BUNDLE_FORMATION 0.565285327855191 1.19130055047455 0.269600680435304 0.749951303237749 5 ZMYND10,MAP1B,CDK5RAP2,TPPP3 GO:0031145 anaphase promoting complex dependent catabolic process GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS 0.322627599655979 1.13206004119887 0.270337193212439 0.749951303237749 26 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 NA protein oligomerization GO_PROTEIN_OLIGOMERIZATION 0.236388929704308 1.09424159644564 0.270538044851104 0.749951303237749 91 GJA1,EHD4,PFKL,COL1A1,CRYAB,PCBD1,STOM,AHNAK,COL1A2,ANXA6,ATL3,MIF,ME1 GO:0006282 regulation of dna repair GO_REGULATION_OF_DNA_REPAIR -0.521836928913677 -1.18063725740703 0.271089567356388 0.749951303237749 7 TRIM28,OTUB1,RPS3 GO:0097194 execution phase of apoptosis GO_EXECUTION_PHASE_OF_APOPTOSIS 0.498297293121155 1.17462877301672 0.271249357096536 0.749951303237749 7 H1F0,BCAP31,KPNB1 GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS 0.498297293121155 1.17462877301672 0.271249357096536 0.749951303237749 7 H1F0,BCAP31,KPNB1 GO:0007017 microtubule based process GO_MICROTUBULE_BASED_PROCESS -0.287488231339789 -1.12124305809993 0.271776834051934 0.749951303237749 54 EZR,RAN,ACTR3,PAFAH1B1,TUBB,PPP2R1A,DYNC1LI1,DYNC1I2,DYNC1H1,RPS3,TUBA4A,TUBB2B,RANBP1,ACTR2,IFT81,DYNLL2 GO:0034341 response to interferon gamma GO_RESPONSE_TO_INTERFERON_GAMMA -0.479601369829428 -1.17386684140164 0.27250259679788 0.749951303237749 9 RPL13A,DNAJA3,CAMK2D,SYNCRIP GO:0042398 cellular modified amino acid biosynthetic process GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS -0.479352496839299 -1.1732577027102 0.272932411619327 0.749951303237749 9 AHCY,GSS,CKM,MTHFD1,ALDH7A1 GO:0042770 signal transduction in response to dna damage GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE 0.525082436178184 1.17609526747869 0.273365832040771 0.749951303237749 6 UBC,MIF GO:0009566 fertilization GO_FERTILIZATION 0.411258375146612 1.15530095992761 0.273962159539816 0.749951303237749 12 CCT8,FNDC3A,PARK7,CAST,SLIRP,TCP1 GO:0006260 dna replication GO_DNA_REPLICATION -0.478933268167636 -1.17223160339608 0.274006948672947 0.749951303237749 9 DNAJA3,THOC4,PURA GO:0051155 positive regulation of striated muscle cell differentiation GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION 0.496985525707505 1.17153656326794 0.274044589548067 0.749951303237749 7 EHD2,BMP10,MYLK3,PIN1 GO:0046148 pigment biosynthetic process GO_PIGMENT_BIOSYNTHETIC_PROCESS -0.547925847178064 -1.17831453856097 0.274869253056836 0.749951303237749 6 HPRT1,ADA GO:0000041 transition metal ion transport GO_TRANSITION_METAL_ION_TRANSPORT -0.447093675629395 -1.1655093824805 0.274961977858734 0.749951303237749 11 FTL,RAB11B,CLTC,CP,SCO1,FTH1,SFXN1 GO:1903335 regulation of vacuolar transport GO_REGULATION_OF_VACUOLAR_TRANSPORT -0.461270812067047 -1.16725403160759 0.275511292904144 0.749951303237749 10 EZR,ARF1,RAB11B,EHD1,SNX3,VPS35,MSN GO:0070925 organelle assembly GO_ORGANELLE_ASSEMBLY -0.269649465312785 -1.11010784359719 0.275847899611215 0.749951303237749 71 KRT8,CSRP3,EZR,KRT19,ABLIM1,MYOZ1,PAFAH1B1,TUBB,DYNC1H1,RPS3,MFN2,MYL2,RPL10,LDB3,DBNL,RPSA,NEBL,ACTR2,IFT81,EHD1,ACTG1,NPM1 GO:0007600 sensory perception GO_SENSORY_PERCEPTION 0.28773799925517 1.11799491653935 0.276177250347178 0.749951303237749 39 CD36,COL1A1,LAMB2,TIMM13,GNAS,SOD1,OR8J3,TJP1,GPX1,COL18A1,MECP2,PCDH15 GO:0031638 zymogen activation GO_ZYMOGEN_ACTIVATION -0.406000336878985 -1.15807149719027 0.276514161220044 0.749951303237749 15 DNAJA3,ANP32B,FGA,FGB,FGG GO:0061045 negative regulation of wound healing GO_NEGATIVE_REGULATION_OF_WOUND_HEALING 0.360165828823911 1.1413158799532 0.276873972798514 0.749951303237749 18 GJA1,APOE,VTN GO:0010803 regulation of tumor necrosis factor mediated signaling pathway GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY 0.523115883485243 1.17169052423066 0.277110569465987 0.749951303237749 6 UBC,NOL3,GSTP1 GO:0050801 ion homeostasis GO_ION_HOMEOSTASIS 0.250136372017477 1.09724604445378 0.277123439742236 0.749951303237749 69 CD36,GJA1,RAB7A,CACNA2D1,APOE,ANXA6,BCAP31,FABP3,ERO1L,ANK2,SOD1,ANK3,PRKAA2,VAPB,TNNI3,SRI,ITGB1,PYGM,TGM2,ABL2,PLN,TF,NOL3,B2M,ANXA7 GO:0090305 nucleic acid phosphodiester bond hydrolysis GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS 0.400128736855457 1.15135040243825 0.278390066964286 0.752365080032686 13 H1F0,UBC,REXO2,RPS21,KPNB1 GO:0097305 response to alcohol GO_RESPONSE_TO_ALCOHOL -0.298224036550918 -1.12034339887656 0.278998098485345 0.752994867955072 45 EEF2,PAM,SERPINF1,MTAP,BDH1,OXCT1,C3,FGA,CA3,AQP1,ALAD,AIFM1,HNRNPD,H2AFZ,CTSB,MAOB,NME1,MSN,ALDH1A2 NA regulation of glucose transport GO_REGULATION_OF_GLUCOSE_TRANSPORT -0.459401827945542 -1.16252453389439 0.279726124844389 0.753440812394929 10 ITLN1,PIK3R1,C3,PEA15 GO:0018193 peptidyl amino acid modification GO_PEPTIDYL_AMINO_ACID_MODIFICATION -0.285980572871179 -1.11536298577823 0.279913767951503 0.753440812394929 54 HSP90AA1,ERLIN2,EEF2,ARID4A,TRIM28,PRDX3,RPN2,BGN,CAMK2D,LMAN1 GO:0043268 positive regulation of potassium ion transport GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT 0.521301899658955 1.16762750927075 0.28047861732772 0.753950553673443 6 NPPA,ANK2 GO:0050807 regulation of synapse organization GO_REGULATION_OF_SYNAPSE_ORGANIZATION 0.468775375022202 1.15617103010615 0.282837147550575 0.759274053852346 8 APOE,MECP2,LRRC4B,CDH2,CDC42 GO:0006473 protein acetylation GO_PROTEIN_ACETYLATION -0.578588465440835 -1.16991538377165 0.285722199652842 0.765994895731517 5 ESCO2,RUVBL1 GO:0035295 tube development GO_TUBE_DEVELOPMENT 0.296411487988367 1.11367014889007 0.2861946990833 0.766238607679022 34 COL3A1,GJA1,ENG,COL4A1,PFN1,RHOA,LAMA5,PRKACB,PHB2,RALA,DLL1,DAG1,TGM2 GO:0006302 double strand break repair GO_DOUBLE_STRAND_BREAK_REPAIR -0.346126637715462 -1.1312234501406 0.287958293580482 0.769233208974894 25 XRCC6,XRCC5,ESCO2 GO:0001738 morphogenesis of a polarized epithelium GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM -0.577396256215504 -1.16750471712912 0.288252022011301 0.769233208974894 5 EZR,PAFAH1B1 GO:0009124 nucleoside monophosphate biosynthetic process GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS -0.342586816990488 -1.13062460974161 0.289037392235882 0.769233208974894 26 GBAS,HPRT1,ADA,LHPP,AK4,ATP5D,ADK,ATP5J2,ATP5F1,ATP5A1,STOML2 GO:0003143 embryonic heart tube morphogenesis GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS 0.554500976289179 1.16857325980552 0.289163195428871 0.769233208974894 5 GJA1,ENG,DLL1 GO:0090100 positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY 0.554447734611155 1.16846105657432 0.289228621900421 0.769233208974894 5 BMP10,ENG,SDCBP GO:1901018 positive regulation of potassium ion transmembrane transporter activity GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 0.552962245296108 1.16533048843193 0.291932916057837 0.770225429091579 5 NPPA,ANK2 GO:1901381 positive regulation of potassium ion transmembrane transport GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT 0.552962245296108 1.16533048843193 0.291932916057837 0.770225429091579 5 NPPA,ANK2 GO:0032392 dna geometric change GO_DNA_GEOMETRIC_CHANGE -0.440212363056123 -1.14757078302114 0.292063099069784 0.770225429091579 11 XRCC6,XRCC5,PURA,RUVBL1,ASCC3 GO:0098773 skin epidermis development GO_SKIN_EPIDERMIS_DEVELOPMENT 0.515374912989334 1.15435206813566 0.292089519166851 0.770225429091579 6 GNAS,LAMA5,DLL1,CD109,CDC42 GO:0010959 regulation of metal ion transport GO_REGULATION_OF_METAL_ION_TRANSPORT 0.269524616734456 1.09677073269041 0.292665289256198 0.770225429091579 48 GJA1,CACNA2D1,STOM,AHNAK,NPPA,GNAI2,S100A1,ANK2,DMD,GNAO1,ANK3 NA regulation of multicellular organismal metabolic process GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS -0.489435615724322 -1.15470090406175 0.292925657314593 0.770225429091579 8 CYGB,SERPINF2,MFAP4 GO:0009755 hormone mediated signaling pathway GO_HORMONE_MEDIATED_SIGNALING_PATHWAY -0.428382152138648 -1.14573361492247 0.293351199816633 0.770225429091579 12 RAN,YWHAH GO:0030239 myofibril assembly GO_MYOFIBRIL_ASSEMBLY -0.341397555028789 -1.12669973938864 0.293560509445833 0.770225429091579 26 KRT8,CSRP3,KRT19,MYOZ1,MYL2,LDB3,NEBL GO:0009100 glycoprotein metabolic process GO_GLYCOPROTEIN_METABOLIC_PROCESS -0.372426299058408 -1.13303039984324 0.294503182186654 0.770225429091579 19 ERP44,VCAN,RPN2,BGN,LMAN1 GO:0072009 nephron epithelium development GO_NEPHRON_EPITHELIUM_DEVELOPMENT 0.444798515975333 1.14014841295811 0.295356261462178 0.770225429091579 9 LAMB2,LAMA5,IQGAP1,DLL1,CD34,ILK GO:0038061 nik nf kappab signaling GO_NIK_NF_KAPPAB_SIGNALING 0.316469921878413 1.11045351724991 0.295414269414706 0.770225429091579 26 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 0.444412599463907 1.1391591963078 0.296239273665859 0.770225429091579 9 BCAP31,PARK7,CLU,SOD1 GO:0010608 posttranscriptional regulation of gene expression GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION -0.260434269852573 -1.0939292901623 0.2964085967448 0.770225429091579 80 RPL13A,EIF3F,EEF2,RAN,EIF4H,PSMD2,PSME2,EIF4B,PSMB6,RPS3,PSMA2,PSMA1,YWHAZ,CAPRIN2,HNRNPA2B1,ACO1,YWHAB,SYNCRIP,PURA,DROSHA,NPM1,PSMC2,HNRNPC GO:1901654 response to ketone GO_RESPONSE_TO_KETONE -0.347996116494464 -1.12430323161804 0.296639906882799 0.770225429091579 24 SERPINF1,MTAP,BDH1,C3,FGA,AQP1,AIFM1,HNRNPD,MAOB,NME1,MSN GO:0033157 regulation of intracellular protein transport GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT 0.291842143905038 1.10467914044183 0.296802514091884 0.770225429091579 35 CD36,MYO1C,STOM,HCLS1,BCAP31,PDCD5,PARK7,CYB5R1,RHOA,ANK3 GO:1903008 organelle disassembly GO_ORGANELLE_DISASSEMBLY 0.354400737941838 1.12304710138926 0.29695352880928 0.770225429091579 18 MAP1LC3B2,STOM,CDC37,NME2,MDH1,MYH11,PNPO NA positive regulation of protein complex disassembly GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY 0.48594893404487 1.14552017043995 0.296965495650618 0.770225429091579 7 FAM21C,CFL2,DSTN GO:0051240 positive regulation of multicellular organismal process GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS 0.220535851963573 1.07097322621348 0.296994141372509 0.770225429091579 121 CD36,GLIPR2,GJA1,COL1A1,APOE,NPPA,BMP10,HCLS1,MIF,WHSC1,C1QBP,ENG,SPTBN1,NACA,GNAS,MAP1B,RRAS,PFN1,RETN,SDCBP,APOC2,PARK7,DMD,CLU,POSTN,RHOA,SOD1,TPM1 GO:0060485 mesenchyme development GO_MESENCHYME_DEVELOPMENT -0.452522018756135 -1.14511505381687 0.297118975635782 0.770225429091579 10 TRIM28,RTN4,LIMS1 GO:0043410 positive regulation of mapk cascade GO_POSITIVE_REGULATION_OF_MAPK_CASCADE 0.283373584429448 1.10103715078907 0.297714934982957 0.770225429091579 39 CD36,GLIPR2,UBC,PRKCDBP,CRK,GNAI2,MIF,SDCBP,SOD1,PHB2 GO:1903036 positive regulation of response to wounding GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING 0.393217457065714 1.13146354095007 0.297944568452381 0.770225429091579 13 CD36,VTN GO:0086003 cardiac muscle cell contraction GO_CARDIAC_MUSCLE_CELL_CONTRACTION 0.462077649370462 1.13965199608954 0.298139022030199 0.770225429091579 8 GJA1,CACNA2D1,ANK2 GO:1990267 response to transition metal nanoparticle GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE 0.319832459690815 1.11046902610815 0.298423995932893 0.770225429091579 25 SOD3,SORD,S100A13,PARK7,ANK2,SOD1,FN1,HSPA5,PLN,TF,PGAM2,B2M GO:0006749 glutathione metabolic process GO_GLUTATHIONE_METABOLIC_PROCESS -0.365326984992466 -1.12562431268175 0.299050414364641 0.770851389016943 20 CLIC4,CLIC1,GSTK1,GSS,GSTO1,GSTM3,GSTM2 GO:0090174 organelle membrane fusion GO_ORGANELLE_MEMBRANE_FUSION 0.511167528497012 1.1449282431342 0.301307334367383 0.775673240268853 6 RAB7A,DYSF,STX7 GO:0030182 neuron differentiation GO_NEURON_DIFFERENTIATION 0.24493029853402 1.07996174772578 0.302194510999782 0.776254394606843 71 BCL11B,GJA1,KIF5A,APOE,LAMB2,NCAM1,LAMA2,SPTAN1,SPTBN1,MAP1B,GNAO1,CLU,POSTN,SOD1,APOA4,ANK3,MYH10,LAMB1,DPYSL2,IQGAP1,MECP2,PIN1,ITGB1,DLL1,COPS2,DAG1 GO:0033673 negative regulation of kinase activity GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY -0.3357891908607 -1.11834582442572 0.302306243318004 0.776254394606843 27 DNAJA3,H2AFY,PPP2R1A,PRDX3,BGN,PRKAR2A,PTPN1,YWHAG GO:0015931 nucleobase containing compound transport GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT -0.33887085463627 -1.11836097822345 0.303303916067269 0.777821536989879 26 C14orf166,RAN,THOC4,SRSF7,RANBP1,HNRNPA2B1,RPSA GO:0001508 action potential GO_ACTION_POTENTIAL 0.364385839202003 1.11751949216382 0.305061655901351 0.781331383992234 16 GJA1,CACNA2D1,ANK2,DMD,ANK3,SRI,GNA11 GO:0032200 telomere organization GO_TELOMERE_ORGANIZATION -0.36336883017261 -1.11959095964798 0.306370856353591 0.782367695201224 20 XRCC6,XRCC5 GO:0002064 epithelial cell development GO_EPITHELIAL_CELL_DEVELOPMENT 0.301717289711932 1.09853485461188 0.308357915437561 0.782367695201224 30 BCL11B,GJA1,LAMB2,ENG,FNDC3A,SOD1,TMOD1,IQGAP1,TJP1,GPX1,COL18A1,MYADM,DLL1,RDX GO:0010332 response to gamma radiation GO_RESPONSE_TO_GAMMA_RADIATION -0.568444632790815 -1.14940438748239 0.308490600878975 0.782367695201224 5 XRCC6,XRCC5 GO:0010976 positive regulation of neuron projection development GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT -0.348550319463824 -1.11482578643787 0.308632896672025 0.782367695201224 23 DPYSL3,ARHGDIA,SERPINF1,PAFAH1B1,ARF1,CAPRIN2 GO:0050812 regulation of acyl coa biosynthetic process GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS -0.533151059466849 -1.14654135747462 0.308653898718953 0.782367695201224 6 DLAT,PDHA1,PDP1,PDHB,DLD,PDHX NA atp hydrolysis coupled transmembrane transport GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT -0.533045133690371 -1.1463135640915 0.308872569564663 0.782367695201224 6 ATP5A1,ATP1B1,ATP1A3,ATP5B,ATP1A1 GO:0030111 regulation of wnt signaling pathway GO_REGULATION_OF_WNT_SIGNALING_PATHWAY 0.27617148976574 1.09100947487172 0.309719850110887 0.782367695201224 42 PSMB3,UBC,COL1A1,APOE,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PIN1,PSMA5,PSMA3 GO:0006026 aminoglycan catabolic process GO_AMINOGLYCAN_CATABOLIC_PROCESS -0.433428849941426 -1.12988713278782 0.31026067272663 0.782367695201224 11 VCAN,BGN,PRELP,OGN,FMOD,AGRN GO:0001952 regulation of cell matrix adhesion GO_REGULATION_OF_CELL_MATRIX_ADHESION 0.423360519537686 1.12282405462104 0.31038263849229 0.782367695201224 10 CD36,CDH13,POSTN GO:0051172 negative regulation of nitrogen compound metabolic process GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS -0.23864877265159 -1.07654912985241 0.310831835415314 0.782367695201224 124 XRCC6,RPL13A,DNAJA3,EZR,RAN,XRCC5,COQ7,ARID4A,TRIM28,H2AFY,ENO1,APOC1,LIMS1,OTUB1,AEBP1,SRSF7,RPS3,STRAP,CAPRIN2,HNRNPA2B1,YWHAB,S100A11,SYNCRIP,YWHAQ,PURA,DROSHA GO:0045862 positive regulation of proteolysis GO_POSITIVE_REGULATION_OF_PROTEOLYSIS 0.252124363769996 1.07934401345337 0.310934880378955 0.782367695201224 61 PSMB3,UBC,APOE,PSMB2,DIABLO,PSMA6,BCAP31,PSMB1,PDCD5,CLU,PSMA4,PSMD14,PSMC6,HSPE1,FN1,PSMC1,PSMA5,PSMA3 GO:0045471 response to ethanol GO_RESPONSE_TO_ETHANOL -0.378931150135768 -1.11861570086097 0.311363124035444 0.782367695201224 17 EEF2,BDH1,OXCT1,CA3,ALAD,CTSB,MAOB GO:2000279 negative regulation of dna biosynthetic process GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS 0.479542788476294 1.13041905908963 0.311411256960129 0.782367695201224 7 GJA1,HNRNPA1,KCNK2,HNRNPU GO:0031344 regulation of cell projection organization GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION -0.277420061513694 -1.08991033706883 0.31179720822024 0.782367695201224 56 HSP90AA1,EZR,DPYSL3,ARHGDIA,SERPINF1,PAFAH1B1,RTN4,YWHAH,ARF1,CAPRIN2,CAPZB,VDAC3 GO:1901216 positive regulation of neuron death GO_POSITIVE_REGULATION_OF_NEURON_DEATH 0.50593685223813 1.13321241877992 0.311965433192998 0.782367695201224 6 APOE,CLU,PIN1 GO:0006396 rna processing GO_RNA_PROCESSING -0.246725181235857 -1.07847962416932 0.312075941966552 0.782367695201224 101 RPL39,PCBP2,RPL13A,APOBEC2,C14orf166,RPS2,RPL10A,THOC4,PPP2R1A,SRSF7,RPS3,STRAP,RPL10,HNRNPA2B1,FUS,RPSA GO:0010628 positive regulation of gene expression GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION -0.231288956384808 -1.0716575285233 0.312089902318815 0.782367695201224 149 NAMPT,XRCC6,CSRP3,ERLIN2,EEF2,SERPINB9,EZR,C14orf166,RAN,COQ7,ARID4A,TRIM28,SERPINF2,H2AFY,THOC4,LIMS1,PRDX3,YWHAH,RPS3,TAF15,ERP29,PIK3R1,DAZAP1,C3 GO:0015701 bicarbonate transport GO_BICARBONATE_TRANSPORT -0.4631858555649 -1.13368841595941 0.312869372112182 0.783286082437612 9 CA3,CA1,AQP1,HBA2,HBA1,HBB GO:0050766 positive regulation of phagocytosis GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS 0.42182191231339 1.11874340675161 0.313580810965163 0.783286082437612 10 CD36,C4B,LMAN2 GO:1901021 positive regulation of calcium ion transmembrane transporter activity GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 0.421802960342414 1.11869314290339 0.313626499143347 0.783286082437612 10 CACNA2D1,S100A1,ANK2 GO:0032527 protein exit from endoplasmic reticulum GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM -0.565573770491803 -1.14359945674333 0.315156775122798 0.783976381082383 5 TMED9,LMAN1,VCP,SURF4,HSP90B1 GO:0048705 skeletal system morphogenesis GO_SKELETAL_SYSTEM_MORPHOGENESIS 0.455252510386226 1.12281871432928 0.3153086253066 0.783976381082383 8 COL1A1,GNAS,RARB,SERPINH1 GO:0052547 regulation of peptidase activity GO_REGULATION_OF_PEPTIDASE_ACTIVITY -0.26293578575558 -1.08246859600141 0.315990770300597 0.783976381082383 71 SERPINB9,DNAJA3,LXN,SERPINF2,PSME2,SERPINF1,PRDX3,ANP32B,RPS3,GPI,C3,SERPINA3,C5,SERPINA7,SERPINA1,AGT,SERPINA4,ITIH1,AQP1,SERPING1,AHSG,AIFM1,CSTB,COL6A3,HMGB1 GO:0002028 regulation of sodium ion transport GO_REGULATION_OF_SODIUM_ION_TRANSPORT -0.377623627306855 -1.11475585570142 0.316218418907905 0.783976381082383 17 PKP2,YWHAH,ARF1,CAMK2D,AGT,GPD1L GO:0006796 phosphate containing compound metabolic process GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS -0.213830210169611 -1.06006302575816 0.316472060050042 0.783976381082383 259 NAMPT,MARK1,PGM2,TALDO1,GBAS,HSP90AA1,HPRT1,ERLIN2,PSMD2,TRIM28,PPA1,DCXR,NT5C,PSME2,ENO1,PAFAH1B1,ADA,PSMB6,PPP5C,PPP2R1A,MCCC2,SPTB,NDUFB8,NDUFV1,ARF1,GPI,OLA1,NDUFC2,PIK3R1,CAMK2D,NDUFB9,LHPP,BRP44,PSMA2,PSMA1,AK4,COQ9,OGDH,NDUFS3,PTPN1,NDUFA10,DBNL,COX5A,AKR1A1,SUCLG1,CA3,YWHAB,NDUFS8,ATP5D,ADK,NDUFA5,AGT,GPD1L,NDUFA9,ATP5J2,PEA15,ATP5F1,NDUFB2,HDHD2,NDUFB3,PSMC2,NDUFS7,AQP1,COX4I1,ATP5A1,MCEE,COX6C,ALDH1A1,UQCRFS1,STOML2,CYC1,NDUFB11,PDXK,ENO3,OBSCN,PSMC3 GO:0051560 mitochondrial calcium ion homeostasis GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS 0.540008413912672 1.1380311659528 0.316598695832334 0.783976381082383 5 ANXA6,BCAP31,TGM2 GO:0072511 divalent inorganic cation transport GO_DIVALENT_INORGANIC_CATION_TRANSPORT 0.331663562782026 1.09847319036627 0.316784587436657 0.783976381082383 21 CACNA2D1,ANXA6,ERO1L,ANK2,FKBP1A,SRI,PLN,TF,NOL3,TPT1,CAV1,JPH2 GO:0045666 positive regulation of neuron differentiation GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION -0.335189351538271 -1.10621107111377 0.317026305497458 0.783976381082383 26 DPYSL3,ARHGDIA,SERPINF1,PAFAH1B1,ARF1,CAPRIN2 GO:0061448 connective tissue development GO_CONNECTIVE_TISSUE_DEVELOPMENT -0.408793035331183 -1.11954796346694 0.318917116990666 0.787682129049517 13 NAMPT,BDH1,OXCT1 GO:0050820 positive regulation of coagulation GO_POSITIVE_REGULATION_OF_COAGULATION 0.502025100889918 1.12445076169295 0.319942388654997 0.788642721525936 6 CD36,APOH,PLG GO:0061572 actin filament bundle organization GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION -0.399154315997856 -1.11617478658111 0.320408555887857 0.788642721525936 14 EZR,DPYSL3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS -0.563137238075174 -1.13867274816282 0.321028917531484 0.788642721525936 5 OXCT1,BRP44 GO:0050805 negative regulation of synaptic transmission GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION 0.537542997001309 1.13283546675643 0.321614725317864 0.788642721525936 5 ATAD1,GNAI2 GO:0071347 cellular response to interleukin 1 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 -0.499920947054559 -1.1310531377676 0.321643032846187 0.788642721525936 7 OTUB1,FGB,HSPA9 GO:0051494 negative regulation of cytoskeleton organization GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION -0.313123891343395 -1.09697123615564 0.32166254428772 0.788642721525936 33 EZR,RAN,TUBB,PPP2R1A,DYNC1H1,SPTB,RPS3,RANBP1,CAPZB GO:0001558 regulation of cell growth GO_REGULATION_OF_CELL_GROWTH 0.280647059710231 1.0839324579641 0.322324035847347 0.789300809733503 38 GJA1,APOE,CRYAB,NPPA,BMP10,MAP1B,LTBP4,SDCBP,DPYSL2,FN1,PIN1,FBLN5 GO:0007272 ensheathment of neurons GO_ENSHEATHMENT_OF_NEURONS 0.433377632214374 1.11087335464079 0.322888129146195 0.789719078350256 9 LAMA2,ANK2,CLU,SOD1,DAG1 GO:0048589 developmental growth GO_DEVELOPMENTAL_GROWTH 0.282455370219077 1.08359357152073 0.323415038008982 0.789760027984092 37 GJA1,LAMB2,NPPA,BMP10,PKM2,NACA,GNAS,MAP1B,NDUFS6,POSTN,IQGAP1,GPX1 GO:0040008 regulation of growth GO_REGULATION_OF_GROWTH 0.250801442573368 1.07126772195325 0.323931714558371 0.789760027984092 60 CD36,GJA1,APOE,CRYAB,NPPA,BMP10,NACA,GNAS,MAP1B,LTBP4,SDCBP,SOD1,DPYSL2,FN1,PIN1,FBLN5 GO:0034113 heterotypic cell cell adhesion GO_HETEROTYPIC_CELL_CELL_ADHESION -0.49878284882379 -1.12847823150975 0.324084792360006 0.789760027984092 7 PKP2,PARVA,DSP,JUP,DSG2 GO:0034250 positive regulation of cellular amide metabolic process GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS 0.365432315436441 1.09845737136094 0.326272081075375 0.794126471271942 15 RPS4X,APOE,C1QBP,CLU GO:0043408 regulation of mapk cascade GO_REGULATION_OF_MAPK_CASCADE 0.248851430839161 1.06909551381086 0.327307098354545 0.795681178566497 62 CD36,GLIPR2,UBC,APOE,PRKCDBP,BMP10,CRK,GNAI2,MIF,RRAS,AMBP,SDCBP,SOD1,PHB2,FN1 GO:0051235 maintenance of location GO_MAINTENANCE_OF_LOCATION 0.305601447097959 1.08271451807271 0.329657220761515 0.800004061864355 27 CD36,APOE,FBN1,ANK3,VPS13A,HSPA5,SRI,DAG1,FITM2,FLNA,CAV1 GO:0051349 positive regulation of lyase activity GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY 0.471599183129271 1.111693716747 0.329882152999843 0.800004061864355 7 GNAS,PARK7,CALM1,CAP1 GO:1901524 regulation of mitophagy GO_REGULATION_OF_MITOPHAGY 0.471347764765512 1.11110105199001 0.330485923209374 0.800457473590351 7 MAP1LC3B,PARK7 GO:0035050 embryonic heart tube development GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT 0.497180878190856 1.11360052752315 0.330866385996012 0.800457473590351 6 GJA1,ENG,DLL1 GO:0007167 enzyme linked receptor protein signaling pathway GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY 0.255743128621543 1.06840018798842 0.331340712122794 0.800640372975416 54 MYO1C,COL3A1,UBC,COL1A2,NPPA,CDC37,BMP10,CRK,ENG,SPTBN1,LTBP4,SDCBP,RHOA GO:0006892 post golgi vesicle mediated transport GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT -0.425651653622481 -1.10961309230545 0.33224277579316 0.801855160808491 11 KRT18,ARF1,VAMP3,C16orf62 GO:0048592 eye morphogenesis GO_EYE_MORPHOGENESIS 0.447594297748512 1.10393076913016 0.333220819550395 0.802343817153026 8 COL8A1,FBN1,DLL1,RBP4,RARB GO:0051290 protein heterotetramerization GO_PROTEIN_HETEROTETRAMERIZATION 0.338281093288457 1.08925580287322 0.333555433929039 0.802343817153026 19 HIST1H3A,HIST3H3,ANXA2,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0033275 actin myosin filament sliding GO_ACTIN_MYOSIN_FILAMENT_SLIDING 0.322969184931932 1.08340625442699 0.333748921070298 0.802343817153026 22 TPM3,TPM2,DMD,TMOD1,TPM1,TNNI3,TNNC1 GO:0051351 positive regulation of ligase activity GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY 0.296434042711107 1.07929886392182 0.33429203539823 0.802343817153026 30 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PIN1,PSMA5,PSMA3 GO:0070527 platelet aggregation GO_PLATELET_AGGREGATION -0.371834512497501 -1.09766622156205 0.334443115018467 0.802343817153026 17 CLIC1,CSRP1,FGA,FGB,FGG,ACTG1,HBB,HSPB1,ACTN1 GO:0033700 phospholipid efflux GO_PHOSPHOLIPID_EFFLUX 0.469190090668761 1.10601479904056 0.335248999306782 0.803317411226753 7 APOE,APOC2,APOA4,APOC3 GO:0043401 steroid hormone mediated signaling pathway GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY -0.437738610503109 -1.10770537509274 0.335888315845634 0.803576997804427 10 RAN,YWHAH GO:1904837 beta catenin tcf complex assembly GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY 0.355511988288728 1.09030465475999 0.336559013505578 0.803576997804427 16 HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0071345 cellular response to cytokine stimulus GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS -0.265169714162794 -1.07077710113106 0.336687269416894 0.803576997804427 64 RPL13A,KRT8,KRT18,DPYSL3,PSMD2,PSME2,PSMB6,HSP90AB1,OTUB1,BGN,CAMK2D,FGA,PSMA2,PSMA1 GO:0043524 negative regulation of neuron apoptotic process GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS 0.349277013037874 1.08918087368013 0.337254624052158 0.803576997804427 17 APOE,SET,PARK7,SOD1,MECP2,PIN1 GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS -0.471056426288092 -1.11133980410067 0.338132344736984 0.803576997804427 8 HSP90AA1,HSP90AB1,AGT,DDAH2,HBB GO:0021953 central nervous system neuron differentiation GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION -0.520185758183763 -1.11865947696586 0.338520691728775 0.803576997804427 6 HPRT1,PAFAH1B1,OGDH GO:1904035 regulation of epithelial cell apoptotic process GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS -0.470870560337604 -1.11090129988445 0.338618244641604 0.803576997804427 8 FGA,FGB,FGG GO:0055088 lipid homeostasis GO_LIPID_HOMEOSTASIS -0.344337056157305 -1.08901957938228 0.338919957457028 0.803576997804427 22 GCDH,PKP2,IVD,ACAD10,ETFA,EHD1,ACADVL,GOT1 GO:0032677 regulation of interleukin 8 production GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION 0.44524417064189 1.09813449862936 0.338959022480254 0.803576997804427 8 PARK7,SSC5D,ANXA4,APOA2 GO:0051340 regulation of ligase activity GO_REGULATION_OF_LIGASE_ACTIVITY 0.290093813088489 1.07244166374568 0.340183950219402 0.805529919859149 32 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PARK7,PSMA4,PSMD14,PSMC6,PSMC1,PIN1,PSMA5,PSMA3 GO:0035384 thioester biosynthetic process GO_THIOESTER_BIOSYNTHETIC_PROCESS -0.376999897924489 -1.09473922694538 0.340623748411026 0.805621303662356 16 GCDH,ACOT9,BRP44,ACSBG2 GO:0072522 purine containing compound biosynthetic process GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS -0.316544576256658 -1.08302522369174 0.341846195340683 0.807239478900114 30 GBAS,HPRT1,ADA,MTAP,AK4,ATP5D,ADK,ATP5J2,ATP5F1,AQP1,ATP5A1,STOML2 GO:0097006 regulation of plasma lipoprotein particle levels GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS 0.387715611406927 1.08916497537019 0.342111950470118 0.807239478900114 12 CD36,APOE,APOC2,APOA4 GO:0006886 intracellular protein transport GO_INTRACELLULAR_PROTEIN_TRANSPORT -0.228704175384376 -1.0557594734136 0.343140171346978 0.807334335888965 145 RPL39,RPL13A,HSP90AA1,KRT18,TOMM40,RAN,MTX2,RPS2,RPL10A,YWHAH,PARD3,RPS3,MFN2,ERP29,PIK3R1,TMED9,RPL10,YWHAZ,RANBP1,LMAN1,TBC1D4,RPSA,YWHAB,YWHAG,VAMP3,SSR1,TOM1,IFT81,HSPA9,YWHAQ,AGT,RAB11B,EHD1 GO:0046887 positive regulation of hormone secretion GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION -0.400250540314169 -1.09615291493956 0.343515334409432 0.807334335888965 13 GLUD1,OXCT1,FGA,BRP44,FGB,FGG GO:0060491 regulation of cell projection assembly GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY -0.369347323722566 -1.09032396845446 0.343529452565503 0.807334335888965 17 HSP90AA1,DPYSL3,CAPZB,VDAC3 GO:0045933 positive regulation of muscle contraction GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION -0.553685871047722 -1.11956192874014 0.343760387044355 0.807334335888965 5 HSP90AA1,ADA,GSTO1 GO:0042063 gliogenesis GO_GLIOGENESIS -0.339243713869294 -1.08505893981168 0.34454629407942 0.807905475355847 23 EEF2,MATN2,PAFAH1B1,RTN4,VCAN,PARD3 GO:0072330 monocarboxylic acid biosynthetic process GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS 0.30938757108055 1.07420402256829 0.344953639818917 0.807905475355847 25 PRKAG2,MLYCD,PKM2,MIF,PARK7,NDUFAB1,PRKAA2,HSD17B8,ACADM,TMLHE,CBR4 GO:0010769 regulation of cell morphogenesis involved in differentiation GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION 0.268639193967622 1.06669908825877 0.345694451533868 0.807905475355847 43 GLIPR2,COL1A1,APOE,CFL1,FAM21C,C1QBP,MAP1B,SDCBP,POSTN,RHOA,DPYSL2,FN1 GO:0003231 cardiac ventricle development GO_CARDIAC_VENTRICLE_DEVELOPMENT 0.328828665012677 1.07475874012478 0.346228791407252 0.807905475355847 20 BMP10,WHSC1,NACA,XIRP2,TPM1,FKBP1A,TNNI3,TNNC1,KCNK2 GO:0032868 response to insulin GO_RESPONSE_TO_INSULIN -0.338831595234273 -1.08374079303133 0.346427472038855 0.807905475355847 23 NAMPT,PIK3R1,BDH1,PTPN1,TBC1D4,YWHAG GO:0009636 response to toxic substance GO_RESPONSE_TO_TOXIC_SUBSTANCE -0.286656270103641 -1.07105650819239 0.346499161377314 0.807905475355847 44 HSP90AA1,CYGB,MPST,PRDX3,GSTK1,HP,BDH1,HSPA9,GSTO1,GSTM3,GSTM2,PRDX2,CES1,ALAD,UQCRFS1,AIFM1,HBA2,HBA1,ALB,HBB,GPX3,MAOB GO:0006521 regulation of cellular amino acid metabolic process GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS 0.30482123796134 1.06957973704904 0.347704707110431 0.807905475355847 26 PSMB3,PSMB2,PSMA6,PSMB1,PARK7,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0001667 ameboidal type cell migration GO_AMEBOIDAL_TYPE_CELL_MIGRATION 0.366817129234905 1.08026608964931 0.347927612375949 0.807905475355847 14 KRT2,CDH13,RHOA,LAMA5,GPX1,ITGB1,TNS1 GO:0009791 post embryonic development GO_POST_EMBRYONIC_DEVELOPMENT 0.441377477365768 1.08859782288578 0.348365174733905 0.807905475355847 8 BCL11B,FBN1,GNAS,MECP2 GO:0045995 regulation of embryonic development GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT 0.385688408411601 1.08347018662422 0.348464897082265 0.807905475355847 12 LAMA2,LAMA5,PRKACB,MYADM,DLL1,DAG1 GO:0019637 organophosphate metabolic process GO_ORGANOPHOSPHATE_METABOLIC_PROCESS -0.221285486366545 -1.05114531401313 0.349251562272925 0.807905475355847 180 NAMPT,PGM2,TALDO1,GBAS,HPRT1,DCXR,NT5C,ENO1,PAFAH1B1,ADA,MCCC2,NDUFB8,NDUFV1,ARF1,GPI,OLA1,NDUFC2,PIK3R1,NDUFB9,LHPP,BRP44,AK4,COQ9,OGDH,NDUFS3,NDUFA10,COX5A,AKR1A1,SUCLG1,NDUFS8,ATP5D,ADK,NDUFA5,GPD1L,NDUFA9,ATP5J2,ATP5F1,NDUFB2,NDUFB3,NDUFS7,AQP1,COX4I1,ATP5A1,MCEE,COX6C,ALDH1A1,UQCRFS1,STOML2,CYC1,NDUFB11,PDXK,ENO3 GO:0015949 nucleobase containing small molecule interconversion GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION 0.39651486536492 1.08328287967908 0.34932578581619 0.807905475355847 11 CMPK1,GSR,NME2,TXNRD1,AK1 GO:0090596 sensory organ morphogenesis GO_SENSORY_ORGAN_MORPHOGENESIS 0.396219490042284 1.08247591111865 0.350269225459064 0.807905475355847 11 COL8A1,FBN1,SOD1,DLL1,RBP4,RARB GO:0071824 protein dna complex subunit organization GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION 0.288187511631195 1.06539429832724 0.350397897711778 0.807905475355847 32 H1F0,UBC,HIST1H1D,SET,HIST1H3A,HIST3H3,HP1BP3,RBBP7,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,CETN2,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0050679 positive regulation of epithelial cell proliferation GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION 0.40741149200572 1.08052452281713 0.351753283837807 0.807905475355847 10 LAMC1,CDH13,LAMB1,NME2 GO:0010288 response to lead ion GO_RESPONSE_TO_LEAD_ION -0.514658988317445 -1.10677415832593 0.351950726169433 0.807905475355847 6 QDPR,PPP5C,ALAD,CAT,ANXA5 GO:0051052 regulation of dna metabolic process GO_REGULATION_OF_DNA_METABOLIC_PROCESS -0.295869804220095 -1.07055815792804 0.352350774743688 0.807905475355847 38 XRCC5,TRIM28,ESCO2,THOC4,PPP2R1A,OTUB1,RPS3,CCT6A,S100A11,NPM1,HNRNPC,STOML2,AIFM1 GO:1903426 regulation of reactive oxygen species biosynthetic process GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS -0.407320661727654 -1.08940340269544 0.352733748258899 0.807905475355847 12 HSP90AA1,HSP90AB1,AGT,DDAH2,HBB GO:0006221 pyrimidine nucleotide biosynthetic process GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS 0.521055018793539 1.09808816915779 0.353869975792206 0.807905475355847 5 CMPK1,NME2,ERH GO:1903364 positive regulation of cellular protein catabolic process GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS 0.269863287667331 1.06052162928982 0.354387214983713 0.807905475355847 41 PSMB3,UBC,APOE,PSMB2,PSMA6,BCAP31,PSMB1,CLU,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0009410 response to xenobiotic stimulus GO_RESPONSE_TO_XENOBIOTIC_STIMULUS -0.372770000191882 -1.08245637223018 0.354415170564369 0.807905475355847 16 DNAJA2,AKR7A2,CRYZ,GSS,GSTO1,GSTM3,GSTM2,CES1 GO:0070482 response to oxygen levels GO_RESPONSE_TO_OXYGEN_LEVELS 0.259341229683198 1.05533169453204 0.35573347107438 0.807905475355847 48 UBC,COL1A1,CRYAB,SOD3,NPPA,PKM2,ENG,TCEB1,ERO1L,POSTN GO:0015914 phospholipid transport GO_PHOSPHOLIPID_TRANSPORT 0.43800696944331 1.08028492117565 0.356803708454286 0.807905475355847 8 APOE,APOC2,APOA4,APOC3,SCP2 GO:1903533 regulation of protein targeting GO_REGULATION_OF_PROTEIN_TARGETING 0.294487797224686 1.063280348121 0.356904750232855 0.807905475355847 29 CD36,MYO1C,STOM,HCLS1,PDCD5,CYB5R1,RHOA,ANK3 GO:0009605 response to external stimulus GO_RESPONSE_TO_EXTERNAL_STIMULUS 0.202054944822381 1.03671919194294 0.356995131884565 0.807905475355847 174 CD36,BCL11B,MAP1LC3B,MAP1LC3B2,COL3A1,GJA1,KIF5A,COL1A1,APOE,LAMB2,CFL1,SORD,STOM,SERPINC1,NCAM1,NPPA,GNAI2,LAMA2,PKM2,MIF,SPTAN1,ENG,SPTBN1,GNG12,RETN,DMD,CLU,SSC5D,POSTN,RHOA,SOD1,ANK3,MYH10,DPYSL2,HIST1H3A,FN1,PRKAA2,GPX1 GO:0010632 regulation of epithelial cell migration GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION 0.332269478905413 1.06989857014196 0.357256740356471 0.807905475355847 19 GLIPR2,APOE,BMP10,PFN1,RHOA GO:0007267 cell cell signaling GO_CELL_CELL_SIGNALING 0.270628113108093 1.05747807954486 0.357399989859555 0.807905475355847 40 GJA1,KIF5A,APOE,GNAI2,LTBP4,SDCBP,PARK7,ANK2,RAPGEF4,TOLLIP,TJP1,SNCG,MECP2 GO:1903053 regulation of extracellular matrix organization GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION 0.484668712270642 1.08557540592171 0.358409040549524 0.807905475355847 6 PARK7,GPX1,DAG1,FSCN1,HSPA8 GO:0072331 signal transduction by p53 class mediator GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR 0.48451549710624 1.08523223003666 0.35883004653224 0.807905475355847 6 UBC,MIF GO:0031952 regulation of protein autophosphorylation GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION 0.518480439225677 1.09266241705474 0.359038667044686 0.807905475355847 5 ENG,CALM1,CAV1 GO:0042303 molting cycle GO_MOLTING_CYCLE 0.518471573757855 1.09264373368163 0.359060475868536 0.807905475355847 5 GNAS,LAMA5,CD109,CDC42 GO:1900006 positive regulation of dendrite development GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT -0.445067809753528 -1.08934289372595 0.359164010172284 0.807905475355847 9 PAFAH1B1,ARF1,CAPRIN2 GO:0030490 maturation of ssu rrna GO_MATURATION_OF_SSU_RRNA 0.484367908049737 1.08490165567553 0.35922889430534 0.807905475355847 6 RPS8,RPS21,RPS24,RPS14 NA maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ 0.484367908049737 1.08490165567553 0.35922889430534 0.807905475355847 6 RPS8,RPS21,RPS24,RPS14 GO:0060999 positive regulation of dendritic spine development GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT -0.483802270117062 -1.09458521172003 0.359680219939227 0.807905475355847 7 PAFAH1B1,ARF1,CAPRIN2 GO:0043542 endothelial cell migration GO_ENDOTHELIAL_CELL_MIGRATION 0.436808803469199 1.07732980693045 0.360021602646324 0.807905475355847 8 CDH13,RHOA,GPX1,ITGB1 GO:0000819 sister chromatid segregation GO_SISTER_CHROMATID_SEGREGATION -0.444588814719115 -1.0881705109442 0.360471363587521 0.807905475355847 9 PAFAH1B1,PPP2R1A,MAPRE1 GO:0046364 monosaccharide biosynthetic process GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS -0.321504307481826 -1.07077002355427 0.360717497921157 0.807905475355847 27 TALDO1,ENO1,GPI,AKR1A1,GSTO1,GOT1,ENO3,SLC25A11,PGK1,TPI1,PGM1,SLC25A12,PGD,BPGM GO:1901292 nucleoside phosphate catabolic process GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS -0.415599793877416 -1.08340932901634 0.360803593534468 0.807905475355847 11 HPRT1,NT5C,ADA GO:2000116 regulation of cysteine type endopeptidase activity GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY -0.315015712977584 -1.06810784569613 0.361158029862847 0.807905475355847 29 SERPINB9,DNAJA3,PRDX3,ANP32B,RPS3,GPI GO:1902176 negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 0.483278174161784 1.08246083728182 0.36148903168624 0.807905475355847 6 PARK7,GPX1,NOL3 NA positive regulation of camp metabolic process GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS 0.483257749476639 1.08241508946418 0.361533348105473 0.807905475355847 6 GNAS,AKAP12,CALM1,CAP1 GO:0031346 positive regulation of cell projection organization GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION -0.3023168186831 -1.06636514217229 0.361605800394266 0.807905475355847 34 HSP90AA1,DPYSL3,ARHGDIA,SERPINF1,PAFAH1B1,ARF1,CAPRIN2 GO:0002237 response to molecule of bacterial origin GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 0.331160111098879 1.06632643636103 0.361706684434714 0.807905475355847 19 CD36,GNG12,SSC5D,FN1,C4B,CTSG,B2M,GSTP1,NCL GO:0046890 regulation of lipid biosynthetic process GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS 0.32530046649913 1.06322701374933 0.362268903569222 0.808262175963331 20 APOE,PRKAG2,FABP3,APOC2,SOD1,APOA4,PRKAA2 GO:0010634 positive regulation of epithelial cell migration GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION 0.482483009727563 1.08067980431725 0.363549745180589 0.808763945140175 6 GLIPR2,PFN1 GO:0006936 muscle contraction GO_MUSCLE_CONTRACTION 0.237659911806906 1.04535830508472 0.363757223865209 0.808763945140175 70 GJA1,CACNA2D1,CRYAB,TPM3,MYL9,TPM2,NDUFS6,DYSF,SSPN,ANK2,DMD,GNAO1,TMOD1,TPM1 GO:0033344 cholesterol efflux GO_CHOLESTEROL_EFFLUX 0.435081653531489 1.07307002531855 0.364364634667747 0.808763945140175 8 APOE,APOC2,APOA4,APOC3,CAV1 GO:0035036 sperm egg recognition GO_SPERM_EGG_RECOGNITION 0.456962177045474 1.07719012073274 0.364923187012232 0.808763945140175 7 CCT8,TCP1,CCT5 GO:0009988 cell cell recognition GO_CELL_CELL_RECOGNITION 0.456962177045474 1.07719012073274 0.364923187012232 0.808763945140175 7 CCT8,TCP1,CCT5 GO:0007339 binding of sperm to zona pellucida GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA 0.456962177045474 1.07719012073274 0.364923187012232 0.808763945140175 7 CCT8,TCP1,CCT5 GO:0035337 fatty acyl coa metabolic process GO_FATTY_ACYL_COA_METABOLIC_PROCESS -0.414058125109906 -1.0793904186377 0.365313196335727 0.808763945140175 11 GCDH,ACOT9,ACSBG2,MCEE,HSD17B4 GO:0016925 protein sumoylation GO_PROTEIN_SUMOYLATION -0.508760486239841 -1.09408942956278 0.36638300198626 0.810239061661245 6 TRIM28,HNRNPC GO:0048872 homeostasis of number of cells GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS -0.341281071816625 -1.06589394358946 0.368325138397002 0.811946599050792 21 DNAJA3,ARID4A,GPI,FH GO:1901616 organic hydroxy compound catabolic process GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS 0.416278730331657 1.06704387872143 0.368578350352073 0.811946599050792 9 APOE,SORD GO:0043535 regulation of blood vessel endothelial cell migration GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION 0.455399113866237 1.07350553522582 0.368747065005926 0.811946599050792 7 APOE,RHOA GO:0048729 tissue morphogenesis GO_TISSUE_MORPHOGENESIS 0.246582174782148 1.04534272734974 0.369180275800005 0.811946599050792 58 COL3A1,GJA1,BMP10,ENG,COL4A1,PFN1,XIRP2,ARHGAP12,RHOA,LAMA5,TPM1,PRKACB,PHB2,FKBP1A,TXNRD1,TNNI3,RALA,ITGB1,DLL1,TNNC1,DAG1,TGM2 GO:0032147 activation of protein kinase activity GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY 0.323577185716656 1.05759456354131 0.369564184211777 0.811946599050792 20 UBC,PRKAG2,CRK,GNAI2,PARK7,SOD1,PRKACB GO:0034220 ion transmembrane transport GO_ION_TRANSMEMBRANE_TRANSPORT 0.234196449544668 1.0413858561986 0.369581270683478 0.811946599050792 74 GJA1,CACNA2D1,UBC,ATP5I,ANXA6,SLC25A20,NDUFA4,PRKAG2,CYB5A,UQCRH,COX7A2L,ERO1L GO:0007281 germ cell development GO_GERM_CELL_DEVELOPMENT -0.440964463057772 -1.07929958916526 0.371037644614778 0.813774413102881 9 RAN,PAFAH1B1 GO:0007179 transforming growth factor beta receptor signaling pathway GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY 0.360426397164053 1.06144556412321 0.371768826619965 0.813774413102881 14 COL3A1,UBC,COL1A2,ENG,RHOA,FKBP1A,ITGB1 GO:0071377 cellular response to glucagon stimulus GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS 0.453866715401879 1.06989323519366 0.372302600684273 0.813774413102881 7 GNAS,GNG12,PRKACB,GNB2 GO:0045785 positive regulation of cell adhesion GO_POSITIVE_REGULATION_OF_CELL_ADHESION 0.259168926520633 1.04561781225216 0.373322728788773 0.813774413102881 46 CD36,COL8A1,VTN,CD59,NID1,C1QBP,HLA-DRA,CDH13,TPM1,ANK3,FN1,LGALS1,MYADM,ITGB1,TGM2 GO:0031109 microtubule polymerization or depolymerization GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION 0.510719673338116 1.07630712846263 0.374675593745229 0.813774413102881 5 CRYAB,CAV1,TPPP3 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS -0.505276468850245 -1.08659705013972 0.3747836069756 0.813774413102881 6 FGA,FGB,FGG,PEA15 GO:0043085 positive regulation of catalytic activity GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY 0.202855165881845 1.03124881574891 0.374972585142714 0.813774413102881 163 PSMB3,UBC,APOE,ARHGDIB,PSMB2,PRKAG2,DIABLO,NCAM1,CRK,GNAI2,MIF,SPTAN1,PSMA6,SPTBN1,BCAP31,GNAS,PSMB1,PFN1,PDCD5,PPP1R12B,APOC2,PARK7,GNAO1,ARHGAP12,CLU,RHOA,SOD1,RAPGEF4,TPM1,PSMA4,PRKACB,APOA4,RGL2,PSMD14,PSMC6,HSPE1,FN1,IQGAP1,DNAJC1,PSMC1,HSPA5,PIN1,PSMA5,PSMA3,VAPB NA regulation of protein complex disassembly GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY -0.290940064399127 -1.05272067297173 0.376372805998872 0.813774413102881 38 EZR,RAN,TUBB,PPP2R1A,DYNC1H1,SPTB,RPS3,RANBP1,CAPZB NA modification of morphology or physiology of other organism GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM 0.338712320876558 1.05623607568629 0.376798242505846 0.813774413102881 17 APOE,CFL1,STOM,KPNB1,VAPB,DAG1,CTSG GO:0051346 negative regulation of hydrolase activity GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY -0.257992625443913 -1.04468834082033 0.377496968536601 0.813774413102881 65 SERPINB9,DNAJA3,LXN,SERPINF2,SERPINF1,APOC1,PRDX3,GPI,C3,SERPINA3,C5,SERPINA7,SERPINA1,AGT,SERPINA4,ITIH1,AQP1,SERPING1,AHSG GO:0086019 cell cell signaling involved in cardiac conduction GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION 0.508947375904162 1.07257213163071 0.378622990862103 0.813774413102881 5 GJA1,ANK2 GO:0007589 body fluid secretion GO_BODY_FLUID_SECRETION -0.45463989615987 -1.07260910782193 0.379739773606637 0.813774413102881 8 PAM,VAMP3,AQP1,NME1 GO:0032387 negative regulation of intracellular transport GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT 0.321441073880942 1.05061279732203 0.379877382253695 0.813774413102881 20 CD36,CRYAB,MAP1B,PARK7,FKBP1A,SRI,PLN GO:0043269 regulation of ion transport GO_REGULATION_OF_ION_TRANSPORT 0.237624058443173 1.03692083306315 0.380449673623983 0.813774413102881 67 GJA1,CACNA2D1,APOE,STOM,AHNAK,NPPA,GNAI2,MIF,S100A1,PARK7,PPIF,ANK2,DMD,GNAO1,ANK3,DPYSL2 GO:0060538 skeletal muscle organ development GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT -0.379734330765921 -1.06186972960716 0.38079997201672 0.813774413102881 14 CSRP3,EEF2 GO:1904377 positive regulation of protein localization to cell periphery GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY -0.502452235533589 -1.08052353637058 0.381343732346885 0.813774413102881 6 EZR,PIK3R1,DPP10 GO:0005996 monosaccharide metabolic process GO_MONOSACCHARIDE_METABOLIC_PROCESS -0.274879823480265 -1.04710254929602 0.381776051695441 0.813774413102881 48 PGM2,TALDO1,DCXR,ABHD10,ENO1,GPI,AKR1A1,GSTO1,CYB5R3,PGM5,GOT1,ALDH1A1,ENO3,DLAT,PDHA1,SLC25A11,PGK1,ALDH5A1,TPI1,PGM1,SLC25A12,PDHB,HK1,PGD,BPGM GO:0060998 regulation of dendritic spine development GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT 0.411899259919782 1.05581801788701 0.381868816084407 0.813774413102881 9 APOE,CFL1 GO:0006883 cellular sodium ion homeostasis GO_CELLULAR_SODIUM_ION_HOMEOSTASIS -0.537568306010929 -1.08697194741184 0.381892380987554 0.813774413102881 5 AGT,ATP1B1,ATP1A3,ATP1A1,SLC8A1 GO:0055078 sodium ion homeostasis GO_SODIUM_ION_HOMEOSTASIS -0.537568306010929 -1.08697194741184 0.381892380987554 0.813774413102881 5 AGT,ATP1B1,ATP1A3,ATP1A1,SLC8A1 GO:0048644 muscle organ morphogenesis GO_MUSCLE_ORGAN_MORPHOGENESIS 0.320910124079854 1.04887741655994 0.382063590133549 0.813774413102881 20 COL3A1,BMP10,XIRP2,TPM1,FKBP1A,TNNI3,TNNC1 GO:0021700 developmental maturation GO_DEVELOPMENTAL_MATURATION 0.396790914195096 1.05235694532841 0.382478583666476 0.813774413102881 10 GJA1,RHOA,MECP2,DAG1,CD63 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS -0.45328041620763 -1.06940175494553 0.38326704698832 0.813774413102881 8 FGA,FGB,FGG,PEA15 GO:0010212 response to ionizing radiation GO_RESPONSE_TO_IONIZING_RADIATION -0.397184547959704 -1.06229376189775 0.383923691309484 0.813774413102881 12 XRCC6,XRCC5 GO:0044283 small molecule biosynthetic process GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS -0.247629254503737 -1.04014304552176 0.384119901966945 0.813774413102881 80 TALDO1,COQ7,ENO1,ALDH4A1,VCAN,BCAT2,CBR1,BGN,AHCY,MTAP,GPI,BDH1,GLUD1,COQ9,AKR1A1,GSTO1,NDUFA9,CYB5R3,COQ3,GOT1,COQ5,PTGES2,ENO3,HSD17B4,ALDH1A2,SUCLA2,SLC25A11,PGK1,MTHFD1,ACAT1,TPI1,PGM1,ADI1,SLC25A12,ACAA2,COQ6 GO:0002703 regulation of leukocyte mediated immunity GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY -0.397083290182483 -1.06202294193348 0.384276319269355 0.813774413102881 12 SERPINB9,C3,VAMP3,HPX,IFNA2,HMGB1 GO:0070555 response to interleukin 1 GO_RESPONSE_TO_INTERLEUKIN_1 -0.452866159973835 -1.06842442098717 0.384544783774542 0.813774413102881 8 OTUB1,FGB,HSPA9 GO:0014044 schwann cell development GO_SCHWANN_CELL_DEVELOPMENT 0.449037399510016 1.05850916090934 0.384713432769069 0.813774413102881 7 LAMB2,LAMA2,SOD1,DAG1 GO:0014037 schwann cell differentiation GO_SCHWANN_CELL_DIFFERENTIATION 0.449037399510016 1.05850916090934 0.384713432769069 0.813774413102881 7 LAMB2,LAMA2,SOD1,DAG1 GO:0048640 negative regulation of developmental growth GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH 0.473713028104522 1.0610365384754 0.384865942831819 0.813774413102881 6 GJA1,GNAS,KCNK2,RBP4 GO:0048232 male gamete generation GO_MALE_GAMETE_GENERATION -0.312570275548168 -1.05038516643123 0.386086455721932 0.813774413102881 28 RAN,ARID4A,PAFAH1B1,DAZAP1,ACSBG2,IFT81,RUVBL1,PAFAH1B2 GO:0032922 circadian regulation of gene expression GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION -0.535767865428728 -1.08333142697202 0.386102596299442 0.813774413102881 5 NAMPT GO:0018209 peptidyl serine modification GO_PEPTIDYL_SERINE_MODIFICATION -0.535680736863258 -1.08315525158105 0.386287254865753 0.813774413102881 5 BGN,CAMK2D GO:0060193 positive regulation of lipase activity GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY 0.395459139380792 1.04882485216471 0.386544831524843 0.813774413102881 10 APOC2,RHOA,APOA4,ABL2,APOH GO:0071241 cellular response to inorganic substance GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE -0.320636186561077 -1.04791464648762 0.388016219163146 0.813774413102881 25 CLIC4,SERPINF1,PPP5C,CAMK2D,FUS,AQP1,ALAD,AIFM1,HNRNPD GO:0003158 endothelium development GO_ENDOTHELIUM_DEVELOPMENT 0.335778201670727 1.04708635669307 0.388066047764156 0.813774413102881 17 GJA1,ENG,RHOA,LAMA5,TJP1,GPX1,COL18A1,MYADM,DLL1,RDX GO:0009743 response to carbohydrate GO_RESPONSE_TO_CARBOHYDRATE 0.314884887469292 1.04290204216325 0.388995123816809 0.813774413102881 21 GJA1,PFKL,ME1,FN1,LGALS1 GO:0051648 vesicle localization GO_VESICLE_LOCALIZATION -0.335980719670951 -1.04933980766598 0.390124815184128 0.813774413102881 21 PAFAH1B1,ARF1,TMED9,LMAN1,SERPINA1,RAB11B,TFG,SEC22B,NAPA,ACTN4,SAR1B,CTNNB1 GO:0009799 specification of symmetry GO_SPECIFICATION_OF_SYMMETRY 0.503430222887965 1.06094510524001 0.390247093974222 0.813774413102881 5 GJA1,ENG,DLL1 GO:0010765 positive regulation of sodium ion transport GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT -0.433756210466045 -1.061656752355 0.390522583187077 0.813774413102881 9 PKP2,ARF1,GPD1L,ATP1B1,ACTN4,GLRX GO:0045444 fat cell differentiation GO_FAT_CELL_DIFFERENTIATION -0.450391097663886 -1.06258513059823 0.391185415804344 0.813774413102881 8 ALDH6A1,LRG1 GO:1901068 guanosine containing compound metabolic process GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS -0.533543759532005 -1.07883424830508 0.391402297152565 0.813774413102881 5 HPRT1,AK4 GO:0042168 heme metabolic process GO_HEME_METABOLIC_PROCESS -0.470628969829822 -1.06478109426421 0.391857184199103 0.813774413102881 7 BLVRA,HPX,ALAD GO:1904427 positive regulation of calcium ion transmembrane transport GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT 0.371966862226835 1.04492382152394 0.392473490886409 0.813774413102881 12 CACNA2D1,S100A1,ANK2,SRI,CALM1,JPH2 GO:0043523 regulation of neuron apoptotic process GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS 0.314034099192918 1.0400842224895 0.392676164069223 0.813774413102881 21 APOE,SET,PARK7,SOD1,GPX1,MECP2,PIN1 GO:0045184 establishment of protein localization GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION 0.194225072548955 1.02158913980062 0.392700191217418 0.813774413102881 210 CD36,RAB2A,RPS4X,MYO1C,RAB7A,ARL8B,COL1A1,APOE,FAM21C,RPS8,S100A13,RRBP1,TIMM8A,RPS23,CDC37,RPL14,SCARB2,SPTBN1,BCAP31,NACA,TIMM13,GNAS,RRAS,RPL18,RPL19,SDCBP,RPL35,RPL7A,ANK2,CLTA,CLU,AKAP12,RHOA,LAMA5,RAPGEF4,STX7,RPL24,ANK3,RPS21,CLTB,VPS13A,RPL3,PHB2,KPNB1 GO:0006816 calcium ion transport GO_CALCIUM_ION_TRANSPORT 0.318247009692477 1.04017317095022 0.392875813887173 0.813774413102881 20 CACNA2D1,ANXA6,ERO1L,ANK2,FKBP1A,SRI,PLN,NOL3,TPT1,CAV1,JPH2 NA mrna 3 end processing GO_MRNA_3_END_PROCESSING -0.432658093763655 -1.05896901444178 0.393602922740786 0.813774413102881 9 THOC4,SRSF7 GO:0080171 lytic vacuole organization GO_LYTIC_VACUOLE_ORGANIZATION 0.424472455949874 1.04690387506812 0.394023267850312 0.813774413102881 8 RAB7A GO:0051928 positive regulation of calcium ion transport GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT 0.346809714320705 1.04247947174617 0.39437445750346 0.813774413102881 15 CACNA2D1,S100A1,ANK2,SRI,CALM1,CAV1,JPH2,LGALS3,RYR2 GO:0016358 dendrite development GO_DENDRITE_DEVELOPMENT -0.496679540262779 -1.0681093551464 0.394955992492301 0.813774413102881 6 HPRT1,MATN2 GO:0048469 cell maturation GO_CELL_MATURATION 0.469114854982818 1.05073741347163 0.395546199867051 0.813774413102881 6 GJA1,MECP2 GO:0042787 protein ubiquitination involved in ubiquitin dependent protein catabolic process GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS 0.500614144752109 1.05501041125785 0.395917388175256 0.813774413102881 5 UBC,TCEB1 GO:0003081 regulation of systemic arterial blood pressure by renin angiotensin GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN -0.531680228811304 -1.07506615856859 0.396111090593493 0.813774413102881 5 SERPINF2,AGT GO:0001990 regulation of systemic arterial blood pressure by hormone GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE -0.531680228811304 -1.07506615856859 0.396111090593493 0.813774413102881 5 SERPINF2,AGT GO:0050886 endocrine process GO_ENDOCRINE_PROCESS -0.531680228811304 -1.07506615856859 0.396111090593493 0.813774413102881 5 SERPINF2,AGT GO:0051353 positive regulation of oxidoreductase activity GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY 0.468894276553338 1.05024335534066 0.396144471526701 0.813774413102881 6 APOE,PARK7,ABL2,CALM1 GO:0048814 regulation of dendrite morphogenesis GO_REGULATION_OF_DENDRITE_MORPHOGENESIS -0.448359982425397 -1.05779322227201 0.396242374070941 0.813774413102881 8 PAFAH1B1,YWHAH,CAPRIN2 GO:0009725 response to hormone GO_RESPONSE_TO_HORMONE -0.229718947417241 -1.03010816886572 0.397363236854069 0.813774413102881 119 NAMPT,HSP90AA1,EEF2,SERPINB9,RAN,KRT19,PAM,QDPR,SERPINF1,YWHAH,MTAP,PRKAR2A,PIK3R1,BDH1,OXCT1,C3,FGA,PTPN1,TBC1D4,FGB,YWHAG,LONP1,GSTM3,AGT,UBE2L3,GOT1,AQP1,ALAD,UQCRFS1,CYC1,PRKAR2B,AIFM1,HNRNPD,H2AFZ,CTSB,HMGB1,MAOB,NME1,MSN,ALDH1A2,ATP1A3,ANXA3,ATP2A2,ACAT1,PAQR8,CAT GO:0051347 positive regulation of transferase activity GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY 0.229514808889962 1.02633206320398 0.397688051279242 0.813774413102881 76 PSMB3,UBC,PSMB2,PRKAG2,CRK,GNAI2,MIF,PSMA6,PSMB1,PARK7,CLU,RHOA,SOD1,PSMA4,PRKACB,PSMD14,PSMC6,IQGAP1,PSMC1,HSPA5,PIN1,PSMA5,PSMA3,VAPB GO:0010664 negative regulation of striated muscle cell apoptotic process GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS 0.499672217933364 1.05302536426939 0.397836564674067 0.813774413102881 5 NACA,SIRT5,NOL3,ILK GO:0050852 t cell receptor signaling pathway GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0.279443787394662 1.03306980968087 0.398839774896497 0.813774413102881 32 PSMB3,UBC,PSMB2,PSMA6,HLA-DRA,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0001775 cell activation GO_CELL_ACTIVATION 0.24448804211351 1.02992938043094 0.398992284679578 0.813774413102881 56 BCL11B,COL3A1,COL1A1,S100A13,KRT2,MYL9,COL1A2,CD59,GNAS,CLU,CAST,RHOA,TOLLIP,FN1,LGALS1,FKBP1A GO:0051276 chromosome organization GO_CHROMOSOME_ORGANIZATION -0.248779307750154 -1.03145507770829 0.39902898847712 0.813774413102881 74 XRCC6,XRCC5,ARID4A,TRIM28,NAP1L4,H2AFY,PAFAH1B1,PPP5C,PPP2R1A,ANP32B GO:0055119 relaxation of cardiac muscle GO_RELAXATION_OF_CARDIAC_MUSCLE -0.447069559726878 -1.05474879271125 0.399067792034841 0.813774413102881 8 CAMK2D,GSTM2,ATP1B1,ATP2A2,PDE5A GO:0010596 negative regulation of endothelial cell migration GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION 0.405954464872401 1.04057977316452 0.399189440079698 0.813774413102881 9 APOE,BMP10,RHOA,APOH GO:0042147 retrograde transport endosome to golgi GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI 0.380589004224937 1.03977325564212 0.399213033273505 0.813774413102881 11 RAB7A,FAM21C GO:0042742 defense response to bacterium GO_DEFENSE_RESPONSE_TO_BACTERIUM -0.321785393673296 -1.03962182578013 0.399650810496226 0.813774413102881 24 RPL39,HP,FGA,IGJ,FGB,IGHG3,DROSHA,IGHG2,IGHA1 GO:0070167 regulation of biomineral tissue development GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT 0.498524871179346 1.05060740867724 0.40003925588293 0.813774413102881 5 GJA1,ASPN GO:1903827 regulation of cellular protein localization GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION -0.249720859298733 -1.03046921281856 0.400151476899773 0.813774413102881 72 HSP90AA1,EZR,TRIM28,H2AFY,HSP90AB1,ANP32B,YWHAH,PIK3R1,YWHAZ,PTPN1,CCT6A,YWHAB,YWHAG,DPP10,NPEPPS,YWHAQ,RAB11B,GPD1L,DYNLL2,UBE2L3,RUVBL1 GO:0006903 vesicle targeting GO_VESICLE_TARGETING -0.402123353132068 -1.04827817197406 0.400152088565062 0.813774413102881 11 TMED9,LMAN1,SERPINA1,TFG,SEC22B,NAPA,SAR1B GO:0006901 vesicle coating GO_VESICLE_COATING -0.402123353132068 -1.04827817197406 0.400152088565062 0.813774413102881 11 TMED9,LMAN1,SERPINA1,TFG,SEC22B,NAPA,SAR1B GO:0003018 vascular process in circulatory system GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM 0.338386564253235 1.03778341734542 0.40063417498532 0.813774413102881 16 GJA1,APOE,NPPA,SOD1,MYLK3,GPX1 GO:0034097 response to cytokine GO_RESPONSE_TO_CYTOKINE -0.24800660496741 -1.03036554412823 0.400866619396518 0.813774413102881 75 RPL13A,KRT8,KRT18,DNAJA3,DPYSL3,PSMD2,PSME2,PSMB6,HSP90AB1,OTUB1,BGN,CAMK2D,FGA,PSMA2,PSMA1,FGB,GSS,HSPA9,SYNCRIP GO:0003012 muscle system process GO_MUSCLE_SYSTEM_PROCESS 0.226903079382578 1.02505756451762 0.401045392022008 0.813774413102881 80 GJA1,CACNA2D1,CRYAB,TPM3,MYL9,NPPA,TPM2,NDUFS6,DYSF,SSPN,ANK2,DMD,GNAO1,SOD1,TMOD1,TPM1 GO:0050999 regulation of nitric oxide synthase activity GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY -0.414674157317515 -1.04934036420669 0.401813978303397 0.813774413102881 10 HSP90AA1,CYGB GO:0051917 regulation of fibrinolysis GO_REGULATION_OF_FIBRINOLYSIS -0.529476171337991 -1.07060951814321 0.401983233002179 0.813774413102881 5 SERPINF2 GO:0040007 growth GO_GROWTH 0.260748272125133 1.03008038840742 0.402024012847638 0.813774413102881 42 GJA1,LAMB2,NPPA,BMP10,PKM2,NACA,GNAS,MAP1B,NDUFS6,POSTN,IQGAP1,GPX1 NA modification by symbiont of host morphology or physiology GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY -0.429062235161235 -1.0501678319488 0.403237938321573 0.814147581895172 9 SERPINB9,VAPA GO:0061337 cardiac conduction GO_CARDIAC_CONDUCTION 0.331678828529283 1.03430292505265 0.404979566768242 0.814147581895172 17 GJA1,CACNA2D1,ANK2 GO:0044275 cellular carbohydrate catabolic process GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS 0.359889749615267 1.03556473176437 0.40522693452381 0.814147581895172 13 GYG1,SORD,PYGB GO:0043486 histone exchange GO_HISTONE_EXCHANGE 0.331508777999615 1.03377264170288 0.405570122599391 0.814147581895172 17 RBBP7,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0034508 centromere complex assembly GO_CENTROMERE_COMPLEX_ASSEMBLY 0.331508777999615 1.03377264170288 0.405570122599391 0.814147581895172 17 RBBP7,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0034724 dna replication independent nucleosome organization GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION 0.331508777999615 1.03377264170288 0.405570122599391 0.814147581895172 17 RBBP7,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0060537 muscle tissue development GO_MUSCLE_TISSUE_DEVELOPMENT 0.239700271151196 1.02385042443526 0.405842434524441 0.814147581895172 60 COL3A1,NEXN,NPPA,BMP10,ENG,FHL2,SGCD,XIRP2,TPM1,MYH10,MYLK3,GPX1,SGCG,FKBP1A,TNNI3,MYH11,ITGB1,DLL1,COPS2,TNNC1,PLN GO:0050900 leukocyte migration GO_LEUKOCYTE_MIGRATION 0.306840088416432 1.02930089435423 0.405845401361849 0.814147581895172 22 COL1A1,COL1A2,MIF,FN1,ITGB1 GO:0043405 regulation of map kinase activity GO_REGULATION_OF_MAP_KINASE_ACTIVITY 0.29030362489639 1.02851590628661 0.405857434998539 0.814147581895172 27 UBC,APOE,CRK,GNAI2,MIF GO:0016042 lipid catabolic process GO_LIPID_CATABOLIC_PROCESS -0.276660196492599 -1.02918643075682 0.408484051298915 0.818598777453314 43 GCDH,ECI2,PCCB,PAFAH1B1,IVD,YWHAH,ACAD10,ETFA,ECHS1,ACADVL,CRAT,PAFAH1B2,MCEE,PCCA,HSD17B4 GO:0032371 regulation of sterol transport GO_REGULATION_OF_STEROL_TRANSPORT 0.366989823384272 1.03094239743657 0.409637997551228 0.81918590674682 12 APOE,APOC2,APOA4,PON1,APOC3,SCP2,LRP1 GO:0031032 actomyosin structure organization GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION -0.294409567004462 -1.03140908624807 0.41025469616953 0.81918590674682 33 KRT8,CSRP3,KRT19,MYOZ1,MYL2,LDB3,NEBL GO:0032233 positive regulation of actin filament bundle assembly GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY 0.41840074235181 1.03192881507302 0.410292760863206 0.81918590674682 8 PFN1,RHOA,TPM1,PFN2 GO:0051348 negative regulation of transferase activity GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY -0.262152229118784 -1.0262173407849 0.410487836438923 0.81918590674682 55 GBAS,DNAJA3,PSMD2,PSME2,H2AFY,PSMB6,PPP2R1A,PRDX3,BGN,PRKAR2A,PSMA2,PSMA1,PTPN1,YWHAG GO:1901659 glycosyl compound biosynthetic process GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS -0.304138421325488 -1.03122676302342 0.410816836700223 0.81918590674682 29 GBAS,HPRT1,ADA,MTAP,AK4,ATP5D,ADK,ATP5J2,ATP5F1,ATP5A1,STOML2 GO:0061387 regulation of extent of cell growth GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH 0.417834402935991 1.03053201553818 0.411957964850694 0.8195792521699 8 APOE,MAP1B,DPYSL2,FN1 GO:1901137 carbohydrate derivative biosynthetic process GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS -0.253861473682331 -1.02511349660219 0.412294571414882 0.8195792521699 64 GBAS,HPRT1,DCXR,ADA,VCAN,RPN2,BGN,MTAP,AK4,LMAN1,AKR1A1,PRELP,ATP5D,ADK,ATP5J2,ATP5F1,OGN,FMOD,AQP1,ATP5A1 NA negative regulation of stat cascade GO_NEGATIVE_REGULATION_OF_STAT_CASCADE -0.462630096268141 -1.04668393091498 0.412729706265374 0.8195792521699 7 PPP2R1A,BGN GO:0006000 fructose metabolic process GO_FRUCTOSE_METABOLIC_PROCESS 0.492611003280548 1.03814433253479 0.412950079602207 0.8195792521699 5 SORD,ALDOC,ALDOA,AKR1B1 GO:0000226 microtubule cytoskeleton organization GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION -0.296473607533071 -1.03104429727398 0.413123271599765 0.8195792521699 32 EZR,RAN,PAFAH1B1,TUBB,PPP2R1A,DYNC1H1,RPS3,RANBP1 GO:0034504 protein localization to nucleus GO_PROTEIN_LOCALIZATION_TO_NUCLEUS -0.350679370779134 -1.0352156321301 0.413463039067783 0.8195792521699 17 TOR1AIP1,RAN,PIK3R1,RANBP1,AGT GO:0032386 regulation of intracellular transport GO_REGULATION_OF_INTRACELLULAR_TRANSPORT -0.241668496491369 -1.02178479478979 0.414806570944887 0.819600768492247 83 HSP90AA1,EZR,TRIM28,HRC,HSP90AB1,ANP32B,YWHAH,ARF1,PIK3R1,CAMK2D,YWHAZ,PTPN1,YWHAB,YWHAG,VAMP3,NPEPPS,YWHAQ,GSTO1,RAB11B,EHD1,DYNLL2,UBE2L3,GSTM2,RUVBL1,SNX3 GO:0098911 regulation of ventricular cardiac muscle cell action potential GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL -0.488768822472453 -1.0510973564776 0.415110155438526 0.819600768492247 6 PKP2,DSP,JUP,DSG2 GO:0090288 negative regulation of cellular response to growth factor stimulus GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS 0.341401836158195 1.02622386604273 0.41576934806578 0.819600768492247 15 UBC,FBN1,ENG,HSPA5,PIN1,ASPN GO:0030262 apoptotic nuclear changes GO_APOPTOTIC_NUCLEAR_CHANGES 0.491354586859692 1.03549652000537 0.415894270821975 0.819600768492247 5 H1F0,KPNB1 GO:0072528 pyrimidine containing compound biosynthetic process GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS 0.460866890924976 1.03226337810802 0.415931752714381 0.819600768492247 6 CMPK1,NME2,ERH GO:1903311 regulation of mrna metabolic process GO_REGULATION_OF_MRNA_METABOLIC_PROCESS -0.369327416303818 -1.03276836438788 0.416146352554349 0.819600768492247 14 SRSF7,DAZAP1,HNRNPA2B1,SYNCRIP,HNRNPL,HSPA1A,U2AF2,SRSF2 GO:1903312 negative regulation of mrna metabolic process GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS -0.488309652650826 -1.05010991177267 0.416331067660404 0.819600768492247 6 SRSF7,HNRNPA2B1,SYNCRIP GO:0034612 response to tumor necrosis factor GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR 0.273970288447353 1.02070568429552 0.418488273664293 0.822598136280621 33 PSMB3,UBC,COL1A1,PSMB2,PSMA6,PSMB1,POSTN,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0030307 positive regulation of cell growth GO_POSITIVE_REGULATION_OF_CELL_GROWTH 0.356043439309447 1.02449716647698 0.418712797619048 0.822598136280621 13 MAP1B,SDCBP,FN1,PIN1 GO:0033574 response to testosterone GO_RESPONSE_TO_TESTOSTERONE -0.522592815165701 -1.05669125886404 0.419082616242567 0.822598136280621 5 MTAP,NME1,MSN GO:0032091 negative regulation of protein binding GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING 0.364115239442536 1.02286715863785 0.419895118626839 0.823388084182318 12 PARK7,ANXA2,HSPA5,PIN1,B2M,CAV1,LRPAP1 GO:0010822 positive regulation of mitochondrion organization GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION -0.316957980491605 -1.02402545563898 0.420585063590147 0.823936397745381 24 YWHAH,YWHAZ,YWHAB,YWHAG,NPEPPS,YWHAQ,DYNLL2,UBE2L3,RUVBL1 GO:2000008 regulation of protein localization to cell surface GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE -0.486211282451244 -1.04559736664237 0.421579167957432 0.825078917405968 6 RAB11B,GPD1L,CTNNB1,ACTN2 GO:0016310 phosphorylation GO_PHOSPHORYLATION -0.217658234090212 -1.01577242367755 0.423396849743378 0.82775179442186 157 MARK1,GBAS,HSP90AA1,ERLIN2,PSMD2,TRIM28,PSME2,ENO1,PSMB6,PPP5C,SPTB,NDUFB8,NDUFV1,GPI,NDUFC2,PIK3R1,CAMK2D,NDUFB9,PSMA2,PSMA1,AK4,COQ9,OGDH,NDUFS3,PTPN1,NDUFA10,DBNL,COX5A,YWHAB,NDUFS8,ATP5D,ADK,NDUFA5,AGT,NDUFA9,PEA15,NDUFB2,NDUFB3,PSMC2,NDUFS7,COX4I1,COX6C,UQCRFS1,CYC1,NDUFB11,PDXK,ENO3,OBSCN,PSMC3,NME1,CKM,PSMD11,NDUFA7,UQCRC2,PGK1,DYRK4,EFEMP1,NDUFB10,NDUFS4,PSMA7,PRDX4,NDUFA3,TPI1,PGM1,UQCR10 GO:2000249 regulation of actin cytoskeleton reorganization GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION 0.487544437813132 1.02746688889186 0.424094388589623 0.82775179442186 5 ARHGDIB,HCLS1,ABL2 GO:0031400 negative regulation of protein modification process GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS -0.238533395630713 -1.01765893248184 0.424181571942278 0.82775179442186 87 DNAJA3,EZR,PSMD2,PSME2,H2AFY,PAFAH1B1,PSMB6,PPP5C,PPP2R1A,OTUB1,BGN,PARD3,RPS3,PRKAR2A,STRAP,PSMA2,PSMA1,PTPN1,YWHAB,YWHAG GO:1903391 regulation of adherens junction organization GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION -0.520127137332439 -1.05170561777221 0.425157883074196 0.82787727242874 5 LIMS1 GO:0045786 negative regulation of cell cycle GO_NEGATIVE_REGULATION_OF_CELL_CYCLE 0.299147250305489 1.01506232623838 0.426435176266615 0.82787727242874 23 UBC,PRKAG2,MIF,CAST,PRKACB,PRKAA2,AK1 GO:0007229 integrin mediated signaling pathway GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY 0.362306818832461 1.01778697014071 0.426756300967958 0.82787727242874 12 COL3A1,LAMA5,NME2,ITGB1 GO:0006109 regulation of carbohydrate metabolic process GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS 0.353412208011831 1.01692593018632 0.427850632440476 0.82787727242874 13 PRKAG2,MLYCD,PRKAA2,PGAM2 GO:0048732 gland development GO_GLAND_DEVELOPMENT -0.279739394707838 -1.01839797374302 0.428133847707668 0.82787727242874 39 EZR,PAM,QDPR,MPST,ADA,BDH1,FGA,AK4 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION 0.432602258566384 1.01976684842345 0.428296697153335 0.82787727242874 7 CD36,CLU GO:0003013 circulatory system process GO_CIRCULATORY_SYSTEM_PROCESS 0.235382411417315 1.01123099524744 0.428723574205229 0.82787727242874 62 GJA1,CACNA2D1,APOE,COL1A2,NPPA,ENG,SGCD,ANK2,DMD,POSTN,SOD1,TPM1,MYLK3,GPX1,SGCG,MECP2,TNNI3 GO:0046631 alpha beta t cell activation GO_ALPHA_BETA_T_CELL_ACTIVATION 0.485465943997641 1.02308660391976 0.429023182779753 0.82787727242874 5 BCL11B,ANXA1,HMGB1,RPL22,STOML2 GO:0072594 establishment of protein localization to organelle GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE -0.237593032318514 -1.01546825914245 0.429502839803937 0.82787727242874 88 RPL39,RPL13A,HSP90AA1,TOMM40,RAN,MTX2,RPS2,RPL10A,H2AFY,RPS3,MFN2,PIK3R1,RPL10,RANBP1 GO:0030855 epithelial cell differentiation GO_EPITHELIAL_CELL_DIFFERENTIATION 0.235263056263541 1.01071823122989 0.429655466212258 0.82787727242874 62 BCL11B,GJA1,LAMB2,KRT2,ENG,COL4A1,TAGLN,PTER,FNDC3A,LAMA5,SOD1,TMOD1,TOLLIP,IQGAP1,TJP1,GPX1,ALDOC,COL18A1,MYADM,DLL1,RDX,ANXA4 GO:1900101 regulation of endoplasmic reticulum unfolded protein response GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE -0.517581102510392 -1.04655749352874 0.43132547918898 0.82787727242874 5 PIK3R1,PTPN1 GO:0009894 regulation of catabolic process GO_REGULATION_OF_CATABOLIC_PROCESS 0.21374531506296 1.01054296005589 0.431797314357856 0.82787727242874 103 MAP1LC3B,PSMB3,GJA1,RAB7A,UBC,APOE,PSMB2,PRKAG2,PSMA6,BCAP31,PSMB1,SDCBP,APOC2,PARK7,CLU,PSMA4,APOA4,PSMD14,PSMC6,PRKAA2,GPX1,ANXA2,PSMC1,PIN1,PSMA5,PSMA3,SLIRP,ITGB1,RDX,ABL2,CD81,APOH,PGAM2 GO:0006584 catecholamine metabolic process GO_CATECHOLAMINE_METABOLIC_PROCESS -0.455411097080479 -1.03035120524935 0.431811604688178 0.82787727242874 7 HPRT1 GO:0006778 porphyrin containing compound metabolic process GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS -0.43525979874235 -1.02688661585392 0.432180970720032 0.82787727242874 8 BLVRA,HPX,ALAD,SUCLA2 GO:0033013 tetrapyrrole metabolic process GO_TETRAPYRROLE_METABOLIC_PROCESS -0.43525979874235 -1.02688661585392 0.432180970720032 0.82787727242874 8 BLVRA,HPX,ALAD,SUCLA2 GO:1903035 negative regulation of response to wounding GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING 0.279947867694946 1.01078234488374 0.432423157997941 0.82787727242874 29 GJA1,APOE,VTN,SERPINC1 GO:0006826 iron ion transport GO_IRON_ION_TRANSPORT -0.419145568166435 -1.02589591094374 0.432429528278233 0.82787727242874 9 FTL,RAB11B,CLTC,FTH1,SFXN1 GO:1903320 regulation of protein modification by small protein conjugation or removal GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL -0.267610208381639 -1.01475564238509 0.432575547093337 0.82787727242874 47 HSP90AA1,DNAJA3,PSMD2,PSME2,PSMB6,HSP90AB1,DYNC1LI1,OTUB1,RPS3,PSMA2,PSMA1 GO:1901379 regulation of potassium ion transmembrane transport GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT 0.370447589638396 1.01206680184444 0.432854710294997 0.82787727242874 11 NPPA,ANK2,ANK3,CAV1,YWHAE GO:0043266 regulation of potassium ion transport GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT 0.370447589638396 1.01206680184444 0.432854710294997 0.82787727242874 11 NPPA,ANK2,ANK3,CAV1,YWHAE GO:0032970 regulation of actin filament based process GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS -0.247268545848777 -1.01277030195162 0.433541042350442 0.82787727242874 69 CSRP3,EZR,ARPC3,ARHGDIA,SERPINF2,ACTR3,PAM,PKP2,SPTB,ARF1,PIK3R1,CAMK2D GO:0032722 positive regulation of chemokine production GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION 0.483324492753807 1.01857364043056 0.433842932850631 0.82787727242874 5 MIF,POSTN GO:0019748 secondary metabolic process GO_SECONDARY_METABOLIC_PROCESS -0.434564997941244 -1.02524740716659 0.433908614825346 0.82787727242874 8 PAM,AKR7A2 GO:0051056 regulation of small gtpase mediated signal transduction GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION 0.297715782147711 1.01020508821702 0.434140820651127 0.82787727242874 23 COL3A1,APOE,ARHGDIB,CRK,ARHGAP12,RHOA GO:0050773 regulation of dendrite development GO_REGULATION_OF_DENDRITE_DEVELOPMENT -0.372386422281902 -1.01984237659697 0.435030528458137 0.828084064980912 13 PAFAH1B1,YWHAH,ARF1,CAPRIN2 GO:0032088 negative regulation of nf kappab transcription factor activity GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY -0.515813799752597 -1.04298397831434 0.435074048085091 0.828084064980912 5 DNAJA3 GO:0050715 positive regulation of cytokine secretion GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION 0.429424349513649 1.01227561083716 0.436436414052193 0.829220211153467 7 MIF,SPTBN1,POSTN,NCL,CD34 GO:0032272 negative regulation of protein polymerization GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION 0.329404835062705 1.01023773262361 0.436617733411627 0.829220211153467 16 SPTAN1,SPTBN1,PFN1,TMOD1,MYADM,PFN2,RDX,TMOD3 GO:0007015 actin filament organization GO_ACTIN_FILAMENT_ORGANIZATION -0.271860498384946 -1.01133137163827 0.437076619533048 0.829220211153467 43 EZR,DPYSL3,ARPC3,SORBS2,ACTR3 GO:1902175 regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 0.393693999871042 1.00915262309237 0.437906129010347 0.829220211153467 9 PARK7,SOD1,GPX1,NOL3 GO:0022407 regulation of cell cell adhesion GO_REGULATION_OF_CELL_CELL_ADHESION -0.288854114560071 -1.01194659327387 0.438130891102346 0.829220211153467 33 DNAJA3,SERPINF2,ADA,PIK3R1,FGA,FGB,ADK,FGG GO:1903201 regulation of oxidative stress induced cell death GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH 0.368936194870957 1.00793765507337 0.438239219476276 0.829220211153467 11 PARK7,SOD1,GPX1,NOL3,PSAP GO:0010038 response to metal ion GO_RESPONSE_TO_METAL_ION -0.247740629901521 -1.00895772826628 0.438773397052967 0.829220211153467 67 CLIC4,PAM,QDPR,SERPINF1,PPP5C,CAMK2D,BDH1,C3,FGA,FUS,ACO1,FGB,ATP5D,LONP1,GSS,FGG GO:0001895 retina homeostasis GO_RETINA_HOMEOSTASIS -0.35587764479189 -1.01510200727625 0.439442265795207 0.829220211153467 15 IGJ,IGHG3,ACTG1,IGHA1,ALB,IGKC,LTF,HSPB1 GO:1902305 regulation of sodium ion transmembrane transport GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT -0.362719316934664 -1.01428981209004 0.439652307746122 0.829220211153467 14 YWHAH,ARF1,CAMK2D,AGT,GPD1L,ATP1B1,ACTN4,GLRX GO:0045930 negative regulation of mitotic cell cycle GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE 0.451111152579226 1.01041218502164 0.440283625083093 0.829220211153467 6 UBC,TOM1L2 GO:0045667 regulation of osteoblast differentiation GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION 0.40819756646706 1.00676406239703 0.440626476743401 0.829220211153467 8 GJA1,GNAS GO:0045669 positive regulation of osteoblast differentiation GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION 0.40819756646706 1.00676406239703 0.440626476743401 0.829220211153467 8 GJA1,GNAS GO:2000278 regulation of dna biosynthetic process GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS 0.323114164856775 1.00759498976523 0.44145229489996 0.829781578390207 17 GJA1,CCT8,TCP1,HNRNPA1,KCNK2 GO:0050795 regulation of behavior GO_REGULATION_OF_BEHAVIOR 0.479556000035324 1.01063179720773 0.442152094737531 0.829781578390207 5 GJA1,RETN GO:0043462 regulation of atpase activity GO_REGULATION_OF_ATPASE_ACTIVITY 0.296095667509878 1.00470773755987 0.442544789057985 0.829781578390207 23 TPM2,PFN1,PPIF,TPM1,DNAJC1,TNNI3,PFN2,TNNC1,PLN GO:1900034 regulation of cellular response to heat GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT -0.388738964425115 -1.01338698145396 0.442577724330633 0.829781578390207 11 HSP90AA1,HSP90AB1,CAMK2D GO:1904062 regulation of cation transmembrane transport GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT 0.260040173462169 1.00434326545693 0.443233309837881 0.830235528129166 38 CACNA2D1,STOM,AHNAK,NPPA,S100A1,PPIF,ANK2,DMD,ANK3 GO:0061326 renal tubule development GO_RENAL_TUBULE_DEVELOPMENT 0.449332489093157 1.00642828161092 0.444848216264126 0.830434185420616 6 COL4A1,LAMA5,DLL1,ILK GO:0006369 termination of rna polymerase ii transcription GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION -0.401046043172984 -1.01485417786612 0.445082696069714 0.830434185420616 10 THOC4,SRSF7 GO:0032880 regulation of protein localization GO_REGULATION_OF_PROTEIN_LOCALIZATION -0.223349247354328 -1.00645580653563 0.4452251435479 0.830434185420616 123 HSP90AA1,EZR,TRIM28,PAM,H2AFY,HSP90AB1,ANP32B,YWHAH,ARF1,ERP29,PIK3R1,GLUD1,OXCT1,FGA,BRP44,YWHAZ,C5,PTPN1,FGB,CCT6A,YWHAB,YWHAG,VAMP3,DPP10,NPEPPS,FGG,YWHAQ,RAB11B,GPD1L,DYNLL2,UBE2L3,RUVBL1,SNX3 GO:0019953 sexual reproduction GO_SEXUAL_REPRODUCTION -0.271641293337791 -1.0052693948112 0.445296430980863 0.830434185420616 42 CLIC4,RAN,EIF4H,ARID4A,PAFAH1B1,DAZAP1,ACSBG2 GO:1903727 positive regulation of phospholipid metabolic process GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS 0.478077666963918 1.00751631036424 0.445859594792053 0.830434185420616 5 FABP3,APOC2,CD81,CDC42 GO:0070647 protein modification by small protein conjugation or removal GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL -0.256745762690471 -1.00505326516458 0.445878623188406 0.830434185420616 55 EIF3F,PSMD2,TRIM28,NEDD8,PSME2,UBA1,PSMB6,OTUB1,PSMA2,PSMA1,NPEPPS,UBE2L3,PSMC2,HNRNPC,UBR4,CAND1 GO:0007029 endoplasmic reticulum organization GO_ENDOPLASMIC_RETICULUM_ORGANIZATION -0.475964474260392 -1.02356160554931 0.446234305811178 0.830434185420616 6 RTN4,VAPA,LMAN1 GO:0001906 cell killing GO_CELL_KILLING -0.4494874185571 -1.01694909593493 0.447257994501519 0.830529907198327 7 TUBB,ALB,TUBB4B GO:0051961 negative regulation of nervous system development GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT -0.307621002897106 -1.00537795799191 0.447628458498024 0.830529907198327 25 DPYSL3,ARHGDIA,PAFAH1B1,RTN4,YWHAH GO:0033138 positive regulation of peptidyl serine phosphorylation GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION 0.356578071124246 1.00169385659834 0.447732575600065 0.830529907198327 12 HCLS1,MIF,PARK7,PFN2,CAV1,CDC42 GO:0071214 cellular response to abiotic stimulus GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS 0.285442845585629 1.00158337314649 0.447940184011847 0.830529907198327 26 GJA1,COL1A1,CRYAB,NPPA GO:0033674 positive regulation of kinase activity GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY 0.253550921707146 1.00164741182951 0.449183002370695 0.83084398496179 42 UBC,PRKAG2,CRK,GNAI2,MIF,PARK7,CLU,RHOA,SOD1,PRKACB,IQGAP1,HSPA5,VAPB GO:0000726 non recombinational repair GO_NON_RECOMBINATIONAL_REPAIR -0.321791203133221 -1.00502290588317 0.449300278513221 0.83084398496179 21 XRCC6,XRCC5 GO:0022412 cellular process involved in reproduction in multicellular organism GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM -0.399628050966143 -1.01126592325099 0.449350880313 0.83084398496179 10 RAN,PAFAH1B1 GO:0007018 microtubule based movement GO_MICROTUBULE_BASED_MOVEMENT -0.321357759570359 -1.00366916872428 0.450916342880721 0.832430620945369 21 ACTR3,PAFAH1B1,DYNC1LI1,DYNC1I2,DYNC1H1,ACTR2,IFT81 GO:0045778 positive regulation of ossification GO_POSITIVE_REGULATION_OF_OSSIFICATION 0.389523541863705 0.99846252205202 0.45103810537279 0.832430620945369 9 GJA1,GNAS GO:0030308 negative regulation of cell growth GO_NEGATIVE_REGULATION_OF_CELL_GROWTH -0.334753815770501 -1.00435406429066 0.451455557662145 0.83243595939907 18 ENO1,RTN4,PPP2R1A,MYL2,CAPRIN2,NDUFS3,AGT GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II 0.325821002332016 0.99924662785957 0.452025836758661 0.832722825882011 16 RAB7A,KIF5A,DCTN2,HLA-DRA,CLTA GO:0010256 endomembrane system organization GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION -0.253907512325412 -1.00130034539287 0.453575171301894 0.834426560483524 57 KRT18,EZR,TOR1AIP1,PKP2,PAFAH1B1,RTN4,PPP2R1A,VAPA,TMED9,YWHAZ,LMAN1,VAMP3,DPP10 GO:0050764 regulation of phagocytosis GO_REGULATION_OF_PHAGOCYTOSIS 0.338740190707905 0.997580298352842 0.453870402802102 0.834426560483524 14 CD36,C4B,LMAN2 NA movement in environment of other organism involved in symbiotic interaction GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION 0.374199423465537 0.992440472132945 0.454391776127927 0.834426560483524 10 NCAM1,SCARB2,ITGB1,DAG1,CD81,CAV1 GO:0006275 regulation of dna replication GO_REGULATION_OF_DNA_REPLICATION -0.329420819139056 -1.00219507421864 0.454612877076183 0.834426560483524 19 ESCO2,PPP2R1A,CCT6A,S100A11,HNRNPC,STOML2 GO:0001885 endothelial cell development GO_ENDOTHELIAL_CELL_DEVELOPMENT -0.37467348849561 -1.00208659078483 0.456811890614807 0.836215234111466 12 CLIC4,EZR GO:0006910 phagocytosis recognition GO_PHAGOCYTOSIS_RECOGNITION 0.402439756827668 0.992563204040054 0.457413533157812 0.836215234111466 8 CD36,IGLC7,IGHG1,IGHM,IGKC,IGHA1,IGHG2,IGHG3 GO:0030216 keratinocyte differentiation GO_KERATINOCYTE_DIFFERENTIATION 0.402291669845201 0.992197967536204 0.457931096559329 0.836215234111466 8 BCL11B,KRT2 GO:0001824 blastocyst development GO_BLASTOCYST_DEVELOPMENT -0.4712491992924 -1.01342140669446 0.459500337117554 0.836215234111466 6 ADA,MFN2 GO:0003007 heart morphogenesis GO_HEART_MORPHOGENESIS 0.267203454456757 0.995495118733722 0.45951800029876 0.836215234111466 33 GJA1,BMP10,WHSC1,ENG,FHL2,XIRP2,TPM1,FKBP1A,TNNI3,DLL1,TNNC1 NA regulation of transcription factor import into nucleus GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS 0.386607706710017 0.990988385553082 0.460207847487943 0.836215234111466 9 CD36,HCLS1,RHOA,SRI,NOL3,FLNA GO:1903725 regulation of phospholipid metabolic process GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS -0.410241707182285 -1.00410292237605 0.460313764819657 0.836215234111466 9 APOC1,ARF1,PIK3R1 GO:0032881 regulation of polysaccharide metabolic process GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS -0.504800115782842 -1.02071412836426 0.460778520515567 0.836215234111466 5 HMGB1,CLTC,SORBS1,PPP1CB GO:0051604 protein maturation GO_PROTEIN_MATURATION -0.282560327195349 -0.996677871890954 0.460857362424404 0.836215234111466 34 DNAJA3,ANP32B,AEBP1,FGA,FGB,FGG,AGT,CAPN1,STOML2,AIFM1 GO:0000187 activation of mapk activity GO_ACTIVATION_OF_MAPK_ACTIVITY -0.409964266607595 -1.00342386199054 0.46120921236434 0.836215234111466 9 ERP29,C5,PTPN1,DBNL,PEA15 GO:0002275 myeloid cell activation involved in immune response GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 0.471422023269392 0.993489991961225 0.461213006782544 0.836215234111466 5 S100A13,STXBP2 GO:0042493 response to drug GO_RESPONSE_TO_DRUG -0.255454488036673 -0.996307118509685 0.461746685253023 0.836215234111466 54 EEF2,COQ7,PAM,QDPR,ADA,RPN2,BDH1,OXCT1,AK4,NDUFA10,ADD3,AQP1,ALAD,UQCRFS1,PRKAR2B,ENO3,SRP14,HNRNPD,MAOB,NME1 GO:1901653 cellular response to peptide GO_CELLULAR_RESPONSE_TO_PEPTIDE -0.290966188928577 -0.995511360762029 0.462509692862682 0.836215234111466 30 NAMPT,PRKAR2A,PIK3R1,PTPN1,TBC1D4,YWHAG,AGT,GOT1,PRKAR2B,CTNNB1,PRKAR1A,ANXA5,ACTN2,GRB2,RAB10,SORBS1,SLC2A4,CA2 GO:0086005 ventricular cardiac muscle cell action potential GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL -0.504176024155617 -1.01945220483971 0.462662037891938 0.836215234111466 5 PKP2,GPD1L GO:0072657 protein localization to membrane GO_PROTEIN_LOCALIZATION_TO_MEMBRANE -0.23211055225501 -0.996948057092245 0.462693986609293 0.836215234111466 91 RPL39,RPL13A,HSP90AA1,KRT18,DNAJA3,EZR,FERMT2,RPS2,RPL10A,PKP2 GO:0060627 regulation of vesicle mediated transport GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT 0.231878055741829 0.992669599929934 0.463421773957474 0.836215234111466 61 CD36,RAB7A,EHD4,VTN,PACSIN2,EHD2,ATAD1,CDH13,SDCBP,APOC2,RAPGEF4,ANXA2,RALA,PFN2,ITGB1,DLL1,RDX,C4B,ABL2,TF,LMAN2,B2M,CD63 GO:0006893 golgi to plasma membrane transport GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT -0.443223402218924 -1.00277698457199 0.4635183041528 0.836215234111466 7 KRT18,VAMP3,C16orf62 GO:0006103 2 oxoglutarate metabolic process GO_2_OXOGLUTARATE_METABOLIC_PROCESS -0.395236659663525 -1.00015342909733 0.463524808820914 0.836215234111466 10 OGDH,IDH2,GOT1 NA rna 3 end processing GO_RNA_3_END_PROCESSING -0.382339184015698 -0.996703667599225 0.463693276270647 0.836215234111466 11 THOC4,SRSF7,RPSA GO:1903305 regulation of regulated secretory pathway GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY -0.443076677899906 -1.00244502608457 0.463916220518015 0.836215234111466 7 ARF1,VAMP3,NAPA,ATP2A2 GO:0050000 chromosome localization GO_CHROMOSOME_LOCALIZATION -0.503526988241528 -1.01813984355727 0.464453225985153 0.836432356751738 5 ACTR3,ACTR2 GO:0007186 g protein coupled receptor signaling pathway GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY 0.260265543709877 0.99194019907782 0.464987115658853 0.836643484088688 36 APOE,NPPA,GNAI2,GNAS,GNG12,GNAO1,AKAP12,OR8J3,RAPGEF4,PRKACB,GNB2,OR4K15,TGM2,GNA11,PLN,KCNK2,PSAP,APOC3,CALM1,FLNA,CAV1 GO:0046661 male sex differentiation GO_MALE_SEX_DIFFERENTIATION -0.408532920639904 -0.999920515929113 0.465525269529711 0.836861899029239 9 ARID4A,HSD17B10,HSD17B4,PRDX4,CTNNB1 GO:0030832 regulation of actin filament length GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH 0.267965718263374 0.990636779397694 0.466172496715175 0.837058930366541 32 FAM21C,HCLS1,SPTAN1,SPTBN1,ARPC5L,CFL2,PFN1,TMOD1,DSTN,MYADM,PFN2,RDX,TMOD3 GO:0060759 regulation of response to cytokine stimulus GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS -0.355348530500378 -0.993678520553193 0.466533746086713 0.837058930366541 14 DNAJA3,PAFAH1B1,HSP90AB1,PTPN1,HPX GO:0050776 regulation of immune response GO_REGULATION_OF_IMMUNE_RESPONSE 0.204160966724889 0.994201838512256 0.466885459168588 0.837058930366541 123 CD36,MYO1C,PSMB3,COL3A1,UBC,COL1A1,VTN,PSMB2,COL1A2,CDC37,CD59,CRK,MIF,WHSC1,C1QBP,PSMA6,AMBP,HLA-DRA,PSMB1,CLU,STX7,PSMA4,PRKACB,PHB2,PSMD14,PSMC6,GPX1,PSMC1,FKBP1A,PSMA5,PSMA3 GO:0033365 protein localization to organelle GO_PROTEIN_LOCALIZATION_TO_ORGANELLE -0.223940034993696 -0.994845521208984 0.468558971935548 0.837764630087857 112 RPL39,RPL13A,HSP90AA1,CSRP3,TOR1AIP1,TOMM40,RAN,MTX2,RPS2,RPL10A,ESCO2,H2AFY,VAPA,RPS3,MFN2,PIK3R1,RPL10,RANBP1,RPSA,MTCH2,MAPRE1,AGT,EHD1 GO:0048870 cell motility GO_CELL_MOTILITY 0.22793573704594 0.991876381649576 0.469271043093033 0.837764630087857 66 GJA1,LAMC1,COL1A1,SORD,DNAH6,KRT2,COL1A2,MIF,ENG,CDH13,SDCBP,RHOA,LAMA5,MYH10,LAMB1,FN1,GPX1 GO:0046822 regulation of nucleocytoplasmic transport GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT -0.3261288878363 -0.992180050441722 0.46934234809155 0.837764630087857 19 HSP90AA1,TRIM28,HSP90AB1,ANP32B,PIK3R1 GO:0045834 positive regulation of lipid metabolic process GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS 0.306414604577668 0.986646586945732 0.469362016038836 0.837764630087857 19 APOE,MLYCD,FABP3,APOC2,APOA4,CD81,APOH GO:0060192 negative regulation of lipase activity GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY -0.501502054125625 -1.0140453935037 0.469365143849023 0.837764630087857 5 APOC1 GO:0022600 digestive system process GO_DIGESTIVE_SYSTEM_PROCESS -0.440795762299031 -0.997284536686095 0.469866878888728 0.837915357734073 7 EZR,STRAP,SERPINA3,ACO1,AQP1 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION -0.380133912916847 -0.990954840682794 0.470731793583985 0.838001229777407 11 HRC,CAMK2D,GSTO1,GSTM2 GO:0072073 kidney epithelium development GO_KIDNEY_EPITHELIUM_DEVELOPMENT 0.350350932263338 0.984200669982886 0.4709728093885 0.838001229777407 12 LAMB2,LAMA5,IQGAP1,DLL1,CD34,RARB,ILK,RARA GO:1903649 regulation of cytoplasmic transport GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT -0.255114791956634 -0.991053055177359 0.471235057172557 0.838001229777407 53 HSP90AA1,EZR,TRIM28,HRC,HSP90AB1,ANP32B,ARF1,PIK3R1,CAMK2D,NPEPPS,GSTO1,UBE2L3,GSTM2,RUVBL1,SNX3 GO:0009792 embryo development ending in birth or egg hatching GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING -0.268683301618246 -0.989423880569606 0.471584357394656 0.838001229777407 41 KRT8,KRT19,TRIM28,ENO1,ADA,MFN2,GPI,C5,IFT52 GO:0006941 striated muscle contraction GO_STRIATED_MUSCLE_CONTRACTION -0.275413868407305 -0.990407166394208 0.472091515222054 0.838160709607325 37 HSP90AA1,CSRP3,EEF2,PKP2,MYL2,CAMK2D,SMPX,GPD1L GO:0008053 mitochondrial fusion GO_MITOCHONDRIAL_FUSION -0.465714755765825 -1.00151958584809 0.473149042403921 0.839073624660484 6 MFN2,STOML2,FIS1 GO:0090407 organophosphate biosynthetic process GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS -0.250019780241817 -0.98993147201318 0.473441442599765 0.839073624660484 58 NAMPT,GBAS,HPRT1,DCXR,ADA,ARF1,PIK3R1,LHPP,AK4,AKR1A1,SUCLG1,ATP5D,ADK,GPD1L,ATP5J2,ATP5F1,AQP1,ATP5A1,STOML2,PDXK GO:0018208 peptidyl proline modification GO_PEPTIDYL_PROLINE_MODIFICATION 0.397192382880298 0.979621266247789 0.474110578545872 0.83907720625536 8 PPIF,FKBP1A,PIN1 GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL 0.266658484134629 0.985804093277949 0.474279197758881 0.83907720625536 32 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PARK7,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0007276 gamete generation GO_GAMETE_GENERATION -0.286486746103952 -0.987973986943485 0.47502690703619 0.839660237085096 31 RAN,ARID4A,PAFAH1B1,DAZAP1,ACSBG2,IFT81,RUVBL1,PAFAH1B2,CTSB,PAQR8,PRDX4,CTNNB1,TSNAX GO:0050850 positive regulation of calcium mediated signaling GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING -0.438489803007513 -0.992067386839498 0.476016495442049 0.839811839303718 7 ADA,GSTO1,GSTM2 GO:0046488 phosphatidylinositol metabolic process GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS 0.464874917781645 0.979692410479389 0.476849933483087 0.839811839303718 5 CDIPT GO:0006661 phosphatidylinositol biosynthetic process GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS 0.464874917781645 0.979692410479389 0.476849933483087 0.839811839303718 5 CDIPT GO:0006820 anion transport GO_ANION_TRANSPORT 0.244624406215021 0.986937901406439 0.477024912127665 0.839811839303718 46 CD36,GJA1,APOE,SLC25A20,PRKAG2,FABP3,APOC2,CYB5R1,APOA4,PRKAA2,CPT1B GO:0009617 response to bacterium GO_RESPONSE_TO_BACTERIUM -0.266413167490585 -0.985921545145789 0.477481776446777 0.839811839303718 42 RPL39,SERPINB9,PRDX3,HP,FGA,IGJ,FGB,IGHG3,DROSHA,IGHG2,SNX3,IGHA1,ALAD GO:0007528 neuromuscular junction development GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT 0.464124200797368 0.978110325269407 0.478660065862648 0.839811839303718 5 LAMB2,COL4A1,ANK3 GO:0051489 regulation of filopodium assembly GO_REGULATION_OF_FILOPODIUM_ASSEMBLY -0.463144394817709 -0.995992024609448 0.479490496929497 0.839811839303718 6 DPYSL3,CAPZB GO:0046486 glycerolipid metabolic process GO_GLYCEROLIPID_METABOLIC_PROCESS 0.272050635260558 0.982268524850568 0.479606843472719 0.839811839303718 29 CDIPT,APOE,DBI,FABP3,FABP5,APOA4,GPX1,MECP2 GO:0051338 regulation of transferase activity GO_REGULATION_OF_TRANSFERASE_ACTIVITY -0.226340988194493 -0.989376692964136 0.480160622797975 0.839811839303718 101 GBAS,DNAJA3,PSMD2,RPS2,PSME2,H2AFY,PSMB6,PPP2R1A,HSP90AB1,DYNC1LI1,PRDX3,BGN,RPS3,ERP29,PRKAR2A,PIK3R1,PSMA2,PSMA1,C5,PTPN1,DBNL,YWHAG,AGT,UBE2L3,PEA15,NPM1,PSMC2 GO:0072089 stem cell proliferation GO_STEM_CELL_PROLIFERATION -0.497092838956038 -1.00512988798402 0.480315396831259 0.839811839303718 5 PAFAH1B1,NES,CTNNB1,RAB10 GO:0002687 positive regulation of leukocyte migration GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION 0.463319425563326 0.976414315958569 0.480557433537609 0.839811839303718 5 C1QBP,LGALS3,CALR,LBP GO:0006107 oxaloacetate metabolic process GO_OXALOACETATE_METABOLIC_PROCESS 0.463251226745691 0.976270591568449 0.480775521776111 0.839811839303718 5 NIT2,MDH1,GOT2 GO:0016125 sterol metabolic process GO_STEROL_METABOLIC_PROCESS 0.331667359199737 0.976751009240815 0.481260945709282 0.839811839303718 14 APOE,PRKAG2,CYB5R1,APOA4,PRKAA2,FDPS GO:0032369 negative regulation of lipid transport GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT 0.463085462613188 0.975921254883823 0.481386168843914 0.839811839303718 5 APOE,APOC2,APOC3 GO:0032372 negative regulation of sterol transport GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT 0.463085462613188 0.975921254883823 0.481386168843914 0.839811839303718 5 APOE,APOC2,APOC3 GO:0032535 regulation of cellular component size GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE -0.259865257865349 -0.985387434483283 0.48214490006047 0.839944483587263 47 HSP90AA1,EZR,ARPC3,ACTR3,PAFAH1B1,RTN4,HSP90AB1,SPTB,ARF1 GO:0006897 endocytosis GO_ENDOCYTOSIS 0.216360366506027 0.986880293432613 0.482298799589698 0.839944483587263 84 CD36,MYO1C,RAB7A,EHD4,APOE,VTN,PACSIN2,EHD2,CRK,LGALS3BP GO:0007043 cell cell junction assembly GO_CELL_CELL_JUNCTION_ASSEMBLY 0.3249772688212 0.976853062474936 0.482839514861473 0.840157492063984 15 GJA1,ANK2,RHOA,TJP1,INADL,ITGB1,FSCN1 GO:0006898 receptor mediated endocytosis GO_RECEPTOR_MEDIATED_ENDOCYTOSIS 0.248614405440179 0.982145811484421 0.483468862321242 0.840524221247666 42 CD36,APOE,VTN,PACSIN2,LGALS3BP,AMBP,CLTA,SSC5D,CLTB,SRCRB4D,TINAGL1,ITGB1,DLL1 GO:0042439 ethanolamine containing compound metabolic process GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS 0.37902146453482 0.971542632778029 0.484660493128354 0.840635824652227 9 DBI,FABP5,APOA4,MECP2,PON1 GO:0030029 actin filament based process GO_ACTIN_FILAMENT_BASED_PROCESS -0.222537430375816 -0.987186538303167 0.484875770709969 0.840635824652227 111 KRT8,CSRP3,EZR,DPYSL3,RAN,ARPC3,KRT19,SORBS2,ACTR3,MYOZ1,PKP2,PAFAH1B1,PALLD,ARF1,MYL2,CAMK2D,CAPZB,PTPN1,LDB3,PARVA,NEBL,ACTR2 GO:0048747 muscle fiber development GO_MUSCLE_FIBER_DEVELOPMENT 0.346437153788374 0.973206141233268 0.4850416984314 0.840635824652227 12 NEXN,DMD,GPX1,MYH11 GO:0048675 axon extension GO_AXON_EXTENSION 0.412119105117876 0.971482216468031 0.4852076298665 0.840635824652227 7 LAMB2,MAP1B,ITGB1 GO:0061951 establishment of protein localization to plasma membrane GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE -0.326323021702981 -0.979059349524162 0.486754339095813 0.842588545607236 18 KRT18,EZR,PKP2 GO:0019932 second messenger mediated signaling GO_SECOND_MESSENGER_MEDIATED_SIGNALING 0.287735154557856 0.976338960253846 0.487213446349451 0.842656847777517 23 CD36,APOE,BCAP31,ANK2,DMD,RAPGEF4 GO:1903522 regulation of blood circulation GO_REGULATION_OF_BLOOD_CIRCULATION -0.254602349230674 -0.981213413735421 0.489109362527084 0.845207917344565 51 HSP90AA1,CSRP3,PKP2,ADA,HRC,MYL2,CAMK2D,FGA,FGB,FGG,GSTO1,AGT,GPD1L,GSTM2 NA neurological system process GO_NEUROLOGICAL_SYSTEM_PROCESS 0.231452512098359 0.981203124121214 0.490405230142135 0.846718574484443 58 CD36,COL1A1,LAMB2,ATAD1,TIMM13,GNAS,HLA-DRA,SOD1,OR8J3,ANK3,MYH10,TJP1,GPX1,COL18A1,MECP2,TNNI3,PCDH15 GO:0070972 protein localization to endoplasmic reticulum GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 0.22950833177488 0.980316800521763 0.490854628353303 0.846766403551059 60 RPS4X,RPS8,RPS23,RPL14,BCAP31,RPL18,RPL19,RPL35,RPL7A,ANK2,RPL24,RPS21,RPL3,HSPA5,RPL23A,RPS24,RPS14,RPL31,RPL7,RPL29,FAU GO:0060333 interferon gamma mediated signaling pathway GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY 0.458381616625152 0.966008217982343 0.493053889603734 0.84915794452342 5 NCAM1,HLA-DRA,B2M GO:0043901 negative regulation of multi organism process GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS -0.320487235279942 -0.97501648313225 0.493575260007934 0.84915794452342 19 PCBP2,TRIM28,ADA,VAPA GO:0050680 negative regulation of epithelial cell proliferation GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION 0.328261536313476 0.966720956993656 0.493847051955633 0.84915794452342 14 GJA1,APOE,ENG,PHB2 GO:0032104 regulation of response to extracellular stimulus GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS 0.296702365013766 0.969755662882807 0.493940402072145 0.84915794452342 20 MAP1LC3B,RAB7A,PARK7,PRKAA2 GO:1903034 regulation of response to wounding GO_REGULATION_OF_RESPONSE_TO_WOUNDING 0.227672279861588 0.978107347819237 0.494355396985995 0.84915794452342 62 CD36,GJA1,APOE,VTN,SERPINC1,CD59,C1QBP,PSMA6 GO:0090066 regulation of anatomical structure size GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE -0.244053333101111 -0.976576892734078 0.498213856627954 0.855054208640112 61 HSP90AA1,EZR,ARPC3,SERPINF2,ACTR3,PAFAH1B1,RTN4,HSP90AB1,SPTB,ARF1,FGA,CAPZB,FGB,ACTR2,FGG,AGT NA er to golgi vesicle mediated transport GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT 0.26271040630932 0.971208528117515 0.498698465428763 0.855155011597742 32 RAB2A,ATL3,CD59,DCTN2,SPTAN1,SPTBN1,BCAP31,ANK2,ANK3 GO:0046916 cellular transition metal ion homeostasis GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS -0.361845414928338 -0.967777142953392 0.501190119364564 0.85599724493457 12 FTL,ARF1,ACO1,HPX GO:0007422 peripheral nervous system development GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT 0.373905577232162 0.958429120525841 0.501369800982634 0.85599724493457 9 LAMB2,LAMA2,SOD1,DAG1 GO:0043086 negative regulation of catalytic activity GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY -0.214609224605726 -0.980654902789329 0.501580500666657 0.85599724493457 135 GBAS,SERPINB9,DNAJA3,LXN,PSMD2,PPP1R14C,SERPINF2,PSME2,SERPINF1,H2AFY,APOC1,PSMB6,PPP2R1A,PRDX3,BGN,GPI,HP,PRKAR2A,C3,SERPINA3,PSMA2,PSMA1,C5,RNH1,PTPN1,SERPINA7,SERPINA1,YWHAG,AGT,SERPINA4,NPM1,ITIH1,PSMC2,CAND1,AQP1,SERPING1,AHSG GO:0061024 membrane organization GO_MEMBRANE_ORGANIZATION -0.207677791008191 -0.982360886189984 0.501611421404926 0.85599724493457 174 RPL39,RPL13A,HSP90AA1,KRT18,DNAJA3,EZR,TOR1AIP1,FERMT2,RPS2,RPL10A,PKP2,PAFAH1B1,PPP2R1A,VAPA,YWHAH,PARD3,RPS3,MFN2,ARF1,TMED9,RPL10,YWHAZ,LMAN1,TBC1D4,RPSA,MTCH2,SERPINA1,YWHAB,YWHAG,VAMP3,IGHG3,DPP10,SSR1,YWHAQ,RAB11B,DYNLL2 GO:0043406 positive regulation of map kinase activity GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY -0.346205509095335 -0.968111441465076 0.50191510572433 0.85599724493457 14 RPS3,ERP29,C5,PTPN1,DBNL,PEA15 GO:1900182 positive regulation of protein localization to nucleus GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS -0.314685695533942 -0.969591309422374 0.501950966850829 0.85599724493457 20 HSP90AA1,TRIM28,HSP90AB1,PIK3R1,CCT6A GO:0051051 negative regulation of transport GO_NEGATIVE_REGULATION_OF_TRANSPORT 0.228181010341818 0.974647309177112 0.502173682536316 0.85599724493457 60 CD36,PFKL,APOE,CRYAB,PACSIN2,MAP1B,SDCBP,APOC2,PARK7,PPIF,GNAO1,SSC5D,ANK3,FN1,ANXA2,FKBP1A GO:0023014 signal transduction by protein phosphorylation GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION 0.242653296900311 0.973891036855572 0.503128365557208 0.856186649746606 45 PSMB3,UBC,CRYAB,PSMB2,NCAM1,SPTAN1,PSMA6,SPTBN1,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0010975 regulation of neuron projection development GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT -0.266608570539674 -0.970594893521161 0.503137573058264 0.856186649746606 39 DPYSL3,ARHGDIA,SERPINF1,PAFAH1B1,RTN4,YWHAH,ARF1,CAPRIN2 GO:0061640 cytoskeleton dependent cytokinesis GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS 0.405819822234845 0.956633010931648 0.503924506361949 0.856799668733949 7 SPTBN1,RHOA,ANK3,MYH10 GO:0007599 hemostasis GO_HEMOSTASIS 0.225454934199513 0.971863610980418 0.504759365417944 0.8574930674782 63 CD36,COL3A1,COL1A1,MYL9,COL1A2,SERPINC1,EHD2,CD59,C1QBP,GNAS GO:0010984 regulation of lipoprotein particle clearance GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE -0.452933495795886 -0.974033486184663 0.505439437287024 0.85755300325142 6 APOC1,CNPY2 GO:0019058 viral life cycle GO_VIRAL_LIFE_CYCLE -0.234214336432262 -0.973064335251768 0.505648782793666 0.85755300325142 75 RPL39,PCBP2,RPL13A,EIF3F,RAN,RPS2,RPL10A,THOC4,HSP90AB1,RPS3 GO:0046487 glyoxylate metabolic process GO_GLYOXYLATE_METABOLIC_PROCESS -0.344985515756765 -0.964699914269373 0.506409920072757 0.858119088190798 14 OGDH,IDH2,DLAT,PDHA1,DBT,GRHPR,PDHB,BCKDHA,DLD GO:0006310 dna recombination GO_DNA_RECOMBINATION -0.369538213832838 -0.963333365878958 0.506914724295264 0.858250224607833 11 XRCC6,XRCC5 GO:0003008 system process GO_SYSTEM_PROCESS 0.191885632180156 0.981669163367264 0.507390256280132 0.858331621407333 171 CD36,GJA1,CACNA2D1,NFAT5,COL1A1,APOE,CRYAB,LAMB2,TPM3,MYL9,COL1A2,NPPA,TPM2,ATAD1,ENG,TIMM13,SGCD,GNAS,HLA-DRA,NDUFS6,DYSF,SSPN,ANK2,DMD,GNAO1,POSTN,SOD1,OR8J3,TMOD1,TPM1,PRKACB,ANK3,MYH10,MYLK3,TJP1,GPX1,SGCG,COL18A1,MECP2,SGCE,TNNI3,PCDH15 GO:0070373 negative regulation of erk1 and erk2 cascade GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE -0.369115694505196 -0.962231918313293 0.508258762777208 0.858693789751665 11 EZR,PTPN1 GO:0016050 vesicle organization GO_VESICLE_ORGANIZATION -0.289704253388508 -0.964859950568847 0.508459619529248 0.858693789751665 27 PAFAH1B1,VAPA,ARF1,TMED9,LMAN1,SERPINA1,VAMP3,SNX3,TFG,SEC22B,NAPA GO:0032768 regulation of monooxygenase activity GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY -0.368767150248862 -0.961323313197386 0.509337530506137 0.859022782508258 11 HSP90AA1,CYGB GO:0044092 negative regulation of molecular function GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION -0.210028430573577 -0.978536920593656 0.509510026876163 0.859022782508258 155 GBAS,SERPINB9,DNAJA3,LXN,PSMD2,PPP1R14C,SERPINF2,PSME2,SERPINF1,H2AFY,APOC1,PSMB6,PPP2R1A,PRDX3,BGN,GPI,HP,PRKAR2A,CAMK2D,C3,SERPINA3,PSMA2,PSMA1,C5,RNH1,PTPN1,SERPINA7,SERPINA1,YWHAG,MAPRE1,GSTO1,AGT,SERPINA4,GSTM2,NPM1,ITIH1,PSMC2,CAND1,AQP1,SERPING1,AHSG GO:0048024 regulation of mrna splicing via spliceosome GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME -0.358940125858479 -0.960006774062468 0.512015797732602 0.862216874435325 12 SRSF7,DAZAP1,HNRNPA2B1 GO:0021543 pallium development GO_PALLIUM_DEVELOPMENT -0.320218990159718 -0.96074556608028 0.51264241024492 0.862216874435325 18 RAN,PAFAH1B1,RTN4,OGDH GO:0030168 platelet activation GO_PLATELET_ACTIVATION 0.27127673117533 0.961105577372116 0.513365468886941 0.862216874435325 27 COL3A1,COL1A1,MYL9,COL1A2,GNAS,RHOA GO:0034762 regulation of transmembrane transport GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT 0.231856135070215 0.968609165104344 0.513469771327138 0.862216874435325 54 GJA1,CACNA2D1,STOM,AHNAK,NPPA,S100A1,PDCD5,PARK7,PPIF,ANK2,DMD GO:0043583 ear development GO_EAR_DEVELOPMENT -0.379703689313733 -0.960846970094676 0.513551484972435 0.862216874435325 10 PAFAH1B1,ANP32B GO:0048468 cell development GO_CELL_DEVELOPMENT -0.210656760054635 -0.975127710475441 0.515761014884578 0.864792383091211 148 CLIC4,KRT8,HPRT1,CSRP3,EZR,DPYSL3,FERMT2,RAN,ARID4A,KRT19,TRIM28,SORBS2,MYOZ1,MATN2,PAFAH1B1,RTN4,LIMS1,VAPA,PARD3,SPTB,PALLD,MYL2,CAMK2D,OGDH,LDB3,DBNL,PARVA,NEBL,VAMP3,PRELP,GSTM3,AGT,EHD1,DYNLL2,FLNC GO:0097202 activation of cysteine type endopeptidase activity GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY -0.37901607507718 -0.959106949983257 0.515970122710297 0.864792383091211 10 DNAJA3,ANP32B GO:0031532 actin cytoskeleton reorganization GO_ACTIN_CYTOSKELETON_REORGANIZATION -0.378726601122182 -0.95837443096801 0.516805975457941 0.864792383091211 10 EZR,PTPN1,PARVA GO:0033559 unsaturated fatty acid metabolic process GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS -0.349292654332294 -0.956596238228157 0.516808197066461 0.864792383091211 13 CBR1,PTGES2,PTGR2,HSD17B4 GO:0035264 multicellular organism growth GO_MULTICELLULAR_ORGANISM_GROWTH -0.42320855864261 -0.9574941218268 0.519027637100275 0.867293625797814 7 CLIC4 GO:0002706 regulation of lymphocyte mediated immunity GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY -0.377902156854291 -0.956288160017505 0.519775920327227 0.867293625797814 10 SERPINB9,C3,HPX,IFNA2,HMGB1 GO:0006487 protein n linked glycosylation GO_PROTEIN_N_LINKED_GLYCOSYLATION -0.405160033212047 -0.955873748475127 0.520308816383825 0.867293625797814 8 RPN2,LMAN1 GO:0010649 regulation of cell communication by electrical coupling GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING -0.405118395558795 -0.955775514847846 0.520434790433171 0.867293625797814 8 HRC,CAMK2D GO:0002090 regulation of receptor internalization GO_REGULATION_OF_RECEPTOR_INTERNALIZATION 0.420636284142997 0.942153667738612 0.521205406603147 0.867293625797814 6 ATAD1,SDCBP,ANXA2,CD63 GO:0009607 response to biotic stimulus GO_RESPONSE_TO_BIOTIC_STIMULUS -0.233923156361026 -0.965280239193062 0.521916813935875 0.867293625797814 72 RPL39,PCBP2,KRT8,SERPINB9,ENO1,PRDX3,HP,ITLN1,FGA,PSMA2,IGJ,FGB,IGHG3,DROSHA,IGHG2,SNX3,IGHA1,ALAD,IFNA2,BANF1,MAOB,IGKC,LTF,ATP1B1,HSPB1,ANXA3,DDX1 GO:0090316 positive regulation of intracellular protein transport GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT 0.281183094632349 0.954106600829358 0.522514929685995 0.867293625797814 23 MYO1C,STOM,HCLS1,BCAP31,PDCD5,CYB5R1,RHOA,ANK3 NA macromolecular complex remodeling GO_MACROMOLECULAR_COMPLEX_REMODELING 0.38207932954032 0.942346965209036 0.522536510722563 0.867293625797814 8 APOE,APOC2,APOA4 GO:0050772 positive regulation of axonogenesis GO_POSITIVE_REGULATION_OF_AXONOGENESIS -0.446294213369754 -0.959755709276321 0.522787324379977 0.867293625797814 6 ARHGDIA,PAFAH1B1 GO:0006692 prostanoid metabolic process GO_PROSTANOID_METABOLIC_PROCESS -0.421886802529451 -0.954503696224591 0.522789755462306 0.867293625797814 7 CBR1,PTGES2,PTGR2 GO:0010812 negative regulation of cell substrate adhesion GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION 0.381965572849349 0.942066399723754 0.52305407412408 0.867293625797814 8 COL1A1,POSTN,LGALS1,PLG GO:0006942 regulation of striated muscle contraction GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION -0.28174254418121 -0.955290195088624 0.524694277413688 0.869295469510467 29 HSP90AA1,PKP2,HRC,MYL2,CAMK2D,GSTO1,GSTM2,MYL3,DSP,ATP1B1,JUP,ATP2A2,PDE5A GO:0031623 receptor internalization GO_RECEPTOR_INTERNALIZATION 0.381152256933552 0.940060466071365 0.525686896644839 0.869541243330902 8 CD36,ITGB1,CD81,CAV1 GO:0051146 striated muscle cell differentiation GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION -0.249843146843914 -0.959726473697375 0.525708699902248 0.869541243330902 50 KRT8,CSRP3,KRT19,SORBS2,MYOZ1,MYL2,CAMK2D,LDB3,NEBL,AGT,FLNC,ACTG1 GO:0010721 negative regulation of cell development GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT -0.281424267852252 -0.954211031637234 0.526586041483683 0.869683745200383 29 DPYSL3,ARHGDIA,PAFAH1B1,RTN4,YWHAH,STRAP GO:0060314 regulation of ryanodine sensitive calcium release channel activity GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY -0.36368873447004 -0.948084608288347 0.527128355675026 0.869683745200383 11 HRC,CAMK2D,GSTO1,GSTM2 GO:0032780 negative regulation of atpase activity GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY 0.397969931256238 0.938128580071185 0.527382097095194 0.869683745200383 7 PPIF,TNNI3,PLN GO:0007566 embryo implantation GO_EMBRYO_IMPLANTATION -0.444375365585332 -0.955629227101197 0.527962534395102 0.869683745200383 6 TRIM28 GO:0090207 regulation of triglyceride metabolic process GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS 0.397729267784872 0.93756126766154 0.528164762181623 0.869683745200383 7 APOC2,APOA4,APOH,FITM2,APOC3 GO:0000910 cytokinesis GO_CYTOKINESIS 0.353276763599275 0.93695002203111 0.528543689320388 0.869683745200383 10 SPTBN1,RHOA,ANK3,MYH10,RALA GO:0006638 neutral lipid metabolic process GO_NEUTRAL_LIPID_METABOLIC_PROCESS 0.319714830694944 0.941551150236888 0.528826619964974 0.869683745200383 14 APOE,FABP3,FABP5,GPX1,APOH,APOC3,CAV1 GO:0030099 myeloid cell differentiation GO_MYELOID_CELL_DIFFERENTIATION -0.312129946103709 -0.949591150063952 0.530122975560117 0.871102238072597 19 ARID4A,PAFAH1B1,PRDX3 GO:2000378 negative regulation of reactive oxygen species metabolic process GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS 0.379429594747168 0.935811752890851 0.531267580278584 0.872269256908746 8 CRYAB,SIRT5,CAV1,CD34 GO:0009411 response to uv GO_RESPONSE_TO_UV -0.442454105568624 -0.951497557420523 0.533101299269275 0.874500862552505 6 PIK3R1,MFAP4,AQP1,CAT GO:1902579 multi organism localization GO_MULTI_ORGANISM_LOCALIZATION -0.386286800567565 -0.945471166228452 0.533830008238117 0.874500862552505 9 RAN,THOC4 GO:0000272 polysaccharide catabolic process GO_POLYSACCHARIDE_CATABOLIC_PROCESS 0.351514385620127 0.932275896086434 0.534528840662479 0.874500862552505 10 GYG1,PYGB,PFKM,PYGM GO:0045165 cell fate commitment GO_CELL_FATE_COMMITMENT 0.378402292483841 0.933278050867864 0.534868021332613 0.874500862552505 8 BCL11B,ITGB1,DLL1 GO:0048771 tissue remodeling GO_TISSUE_REMODELING 0.325083147497256 0.935410477233643 0.536690848214286 0.874500862552505 13 GJA1,RAB7A GO:0032101 regulation of response to external stimulus GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS 0.2043710696688 0.964600592980345 0.536767653628085 0.874500862552505 102 CD36,MAP1LC3B,GJA1,RAB7A,APOE,VTN,STOM,SERPINC1,CD59,MIF,C1QBP,PSMA6 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY -0.35148572587361 -0.940069536717022 0.537493167833277 0.874500862552505 12 FGA,FGB,FGG,PEA15 GO:0000209 protein polyubiquitination GO_PROTEIN_POLYUBIQUITINATION 0.256435351707405 0.948010411874616 0.538017205047475 0.874500862552505 32 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0048017 inositol lipid mediated signaling GO_INOSITOL_LIPID_MEDIATED_SIGNALING -0.440602488776597 -0.94751565549506 0.538458734989158 0.874500862552505 6 EZR,PIK3R1 NA protein import into nucleus translocation GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION -0.471700525663232 -0.95378621329087 0.540144772315988 0.874500862552505 5 RAN GO:0043393 regulation of protein binding GO_REGULATION_OF_PROTEIN_BINDING 0.287687560916804 0.940291262346592 0.540801292714225 0.874500862552505 20 VTN,PCBD1,PARK7,ANXA2,FKBP1A,HSPA5,PIN1 GO:0040013 negative regulation of locomotion GO_NEGATIVE_REGULATION_OF_LOCOMOTION -0.263389073195952 -0.947165177816733 0.540844321034867 0.874500862552505 37 CLIC4,DPYSL3,CYGB,PKP2,SERPINF1,ADA,STRAP,C5 GO:0007568 aging GO_AGING 0.240573954707258 0.950382185415355 0.541028320885059 0.874500862552505 42 COL3A1,CRYAB,MIF,ENG,NDUFS6,RETN,ERO1L,GNAO1,CLU,CAST,SOD1 GO:0007626 locomotory behavior GO_LOCOMOTORY_BEHAVIOR 0.311211668112455 0.935474878524038 0.541276655640791 0.874500862552505 15 PARK7,GNAO1,SOD1,TMOD1,VPS13A,SNCG,MECP2 GO:0006220 pyrimidine nucleotide metabolic process GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS 0.376440130152692 0.928438642988272 0.541663853822093 0.874500862552505 8 CMPK1,ENTPD4,NME2,ERH GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION 0.316545714399319 0.932218192216473 0.542300058377116 0.874500862552505 14 CD36,CLU,GSTP1,NCL,CD34,GPNMB GO:0010952 positive regulation of peptidase activity GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY -0.291442827492284 -0.941591291541576 0.542527515790555 0.874500862552505 24 DNAJA3,PSME2,ANP32B,RPS3 GO:0035637 multicellular organismal signaling GO_MULTICELLULAR_ORGANISMAL_SIGNALING 0.287231173716541 0.938799585420115 0.543201368756238 0.874500862552505 20 GJA1,CACNA2D1,ANK2,SOD1,ANK3 NA single organism behavior GO_SINGLE_ORGANISM_BEHAVIOR -0.305192516264996 -0.940341476180538 0.543594613259669 0.874500862552505 20 HPRT1,SERPINF1,PAFAH1B1,GPI GO:0042542 response to hydrogen peroxide GO_RESPONSE_TO_HYDROGEN_PEROXIDE -0.282498126353873 -0.940859946105306 0.544334515587082 0.874500862552505 27 EEF2,ADA,PPP5C,PRDX3,RPS3,HP GO:0006970 response to osmotic stress GO_RESPONSE_TO_OSMOTIC_STRESS 0.375626195011365 0.926431182099904 0.544364184612615 0.874500862552505 8 NFAT5,SORD GO:2001020 regulation of response to dna damage stimulus GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS -0.334507229299701 -0.935398968040817 0.546268604508806 0.874500862552505 14 TRIM28,OTUB1,RPS3 GO:0050708 regulation of protein secretion GO_REGULATION_OF_PROTEIN_SECRETION -0.249891640120506 -0.947568305897806 0.547126023501724 0.874500862552505 47 EZR,PAM,ARF1,ERP29,GLUD1,OXCT1,FGA,BRP44,C5,FGB,VAMP3,FGG GO:0008643 carbohydrate transport GO_CARBOHYDRATE_TRANSPORT -0.413385480508726 -0.935269761332753 0.547749963825785 0.874500862552505 7 EZR,PEA15,AQP1,HK1,SORBS1,SLC2A4 GO:0030038 contractile actin filament bundle assembly GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY 0.436750471670274 0.920422044730836 0.54783765511526 0.874500862552505 5 RHOA,ITGB1,PDCD10 GO:0060560 developmental growth involved in morphogenesis GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS 0.347915935611663 0.922732195050574 0.548349514563107 0.874500862552505 10 LAMB2,MAP1B,POSTN,IQGAP1,ITGB1 GO:0014823 response to activity GO_RESPONSE_TO_ACTIVITY -0.333699371969544 -0.93313991697476 0.549276807107753 0.874500862552505 14 SRL,OXCT1,AGT,ALAD,CAT,CTNNB1,UQCRC1 NA protein complex subunit organization GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION -0.194607194125932 -0.967600008461022 0.549971634542209 0.874500862552505 266 XRCC6,HSP90AA1,HPRT1,EZR,DPYSL3,FERMT2,RAN,EIF4H,ARPC3,TRIM28,SORBS2,DCXR,SERPINF2,ACTR3,NAP1L4,PAM,PKP2,H2AFY,EIF4B,PAFAH1B1,SEPT11,RTN4,TUBB,PPP5C,PPP2R1A,ANP32B,DYNC1H1,PARD3,RPS3,NDUFB8,NDUFV1,ARF1,NDUFC2,FH,CAMK2D,NDUFB9,FGA,RANBP1,CRYZ,LMAN1,NDUFS3,NDUFA10,DBNL,SERPINA1,FGB,NEBL,YWHAB,VAMP3,NDUFS8,ACTR2,LONP1,FGG,NDUFA5,EHD1,NDUFA9,PCBD2,MRPS23,RUVBL1,NDUFB2,NPM1,NDUFB3,FMOD,CAND1,NDUFS7,TFG,HSPA4,ALAD,STOML2,TMSB4X,NDUFB11,CORO1B,SEC22B,NAPA,AIFM1,HBA2,HBA1,HSD17B10 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY -0.266842684824952 -0.941236874549387 0.550085201643891 0.874500862552505 34 NAMPT,HSP90AA1,ARPC3,ACTR3 NA protein complex biogenesis GO_PROTEIN_COMPLEX_BIOGENESIS -0.199264652882442 -0.964101025410796 0.550926652494614 0.874500862552505 208 XRCC6,HSP90AA1,HPRT1,DPYSL3,FERMT2,EIF4H,TRIM28,DCXR,NAP1L4,PAM,H2AFY,EIF4B,SEPT11,RTN4,TUBB,PPP5C,PPP2R1A,ANP32B,PARD3,RPS3,NDUFB8,NDUFV1,NDUFC2,FH,CAMK2D,NDUFB9,FGA,CRYZ,LMAN1,NDUFS3,NDUFA10,DBNL,SERPINA1,FGB,YWHAB,VAMP3,NDUFS8,LONP1,FGG,NDUFA5,EHD1,NDUFA9,PCBD2,RUVBL1,NDUFB2,NPM1,NDUFB3,FMOD,CAND1,NDUFS7,TFG,HSPA4,ALAD,STOML2,NDUFB11,SEC22B,NAPA,AIFM1,HBA2,HBA1,HSD17B10,SAMM50,HBB,GPX3,TPPP,NUBPL,NDUFAF3,PSMD11,NDUFA7,ARPC4,JUP,SAR1B,NDUFB10,NDUFS4,ACAT1,COL6A1,NDUFA3,CAT,ALDH5A1,UQCR10,DNM1L,CTNNB1,FIS1,APCS,NDUFS5,ANXA5,GRHPR,ACTN2,SCO1,NDUFS1,DECR1,VCP,NDUFAF2 GO:0033209 tumor necrosis factor mediated signaling pathway GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY -0.278980767975668 -0.937508404749371 0.550968900332001 0.874500862552505 28 KRT8,KRT18,PSMD2,PSME2,PSMB6,PSMA2,PSMA1 GO:0046324 regulation of glucose import GO_REGULATION_OF_GLUCOSE_IMPORT -0.394942599167646 -0.931768268715953 0.551082477009736 0.874500862552505 8 ITLN1,PIK3R1,PEA15 GO:1901701 cellular response to oxygen containing compound GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND 0.206403935097064 0.957311617551508 0.551216767477845 0.874500862552505 92 CD36,COL3A1,COL1A1,SOD3,COL1A2,FBN1,GNAI2,COL4A1,GNAS,GNG12,PARK7,PPIF,POSTN,SOD1,TPM1,PRKACB,APOA4,GNB2,FN1,PRKAA2,LGALS1 GO:0009308 amine metabolic process GO_AMINE_METABOLIC_PROCESS 0.321493463268829 0.925081340632493 0.551641555059524 0.874500862552505 13 AOC3,DBI,FABP5,APOA4,MECP2,SULT1A2,PON1 GO:0008104 protein localization GO_PROTEIN_LOCALIZATION -0.195561613043254 -0.966549713522775 0.551911121023725 0.874500862552505 251 RPL39,RPL13A,HSP90AA1,KRT18,CSRP3,DNAJA3,SELENBP1,EZR,TOR1AIP1,TOMM40,FERMT2,RAN,MTX2,RPS2,NEDD8,RPL10A,ESCO2,PKP2,H2AFY,PAFAH1B1,LIMS1,VAPA,YWHAH,PARD3,RPS3,MFN2,ARF1,ERP29,PIK3R1,TMED9,GDI2,RPL10,YWHAZ,RANBP1,LMAN1,TBC1D4,RPSA,MTCH2,YWHAB,YWHAG,VAMP3,DPP10,SSR1,TOM1,FGG,IFT81,HSPA9,MAPRE1,YWHAQ,AGT,RAB11B,EHD1 GO:0019229 regulation of vasoconstriction GO_REGULATION_OF_VASOCONSTRICTION -0.435648074959434 -0.936861188543234 0.551943437141243 0.874500862552505 6 FGA,FGB,FGG,AGT GO:0010644 cell communication by electrical coupling GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING 0.373089731637705 0.920175338410563 0.552127635635365 0.874500862552505 8 GJA1,RYR2,DBN1 GO:0071900 regulation of protein serine threonine kinase activity GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY 0.236836949167744 0.946061964614555 0.552388486271308 0.874500862552505 44 UBC,APOE,PRKAG2,CDC37,CRK,GNAI2,MIF,RHOA,SOD1 GO:0046033 amp metabolic process GO_AMP_METABOLIC_PROCESS -0.466496216777887 -0.943263015213934 0.552830815821546 0.874500862552505 5 AK4,ADK GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 0.285287166446377 0.932445702602769 0.553395751152512 0.874500862552505 20 MIF,PARK7,PPIF,CLU,GPX1,TXNDC12,NOL3,TPT1 GO:0010948 negative regulation of cell cycle process GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS 0.328193891269228 0.921957437317957 0.553907639707071 0.874500862552505 12 UBC,MIF,CAST GO:0017038 protein import GO_PROTEIN_IMPORT -0.283293963507963 -0.934942943067887 0.554047849818905 0.874500862552505 26 HSP90AA1,TOMM40,RAN,PIK3R1,RANBP1 GO:0048593 camera type eye morphogenesis GO_CAMERA_TYPE_EYE_MORPHOGENESIS 0.434315046883379 0.915289551905885 0.554314875798748 0.874500862552505 5 COL8A1,DLL1,RBP4 GO:0010823 negative regulation of mitochondrion organization GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION 0.358219178082192 0.918220301355998 0.554395815880635 0.874500862552505 9 PPIF,GPX1,NOL3,OPA1,LMNA,FXN,VAT1,HSPA1A,ACAA2 GO:0045777 positive regulation of blood pressure GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE 0.433927750880832 0.914473351806048 0.555187228752753 0.874500862552505 5 ENG,TPM1 GO:0046649 lymphocyte activation GO_LYMPHOCYTE_ACTIVATION -0.306272557460543 -0.931771250091308 0.555425240173166 0.874500862552505 19 HPRT1,DNAJA3,ADA,PIK3R1 GO:0044242 cellular lipid catabolic process GO_CELLULAR_LIPID_CATABOLIC_PROCESS -0.26079756841556 -0.937845948828419 0.556706516136541 0.874500862552505 37 GCDH,ECI2,PCCB,IVD,ACAD10,ETFA,ECHS1,ACADVL,CRAT,MCEE,PCCA,HSD17B4 GO:0035994 response to muscle stretch GO_RESPONSE_TO_MUSCLE_STRETCH -0.392863645353657 -0.926863497237557 0.556949268450699 0.874500862552505 8 CSRP3 GO:0051047 positive regulation of secretion GO_POSITIVE_REGULATION_OF_SECRETION -0.265716365812776 -0.937263998217918 0.55700157038324 0.874500862552505 34 EZR,ARF1,GLUD1,OXCT1,FGA,BRP44,C5,FGB,VAMP3,FGG,AGT GO:0009261 ribonucleotide catabolic process GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS 0.433113696099465 0.912757786477583 0.557128214075415 0.874500862552505 5 ENTPD4,MLYCD NA negative regulation of sequence specific dna binding transcription factor activity GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY -0.392771214525652 -0.926645429820248 0.557309194305973 0.874500862552505 8 DNAJA3 GO:0006665 sphingolipid metabolic process GO_SPHINGOLIPID_METABOLIC_PROCESS -0.392758974030535 -0.926616551433952 0.557309194305973 0.874500862552505 8 PPP2R1A,VAPA GO:0006643 membrane lipid metabolic process GO_MEMBRANE_LIPID_METABOLIC_PROCESS -0.392758974030535 -0.926616551433952 0.557309194305973 0.874500862552505 8 PPP2R1A,VAPA GO:0051055 negative regulation of lipid biosynthetic process GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS -0.378629273357221 -0.926728689987089 0.557595186074 0.874500862552505 9 ERLIN2,APOC1 GO:0032092 positive regulation of protein binding GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING -0.366127482833786 -0.926492137026782 0.557976169304642 0.874500862552505 10 RAN,HSP90AB1,CAPRIN2,MAPRE1 GO:0043470 regulation of carbohydrate catabolic process GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS 0.371316131765517 0.915800994320653 0.558473412993092 0.874500862552505 8 PRKAG2,PRKAA2,PGAM2 GO:0030865 cortical cytoskeleton organization GO_CORTICAL_CYTOSKELETON_ORGANIZATION -0.409744332185618 -0.927031794389792 0.558620315439155 0.874500862552505 7 EZR,PAFAH1B1 GO:0042744 hydrogen peroxide catabolic process GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS -0.34546025951944 -0.923954067589534 0.558809528007476 0.874500862552505 12 PRDX3,PRDX2,HBA2,HBA1,HBB,GPX3,CAT GO:0019218 regulation of steroid metabolic process GO_REGULATION_OF_STEROID_METABOLIC_PROCESS -0.331091958638779 -0.925848679221963 0.559018486454343 0.874500862552505 14 ERLIN2,APOC1,AGT,ACADVL GO:0043255 regulation of carbohydrate biosynthetic process GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS -0.463863949961777 -0.937940528461606 0.559441592495476 0.874500862552505 5 CLTC,SORBS1,PPP1CB,ADIPOQ GO:0035305 negative regulation of dephosphorylation GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION 0.407243832378135 0.912156855704233 0.55982716596499 0.874500862552505 6 CEP192,IQGAP1,FKBP1A,YWHAE GO:0060688 regulation of morphogenesis of a branching structure GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE -0.463737372541186 -0.937684586837407 0.55984784134136 0.874500862552505 5 RTN4,AGT GO:0060284 regulation of cell development GO_REGULATION_OF_CELL_DEVELOPMENT 0.207294668223137 0.952798221096621 0.560063799423567 0.874500862552505 88 BCL11B,COL3A1,GLIPR2,COL1A1,APOE,CFL1,FAM21C,BMP10,C1QBP,NACA,MAP1B,SDCBP,DMD,POSTN,RHOA,DPYSL2,MYLK3,FN1,LGALS1,MECP2,PIN1,MYADM,ITGB1,DLL1,DAG1,ABL2 GO:0022008 neurogenesis GO_NEUROGENESIS -0.211666311516772 -0.952582783999057 0.561983596138131 0.876082937401186 122 MARK1,HSP90AA1,HPRT1,EEF2,EZR,DPYSL3,XRCC5,ARHGDIA,SERPINF1,MATN2,PAFAH1B1,RTN4,VCAN,VAPA,YWHAH,PARD3,SPTB,ARF1,TUBB2B,CAPRIN2,OGDH GO:0042254 ribosome biogenesis GO_RIBOSOME_BIOGENESIS 0.224211569277865 0.944512789400917 0.562089959586417 0.876082937401186 56 RPS4X,RPS8,RPS23,RPL14,RPLP0P6,C1QBP,RPL18,RPL19,RPL35,RPL7A,RPL24,RPS21,RPL3 GO:0007009 plasma membrane organization GO_PLASMA_MEMBRANE_ORGANIZATION 0.254329617474424 0.933722583650559 0.562385909516996 0.876082937401186 31 PACSIN2,EHD2,SPTBN1,DYSF,ANK2,CLU,LAMA5,SOD1,ANK3,MYH10,ANXA2,MYADM,RDX GO:0006909 phagocytosis GO_PHAGOCYTOSIS 0.241377705454066 0.937863780112909 0.562883474308799 0.876178307296178 39 CD36,MYO1C,RAB7A,CRK GO:2000106 regulation of leukocyte apoptotic process GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS 0.405926150072307 0.909205471660226 0.563505428761356 0.876467003061815 6 HCLS1,MIF,TCP1 GO:0048013 ephrin receptor signaling pathway GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY -0.335833194045605 -0.919735259564176 0.565232647905116 0.876982156859987 13 ARPC3,ACTR3,ACTR2,ACTG1 NA respiratory gaseous exchange GO_RESPIRATORY_GASEOUS_EXCHANGE 0.385772913816689 0.909376732876227 0.565397258436012 0.876982156859987 7 MECP2,TNNC1,NDUFA12,GAA,COX5B,ADH5,BPGM GO:0006468 protein phosphorylation GO_PROTEIN_PHOSPHORYLATION -0.231982324033971 -0.942102676108406 0.565912965884284 0.876982156859987 66 MARK1,HSP90AA1,ERLIN2,PSMD2,TRIM28,PSME2,PSMB6,PPP5C,SPTB,PIK3R1,CAMK2D,PSMA2,PSMA1,PTPN1,DBNL,YWHAB GO:0032069 regulation of nuclease activity GO_REGULATION_OF_NUCLEASE_ACTIVITY -0.407121634475086 -0.921098035277696 0.566687165388511 0.876982156859987 7 RPS3,PTPN1,NPM1,HMGB1,HSPA1A GO:0048568 embryonic organ development GO_EMBRYONIC_ORGAN_DEVELOPMENT -0.286707666458595 -0.926292968945228 0.567073483849985 0.876982156859987 24 KRT8,KRT19,TRIM28,ADA GO:0055123 digestive system development GO_DIGESTIVE_SYSTEM_DEVELOPMENT 0.429398701152057 0.904928686184729 0.567094846574924 0.876982156859987 5 COL3A1,RARB GO:0036498 ire1 mediated unfolded protein response GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE -0.335140419087315 -0.917837979702091 0.567741595901467 0.876982156859987 13 PTPN1,SSR1,ACADVL,TPP1 GO:0018022 peptidyl lysine methylation GO_PEPTIDYL_LYSINE_METHYLATION 0.404519519553823 0.906054858762332 0.567804121426989 0.876982156859987 6 HIST1H1D,WHSC1 GO:0071346 cellular response to interferon gamma GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA -0.389117825067349 -0.918026171280696 0.568304929184588 0.876982156859987 8 RPL13A,CAMK2D,SYNCRIP GO:0030835 negative regulation of actin filament depolymerization GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION 0.332871667774192 0.909408978899548 0.568525933084817 0.876982156859987 11 SPTAN1,SPTBN1,TMOD1,RDX,TMOD3,ADD1,CAPZA1 GO:0002683 negative regulation of immune system process GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS -0.241633832550492 -0.935422515822463 0.568640820832522 0.876982156859987 52 PCBP2,SERPINB9,DNAJA3,EZR GO:0051258 protein polymerization GO_PROTEIN_POLYMERIZATION -0.334619074531623 -0.916410190612884 0.569461014808057 0.87757307577481 13 FGA,FGB,FGG,TPPP,ARPC4,DNM1L,HDGFRP3 GO:0032642 regulation of chemokine production GO_REGULATION_OF_CHEMOKINE_PRODUCTION 0.383910038248733 0.904985404099453 0.57145732239093 0.879393955165867 7 MIF,POSTN,GSTP1 GO:0045446 endothelial cell differentiation GO_ENDOTHELIAL_CELL_DIFFERENTIATION -0.327835272410472 -0.916741847828308 0.571733389299893 0.879393955165867 14 CLIC4,EZR GO:1904018 positive regulation of vasculature development GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT -0.32134062917707 -0.91658895260984 0.571956427015251 0.879393955165867 15 LRG1,C3,C5,AQP1,HMGB1,HSPB1,ANXA3 GO:0042129 regulation of t cell proliferation GO_REGULATION_OF_T_CELL_PROLIFERATION -0.373440772676234 -0.914029374911807 0.573211791253268 0.879412148302724 9 DNAJA3,ADK,HMGB1,PDE5A,CTNNB1,PRKAR1A GO:0007586 digestion GO_DIGESTION -0.387357902218297 -0.913874073559176 0.573667824428168 0.879412148302724 8 EZR,STRAP,SERPINA3,ACO1 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to dna damage GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE 0.40236100222297 0.901220147405265 0.573720363394638 0.879412148302724 6 MIF,CLU,TPT1 GO:0022037 metencephalon development GO_METENCEPHALON_DEVELOPMENT 0.352860581375572 0.904484654065588 0.574071139085743 0.879412148302724 9 MYH10,HSPA5,MECP2,DLL1 GO:0038095 fc epsilon receptor signaling pathway GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY 0.24728027362733 0.929075526110964 0.574158031088083 0.879412148302724 34 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:1903729 regulation of plasma membrane organization GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION -0.372581796872584 -0.91192695553417 0.575880224936423 0.880158367267454 9 EZR,PIK3R1,DPP10 GO:0043484 regulation of rna splicing GO_REGULATION_OF_RNA_SPLICING -0.320163887481825 -0.913232425796848 0.576278867102397 0.880158367267454 15 SRSF7,PIK3R1,DAZAP1,HNRNPA2B1 GO:2000379 positive regulation of reactive oxygen species metabolic process GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS 0.308667740944722 0.909017782802906 0.576415645067134 0.880158367267454 14 CD36,PARK7,CLU,SOD1 GO:0040014 regulation of multicellular organism growth GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH -0.426196629683759 -0.916535855405369 0.576616797565465 0.880158367267454 6 EZR GO:0043489 rna stabilization GO_RNA_STABILIZATION -0.386245170447653 -0.91124886129374 0.577177101517087 0.880158367267454 8 SYNCRIP,HNRNPC,HNRNPD GO:0033238 regulation of cellular amine metabolic process GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS -0.271611942500694 -0.920940876337813 0.577275184109182 0.880158367267454 29 HPRT1,PSMD2,PSME2,APOC1,PSMB6,PSMA2,PSMA1 GO:0042274 ribosomal small subunit biogenesis GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS 0.33038647768418 0.902619412826709 0.578144415297529 0.880727647730719 11 RPS8,RPS21,RPS24,RPS14 GO:0043502 regulation of muscle adaptation GO_REGULATION_OF_MUSCLE_ADAPTATION -0.314134665936289 -0.912190011819891 0.578525780556184 0.880727647730719 16 SRL,CAMK2D,ADK,AGT GO:0071902 positive regulation of protein serine threonine kinase activity GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY -0.281343529338894 -0.919496979585573 0.579170641951751 0.88104140078721 25 HSP90AB1,RPS3,ERP29,C5,PTPN1,DBNL GO:0016053 organic acid biosynthetic process GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS -0.254423061238388 -0.926233254737974 0.579664552875143 0.881125224960853 39 ALDH4A1,VCAN,BCAT2,CBR1,BGN,AHCY,MTAP,GLUD1,AKR1A1,GSTO1 NA single organism cell adhesion GO_SINGLE_ORGANISM_CELL_ADHESION -0.237530212535192 -0.929832349254931 0.58105266563147 0.882567135089252 55 DNAJA3,EZR,FERMT2,CLIC1,PKP2,CSRP1,ADA,FGA,PARVA,FGB,VAMP3,FGG,ACTG1,STOML2,IFNA2,RPL22,HMGB1,HBB,MSN,DSP,HSPB1,JUP,ACTN1 GO:0046596 regulation of viral entry into host cell GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL -0.424205947111773 -0.912254892519035 0.581792007580589 0.882687954993112 6 SNX3,P4HB,IFNA2,APCS GO:0034333 adherens junction assembly GO_ADHERENS_JUNCTION_ASSEMBLY -0.384316094635555 -0.906697689469155 0.583403818813324 0.882687954993112 8 FERMT2,JUP,ACTN1,CTNNB1,ACTN2,SORBS1 GO:0048678 response to axon injury GO_RESPONSE_TO_AXON_INJURY -0.347957846848206 -0.907076430097986 0.583560287199802 0.882687954993112 11 DPYSL3,MATN2 GO:0030278 regulation of ossification GO_REGULATION_OF_OSSIFICATION 0.338722042285222 0.898348427301467 0.583597944031982 0.882687954993112 10 GJA1,GNAS GO:0048857 neural nucleus development GO_NEURAL_NUCLEUS_DEVELOPMENT -0.308184502125312 -0.909769552373507 0.585427179247083 0.882687954993112 17 YWHAH,GLUD1,NDUFS3,YWHAQ,ATP5F1,NDRG2,MAOB GO:0021762 substantia nigra development GO_SUBSTANTIA_NIGRA_DEVELOPMENT -0.308184502125312 -0.909769552373507 0.585427179247083 0.882687954993112 17 YWHAH,GLUD1,NDUFS3,YWHAQ,ATP5F1,NDRG2,MAOB GO:0021987 cerebral cortex development GO_CEREBRAL_CORTEX_DEVELOPMENT 0.328584609832729 0.897696690463893 0.585645910994523 0.882687954993112 11 COL3A1,GNG12,LAMB1 NA monosaccharide transport GO_MONOSACCHARIDE_TRANSPORT -0.453166876223836 -0.9163108696024 0.58595856261772 0.882687954993112 5 EZR GO:0045814 negative regulation of gene expression epigenetic GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC 0.26983526466753 0.915601300613215 0.586062415719515 0.882687954993112 23 HIST1H3A,SIRT5,MECP2,RBBP7,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM -0.33800452142244 -0.904013251383385 0.586085300703493 0.882687954993112 12 HRC,CAMK2D,GSTO1,GSTM2 GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION 0.261355686788305 0.917064534679042 0.58709003956983 0.882687954993112 26 GLIPR2,COL1A1,C1QBP,MAP1B,SDCBP,RHOA,FN1 GO:0001678 cellular glucose homeostasis GO_CELLULAR_GLUCOSE_HOMEOSTASIS -0.357080987212648 -0.903599818220885 0.587426640583319 0.882687954993112 10 SERPINF1,PIK3R1,RAB11B GO:0033119 negative regulation of rna splicing GO_NEGATIVE_REGULATION_OF_RNA_SPLICING -0.452537134697336 -0.915037521888683 0.5874912287181 0.882687954993112 5 SRSF7,HNRNPA2B1 GO:0048025 negative regulation of mrna splicing via spliceosome GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME -0.452537134697336 -0.915037521888683 0.5874912287181 0.882687954993112 5 SRSF7,HNRNPA2B1 GO:0032757 positive regulation of interleukin 8 production GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION 0.421961813840817 0.889255949760961 0.587725993937147 0.882687954993112 5 PARK7,APOA2,LBP,ADIPOQ GO:0072378 blood coagulation fibrin clot formation GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION -0.337302646202304 -0.902136044246776 0.588765273198512 0.883587943634239 12 FGA,FGB,FGG,SERPING1 GO:0051174 regulation of phosphorus metabolic process GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS 0.187450687355204 0.952937523212828 0.589967728796566 0.884060581459345 163 CD36,GLIPR2,EHD4,UBC,APOE,VTN,PRKCDBP,PRKAG2,CDC37,BMP10,CRK,HCLS1,GNAI2,MIF,ME1,ENG,GNAS,RRAS,FABP3,AMBP,SET,SDCBP,APOC2,PARK7,PPIF,DMD,CLU,AKAP12,RHOA,SOD1,CEP192,PRKACB,PHB2,FN1,IQGAP1,PRKAA2,ANXA2,FKBP1A,HSPA5,PIN1,VAPB,LRRC4B GO:0032355 response to estradiol GO_RESPONSE_TO_ESTRADIOL -0.295126188963613 -0.909325692470823 0.590366022099448 0.884060581459345 20 EEF2,PAM,BDH1,C3,FGA GO:0019221 cytokine mediated signaling pathway GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY -0.248829392133762 -0.920848849480669 0.590591216494167 0.884060581459345 42 KRT8,KRT18,PSMD2,PSME2,PSMB6,BGN,CAMK2D,PSMA2,PSMA1 GO:0009306 protein secretion GO_PROTEIN_SECRETION 0.299983533748377 0.901724095033194 0.591620334529758 0.884060581459345 15 CD36,S100A13,GNAS,RAPGEF4,SNCG GO:0031399 regulation of protein modification process GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS -0.200204147749898 -0.944389677186818 0.592753495992043 0.884060581459345 170 HSP90AA1,DNAJA3,EZR,PSMD2,PPP1R14C,SERPINF2,PSME2,H2AFY,PAFAH1B1,PSMB6,HRC,PPP5C,PPP2R1A,HSP90AB1,DYNC1LI1,OTUB1,BGN,PARD3,RPS3,ERP29,ITLN1,PRKAR2A,STRAP,CAMK2D,C3,FGA,PSMA2,PSMA1,CAPRIN2,C5,PTPN1,DBNL,FGB,YWHAB,YWHAG,FGG,HPX,AGT,GPD1L GO:0060263 regulation of respiratory burst GO_REGULATION_OF_RESPIRATORY_BURST -0.450285585189681 -0.910484851789527 0.592809395427854 0.884060581459345 5 IGJ,IGHA1 GO:0018196 peptidyl asparagine modification GO_PEPTIDYL_ASPARAGINE_MODIFICATION -0.419986962103091 -0.903181965225491 0.593071778705104 0.884060581459345 6 RPN2,LMAN1 GO:1903337 positive regulation of vacuolar transport GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT -0.397946289530985 -0.900339147797046 0.593383736072927 0.884060581459345 7 EZR,ARF1,EHD1 GO:0032434 regulation of proteasomal ubiquitin dependent protein catabolic process GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS 0.318351074719556 0.894307142283421 0.593965855799663 0.884060581459345 12 BCAP31,SDCBP,PARK7,CLU GO:0043409 negative regulation of mapk cascade GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE -0.297898799609452 -0.906295814467669 0.594232394487659 0.884060581459345 19 EZR,PAFAH1B1,PPP2R1A,PTPN1 GO:0001763 morphogenesis of a branching structure GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE 0.326424482927858 0.891795200511358 0.594297942841364 0.884060581459345 11 ENG,COL4A1,LAMA5,PHB2,DAG1,TGM2 GO:1904950 negative regulation of establishment of protein localization GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION 0.268305632168132 0.910410972700981 0.594683105374687 0.884060581459345 23 CD36,PFKL,PARK7,SSC5D,FN1,SRI,ANXA4 GO:0046605 regulation of centrosome cycle GO_REGULATION_OF_CENTROSOME_CYCLE -0.449593579920492 -0.909085605765051 0.594803707944011 0.884060581459345 5 RANBP1,NPM1 GO:0007044 cell substrate junction assembly GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY 0.325997646348146 0.890629078381745 0.595954714897142 0.884815201761767 11 LAMC1,KRT5,LAMA5,FN1 GO:0038093 fc receptor signaling pathway GO_FC_RECEPTOR_SIGNALING_PATHWAY -0.239780799898205 -0.921073819528884 0.596709025741284 0.884815201761767 50 HSP90AA1,PSMD2,ARPC3,ACTR3,PSME2,PSMB6,HSP90AB1,PIK3R1,PSMA2,PSMA1,IGHG3,ACTR2,IGHG2,ACTG1,PSMC2 GO:0034375 high density lipoprotein particle remodeling GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING 0.394171047207187 0.882876042420467 0.59727454021715 0.884815201761767 6 APOE,APOA4,APOC3 GO:0051726 regulation of cell cycle GO_REGULATION_OF_CELL_CYCLE 0.207671219014596 0.935379068712257 0.598607633251699 0.884815201761767 79 PSMB3,UBC,PSMB2,PRKAG2,CDC37,MIF,PSMA6,PSMB1,SDCBP,CAST,RHOA,PSMA4,PRKACB,PHB2,PSMD14,PSMC6,PRKAA2,PSMC1,PIN1,PSMA5,PSMA3,AK1 GO:0031330 negative regulation of cellular catabolic process GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS -0.320870997038953 -0.897267303109771 0.599471815590185 0.884815201761767 14 APOC1,HSP90AB1,HP GO:0060041 retina development in camera type eye GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE -0.353493568977608 -0.894521792279576 0.599679886181753 0.884815201761767 10 CLIC4,SERPINF1 NA regulation of stat cascade GO_REGULATION_OF_STAT_CASCADE -0.334316926087262 -0.894150557728547 0.600260944690304 0.884815201761767 12 PPP2R1A,BGN,HPX,AGT GO:0051147 regulation of muscle cell differentiation GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION 0.292373733619735 0.896668616520075 0.600352319436289 0.884815201761767 16 EHD2,BMP10,NACA,MYLK3,PIN1,DLL1,CDH2 GO:0070372 regulation of erk1 and erk2 cascade GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE 0.256805341948514 0.909834932676734 0.600374914792093 0.884815201761767 27 CD36,GLIPR2,PRKCDBP,MIF,RRAS,PHB2,FN1,PIN1 GO:0006415 translational termination GO_TRANSLATIONAL_TERMINATION 0.41718282100706 0.879184545970648 0.601182038252677 0.884815201761767 5 MRPS36,MRPL50,MRPL12 GO:0045597 positive regulation of cell differentiation GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION -0.221722695271569 -0.925580883028447 0.601393541892763 0.884815201761767 77 CSRP3,DPYSL3,XRCC5,ARHGDIA,SERPINF2,CLIC1,SERPINF1,H2AFY,PAFAH1B1,ADA,LIMS1,ARF1,FGA,CAPRIN2,FGB,FGG,AGT,EHD1 GO:0010460 positive regulation of heart rate GO_POSITIVE_REGULATION_OF_HEART_RATE -0.416871081378223 -0.896481263702753 0.601709277110629 0.884815201761767 6 ADA,HRC GO:0006885 regulation of ph GO_REGULATION_OF_PH -0.394821099426319 -0.893268517740776 0.60251772536536 0.884815201761767 7 CLIC4 GO:0030641 regulation of cellular ph GO_REGULATION_OF_CELLULAR_PH -0.394821099426319 -0.893268517740776 0.60251772536536 0.884815201761767 7 CLIC4 GO:0035690 cellular response to drug GO_CELLULAR_RESPONSE_TO_DRUG -0.39459384668505 -0.892754366598295 0.602969903053104 0.884815201761767 7 QDPR,NME1,PPP1R12A GO:0002274 myeloid leukocyte activation GO_MYELOID_LEUKOCYTE_ACTIVATION 0.357702430726228 0.882224642846546 0.603028871036702 0.884815201761767 8 S100A13,CLU,CD93,STXBP2 GO:1901700 response to oxygen containing compound GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND 0.185738666620522 0.9496318336968 0.603419938049181 0.884815201761767 170 CD36,COL3A1,GJA1,PFKL,COL1A1,APOE,CRYAB,SOD3,COL1A2,FBN1,NPPA,GNAI2,PKM2,ME1,GSR,COL4A1,GNAS,FABP3,GNG12,RETN,PARK7,ERO1L,PPIF,GNAO1,POSTN,SOD1,TPM1,PRKACB,APOA4,GNB2,DPYSL2,PSMD14,FN1,PRKAA2,GPX1,LGALS1,COL18A1,TXNRD1,MECP2 GO:0021695 cerebellar cortex development GO_CEREBELLAR_CORTEX_DEVELOPMENT 0.392049948011136 0.878125141315328 0.603589629957899 0.884815201761767 6 MYH10,HSPA5,DLL1 GO:0010498 proteasomal protein catabolic process GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS 0.235478627413207 0.914943139533561 0.60504986744098 0.884815201761767 39 PSMB3,UBC,PSMB2,PSMA6,NSFL1C,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,HSPA5,PSMA5,PSMA3 GO:0032231 regulation of actin filament bundle assembly GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY 0.333374892825869 0.884166878102756 0.605094231867504 0.884815201761767 10 PFN1,RHOA,TPM1,PFN2,RDX GO:0034332 adherens junction organization GO_ADHERENS_JUNCTION_ORGANIZATION -0.319146127754532 -0.892443966549811 0.605820522237963 0.884815201761767 14 FERMT2,PKP2 GO:0050728 negative regulation of inflammatory response GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE 0.308441803119945 0.887525842162176 0.6064453125 0.884815201761767 13 APOE,SERPINC1,GPX1 GO:0003015 heart process GO_HEART_PROCESS 0.236587411169828 0.91376255421117 0.606963045010573 0.884815201761767 38 GJA1,CACNA2D1,SGCD,ANK2,DMD,SOD1,TPM1,GPX1,SGCG,TNNI3,TNNC1,PLN GO:0007569 cell aging GO_CELL_AGING -0.332511150173128 -0.889320902348385 0.607542712061639 0.884815201761767 12 DNAJA3,LIMS1,PRELP,NPM1,HSD17B10 GO:0031570 dna integrity checkpoint GO_DNA_INTEGRITY_CHECKPOINT 0.414570042951398 0.873678293141148 0.608008200117768 0.884815201761767 5 UBC,CDC5L,CDK5RAP3,NPM1,PEA15 GO:0000075 cell cycle checkpoint GO_CELL_CYCLE_CHECKPOINT 0.414570042951398 0.873678293141148 0.608008200117768 0.884815201761767 5 UBC,CDC5L,CDK5RAP3,NPM1,PEA15 GO:0051130 positive regulation of cellular component organization GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION 0.1866894171793 0.947099005464503 0.60811107280534 0.884815201761767 161 CD36,MYO1C,GLIPR2,COL1A1,APOE,VTN,FAM21C,STOM,CCT8,EHD2,BMP10,ATAD1,HCLS1,C1QBP,SPTBN1,MAP1B,ARPC5L,CFL2,PFN1,PDCD5,SDCBP,APOC2,PARK7,CYB5R1,PPIF,DMD,CLU,PFDN2,RHOA,TPM1,ANK3,PHB2,MYLK3,PSMC6,FN1,DSTN,GPX1,ANXA2,PSMC1,MECP2,LRRC4B,TCP1,RALA,MYADM,PFN2,ITGB1,DLL1,UBE2N,C4B,DAG1,ABL2,FSCN1,TF,HNRNPA1,LMAN2 GO:0006338 chromatin remodeling GO_CHROMATIN_REMODELING -0.291235334713596 -0.897337418073269 0.608718922651934 0.884815201761767 20 RUVBL1,NPM1,HNRNPC,SMYD1,CTNNB1,HIST1H4H,HIST1H4F,HIST1H4E,HIST1H4D,HIST1H4C,HIST1H4B,HIST1H4A,HIST4H4,HIST2H4B,HIST2H4A,HIST1H4L,HIST1H4K,HIST1H4J,HIST1H4I,RBBP7 GO:1902930 regulation of alcohol biosynthetic process GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS 0.414278579417742 0.873064053480259 0.608771508952522 0.884815201761767 5 APOE,SOD1 GO:0009615 response to virus GO_RESPONSE_TO_VIRUS -0.318298343225034 -0.890073265098383 0.608776256186928 0.884815201761767 14 PCBP2,ENO1,PSMA2,IFNA2,BANF1,HSPB1,DDX1 GO:0002685 regulation of leukocyte migration GO_REGULATION_OF_LEUKOCYTE_MIGRATION -0.350669027474226 -0.887374239538288 0.609229948426107 0.884815201761767 10 ADA,C5,HMGB1,MSN GO:0097193 intrinsic apoptotic signaling pathway GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 0.307750784051356 0.885537469397538 0.609607514880952 0.884815201761767 13 DIABLO,ERO1L,CLU,GPX1,NOL3 GO:0002027 regulation of heart rate GO_REGULATION_OF_HEART_RATE 0.255207932717921 0.90417547595069 0.609991235758107 0.884815201761767 27 GJA1,CACNA2D1,NPPA,ANK2,DMD,TPM1 GO:0006401 rna catabolic process GO_RNA_CATABOLIC_PROCESS -0.231355352437684 -0.916031301104465 0.610485205959403 0.884815201761767 58 RPL39,RPL13A,RPS2,RPL10A,EIF4B,PPP2R1A,RPS3,RPL10,RNH1,RPSA NA macromitophagy GO_MACROMITOPHAGY 0.290065711710205 0.88959024191065 0.610733998825602 0.884815201761767 16 STOM,CDC37,NME2,MDH1,MYH11,PNPO,CD93,SNRPD1 GO:0006605 protein targeting GO_PROTEIN_TARGETING -0.212093049786814 -0.927096421521503 0.611689770297091 0.885560965217417 101 RPL39,RPL13A,HSP90AA1,TOMM40,RAN,MTX2,RPS2,RPL10A,PARD3,RPS3,MFN2,PIK3R1,RPL10,YWHAZ,RANBP1,RPSA,YWHAB,YWHAG,SSR1,YWHAQ,AGT GO:0006213 pyrimidine nucleoside metabolic process GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS -0.360812236876403 -0.883119914757121 0.612665210071994 0.885690935822785 9 APOBEC2,NT5C GO:0072512 trivalent inorganic cation transport GO_TRIVALENT_INORGANIC_CATION_TRANSPORT -0.442276916320324 -0.894291191747142 0.613158769435314 0.885690935822785 5 RAB11B,CLTC GO:1901214 regulation of neuron death GO_REGULATION_OF_NEURON_DEATH 0.252200484049219 0.90239113981219 0.613313479470781 0.885690935822785 28 APOE,SET,PARK7,CLU,SOD1,GPX1,PSMC1,MECP2,PIN1,RRAS2 GO:0016192 vesicle mediated transport GO_VESICLE_MEDIATED_TRANSPORT 0.182697374746327 0.949466292569572 0.613730544588377 0.885690935822785 191 CD36,RAB2A,MYO1C,RAB7A,EHD4,KIF5A,APOE,VTN,FAM21C,S100A13,SCRN1,ATL3,PACSIN2,EHD2,CD59,CRK,LGALS3BP,DCTN2,SPTAN1,SPTBN1,BCAP31,AMBP,DYSF,CYB5R1,ANK2,CLTA,CLU,SSC5D,SOD1,RAPGEF4,STX7,ANK3,MYH10,CLTB,DPYSL2,VPS13A,SRCRB4D GO:2000242 negative regulation of reproductive process GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS -0.390717645144731 -0.883984600216972 0.613984951526552 0.885690935822785 7 SERPINF1,ADA GO:0048010 vascular endothelial growth factor receptor signaling pathway GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY -0.360118874906212 -0.881422849908901 0.614742648375658 0.885917138749519 9 HSP90AA1,PIK3R1,ACTG1 GO:0045921 positive regulation of exocytosis GO_POSITIVE_REGULATION_OF_EXOCYTOSIS -0.390345881208051 -0.883143497699529 0.615178700622196 0.885917138749519 7 ARF1,FGA,FGB,FGG GO:0006954 inflammatory response GO_INFLAMMATORY_RESPONSE -0.252457988812049 -0.902399565074451 0.615465342906165 0.885917138749519 36 LXN,SERPINF2,AHCY,HP,C3,FGA,SERPINA3,C5,SERPINA1 GO:0000027 ribosomal large subunit assembly GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY 0.353568082373186 0.872027832073524 0.616575530502487 0.886266973757998 8 RPL24,RPL3,RPL23A,RPL5,RPL38 GO:0003014 renal system process GO_RENAL_SYSTEM_PROCESS -0.296193408105191 -0.888662172712909 0.616591116703149 0.886266973757998 18 SERPINF2,PRKAR2A,IGJ,AGT,AQP1,IGHA1,PRKAR2B,HBB GO:0034394 protein localization to cell surface GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE 0.411016051790547 0.866188497426182 0.617385994373323 0.886774732976848 5 ANK2,FBLN5,FLNA GO:2001252 positive regulation of chromosome organization GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION -0.315980487765001 -0.883591732218147 0.618168144533641 0.887263498372803 14 TRIM28,H2AFY,CCT6A GO:0070301 cellular response to hydrogen peroxide GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE -0.347952905265528 -0.88050104375936 0.618780010670461 0.887353800285241 10 PPP5C,RPS3,AQP1,AIFM1 GO:0098609 cell cell adhesion GO_CELL_CELL_ADHESION -0.234773703076689 -0.908865309393553 0.619114877589454 0.887353800285241 52 DNAJA3,EZR,CLIC1,PKP2,CSRP1,ADA,FGA,PARVA,FGB,FGG,ACTG1,STOML2,IFNA2,RPL22,HMGB1,HBB,MSN,DSP,HSPB1,JUP,ACTN1 GO:0071901 negative regulation of protein serine threonine kinase activity GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY -0.299750622624006 -0.884872496467837 0.621113596559677 0.888806588397869 17 H2AFY,PPP2R1A,PRKAR2A,PTPN1,YWHAG,PRKAR2B,CDK5RAP3 GO:0055076 transition metal ion homeostasis GO_TRANSITION_METAL_ION_HOMEOSTASIS -0.309224692485637 -0.882029570093138 0.621420479302832 0.888806588397869 15 FTL,ARF1,ACO1,HPX GO:0034614 cellular response to reactive oxygen species GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES 0.263376426659664 0.893685260514681 0.621941822384897 0.888806588397869 23 SOD3,PARK7,PPIF,SOD1,TPM1,APOA4 GO:0007159 leukocyte cell cell adhesion GO_LEUKOCYTE_CELL_CELL_ADHESION -0.291529177424829 -0.886917549321142 0.622190793218234 0.888806588397869 19 DNAJA3,EZR,ADA GO:0033993 response to lipid GO_RESPONSE_TO_LIPID -0.214039433227844 -0.919330013325659 0.622341664983767 0.888806588397869 91 HSP90AA1,EEF2,SERPINB9,RAN,KRT19,PAM,SERPINF1,PRDX3,YWHAH,MTAP,BDH1,C3,FGA NA nuclear import GO_NUCLEAR_IMPORT -0.298690978506478 -0.881744396424418 0.625587403977874 0.892807041355771 17 RAN,PIK3R1,RANBP1,AGT GO:0055001 muscle cell development GO_MUSCLE_CELL_DEVELOPMENT -0.239940452401864 -0.901388449706621 0.62666382532293 0.892836850433584 45 KRT8,CSRP3,KRT19,SORBS2,MYOZ1,MYL2,CAMK2D,LDB3,NEBL,AGT,FLNC,ACTG1 GO:0050810 regulation of steroid biosynthetic process GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS 0.384464155239888 0.861134256906253 0.626900066474629 0.892836850433584 6 APOE,SOD1 GO:0021537 telencephalon development GO_TELENCEPHALON_DEVELOPMENT -0.271757579127354 -0.888167834441624 0.626942210712825 0.892836850433584 25 HPRT1,RAN,PAFAH1B1,RTN4 GO:0046131 pyrimidine ribonucleoside metabolic process GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS 0.384168361805772 0.860471729969442 0.627742078440062 0.893342376688621 6 CMPK1,ENTPD4,NME2 GO:0009913 epidermal cell differentiation GO_EPIDERMAL_CELL_DIFFERENTIATION -0.326784143060789 -0.874003680263505 0.628682758255902 0.894047435253436 12 CLIC4,PAFAH1B1,PALLD GO:0090502 rna phosphodiester bond hydrolysis endonucleolytic GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC -0.43553585804897 -0.88066066116173 0.629944233112974 0.895207374445047 5 RPSA,DROSHA,ERVK-7,HRSP12 GO:0034446 substrate adhesion dependent cell spreading GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING 0.349383607086504 0.861707390001608 0.630774769909314 0.895753704369096 8 LAMC1,LAMA5,LAMB1,FN1 GO:0010633 negative regulation of epithelial cell migration GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION 0.308823979301226 0.867543766393034 0.63217594196872 0.895796431530496 12 APOE,BMP10,RHOA,PFN2,APOH,CD63 GO:0034660 ncrna metabolic process GO_NCRNA_METABOLIC_PROCESS -0.225797589747092 -0.906035898856999 0.632198449811031 0.895796431530496 62 RPL39,RPL13A,C14orf166,RPS2,PPA1,RPL10A NA cofactor catabolic process GO_COFACTOR_CATABOLIC_PROCESS -0.404919521031727 -0.870779433085902 0.63478324252419 0.895796431530496 6 BLVRA GO:0010720 positive regulation of cell development GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT -0.234281397510225 -0.899948877228363 0.635858585858586 0.895796431530496 50 DPYSL3,XRCC5,ARHGDIA,SERPINF1,PAFAH1B1,LIMS1,ARF1,FGA,CAPRIN2,FGB,FGG GO:0045595 regulation of cell differentiation GO_REGULATION_OF_CELL_DIFFERENTIATION 0.188337999195587 0.931998353396162 0.636177453844532 0.895796431530496 136 CD36,BCL11B,COL3A1,GLIPR2,GJA1,COL1A1,APOE,CFL1,FAM21C,EHD2,BMP10,HCLS1,C1QBP,NACA,GNAS,MAP1B,LTBP4,SDCBP,DMD,CLU,POSTN,RHOA,SOD1 GO:0051099 positive regulation of binding GO_POSITIVE_REGULATION_OF_BINDING -0.288433217358868 -0.877498727717236 0.636178616395591 0.895796431530496 19 RAN,ENO1,HSP90AB1,CAPRIN2,MAPRE1 GO:0071705 nitrogen compound transport GO_NITROGEN_COMPOUND_TRANSPORT -0.235617036672162 -0.897538410179849 0.636190072125583 0.895796431530496 48 C14orf166,RAN,THOC4,ADA,SRSF7,RANBP1,HNRNPA2B1,SERPINA7,RPSA,VDAC3,HPX,RAB11B GO:2000241 regulation of reproductive process GO_REGULATION_OF_REPRODUCTIVE_PROCESS -0.317238017634332 -0.868809265033268 0.63644817180153 0.895796431530496 13 SERPINF1,ADA,PPP2R1A GO:0002040 sprouting angiogenesis GO_SPROUTING_ANGIOGENESIS 0.404452339997722 0.852355919280881 0.636795847599939 0.895796431530496 5 CDH13,ITGB1,DLL1,CDC42 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL -0.383135241251947 -0.866829684494231 0.636847055418897 0.895796431530496 7 SERPINF2,AGT GO:0051238 sequestering of metal ion GO_SEQUESTERING_OF_METAL_ION 0.404371584699454 0.85218573295808 0.63705755348614 0.895796431530496 5 SRI,CASQ2,CALR,HSP90B1,FTH1 GO:0015672 monovalent inorganic cation transport GO_MONOVALENT_INORGANIC_CATION_TRANSPORT 0.224120106965229 0.904213244515043 0.63765810606255 0.895796431530496 46 ATP5I,SLC25A20,NDUFA4,PRKAG2,CYB5A,UQCRH,COX7A2L,PARK7,COX7A2,PRKAA2,CPT1B,SLC10A4,ATP5EP2 GO:0038128 erbb2 signaling pathway GO_ERBB2_SIGNALING_PATHWAY 0.403964778930687 0.851328417347029 0.637799053497045 0.895796431530496 5 UBC,CDC37 NA cell substrate adherens junction assembly GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY -0.432083833702996 -0.873680611214774 0.637939949034236 0.895796431530496 5 FERMT2 GO:1903828 negative regulation of cellular protein localization GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION 0.315415460499032 0.861718432750902 0.638041327258502 0.895796431530496 11 CD36,PARK7,SRI,TAX1BP3 GO:0030879 mammary gland development GO_MAMMARY_GLAND_DEVELOPMENT -0.403489705820274 -0.867704615462701 0.638373088907921 0.895796431530496 6 PAM,CAPN1,NME1 GO:1903650 negative regulation of cytoplasmic transport GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT 0.294980734848319 0.868709936259298 0.638388791593695 0.895796431530496 14 CD36,PARK7,FKBP1A,SRI,PLN GO:0043044 atp dependent chromatin remodeling GO_ATP_DEPENDENT_CHROMATIN_REMODELING -0.290833907649897 -0.872582188523774 0.641307157999966 0.897622994994803 18 RUVBL1,NPM1,HNRNPC,HIST1H4H,HIST1H4F,HIST1H4E,HIST1H4D,HIST1H4C,HIST1H4B,HIST1H4A,HIST4H4,HIST2H4B,HIST2H4A,HIST1H4L,HIST1H4K,HIST1H4J,HIST1H4I,RBBP7 GO:0042776 mitochondrial atp synthesis coupled proton transport GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT -0.323427220306613 -0.865025390148112 0.641342102015269 0.897622994994803 12 ATP5D,ATP5J2,ATP5F1,ATP5A1,STOML2 GO:0043414 macromolecule methylation GO_MACROMOLECULE_METHYLATION -0.323256523563523 -0.864568851528238 0.641959200945043 0.897622994994803 12 ARID4A,TRIM28 GO:0033500 carbohydrate homeostasis GO_CARBOHYDRATE_HOMEOSTASIS -0.294916671644549 -0.87060253354482 0.642008704850093 0.897622994994803 17 SERPINF1,GPI,PIK3R1,RAB11B GO:0051016 barbed end actin filament capping GO_BARBED_END_ACTIN_FILAMENT_CAPPING -0.430230051373119 -0.869932232884703 0.642297891199173 0.897622994994803 5 CAPZB GO:0001649 osteoblast differentiation GO_OSTEOBLAST_DIFFERENTIATION 0.259812706078989 0.881592892963284 0.64262666152957 0.897622994994803 23 GJA1,COL1A1,RRBP1,FHL2 GO:0034330 cell junction organization GO_CELL_JUNCTION_ORGANIZATION 0.231648555926328 0.894687401565199 0.642936260195348 0.897622994994803 38 GJA1,LAMC1,KRT5,CDH13,ANK2,XIRP2,RHOA,LAMA5,FN1,TJP1,INADL,MYADM,ITGB1 GO:0010638 positive regulation of organelle organization GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION -0.2159910138497 -0.905571858096632 0.643266678186017 0.897622994994803 79 ARPC3,TRIM28,SERPINF2,ACTR3,H2AFY,YWHAH,RPS3,TMED9,YWHAZ,RANBP1,LMAN1,CCT6A,YWHAB,YWHAG,ACTR2,NPEPPS,YWHAQ,DYNLL2,UBE2L3,RUVBL1 GO:0017158 regulation of calcium ion dependent exocytosis GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS -0.42891111218849 -0.867265316182206 0.645751006389186 0.899846953046277 5 ARF1,NAPA,ATP2A2 GO:0046677 response to antibiotic GO_RESPONSE_TO_ANTIBIOTIC 0.378055568200755 0.846780112930674 0.645756702858409 0.899846953046277 6 AOC3,SOD1,HSPA5 NA cellular macromolecular complex assembly GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY -0.199794238106022 -0.918361619679785 0.64727582292849 0.901338316532877 141 HSP90AA1,EIF3F,EIF4H,NAP1L4,H2AFY,EIF4B,RTN4,ANP32B,DYNC1H1,NDUFB8,NDUFV1,NDUFC2,STRAP,NDUFB9,FGA,RPL10,NDUFS3,NDUFA10,RPSA,FGB,VAMP3,NDUFS8,LONP1,FGG,NDUFA5,NDUFA9,RUVBL1,NDUFB2,NPM1,NDUFB3,FMOD,CAND1,NDUFS7 GO:0032259 methylation GO_METHYLATION -0.285644167385077 -0.869013616931618 0.648838372514186 0.902632274692937 19 ARID4A,TRIM28,AHCY,MTAP,GSTO1,COQ3,COQ5 GO:0050953 sensory perception of light stimulus GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS 0.278038736489133 0.867032362915093 0.649186214064678 0.902632274692937 17 COL1A1,LAMB2,COL18A1,PCDH15 GO:0050777 negative regulation of immune response GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE -0.292917406241083 -0.864700644323772 0.650228025455617 0.902632274692937 17 SERPINB9,DNAJA3 GO:0045017 glycerolipid biosynthetic process GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS 0.312275761395207 0.853140741008152 0.650513139122831 0.902632274692937 11 CDIPT,FABP5 GO:0006979 response to oxidative stress GO_RESPONSE_TO_OXIDATIVE_STRESS 0.204014343297574 0.90984076847703 0.650819716999206 0.902632274692937 75 CD36,COL1A1,APOE,CRYAB,SOD3,DIABLO,GSR,PARK7,ERO1L,PPIF,GNAO1,SOD1,TPM1,APOA4,FN1,GPX1 GO:0030900 forebrain development GO_FOREBRAIN_DEVELOPMENT 0.248494223102565 0.880389492802711 0.651426623819262 0.902632274692937 27 BCL11B,COL3A1,GNG12,GNAO1,MYH10,LAMB1,DPYSL2 GO:0045088 regulation of innate immune response GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE 0.217577565143219 0.898334394148482 0.651674046453818 0.902632274692937 51 CD36,PSMB3,UBC,PSMB2,CDC37,C1QBP,PSMA6,PSMB1,PSMA4,PRKACB,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:2000257 regulation of protein activation cascade GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE 0.257998846368365 0.875438129195755 0.65180119437488 0.902632274692937 23 VTN,SERPINC1,CD59,C1QBP GO:0034101 erythrocyte homeostasis GO_ERYTHROCYTE_HOMEOSTASIS -0.313036167264378 -0.857301796417361 0.653256368867991 0.903189850971337 13 ARID4A,GPI GO:0048738 cardiac muscle tissue development GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT 0.219210410155296 0.896642401228755 0.653345029541526 0.903189850971337 49 NEXN,NPPA,BMP10,FHL2,SGCD,XIRP2,TPM1,MYH10,MYLK3,SGCG,FKBP1A,TNNI3,MYH11,ITGB1,TNNC1,PLN GO:0006644 phospholipid metabolic process GO_PHOSPHOLIPID_METABOLIC_PROCESS 0.263066861775377 0.871280198856081 0.653695381967683 0.903189850971337 21 CDIPT,DBI,FABP5,APOA4,FDPS,MECP2 GO:0045070 positive regulation of viral genome replication GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION 0.398188136731772 0.839154535074916 0.654003009617691 0.903189850971337 5 STOM,VAPB GO:0033135 regulation of peptidyl serine phosphorylation GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION 0.286131926032396 0.860087381589699 0.654749337274497 0.903599085393258 15 HCLS1,MIF,PARK7,DMD,PFN2 GO:0032024 positive regulation of insulin secretion GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION -0.348020817403985 -0.851811782383624 0.655986962283749 0.904685316116599 9 GLUD1,OXCT1,BRP44 GO:0051094 positive regulation of developmental process GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS -0.205811282206421 -0.906391523419647 0.65880117675901 0.904985871858628 106 CSRP3,EZR,DPYSL3,XRCC5,ARHGDIA,SERPINF2,CLIC1,SERPINF1,H2AFY,PAFAH1B1,ADA,LIMS1,LRG1,PARD3,ARF1,C3,FGA,CAPRIN2,C5 GO:0031347 regulation of defense response GO_REGULATION_OF_DEFENSE_RESPONSE 0.193785746971371 0.914639468015957 0.659670121986141 0.904985871858628 102 CD36,PSMB3,GJA1,UBC,APOE,VTN,STOM,PSMB2,SERPINC1,CDC37,CD59,C1QBP,PSMA6,PSMB1,PARK7,PSMA4,PRKACB,PHB2,PSMD14,HIST1H3A,PSMC6,GPX1,PSMC1,PSMA5,PSMA3 GO:0048754 branching morphogenesis of an epithelial tube GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE 0.328734745139635 0.842643094555492 0.659678040165735 0.904985871858628 9 ENG,COL4A1,LAMA5,PHB2,DAG1 GO:0009628 response to abiotic stimulus GO_RESPONSE_TO_ABIOTIC_STIMULUS -0.204949689262119 -0.90667836117041 0.659718507877806 0.904985871858628 109 XRCC6,KRT8,HSP90AA1,CSRP3,DNAJA3,XRCC5,LXN,CYGB,PAM,SERPINF1,ADA,DNAJA2,HSP90AB1,AHCY,PIK3R1,CAMK2D GO:0048167 regulation of synaptic plasticity GO_REGULATION_OF_SYNAPTIC_PLASTICITY -0.335696450096047 -0.849485864963017 0.660092477325271 0.904985871858628 10 YWHAH,ARF1,YWHAG,AGT GO:0009064 glutamine family amino acid metabolic process GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS -0.35988195489354 -0.849051448894036 0.660481940720212 0.904985871858628 8 ALDH4A1,GLUD1,GOT1,DDAH2,ALDH5A1 GO:0032075 positive regulation of nuclease activity GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY -0.422967977248061 -0.855248199682413 0.661040735679728 0.904985871858628 5 RPS3,PTPN1 GO:2001021 negative regulation of response to dna damage stimulus GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS -0.3750285882893 -0.848488674132058 0.661119953697005 0.904985871858628 7 OTUB1,RPS3 NA positive regulation of cell proliferation GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION 0.206749842043518 0.902194920211365 0.661213635264727 0.904985871858628 67 RPS4X,LAMC1,S100A13,CD59,BMP10,HCLS1,GNAI2,MIF,NACA,RETN,CDH13,SDCBP,CLU,LAMB1,FN1,NME2,ANXA2,COL18A1,MECP2 GO:0018149 peptide cross linking GO_PEPTIDE_CROSS_LINKING 0.340404856286253 0.839562516113339 0.661356016111974 0.904985871858628 8 COL3A1,FN1,TGM2 GO:0030183 b cell differentiation GO_B_CELL_DIFFERENTIATION -0.395438750775688 -0.850391036577539 0.661424640559797 0.904985871858628 6 ADA,PIK3R1 NA positive regulation of transcription factor import into nucleus GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS -0.422711935786997 -0.854730479641185 0.661613177235292 0.904985871858628 5 TRIM28,PIK3R1 GO:0006811 ion transport GO_ION_TRANSPORT 0.188778919248042 0.919295943781792 0.664508308201762 0.907178832721215 123 CD36,GJA1,CACNA2D1,UBC,APOE,ATP5I,ANXA6,SLC25A20,NDUFA4,PRKAG2,CYB5A,UQCRH,FABP3,COX7A2L,APOC2,PARK7,CYB5R1,ERO1L,ANK2 GO:0008360 regulation of cell shape GO_REGULATION_OF_CELL_SHAPE -0.285703280509517 -0.857188887602199 0.664523690515176 0.907178832721215 18 EZR,FERMT2 GO:0080135 regulation of cellular response to stress GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS -0.211246770353533 -0.897035895981886 0.664748921268213 0.907178832721215 85 HSP90AA1,CAPNS1,EZR,TRIM28,SERPINF2,PAFAH1B1,HSP90AB1,OTUB1,RPS3,ERP29,HP,PIK3R1,CAMK2D,PTPN1,DBNL GO:1904589 regulation of protein import GO_REGULATION_OF_PROTEIN_IMPORT -0.285594416384881 -0.856862265108646 0.665023526775711 0.907178832721215 18 HSP90AA1,TRIM28,HSP90AB1,PIK3R1 GO:0006457 protein folding GO_PROTEIN_FOLDING 0.207123778642442 0.898557118190871 0.665809355409098 0.907180534164309 65 CRYAB,PFDN6,CDC37,CCT8,GNAI2,TBCA,LTBP4,ERO1L,PPIF,GNAO1,CLU,PFDN2,GNB2,UGGT1,HSPE1,DNAJC1,FKBP1A,HSPA5,TCP1,PFDN5 GO:0001909 leukocyte mediated cytotoxicity GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY -0.420216306790129 -0.849684276804427 0.667762307493445 0.907180534164309 5 TUBB GO:0043473 pigmentation GO_PIGMENTATION 0.393053505745368 0.82833364795974 0.668091509824875 0.907180534164309 5 DCTN2,GNA11,CD63 GO:0061035 regulation of cartilage development GO_REGULATION_OF_CARTILAGE_DEVELOPMENT 0.39294938574659 0.828114222112743 0.668287789239526 0.907180534164309 5 BMP10,RARB,RARA GO:0043549 regulation of kinase activity GO_REGULATION_OF_KINASE_ACTIVITY -0.219688125355429 -0.887118707216261 0.669765064762909 0.907180534164309 64 DNAJA3,H2AFY,PPP2R1A,HSP90AB1,PRDX3,BGN,RPS3,ERP29,PRKAR2A,PIK3R1,C5,PTPN1,DBNL,YWHAG,AGT,PEA15,NPM1,EEF1A2 GO:0016072 rrna metabolic process GO_RRNA_METABOLIC_PROCESS 0.214771611879114 0.889654164313086 0.669765140863407 0.907180534164309 52 RPS4X,RPS8,RPS23,RPL14,RPL18,RPL19,RPL35,RPL7A,RPL24,RPS21,RPL3,RPL23A,RPS24,RPS14,RPL31,RPL7,RPL29,FAU GO:0048871 multicellular organismal homeostasis GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS -0.242112018032379 -0.870651427671793 0.670851138120812 0.907180534164309 37 PRKAR2A,FH,STRAP,SERPINA3,IGJ,IGHG3,ACADVL,ACTG1,AQP1,IGHA1,PRKAR2B,TPP1,ALB,IGKC,LTF,HSPB1 NA organ regeneration GO_ORGAN_REGENERATION 0.307022868747322 0.838789781759731 0.670923650421096 0.907180534164309 11 PKM2,CAST,APOH,GSTP1,NCL,CAV1 GO:2000649 regulation of sodium ion transmembrane transporter activity GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY -0.322978833049271 -0.841959707284173 0.671842393803275 0.907180534164309 11 YWHAH,CAMK2D,AGT,GPD1L,ATP1B1,ACTN4,GLRX GO:0072599 establishment of protein localization to endoplasmic reticulum GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 0.213266951692753 0.890950433383645 0.671948418084995 0.907180534164309 54 RPS4X,RPS8,RPS23,RPL14,RPL18,RPL19,RPL35,RPL7A,RPL24,RPS21,RPL3,RPL23A,RPS24,RPS14,RPL31,RPL7,RPL29,FAU GO:0048193 golgi vesicle transport GO_GOLGI_VESICLE_TRANSPORT 0.220316086161025 0.88424045470716 0.672137032668342 0.907180534164309 45 RAB2A,KIF5A,ATL3,CD59,DCTN2,SPTAN1,SPTBN1,BCAP31,ANK2,ANK3,VPS13A GO:0010942 positive regulation of cell death GO_POSITIVE_REGULATION_OF_CELL_DEATH -0.215838878306969 -0.888577440655607 0.672345671207763 0.907180534164309 71 DNAJA3,PPP2R1A,ANP32B,YWHAH,RPS3,HP,CAMK2D,YWHAZ,MTCH2,YWHAB,YWHAG,YWHAQ,AGT,DYNLL2,PEA15,EEF1A2,ZMAT3,AIFM1,OBSCN,HBA2,HBA1,HMGB1,HBB GO:0018958 phenol containing compound metabolic process GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS -0.342652948910749 -0.838673448697347 0.67283928507468 0.907180534164309 9 HPRT1 GO:0048588 developmental cell growth GO_DEVELOPMENTAL_CELL_GROWTH 0.287099159117987 0.845498918245393 0.673274956217163 0.907180534164309 14 LAMB2,NPPA,MAP1B,POSTN,IQGAP1,ITGB1 GO:0042113 b cell activation GO_B_CELL_ACTIVATION -0.37070696730567 -0.838711162302286 0.673292577051078 0.907180534164309 7 ADA,PIK3R1 NA macromolecular complex assembly GO_MACROMOLECULAR_COMPLEX_ASSEMBLY -0.187213602008746 -0.920673039445944 0.673432174266758 0.907180534164309 241 XRCC6,HSP90AA1,HPRT1,EIF3F,DPYSL3,FERMT2,EIF4H,TRIM28,DCXR,NAP1L4,PAM,H2AFY,EIF4B,APOC1,SEPT11,RTN4,TUBB,PPP5C,PPP2R1A,ANP32B,DYNC1H1,PARD3,RPS3,NDUFB8,NDUFV1,ARF1,NDUFC2,FH,STRAP,CAMK2D,NDUFB9,FGA,RPL10,CRYZ,LMAN1,NDUFS3,NDUFA10,DBNL,RPSA,SERPINA1,FGB,YWHAB,VAMP3,NDUFS8,LONP1,FGG,NDUFA5,EHD1,NDUFA9,PCBD2,RUVBL1,NDUFB2,NPM1,NDUFB3,FMOD,CAND1,NDUFS7,TFG,HSPA4,ALAD,STOML2,NDUFB11,SEC22B,NAPA,AIFM1,HBA2,HBA1,HSD17B10,SAMM50,HMGB1,HBB,GPX3,TPPP,NUBPL,NDUFAF3,PSMD11,NDUFA7,ARPC4,JUP,SAR1B,NDUFB10,NDUFS4,ACAT1,COL6A1,DDX1,RPS5,NDUFA3,CAT,ALDH5A1,UQCR10,DNM1L,CTNNB1,FIS1,APCS,NDUFS5,ANXA5,GRHPR,ACTN2,SCO1,NDUFS1,DECR1,VCP,NDUFAF2 GO:0048261 negative regulation of receptor mediated endocytosis GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS 0.369102421581355 0.826726588678824 0.673454464879238 0.907180534164309 6 SDCBP,APOC2,ANXA2,APOC3 GO:0007610 behavior GO_BEHAVIOR -0.258022083343936 -0.859342490381179 0.67525921903372 0.907180534164309 27 HPRT1,SERPINF1,PAFAH1B1,AHCY,GPI NA regulation of receptor activity GO_REGULATION_OF_RECEPTOR_ACTIVITY 0.275957577660825 0.846322603319728 0.675490311215502 0.907180534164309 16 STOM,PARK7,DMD,ANXA2,FKBP1A,SRI,PLN,CALM1,CAV1,JPH2 GO:0090150 establishment of protein localization to membrane GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE -0.211414699760122 -0.88984731317282 0.675556323862208 0.907180534164309 81 RPL39,RPL13A,HSP90AA1,KRT18,EZR,RPS2,RPL10A,PKP2 GO:1902115 regulation of organelle assembly GO_REGULATION_OF_ORGANELLE_ASSEMBLY 0.27249318761418 0.849739195763545 0.67564311530012 0.907180534164309 17 RAB7A,BMP10,SDCBP,MYLK3,RDX,FSCN1,CDK5RAP2 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING -0.307142351632821 -0.841160598507731 0.675942171380448 0.907180534164309 13 HRC,CAMK2D,GSTO1,GSTM2,ATP1B1,ATP2A2 GO:0030004 cellular monovalent inorganic cation homeostasis GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS -0.307000322044315 -0.840771626771863 0.676538704470489 0.907180534164309 13 CLIC4,CAMK2D,AGT,ATP1B1,ATP1A3,CA2,SLC4A1,PPT1,ATP5B,ATP1A1,SLC8A1 GO:0055067 monovalent inorganic cation homeostasis GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS -0.307000322044315 -0.840771626771863 0.676538704470489 0.907180534164309 13 CLIC4,CAMK2D,AGT,ATP1B1,ATP1A3,CA2,SLC4A1,PPT1,ATP5B,ATP1A1,SLC8A1 GO:0016571 histone methylation GO_HISTONE_METHYLATION 0.350941270757547 0.827268620483232 0.676759319304993 0.907180534164309 7 HIST1H1D,WHSC1,MECP2 GO:0045939 negative regulation of steroid metabolic process GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS 0.389834627603354 0.82155008023998 0.677120362898829 0.907180534164309 5 APOE,SOD1 GO:0002819 regulation of adaptive immune response GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE -0.321377032784995 -0.837784042678215 0.677554557351537 0.907180534164309 11 ADA,C3,HPX,IFNA2,HMGB1 GO:0060326 cell chemotaxis GO_CELL_CHEMOTAXIS -0.34121523149468 -0.835154507951557 0.677674701815968 0.907180534164309 9 C5,PARVA,CORO1B,HMGB1 GO:0000070 mitotic sister chromatid segregation GO_MITOTIC_SISTER_CHROMATID_SEGREGATION -0.415690676329483 -0.840533377653437 0.678804889758836 0.907867301532224 5 PPP2R1A GO:0006066 alcohol metabolic process GO_ALCOHOL_METABOLIC_PROCESS 0.227414029026232 0.872436518857196 0.679721016583457 0.907867301532224 37 APOE,SORD,PRKAG2,DBI,FABP5,PARK7,CYB5R1,APOA4,PRKAA2,FDPS,MECP2 GO:0045833 negative regulation of lipid metabolic process GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS -0.31271241288909 -0.836367998670925 0.680060652009098 0.907867301532224 12 ERLIN2,APOC1 GO:0016055 wnt signaling pathway GO_WNT_SIGNALING_PATHWAY 0.218480529756318 0.881460353331774 0.680324293814301 0.907867301532224 46 PSMB3,UBC,PSMB2,PSMA6,PSMB1,PFN1,GNAO1,RHOA,PSMA4,PSMD14,PSMC6,PRKAA2,PSMC1,PSMA5,PSMA3 GO:0003382 epithelial cell morphogenesis GO_EPITHELIAL_CELL_MORPHOGENESIS -0.41502078167035 -0.83917883964579 0.680448350999003 0.907867301532224 5 CLIC4,PALLD GO:0007346 regulation of mitotic cell cycle GO_REGULATION_OF_MITOTIC_CELL_CYCLE -0.228246214055933 -0.87275278902122 0.682249399931421 0.908668499264875 49 PSMD2,PSME2,H2AFY,PAFAH1B1,PSMB6,DYNC1LI1,CAMK2D,PSMA2,PSMA1,RANBP1 GO:0048736 appendage development GO_APPENDAGE_DEVELOPMENT 0.334264944824144 0.824419255314773 0.682441099034632 0.908668499264875 8 GJA1,GNAS GO:0010506 regulation of autophagy GO_REGULATION_OF_AUTOPHAGY 0.249553237751298 0.857842455934419 0.6828118611866 0.908668499264875 24 MAP1LC3B,RAB7A,PARK7,PRKAA2 GO:0030595 leukocyte chemotaxis GO_LEUKOCYTE_CHEMOTAXIS -0.413871157652895 -0.836854280993296 0.683236695350297 0.908668499264875 5 HMGB1,ANXA1,RPS19 GO:0060341 regulation of cellular localization GO_REGULATION_OF_CELLULAR_LOCALIZATION -0.193880533607162 -0.905488019300445 0.683311471060738 0.908668499264875 158 HSP90AA1,EZR,TRIM28,PAM,H2AFY,HRC,HSP90AB1,ANP32B,YWHAH,PARD3,ARF1,ERP29,PIK3R1,CAMK2D,GLUD1,OXCT1,FGA,BRP44,YWHAZ,C5,PTPN1,FGB,CCT6A,YWHAB,YWHAG,VAMP3,DPP10,NPEPPS,FGG,YWHAQ,GSTO1,AGT,RAB11B,EHD1,GPD1L,DYNLL2,UBE2L3,GSTM2,RUVBL1,SNX3 GO:0007052 mitotic spindle organization GO_MITOTIC_SPINDLE_ORGANIZATION -0.367155275312748 -0.83067558708455 0.684379973954565 0.909487086499515 7 RAN,DYNC1H1 GO:0030901 midbrain development GO_MIDBRAIN_DEVELOPMENT -0.277327816588689 -0.843712830462212 0.686282964521637 0.911017592425379 19 YWHAH,GLUD1,NDUFS3,YWHAQ,ATP5F1,NDRG2,MAOB GO:0006342 chromatin silencing GO_CHROMATIN_SILENCING 0.254363231193645 0.85326628182665 0.68643905245996 0.911017592425379 22 HIST1H3A,SIRT5,MECP2,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:1904063 negative regulation of cation transmembrane transport GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT -0.309973530983049 -0.82904269566428 0.69046317682529 0.915753011271587 12 CAMK2D,GSTO1,AGT,GSTM2 GO:0007173 epidermal growth factor receptor signaling pathway GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY -0.409600553084532 -0.828219048386771 0.693411382354027 0.917796784963446 5 PIK3R1,ARF4,EFEMP1,GRB2 GO:0071103 dna conformation change GO_DNA_CONFORMATION_CHANGE -0.233593975940437 -0.86020774927449 0.694428886765723 0.917796784963446 41 XRCC6,XRCC5,NAP1L4,H2AFY,ANP32B GO:0016049 cell growth GO_CELL_GROWTH 0.264518936976516 0.838224060026638 0.694662125145892 0.917796784963446 18 LAMB2,NPPA,MAP1B,POSTN,IQGAP1,ITGB1 GO:0001819 positive regulation of cytokine production GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION -0.252296929461488 -0.847837983882938 0.694931905955688 0.917796784963446 28 XRCC6,XRCC5,SERPINF2,PIK3R1,C3,C5 GO:0051225 spindle assembly GO_SPINDLE_ASSEMBLY -0.383140613232182 -0.823943891695858 0.695282176503818 0.917796784963446 6 TUBB,RPS3 GO:0070665 positive regulation of leukocyte proliferation GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION -0.348568148955513 -0.822359353906862 0.695664693073227 0.917796784963446 8 DNAJA3,ADA,ADK GO:0007050 cell cycle arrest GO_CELL_CYCLE_ARREST 0.318494157032966 0.816393478474883 0.695677768469672 0.917796784963446 9 PRKAG2,PRKAA2,AK1 GO:0007219 notch signaling pathway GO_NOTCH_SIGNALING_PATHWAY 0.318461858313583 0.816310687430575 0.695994747209455 0.917796784963446 9 UBC,DLL1,ANXA4,PLN,PGAM2 GO:0009268 response to ph GO_RESPONSE_TO_PH -0.382767318054453 -0.823141120413288 0.696430198443793 0.917796784963446 6 PAM,SERPINF1,RAB11B GO:0048585 negative regulation of response to stimulus GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS 0.180486249890228 0.91562955390707 0.696680979095496 0.917796784963446 161 PSMB3,COL3A1,GJA1,RAB7A,UBC,APOE,VTN,PRKCDBP,PSMB2,SERPINC1,FBN1,CD59,MIF,C1QBP,PSMA6,ENG,AMBP,PSMB1,RETN,PARK7,PPIF,CLTA,CLU,PSMA4,PRKACB,PHB2,PSMD14,PSMC6,PRKAA2,GPX1,ANXA2,PSMC1,FKBP1A,HSPA5,PIN1,PSMA5,PSMA3,LRRC4B,TXNDC12,PFDN5,SRI,MYADM,ITGB1 GO:0046883 regulation of hormone secretion GO_REGULATION_OF_HORMONE_SECRETION -0.253754991198675 -0.845130940953815 0.697031920851223 0.917796784963446 27 GLUD1,OXCT1,FGA,BRP44,FGB,VAMP3,FGG,AGT GO:0014850 response to muscle activity GO_RESPONSE_TO_MUSCLE_ACTIVITY -0.407133246268887 -0.823230113465802 0.699135797909665 0.919419150204615 5 SRL,AGT NA negative regulation of homeostatic process GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS -0.28174964787529 -0.831733099040359 0.699179801973331 0.919419150204615 17 XRCC5,ADA,GSTO1,GSTM2,HNRNPC GO:0002821 positive regulation of adaptive immune response GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE -0.346653061401878 -0.817841183878989 0.701027588316807 0.920523724479391 8 ADA,C3,HPX GO:1990778 protein localization to cell periphery GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY -0.261859423760565 -0.837548043218304 0.701867496665185 0.920523724479391 23 KRT18,EZR,PKP2 GO:0003254 regulation of membrane depolarization GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION 0.342939030656036 0.808405059308844 0.701871687649545 0.920523724479391 7 GJA1,ANK3,B2M GO:0043112 receptor metabolic process GO_RECEPTOR_METABOLIC_PROCESS 0.307748213392079 0.816200568585412 0.702067390062821 0.920523724479391 10 CD36,ITGB1,CD81 GO:0043001 golgi to plasma membrane protein transport GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT -0.405797703085784 -0.820529623205573 0.702311925250212 0.920523724479391 5 KRT18,VAMP3 GO:0034975 protein folding in endoplasmic reticulum GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM -0.380215404077988 -0.817653229387318 0.703300107513166 0.920775796509811 6 VAPA NA single organism membrane fusion GO_SINGLE_ORGANISM_MEMBRANE_FUSION 0.291728301146861 0.819518839544285 0.703421350520942 0.920775796509811 12 RAB7A,DYSF,STX7 GO:0001503 ossification GO_OSSIFICATION 0.233841039019635 0.85140142961972 0.704080629301868 0.921038373705636 30 GJA1,COL1A1,RRBP1,FHL2,GNAS,RHOA,HSPE1,RRAS2,ASPN,ERH GO:0045103 intermediate filament based process GO_INTERMEDIATE_FILAMENT_BASED_PROCESS -0.313524068493231 -0.817312485907812 0.705107346231387 0.921365273607049 11 KRT18,PKP2 GO:0050821 protein stabilization GO_PROTEIN_STABILIZATION 0.229519043347646 0.855097804680486 0.705248219887467 0.921365273607049 33 CDC37,CCT8,PFN1,PARK7,ANK2,CLU,PHB2,PIN1,LAMP2,TCP1,PFN2 GO:0042752 regulation of circadian rhythm GO_REGULATION_OF_CIRCADIAN_RHYTHM -0.331979432986121 -0.812549072885932 0.70824528099144 0.922643650266074 9 ADA,HNRNPD,ALB GO:0048284 organelle fusion GO_ORGANELLE_FUSION 0.28349938159291 0.815755273298211 0.709216889880952 0.922643650266074 13 RAB7A,DYSF,STX7 GO:1990542 mitochondrial transmembrane transport GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT -0.249484578818162 -0.838387144728857 0.709397655667728 0.922643650266074 28 HSP90AA1,TOMM40,BRP44,ATP5D,ATP5J2,ATP5F1,ATP5A1,HSPA4,STOML2 GO:0032273 positive regulation of protein polymerization GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION -0.287424479987202 -0.819846851425462 0.710152505446623 0.922643650266074 15 ARPC3,ACTR3,RPS3,ACTR2 GO:0002444 myeloid leukocyte mediated immunity GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY -0.402484872962787 -0.813831026264544 0.710215311888319 0.922643650266074 5 SERPINB9 GO:0030902 hindbrain development GO_HINDBRAIN_DEVELOPMENT 0.289892908150254 0.814362880616838 0.710906276711253 0.922643650266074 12 MYH10,HSPA5,MECP2,ITGB1,DLL1 GO:0014743 regulation of muscle hypertrophy GO_REGULATION_OF_MUSCLE_HYPERTROPHY -0.320610022211389 -0.811309389646898 0.7111684154366 0.922643650266074 10 CAMK2D,ADK,AGT GO:0055117 regulation of cardiac muscle contraction GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION -0.258024784000702 -0.83362452837646 0.711559199602882 0.922643650266074 24 HSP90AA1,PKP2,HRC,CAMK2D,GSTO1,GSTM2,DSP,ATP1B1,JUP,ATP2A2,PDE5A GO:0014075 response to amine GO_RESPONSE_TO_AMINE -0.376778318823747 -0.810261777521697 0.71272117644915 0.922643650266074 6 HPRT1 GO:0055006 cardiac cell development GO_CARDIAC_CELL_DEVELOPMENT -0.265379062495977 -0.828835698283025 0.713870646081904 0.922643650266074 21 CSRP3,SORBS2,MYL2,CAMK2D,NEBL,AGT GO:0050819 negative regulation of coagulation GO_NEGATIVE_REGULATION_OF_COAGULATION 0.272908176338364 0.820337954090128 0.714007553897764 0.922643650266074 15 APOE,VTN,ANXA2,APOH,PLG,CD34,KNG1 GO:0019400 alditol metabolic process GO_ALDITOL_METABOLIC_PROCESS 0.376758598041699 0.793993233374832 0.714020892853248 0.922643650266074 5 SORD,AKR1B1 GO:0014742 positive regulation of muscle hypertrophy GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY -0.342378453798156 -0.807756316521672 0.714164882034301 0.922643650266074 8 CAMK2D,ADK,AGT GO:0042692 muscle cell differentiation GO_MUSCLE_CELL_DIFFERENTIATION 0.205811802776144 0.8700783325612 0.714300760986913 0.922643650266074 57 NEXN,NPPA,BMP10,FHL2,SGCD,CFL2,ANK2,DMD,CAST,TMOD1,TPM1,MYH10,MYLK3,GPX1,LGALS1,SGCG GO:0006879 cellular iron ion homeostasis GO_CELLULAR_IRON_ION_HOMEOSTASIS -0.319315159461215 -0.808032716321857 0.715258758669749 0.922643650266074 10 FTL,ACO1,HPX GO:1902235 regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY -0.341816060375772 -0.806429489923029 0.716126477945543 0.922643650266074 8 ERP29,PTPN1 GO:0030162 regulation of proteolysis GO_REGULATION_OF_PROTEOLYSIS 0.183666467509221 0.900941588277747 0.716136316368066 0.922643650266074 128 PSMB3,UBC,APOE,CRYAB,VTN,PSMB2,SERPINC1,DIABLO,CD59,C1QBP,PSMA6,BCAP31,AMBP,PSMB1,LTBP4,PDCD5,SDCBP,PARK7,CLU,CAST,PSMA4,PRKACB,PI16,PHB2,PSMD14,PSMC6,HSPE1,FN1,DNAJC1,GPX1,PSMC1,PSMA5,PSMA3 GO:0050830 defense response to gram positive bacterium GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM 0.312646172288508 0.801403386813322 0.716213462539905 0.922643650266074 9 CD36,SSC5D,CTSG,B2M,FAU,PGLYRP2 GO:0044782 cilium organization GO_CILIUM_ORGANIZATION -0.329609352403257 -0.806748090689689 0.716304308893585 0.922643650266074 9 ABLIM1,ACTR2,IFT81,EHD1 NA transcription from rna polymerase ii promoter GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER 0.235319228756707 0.841988816389618 0.716789532783284 0.922643650266074 28 BCL11B,NFAT5,NPPA,TCEB1 GO:0034763 negative regulation of transmembrane transport GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT -0.281896828281186 -0.818577186810567 0.716840510561234 0.922643650266074 16 CAMK2D,YWHAQ,GSTO1,AGT,GSTM2 NA chromatin modification GO_CHROMATIN_MODIFICATION -0.234259312594895 -0.842412560159992 0.717556490364631 0.922643650266074 37 ARID4A,TRIM28,H2AFY,PPP5C GO:0045454 cell redox homeostasis GO_CELL_REDOX_HOMEOSTASIS -0.261418619240485 -0.826777105970013 0.718015576217106 0.922643650266074 22 ERP44,TXNDC5,P4HB,PTGES2,AIFM1,LTF,GLRX,PRDX4,TXNL1,PDIA6,NNT,TXN,SH3BGRL3,DLD GO:0045580 regulation of t cell differentiation GO_REGULATION_OF_T_CELL_DIFFERENTIATION -0.374596440365235 -0.805569647879925 0.718187947591887 0.922643650266074 6 ADA,IFNA2,HMGB1 GO:0042102 positive regulation of t cell proliferation GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION -0.399034216425114 -0.806853742048449 0.718838866935037 0.922643650266074 5 DNAJA3,ADK,HMGB1 GO:0009057 macromolecule catabolic process GO_MACROMOLECULE_CATABOLIC_PROCESS -0.19178685897688 -0.888627950538453 0.71898102787922 0.922643650266074 149 PGM2,RPL39,PCBP2,RPL13A,ERLIN2,PSMD2,RPS2,NEDD8,RPL10A,LYPLAL1,PSME2,UBA1,EIF4B,PSMB6,PPP2R1A,VCAN,BGN,RPS3,PSMA2,CTSD,RPL10,PSMA1,RANBP1,RNH1,RPSA,STBD1,PRELP,LONP1,DROSHA,UBE2L3,PSMC2,UBR4,OGN,FMOD,CAPN1,RPL21,PABPC4,AIFM1,TPP1,PSMC3,HNRNPD,USP5,CTSB,RPL22,HMGB1,AGRN,PCYOX1 GO:0030163 protein catabolic process GO_PROTEIN_CATABOLIC_PROCESS -0.21267019624438 -0.861164438612126 0.719286489246282 0.922643650266074 65 PCBP2,ERLIN2,PSMD2,NEDD8,LYPLAL1,PSME2,UBA1,PSMB6,PSMA2,CTSD,PSMA1,RANBP1 GO:0009891 positive regulation of biosynthetic process GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS -0.193299198448183 -0.886586766686579 0.719783424819396 0.922643650266074 139 NAMPT,XRCC6,HSP90AA1,CSRP3,ERLIN2,EEF2,C14orf166,RAN,COQ7,ARID4A,TRIM28,SERPINF2,THOC4,HSP90AB1,PRDX3,YWHAH,RPS3,TAF15 GO:0090087 regulation of peptide transport GO_REGULATION_OF_PEPTIDE_TRANSPORT 0.238679077176872 0.83749513752163 0.72060787026922 0.922643650266074 26 GJA1,PFKL,GNAS,RHOA,RAPGEF4,PFKM,SRI GO:0051881 regulation of mitochondrial membrane potential GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL -0.309207503874445 -0.806059818206359 0.720634527641212 0.922643650266074 11 CLIC1,PRDX3 GO:0051302 regulation of cell division GO_REGULATION_OF_CELL_DIVISION -0.272749204820554 -0.818323076506388 0.721522259949327 0.922643650266074 18 H2AFY,DYNC1LI1,RANBP1 GO:0043487 regulation of rna stability GO_REGULATION_OF_RNA_STABILITY 0.219107954999795 0.851335522236219 0.7216513066532 0.922643650266074 39 PSMB3,UBC,PSMB2,PSMA6,PSMB1,SET,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0045927 positive regulation of growth GO_POSITIVE_REGULATION_OF_GROWTH 0.247614983281389 0.830629156256596 0.721995780186055 0.922643650266074 22 BMP10,NACA,MAP1B,SDCBP,FN1,PIN1,DLL1 NA positive regulation of homeostatic process GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS -0.248840726532469 -0.828763983591406 0.722300473467171 0.922643650266074 27 OXCT1,BRP44,CCT6A,GSTO1,AGT,GSTM2 GO:0098657 import into cell GO_IMPORT_INTO_CELL 0.373481063655587 0.787086051592512 0.72276623121715 0.922643650266074 5 PARK7,TF,ATP2B4 GO:0019318 hexose metabolic process GO_HEXOSE_METABOLIC_PROCESS -0.229048935068482 -0.843470676483613 0.723173986096926 0.922643650266074 41 PGM2,DCXR,ENO1,GPI,AKR1A1,PGM5,GOT1,ALDH1A1,ENO3,DLAT,PDHA1,SLC25A11,PGK1,ALDH5A1,TPI1,PGM1,SLC25A12,PDHB,HK1,BPGM GO:0008213 protein alkylation GO_PROTEIN_ALKYLATION 0.310606436977767 0.796174949905668 0.723232277492245 0.922643650266074 9 HIST1H1D,WHSC1,MECP2 GO:2000651 positive regulation of sodium ion transmembrane transporter activity GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 0.352175318364698 0.7888127591283 0.723687126080213 0.922643650266074 6 DMD,ANK3,DNM2,GLRX,ACTN4,ATP1B1 GO:0019725 cellular homeostasis GO_CELLULAR_HOMEOSTASIS 0.188375998627327 0.887703299815607 0.724925010712755 0.923635419740617 101 CD36,GJA1,RAB7A,CACNA2D1,UBC,APOE,ANXA6,GSR,BCAP31,CFL2,ERO1L,ANK2,DMD,SOD1,FN1,GPX1,LGALS1,PFKM,TXNRD1,VAPB,TNNI3,TXNDC12,LAMP2,SRI,ITGB1,PYGM,TGM2,ABL2,PLN,TF GO:0044087 regulation of cellular component biogenesis GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS 0.189404742567747 0.884842302761324 0.727856880006794 0.925437033636 96 CD36,MYO1C,GJA1,RAB7A,APOE,FAM21C,BMP10,HCLS1,SPTAN1,SPTBN1,ARPC5L,PFN1,SDCBP,PARK7,CLU,RHOA,TMOD1,TPM1,HIST3H3,MYLK3,PSMC6,PSMC1,MECP2,LRRC4B,RALA,MYADM,PFN2,RDX,DAG1,TMOD3,FSCN1,CDK5RAP2 GO:1901988 negative regulation of cell cycle phase transition GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION 0.350419221042149 0.784879400082215 0.728717039663195 0.925437033636 6 UBC GO:0098542 defense response to other organism GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM -0.230169463020518 -0.837937448897495 0.729092504594599 0.925437033636 39 RPL39,PCBP2,HP,FGA,IGJ,FGB,IGHG3,DROSHA,IGHG2,IGHA1,IFNA2,IGKC,LTF,ATP1B1,ANXA3 GO:0051354 negative regulation of oxidoreductase activity GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY 0.349966315058038 0.783864967780114 0.729692000886328 0.925437033636 6 ENG,TMLHE,PRDX5,CAV1 GO:0051781 positive regulation of cell division GO_POSITIVE_REGULATION_OF_CELL_DIVISION -0.351703509783449 -0.795716524078822 0.729742439589061 0.925437033636 7 H2AFY,RANBP1 GO:0030031 cell projection assembly GO_CELL_PROJECTION_ASSEMBLY -0.264771892971517 -0.81579979658403 0.729782458563536 0.925437033636 20 EZR,ABLIM1,DBNL,ACTR2,IFT81,EHD1 GO:0006629 lipid metabolic process GO_LIPID_METABOLIC_PROCESS -0.195367981409583 -0.876988682647118 0.730624791786547 0.925437033636 120 GCDH,ERLIN2,CYGB,ECI2,PCCB,PAM,APOC1,PAFAH1B1,IVD,PPP2R1A,VAPA,YWHAH,CBR1,ARF1,PIK3R1,C3,ACAD10,ACSBG2,ETFA,ECHS1,GPD1L,ACADVL,CYB5R3,CRAT,ASAH1,ATP5A1,PAFAH1B2,MCEE,ALDH1A1,PTGES2,PTGR2,PRKAR2B,TPP1,PCCA,HSD17B10,HSD17B4 GO:1901989 positive regulation of cell cycle phase transition GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION 0.369723750778188 0.779167769127737 0.732863716659761 0.925437033636 5 PHB2,RDX,TMOD3 GO:0007417 central nervous system development GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT -0.204678239481941 -0.861493461308986 0.73310598441036 0.925437033636 81 HPRT1,RAN,PAM,MPST,PAFAH1B1,RTN4,VCAN,ANP32B,YWHAH,BDH1,GLUD1,OXCT1,AK4,OGDH,NDUFS3,YWHAQ,ATP5F1,AQP1,PAFAH1B2,NAPA,TPP1,CDK5RAP3,HNRNPD,NDRG2,ARF4,MAOB,NME1,ALDH1A2,NDUFS4,ANXA3,ACAT1,ALDH5A1,BAG3,NES,CTNNB1 GO:0097190 apoptotic signaling pathway GO_APOPTOTIC_SIGNALING_PATHWAY -0.250961412057048 -0.820201057835684 0.734189723320158 0.925437033636 25 KRT8,KRT18 GO:0046365 monosaccharide catabolic process GO_MONOSACCHARIDE_CATABOLIC_PROCESS -0.255058607505383 -0.815795874573714 0.734736806101857 0.925437033636 23 PGM2,DCXR,ENO1,GPI,AKR1A1,PGM5,ALDH1A1,ENO3 GO:0046185 aldehyde catabolic process GO_ALDEHYDE_CATABOLIC_PROCESS -0.368685108521264 -0.792857328704105 0.734843377006761 0.925437033636 6 GPI,AKR1A1,ESD GO:0032103 positive regulation of response to external stimulus GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS 0.249947351885868 0.816939426494412 0.735136162729908 0.925437033636 20 MIF,C1QBP,CDH13,PARK7,FN1,PRKAA2 GO:0006333 chromatin assembly or disassembly GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY 0.228654714510277 0.832518328003976 0.735619469026549 0.925437033636 30 H1F0,HIST1H1D,SET,HIST1H3A,HIST3H3,HP1BP3,RBBP7,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H GO:0048662 negative regulation of smooth muscle cell proliferation GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION -0.335219330366374 -0.790866155623319 0.73595839257113 0.925437033636 8 MFN2,OGN,NDRG2 GO:0070509 calcium ion import GO_CALCIUM_ION_IMPORT 0.332233131653995 0.78316820335476 0.736241865873566 0.925437033636 7 ERO1L,NOL3,JPH2,RYR2,ATP2B4 GO:1903707 negative regulation of hemopoiesis GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS -0.246054064019462 -0.819483004720356 0.736419637857009 0.925437033636 27 PIK3R1,IFNA2,HMGB1,NME1,LTF,CTNNB1,APCS,ANXA1,C1QC,ADIPOQ,RARA,HIST1H4H,HIST1H4F,HIST1H4E,HIST1H4D,HIST1H4C,HIST1H4B,HIST1H4A,HIST4H4,HIST2H4B,HIST2H4A,HIST1H4L,HIST1H4K,HIST1H4J,HIST1H4I,PGLYRP2 GO:0006754 atp biosynthetic process GO_ATP_BIOSYNTHETIC_PROCESS 0.259715316118217 0.809892848250729 0.736446743675147 0.925437033636 17 ATP5I,PRKAG2,PKM2 GO:0032649 regulation of interferon gamma production GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION 0.367996645083925 0.775528010827075 0.737683466730639 0.925437033636 5 C1QBP,PGLYRP2,HSPD1,RARA GO:0090075 relaxation of muscle GO_RELAXATION_OF_MUSCLE -0.322638918466184 -0.789687336105479 0.737777141015079 0.925437033636 9 CAMK2D,GSTM2,ATP1B1,ATP2A2,PDE5A GO:0050851 antigen receptor mediated signaling pathway GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY 0.216792755518961 0.842339903801923 0.737810882464335 0.925437033636 39 PSMB3,UBC,PSMB2,PSMA6,HLA-DRA,PSMB1,PSMA4,PSMD14,PSMC6,PSMC1,PSMA5,PSMA3 GO:0045762 positive regulation of adenylate cyclase activity GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY 0.367930073884926 0.775387716533015 0.73783612849759 0.925437033636 5 GNAS,CALM1,CAP1,WFS1 GO:0006123 mitochondrial electron transport cytochrome c to oxygen GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN 0.33134963242142 0.781085543798213 0.738254433238668 0.925437033636 7 NDUFA4,COX7A2L GO:0042304 regulation of fatty acid biosynthetic process GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS -0.312011680125394 -0.789551131368981 0.739516272452428 0.925437033636 10 ERLIN2,APOC1 GO:0019674 nad metabolic process GO_NAD_METABOLIC_PROCESS -0.243555668104885 -0.818463177693282 0.740192424961041 0.925437033636 28 NAMPT,ENO1,GPI,OGDH,GPD1L GO:0051341 regulation of oxidoreductase activity GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY -0.271668585073705 -0.801973510452358 0.740709913471709 0.925437033636 17 HSP90AA1,CYGB,HP GO:0060541 respiratory system development GO_RESPIRATORY_SYSTEM_DEVELOPMENT -0.284439165608855 -0.795391186426451 0.741294576490547 0.925437033636 14 ADA,HMGB1,ALDH1A2,CP,CTNNB1,HRSP12,CTSZ,BASP1 GO:0045214 sarcomere organization GO_SARCOMERE_ORGANIZATION -0.268199868225605 -0.804673808047873 0.741446767438253 0.925437033636 18 KRT8,KRT19 GO:0033865 nucleoside bisphosphate metabolic process GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS 0.346160924047858 0.775341539743645 0.74163527586971 0.925437033636 6 MLYCD,ABHD14B,SULT1A2,SULT1A3 GO:0098660 inorganic ion transmembrane transport GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT 0.202034580475647 0.856490861758198 0.741774966252878 0.925437033636 58 CACNA2D1,ATP5I,SLC25A20,NDUFA4,PRKAG2,CYB5A,UQCRH,COX7A2L,ERO1L,COX7A2,PRKAA2,CPT1B,FKBP1A GO:0071310 cellular response to organic substance GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE -0.184598558316914 -0.888218307935778 0.741833629944314 0.925437033636 199 NAMPT,RPL13A,KRT8,KRT18,EEF2,SERPINB9,EZR,DPYSL3,FERMT2,RAN,PSMD2,NEDD8,PSME2,SERPINF1,LIMS1,PSMB6,HSP90AB1,OTUB1,YWHAH,BGN,PARD3,PRKAR2A,PIK3R1,CAMK2D,FGA,PSMA2,PSMA1,HNRNPA2B1,PTPN1,TBC1D4,FGB,YWHAG,SSR1,HSPA9,SYNCRIP,AGT,RAB11B,EHD1,DROSHA,UBE2L3,ACADVL,GSTM2,NPM1,PSMC2,GOT1,FMOD GO:0051606 detection of stimulus GO_DETECTION_OF_STIMULUS -0.262032240591833 -0.80735853860542 0.741971685082873 0.925437033636 20 CSRP3,LXN,RPS3 GO:0030534 adult behavior GO_ADULT_BEHAVIOR 0.296786470244626 0.787128162636982 0.742432895488292 0.925437033636 10 PARK7,TMOD1,SNCG,MECP2 GO:0008344 adult locomotory behavior GO_ADULT_LOCOMOTORY_BEHAVIOR 0.296786470244626 0.787128162636982 0.742432895488292 0.925437033636 10 PARK7,TMOD1,SNCG,MECP2 GO:0002697 regulation of immune effector process GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS 0.203596571549921 0.853787107170168 0.743202891717743 0.925437033636 55 CD36,VTN,STOM,CD59,MIF,WHSC1,C1QBP GO:0043087 regulation of gtpase activity GO_REGULATION_OF_GTPASE_ACTIVITY 0.213136793816831 0.841992276955118 0.74483162966173 0.925437033636 42 ARHGDIB,NCAM1,CRK,SPTAN1,SPTBN1,GNAS,GNAO1,ARHGAP12,SOD1,RAPGEF4,RGL2,IQGAP1,PIN1,ITGB1,RDX GO:1903363 negative regulation of cellular protein catabolic process GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS 0.344793528066763 0.77227880553025 0.745380013294926 0.925437033636 6 SDCBP,PARK7,ANXA2 GO:0098901 regulation of cardiac muscle cell action potential GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL -0.310203084330826 -0.78497444739607 0.745562866797083 0.925437033636 10 PKP2,CAMK2D,DSP,JUP,ATP2A2,DSG2 GO:0016052 carbohydrate catabolic process GO_CARBOHYDRATE_CATABOLIC_PROCESS -0.233121183881606 -0.822290686559072 0.745898626749975 0.925437033636 34 PGM2,DCXR,ABHD10,ENO1,GPI,OGDH,AKR1A1,STBD1 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL -0.364295297296004 -0.783417039630496 0.74657871239317 0.925437033636 6 GSTO1,GSTM2 GO:0031641 regulation of myelination GO_REGULATION_OF_MYELINATION -0.387395003381165 -0.783319062032427 0.747294752003545 0.925437033636 5 PARD3 NA regulation of ion homeostasis GO_REGULATION_OF_ION_HOMEOSTASIS 0.232358362263213 0.823221796254575 0.747541143246665 0.925437033636 27 GJA1,ERO1L,ANK2,DMD,ANK3,FKBP1A,SRI,PLN,NOL3,B2M,CALM1,CAV1,JPH2 GO:0043543 protein acylation GO_PROTEIN_ACYLATION -0.363684866289034 -0.782104307745325 0.748164076024564 0.925437033636 6 ESCO2,RUVBL1 GO:0050770 regulation of axonogenesis GO_REGULATION_OF_AXONOGENESIS -0.282403261735355 -0.789698088593291 0.748290396488098 0.925437033636 14 ARHGDIA,PAFAH1B1,RTN4 GO:0009719 response to endogenous stimulus GO_RESPONSE_TO_ENDOGENOUS_STIMULUS -0.186036862362139 -0.881689052099956 0.74843665728904 0.925437033636 177 NAMPT,HSP90AA1,HPRT1,EEF2,SERPINB9,EZR,FERMT2,RAN,KRT19,NEDD8,PAM,QDPR,SERPINF1,ADA,LIMS1,PPP5C,YWHAH,PARD3,MTAP,PRKAR2A,PIK3R1,BDH1,OXCT1,C3,FGA,PTPN1,TBC1D4,FGB,YWHAG,LONP1,GSS,GSTM3,AGT,EHD1,UBE2L3,GSTM2,PEA15 GO:0009132 nucleoside diphosphate metabolic process GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS 0.227931244100953 0.822970645504896 0.749865189470072 0.925437033636 29 PFKL,CMPK1,ENTPD4,PKM2,NME2,ALDOC,PFKM,AK1 GO:0098754 detoxification GO_DETOXIFICATION -0.239465989877104 -0.811945220597061 0.750928991284373 0.925437033636 29 CYGB,PRDX3,GSTK1,HP,GSTO1,GSTM3,GSTM2,PRDX2,HBA2,HBA1,ALB,HBB,GPX3 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY 0.362872126663124 0.764728435259139 0.750986849279218 0.925437033636 5 PARK7,PHB2,PHB GO:0019471 4 hydroxyproline metabolic process GO_4_HYDROXYPROLINE_METABOLIC_PROCESS -0.385950867722994 -0.780398996003353 0.750987923329763 0.925437033636 5 ALDH4A1,P4HB,PRDX4 GO:0022604 regulation of cell morphogenesis GO_REGULATION_OF_CELL_MORPHOGENESIS -0.208039294155 -0.844867713845422 0.751852383001099 0.925437033636 66 EZR,FERMT2,ARHGDIA,PAFAH1B1,RTN4,LIMS1,YWHAH,STRAP,FGA,CAPRIN2,CAPZB,VDAC3,PARVA,FGB,FGG GO:0007597 blood coagulation intrinsic pathway GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY 0.313674326294359 0.773635280932636 0.752312158239384 0.925437033636 8 C1QBP,APOH,KNG1,F9,VWF,F2 GO:0061001 regulation of dendritic spine morphogenesis GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS -0.362211293638552 -0.778935389749155 0.75233704466352 0.925437033636 6 PAFAH1B1,CAPRIN2 GO:0072384 organelle transport along microtubule GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE -0.36209770767975 -0.77869112314388 0.75268327350256 0.925437033636 6 PAFAH1B1 GO:0045109 intermediate filament organization GO_INTERMEDIATE_FILAMENT_ORGANIZATION -0.385305810012911 -0.779094678714775 0.752686782139823 0.925437033636 5 PKP2 GO:0003002 regionalization GO_REGIONALIZATION -0.329868997231793 -0.778243382966308 0.752910900354527 0.925437033636 8 IFT52,ALDH1A2,CTNNB1,BASP1 GO:0098656 anion transmembrane transport GO_ANION_TRANSMEMBRANE_TRANSPORT -0.272742697101659 -0.79199525258193 0.753791770421579 0.925437033636 16 CLIC4,CLIC1,BRP44 GO:0006650 glycerophospholipid metabolic process GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS 0.248480170022527 0.800099303407321 0.754586773909526 0.925437033636 19 CDIPT,DBI,FABP5,APOA4,MECP2 GO:0019217 regulation of fatty acid metabolic process GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS 0.245848289715221 0.803541863073208 0.754788270519462 0.925437033636 20 PRKAG2,MLYCD,FABP3,APOC2,APOA4,PRKAA2 GO:1903708 positive regulation of hemopoiesis GO_POSITIVE_REGULATION_OF_HEMOPOIESIS 0.301587565756352 0.773056950765715 0.754862227454887 0.925437033636 9 HCLS1,GNAS,LGALS1 GO:1902107 positive regulation of leukocyte differentiation GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION 0.301587565756352 0.773056950765715 0.754862227454887 0.925437033636 9 HCLS1,GNAS,LGALS1 GO:0097164 ammonium ion metabolic process GO_AMMONIUM_ION_METABOLIC_PROCESS -0.258866635861751 -0.797604860955263 0.755576657458564 0.925437033636 20 HPRT1,PAFAH1B1,AKR7A2 GO:0006006 glucose metabolic process GO_GLUCOSE_METABOLIC_PROCESS -0.226550464945492 -0.819737076816956 0.755715186303461 0.925437033636 38 PGM2,DCXR,ENO1,GPI,AKR1A1,PGM5,GOT1,ENO3,DLAT,PDHA1,SLC25A11,PGK1,ALDH5A1,TPI1,PGM1,SLC25A12,PDHB,HK1,BPGM GO:0001818 negative regulation of cytokine production GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION -0.24185387714921 -0.805494283296315 0.757598384441767 0.925437033636 27 PCBP2,EZR GO:0051289 protein homotetramerization GO_PROTEIN_HOMOTETRAMERIZATION -0.258237288450707 -0.795665752222276 0.758252762430939 0.925437033636 20 HPRT1,DCXR,CRYZ,PCBD2,HSD17B10,GPX3,CAT,ALDH5A1,DNM1L,ACTN2,DECR1 GO:0050710 negative regulation of cytokine secretion GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION -0.306454185612101 -0.775487792205576 0.758527476436066 0.925437033636 10 EZR GO:0010594 regulation of endothelial cell migration GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION 0.266644761063591 0.785261293441883 0.758785755983654 0.925437033636 14 APOE,BMP10,RHOA GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION 0.311430527036276 0.768101253682492 0.75915299624204 0.925437033636 8 GSTP1,CD34,GPNMB,RARA,LBP,ADIPOQ,ORM1,LTF GO:1901215 negative regulation of neuron death GO_NEGATIVE_REGULATION_OF_NEURON_DEATH -0.249813778231652 -0.799020474887339 0.759363135752642 0.925437033636 23 SERPINF1,PPP5C,HSP90AB1,GPI GO:0030217 t cell differentiation GO_T_CELL_DIFFERENTIATION 0.324490129210842 0.764915739243833 0.759677094747199 0.925437033636 7 BCL11B,B2M GO:1901342 regulation of vasculature development GO_REGULATION_OF_VASCULATURE_DEVELOPMENT -0.243086640437912 -0.80224843557289 0.760291792072642 0.925437033636 26 SERPINF1,LRG1,C3,C5,RNH1,AGT,AQP1,HMGB1,WARS,HSPB1,ANXA3 GO:0030705 cytoskeleton dependent intracellular transport GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT 0.283860383704945 0.775509623337075 0.760389341433108 0.925437033636 11 KIF5A,MAP1B,SOD1 GO:0002285 lymphocyte activation involved in immune response GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE -0.358971047251662 -0.771967239869283 0.760664759370957 0.925437033636 6 ADA,IFNA2,HMGB1 GO:0034470 ncrna processing GO_NCRNA_PROCESSING -0.21082516155016 -0.834743804305846 0.760884588804423 0.925437033636 58 RPL39,RPL13A,C14orf166,RPS2,RPL10A,RPS3,RPL10,HNRNPA2B1,RPSA GO:0008202 steroid metabolic process GO_STEROID_METABOLIC_PROCESS 0.229892758162244 0.81448641433381 0.761101373064563 0.925437033636 27 APOE,PRKAG2,CYB5R1,APOA4,PRKAA2,FDPS,MECP2,HSD17B8,SULT1A2,SULT1A3,PON1 GO:0051668 localization within membrane GO_LOCALIZATION_WITHIN_MEMBRANE -0.252060231157811 -0.797179745850764 0.762068137372628 0.925437033636 22 DNAJA3,VAPA,LMAN1,SERPINA1,SNX3,TFG,SEC22B,NAPA,AGRN,ATP1B1,SAR1B GO:0006353 dna templated transcription termination GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION -0.297018859041527 -0.774285761253999 0.763183956424858 0.925437033636 11 THOC4,SRSF7 GO:2000377 regulation of reactive oxygen species metabolic process GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS 0.232887169549681 0.808592062897314 0.763720434793134 0.925437033636 25 CD36,CRYAB,PARK7,CLU,SOD1,SIRT5,FBLN5 GO:0010660 regulation of muscle cell apoptotic process GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS 0.309982312163191 0.764529427663365 0.763946083395216 0.925437033636 8 NACA,SIRT5,APOH,NOL3,CAV1,ILK GO:0001823 mesonephros development GO_MESONEPHROS_DEVELOPMENT 0.338345864661654 0.75783713714721 0.764081542211389 0.925437033636 6 LAMA5,RARB,ILK,RARA GO:0051279 regulation of release of sequestered calcium ion into cytosol GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL -0.273223041128985 -0.779338802375016 0.765385620915033 0.925437033636 15 HRC,CAMK2D,GSTO1,GSTM2 GO:0023061 signal release GO_SIGNAL_RELEASE 0.337845673235519 0.756716793504805 0.765433192998006 0.925437033636 6 LTBP4,RAPGEF4,HSPA8 GO:0050848 regulation of calcium mediated signaling GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING -0.269879218620552 -0.783680231182613 0.765458756334129 0.925437033636 16 ADA,HRC,CAMK2D,GSTO1,GSTM2 GO:0071825 protein lipid complex subunit organization GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION 0.298605921771375 0.76541412702557 0.765526297914733 0.925437033636 9 APOE,APOC2,APOA4 GO:0046457 prostanoid biosynthetic process GO_PROSTANOID_BIOSYNTHETIC_PROCESS -0.357266198078416 -0.768300961709135 0.765603075969896 0.925437033636 6 CBR1,PTGES2 GO:0008654 phospholipid biosynthetic process GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS 0.269578331918797 0.775698150006808 0.765648251488095 0.925437033636 13 CDIPT,FABP5,FDPS GO:0050727 regulation of inflammatory response GO_REGULATION_OF_INFLAMMATORY_RESPONSE 0.20844493615897 0.832648058123898 0.765974277840155 0.925437033636 44 APOE,VTN,SERPINC1,CD59,C1QBP,PSMA6,PARK7,PHB2,GPX1 GO:1901652 response to peptide GO_RESPONSE_TO_PEPTIDE 0.203886741971205 0.837844637397609 0.766635596292269 0.925679060345686 50 GJA1,COL1A1,FBN1,NPPA,PKM2,GNAS,FABP3,GNG12,RETN,PRKACB,GNB2 GO:0045907 positive regulation of vasoconstriction GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION -0.378952720837152 -0.766248628015284 0.767237877165122 0.92584955369445 5 FGA,FGB,FGG GO:0002009 morphogenesis of an epithelium GO_MORPHOGENESIS_OF_AN_EPITHELIUM 0.216549317217723 0.819681182458612 0.76871851149798 0.927079141794561 35 GJA1,ENG,COL4A1,PFN1,ARHGAP12,RHOA,LAMA5,PRKACB,PHB2,RALA,DLL1,DAG1,TGM2 GO:1901698 response to nitrogen compound GO_RESPONSE_TO_NITROGEN_COMPOUND -0.194749149822664 -0.851283151788466 0.771127898210687 0.927779835904256 101 NAMPT,HPRT1,EEF2,EZR,QDPR,ADA,PPP5C,PRKAR2A,PIK3R1,BDH1,FGA,HNRNPA2B1,PTPN1,TBC1D4,YWHAG,GSS,GSTM3,AGT,DROSHA,GSTM2,PEA15,NPM1,GOT1,AQP1,ALAD,CYC1,PRKAR2B,AIFM1,HNRNPD,IFNA2,CTSB,AGRN,NME1 GO:0018205 peptidyl lysine modification GO_PEPTIDYL_LYSINE_MODIFICATION -0.260921372561602 -0.782836307300535 0.771178407073545 0.927779835904256 18 ARID4A,TRIM28 GO:0070670 response to interleukin 4 GO_RESPONSE_TO_INTERLEUKIN_4 -0.376958148360519 -0.762215569695182 0.772002068175943 0.927779835904256 5 HSP90AB1,ALAD,CTSB GO:0065005 protein lipid complex assembly GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY -0.336402457330855 -0.761098443981123 0.772319490667053 0.927779835904256 7 APOC1,ARF1 GO:0045069 regulation of viral genome replication GO_REGULATION_OF_VIRAL_GENOME_REPLICATION 0.33526679566831 0.750940546780047 0.772523820075338 0.927779835904256 6 STOM,VAPB GO:0044255 cellular lipid metabolic process GO_CELLULAR_LIPID_METABOLIC_PROCESS -0.194757121494993 -0.849768381910268 0.773163924567869 0.927779835904256 100 GCDH,CYGB,ECI2,PCCB,PAM,APOC1,PAFAH1B1,IVD,PPP2R1A,VAPA,CBR1,ARF1,PIK3R1,C3,ACAD10,ACSBG2,ETFA GO:0060419 heart growth GO_HEART_GROWTH -0.336089444894119 -0.760390264616332 0.77329619447258 0.927779835904256 7 SORBS2,CAMK2D,AGT GO:0016482 cytosolic transport GO_CYTOSOLIC_TRANSPORT 0.241774320110494 0.790226313349116 0.774321562663371 0.927779835904256 20 RAB7A,FAM21C,DPYSL2,VPS13A GO:0015985 energy coupled proton transport down electrochemical gradient GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT -0.280511802424512 -0.768228394298297 0.774335041055513 0.927779835904256 13 ATP5D,ATP5J2,ATP5F1,ATP5A1,STOML2 GO:0048639 positive regulation of developmental growth GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH -0.267414030854622 -0.776521773676372 0.774827171887788 0.927779835904256 16 EZR,PAFAH1B1,C3 GO:0034111 negative regulation of homotypic cell cell adhesion GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION -0.322089919197602 -0.759890594263846 0.776288084654561 0.927779835904256 8 IFNA2,HMGB1,PDE5A,PRKAR1A,ANXA1,DUSP3 GO:0030838 positive regulation of actin filament polymerization GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION -0.285694690371716 -0.7641074884413 0.77655729322778 0.927779835904256 12 ARPC3,ACTR3 GO:0033273 response to vitamin GO_RESPONSE_TO_VITAMIN -0.2799116037398 -0.766584650014346 0.776563267597726 0.927779835904256 13 EEF2,ADA GO:0051046 regulation of secretion GO_REGULATION_OF_SECRETION 0.195049756407782 0.843370520139372 0.777019979138249 0.927779835904256 64 GJA1,RAB7A,PFKL,MIF,SPTBN1,GNAS,RETN,SDCBP,SSC5D,POSTN,RAPGEF4,DPYSL2,FN1,DNAJC1,PFKM,SNCG,RALA,SRI,PFN2,ANXA4 GO:0060070 canonical wnt signaling pathway GO_CANONICAL_WNT_SIGNALING_PATHWAY 0.353142076502732 0.744223013411026 0.777048393780123 0.927779835904256 5 CAV1,CDC42,RYR2,MYH6,CTNNB1 GO:0021675 nerve development GO_NERVE_DEVELOPMENT 0.353142076502732 0.744223013411026 0.777048393780123 0.927779835904256 5 DAG1,AFG3L2,TMEM126A,ILK GO:0022408 negative regulation of cell cell adhesion GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION 0.272477693891558 0.765440317658105 0.777184836093977 0.927779835904256 12 MYADM,RDX,PLG,LGALS3,ADIPOQ,APOA1,DUSP3,ANXA1,PRKAR1A,PDE5A,HMGB1,IFNA2 GO:0051960 regulation of nervous system development GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT -0.207038614454586 -0.825467800025721 0.779376344776647 0.927779835904256 60 DPYSL3,XRCC5,ARHGDIA,SERPINF1,PAFAH1B1,RTN4,YWHAH,PARD3,ARF1 GO:0000184 nuclear transcribed mrna catabolic process nonsense mediated decay GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY -0.211225469495784 -0.820554720757442 0.779512084199584 0.927779835904256 53 RPL39,RPL13A,RPS2,RPL10A,PPP2R1A,RPS3,RPL10,RPSA GO:0001817 regulation of cytokine production GO_REGULATION_OF_CYTOKINE_PRODUCTION -0.213549416603472 -0.816556146201235 0.779860555492056 0.927779835904256 49 PCBP2,XRCC6,EZR,XRCC5,SERPINF2 GO:0044089 positive regulation of cellular component biogenesis GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS 0.199487755083151 0.833386047089564 0.781037903310014 0.927779835904256 54 CD36,APOE,FAM21C,BMP10,ARPC5L,PFN1,SDCBP,CLU,RHOA,TPM1,MYLK3,PSMC6,PSMC1,MECP2,LRRC4B,RALA,PFN2,DAG1,FSCN1 GO:0048146 positive regulation of fibroblast proliferation GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION 0.304568153124259 0.751176137011304 0.781520736290196 0.927779835904256 8 MIF,FN1,ANXA2 GO:0010941 regulation of cell death GO_REGULATION_OF_CELL_DEATH -0.183070354706034 -0.867629809807066 0.781540165881959 0.927779835904256 177 KRT18,SERPINB9,DNAJA3,ARHGDIA,SERPINF1,ADA,RTN4,PPP5C,PPP2R1A,HSP90AB1,PRDX3,ANP32B,YWHAH,RPS3,GPI,ERP29,HP,PIK3R1,CAMK2D,FGA,YWHAZ,NDUFS3,PTPN1,MTCH2,FGB,YWHAB,YWHAG,FGG,HSPA9,YWHAQ,AGT,HIGD1A,DYNLL2,PEA15,NPM1,PRDX2,AQP1,EEF1A2,TXNDC5,ZMAT3,VDAC2,P4HB,AIFM1,OBSCN,HBA2,HBA1,DDAH2,ARF4,ALB,CTSB,NDRG1,HMGB1,HBB,NME1,ALDH1A2,LTF,HSPB1,ACTN4,ACTN1,CAT,API5,DNM1L,BAG3,NES,PA2G4,CTNNB1,FIS1,ACAA2,CASP12,HSPA1A,ANXA5,ACTN2 GO:0051093 negative regulation of developmental process GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS -0.199216056054568 -0.835240553894316 0.781655958907337 0.927779835904256 79 CSRP3,DPYSL3,ARHGDIA,PKP2,SERPINF1,PAFAH1B1,RTN4,ANP32B,YWHAH,PIK3R1,STRAP GO:0061136 regulation of proteasomal protein catabolic process GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS 0.233699412464385 0.792985625020431 0.781665382392603 0.927779835904256 23 BCAP31,SDCBP,PARK7,CLU,PSMD14,PSMC6,GPX1,PSMC1 GO:0071300 cellular response to retinoic acid GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID 0.316951445164198 0.747144911839965 0.78179297390371 0.927779835904256 7 COL1A1,ABL2 GO:0010039 response to iron ion GO_RESPONSE_TO_IRON_ION -0.37225413907172 -0.752703985622768 0.782029028326624 0.927779835904256 5 ACO1,ALAD GO:0000245 spliceosomal complex assembly GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY 0.331510594668489 0.742527295992721 0.782450697983603 0.927779835904256 6 NOL3,SNRPD1,SNRPD3,DDX39B,SRSF1,DDX1 GO:0050994 regulation of lipid catabolic process GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS 0.304075047268162 0.749959958141907 0.78273588514593 0.927779835904256 8 APOC2,APOA4,APOH,APOC3 GO:2000177 regulation of neural precursor cell proliferation GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION 0.350409836065574 0.73846500170185 0.783721893878263 0.927779835904256 5 CDH2,ILK,CTNNA1,CTNNB1,NES GO:0051345 positive regulation of hydrolase activity GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY 0.184683867691314 0.854899467894221 0.785399534087401 0.927779835904256 91 ARHGDIB,DIABLO,NCAM1,SPTAN1,SPTBN1,BCAP31,GNAS,PFN1,PDCD5,APOC2,GNAO1,ARHGAP12,RHOA,RAPGEF4,TPM1,APOA4,RGL2,PSMD14,HSPE1,FN1,IQGAP1,DNAJC1,HSPA5,PIN1,VAPB NA modulation by virus of host morphology or physiology GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY 0.349551631384709 0.736656393449778 0.785837349791726 0.927779835904256 5 KPNB1,VAPB,DAG1 GO:0050920 regulation of chemotaxis GO_REGULATION_OF_CHEMOTAXIS 0.276730362177263 0.756030327786397 0.786552533480602 0.927779835904256 11 C1QBP,CDH13,FN1 GO:0005975 carbohydrate metabolic process GO_CARBOHYDRATE_METABOLIC_PROCESS 0.183496568280585 0.857241079737576 0.786933506949359 0.927779835904256 96 GYG1,UBC,PFKL,PGLS,SORD,SPON1,PRKAG2,PYGB,CYB5A,PKM2,GLO1,ME1 GO:0038127 erbb signaling pathway GO_ERBB_SIGNALING_PATHWAY 0.292117734109947 0.748783008441616 0.787080852219983 0.927779835904256 9 UBC,CDC37,IQGAP1 GO:0002253 activation of immune response GO_ACTIVATION_OF_IMMUNE_RESPONSE -0.197911558096739 -0.833012408399467 0.787512572290671 0.927779835904256 81 HSP90AA1,PSMD2,ARPC3,ACTR3,PSME2,PSMB6,HSP90AB1,PIK3R1,C3,PSMA2,PSMA1,C5,IGHG3,ACTR2,IGHG2,ACTG1,CFB,PSMC2,SERPING1,IGHA1,STOML2,C8A,PSMC3,C1R,CFI,CTSB,HMGB1,C8G,PSMD11,IGKC,ARPC4,C8B,PSMA7,CFH,C2 GO:0055007 cardiac muscle cell differentiation GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION -0.239481413128925 -0.782681714970899 0.787873108900095 0.927779835904256 25 CSRP3,SORBS2,MYL2,CAMK2D,NEBL,AGT GO:0035051 cardiocyte differentiation GO_CARDIOCYTE_DIFFERENTIATION -0.239481413128925 -0.782681714970899 0.787873108900095 0.927779835904256 25 CSRP3,SORBS2,MYL2,CAMK2D,NEBL,AGT GO:0090280 positive regulation of calcium ion import GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT -0.330757127077178 -0.748326087602027 0.788706410070901 0.927779835904256 7 GSTO1,GSTM2 GO:0045806 negative regulation of endocytosis GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS 0.263904338935713 0.759371519343271 0.788783482142857 0.927779835904256 13 PACSIN2,SDCBP,APOC2,ANXA2,APOC3,CAV1 GO:0031023 microtubule organizing center organization GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION -0.330419257075789 -0.747561668892469 0.789665026768919 0.927779835904256 7 PAFAH1B1,NPM1,PPP1R12A,CTNNB1 GO:0055082 cellular chemical homeostasis GO_CELLULAR_CHEMICAL_HOMEOSTASIS 0.19006433400644 0.842917353459872 0.789827911685043 0.927779835904256 73 CD36,GJA1,RAB7A,CACNA2D1,APOE,ANXA6,BCAP31,ERO1L,ANK2,SOD1,FN1,LGALS1,VAPB,TNNI3,SRI,ITGB1,PYGM,TGM2,ABL2,PLN,TF,NOL3,ANXA7 GO:0051048 negative regulation of secretion GO_NEGATIVE_REGULATION_OF_SECRETION -0.250686847468215 -0.77240177148585 0.790227900552486 0.927779835904256 20 EZR,ADA,ERP29,VAMP3 NA regulation of cell proliferation GO_REGULATION_OF_CELL_PROLIFERATION 0.178330091953592 0.868413331531836 0.79037312991544 0.927779835904256 123 RPS4X,BCL11B,GJA1,LAMC1,APOE,S100A13,CD59,BMP10,HCLS1,GNAI2,MIF,ENG,NACA,FABP3,RETN,PDCD5,CDH13,SDCBP,CLU,RHOA,LAMA5,TPM1,LAMB1,PHB2,FN1,GPX1,NME2,ANXA2,COL18A1,MECP2 GO:0032102 negative regulation of response to external stimulus GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS -0.222567994994513 -0.795559145613202 0.791041295330746 0.927779835904256 36 PCBP2,SERPINF2,SERPINF1,ADA,FGA,C5,FGB,FGG GO:0010564 regulation of cell cycle process GO_REGULATION_OF_CELL_CYCLE_PROCESS 0.194455949750521 0.830594832996457 0.791671084720602 0.927779835904256 60 PSMB3,UBC,PSMB2,MIF,PSMA6,PSMB1,CAST,RHOA,PSMA4,PHB2,PSMD14,PSMC6,PSMC1,PIN1,PSMA5,PSMA3 GO:0007162 negative regulation of cell adhesion GO_NEGATIVE_REGULATION_OF_CELL_ADHESION 0.225346710367329 0.790713523872382 0.792513291093147 0.927779835904256 26 COL1A1,ARHGDIB,CDH13,POSTN,LGALS1,MYADM,RDX GO:0045664 regulation of neuron differentiation GO_REGULATION_OF_NEURON_DIFFERENTIATION -0.211274526326973 -0.807857571104408 0.794311186584589 0.927779835904256 49 DPYSL3,ARHGDIA,SERPINF1,PAFAH1B1,RTN4,YWHAH,ARF1,CAPRIN2,YWHAG,SNX3,OGN,FMOD GO:0016331 morphogenesis of embryonic epithelium GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM 0.282022333437982 0.74797116242752 0.794517418617933 0.927779835904256 10 PFN1,LAMA5,PRKACB,RALA GO:1901655 cellular response to ketone GO_CELLULAR_RESPONSE_TO_KETONE 0.267764815923127 0.752200970401021 0.794603460623282 0.927779835904256 12 GNAS,POSTN,FN1,PRKAA2 GO:0044070 regulation of anion transport GO_REGULATION_OF_ANION_TRANSPORT 0.262263553823894 0.754650242352138 0.795340401785714 0.927779835904256 13 APOE,MIF,DPYSL2,SNCG GO:0006325 chromatin organization GO_CHROMATIN_ORGANIZATION -0.209556890188633 -0.80761246789389 0.795448251144454 0.927779835904256 51 ARID4A,TRIM28,NAP1L4,H2AFY,PPP5C,ANP32B GO:0051004 regulation of lipoprotein lipase activity GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY 0.326582287787522 0.731488727569873 0.796543319299801 0.927779835904256 6 APOC2,APOA4,APOH,APOC3 GO:1901570 fatty acid derivative biosynthetic process GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS -0.314832347682125 -0.742768169738586 0.796731873234114 0.927779835904256 8 CBR1,PTGES2 GO:0006636 unsaturated fatty acid biosynthetic process GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS -0.314832347682125 -0.742768169738586 0.796731873234114 0.927779835904256 8 CBR1,PTGES2 GO:0006814 sodium ion transport GO_SODIUM_ION_TRANSPORT -0.344870794749101 -0.741644646754327 0.796982342329209 0.927779835904256 6 NDUFA9,ATP1B1,ATP1A3,ATP1A1,SLC8A1 GO:1901987 regulation of cell cycle phase transition GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION -0.217087613485024 -0.795199044519527 0.797083739286953 0.927779835904256 40 PSMD2,PSME2,H2AFY,PSMB6,DYNC1LI1,CAMK2D,PSMA2,PSMA1 GO:0050707 regulation of cytokine secretion GO_REGULATION_OF_CYTOKINE_SECRETION 0.248530727050399 0.762208357187278 0.79715795654727 0.927779835904256 16 MIF,SPTBN1,SSC5D,POSTN,FN1,ANXA4 GO:0043113 receptor clustering GO_RECEPTOR_CLUSTERING -0.365597884806546 -0.739244930131245 0.797503416183477 0.927779835904256 5 DNAJA3 GO:0001836 release of cytochrome c from mitochondria GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA 0.344945355191257 0.726948978283497 0.798224761738599 0.927779835904256 5 CLU,SOD2,TIMM50,FIS1,DNM1L GO:0033762 response to glucagon GO_RESPONSE_TO_GLUCAGON 0.288838424088128 0.740377179773829 0.798560010867842 0.927779835904256 9 GNAS,GNG12,PRKACB,GNB2 GO:0071453 cellular response to oxygen levels GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS 0.236544616510268 0.773133309451818 0.798845111924338 0.927779835904256 20 UBC,TCEB1,ERO1L GO:1901343 negative regulation of vasculature development GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT 0.298604300006263 0.736467100295139 0.799140394698351 0.927779835904256 8 COL4A2,RHOA,APOH GO:0042509 regulation of tyrosine phosphorylation of stat protein GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN -0.344044493612671 -0.739867686154095 0.79931483135011 0.927779835904256 6 PPP2R1A,HPX,IFNA2 GO:0044057 regulation of system process GO_REGULATION_OF_SYSTEM_PROCESS 0.187558580201702 0.840488750450253 0.799769376492875 0.927779835904256 77 GJA1,CACNA2D1,MYL9,ANXA6,NPPA,BMP10,GNAS,S100A1,RETN,PPP1R12B,ANK2,DMD,GNAO1,SOD1,TPM1,APOA4 GO:0045940 positive regulation of steroid metabolic process GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS 0.31088719206277 0.73284973850042 0.799794270891567 0.927779835904256 7 APOE,APOA4 GO:0048584 positive regulation of response to stimulus GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS 0.168536646257938 0.890378928476154 0.800360507431214 0.927900634481454 218 CD36,MYO1C,PSMB3,COL3A1,GLIPR2,GJA1,UBC,COL1A1,VTN,PRKCDBP,S100A13,PSMB2,BMP10,CRK,HCLS1,GNAI2,MIF,WHSC1,C1QBP,PSMA6,ENG,BCAP31,GNAS,HLA-DRA,PSMB1,PDCD5,CDH13,SDCBP,PARK7,PPIF,CLU,AKAP12,RHOA,SOD1,STX7,PSMA4,PRKACB,PHB2,PSMD14,PSMC6,FN1,PRKAA2,GPX1,LGALS1,PSMC1,FKBP1A,PIN1,PSMA5,PSMA3 GO:1901568 fatty acid derivative metabolic process GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS -0.292879092148963 -0.741135775646603 0.800889205050685 0.92797779788908 10 CBR1,PTGES2,PTGR2 GO:0014066 regulation of phosphatidylinositol 3 kinase signaling GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING -0.312883123724111 -0.738169463403726 0.801842820379002 0.928308180203846 8 PIK3R1,AGT,CAT,GRB2,DCN GO:0009142 nucleoside triphosphate biosynthetic process GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS -0.236303109786659 -0.772294270375008 0.802098950524738 0.928308180203846 25 GBAS,AK4,SUCLG1,ATP5D,ADK,ATP5J2,ATP5F1,ATP5A1,STOML2 GO:0031047 gene silencing by rna GO_GENE_SILENCING_BY_RNA -0.247573988714932 -0.762810611679487 0.802883287292818 0.928680668711969 20 RAN,HNRNPA2B1,DROSHA GO:0032526 response to retinoic acid GO_RESPONSE_TO_RETINOIC_ACID 0.296895066075911 0.732251506091083 0.80438353698328 0.92988033521153 8 COL1A1,ABL2,RBP4 GO:0071322 cellular response to carbohydrate stimulus GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS -0.311703218586415 -0.735385772382 0.805082153076466 0.930152453036562 8 SERPINF1,RAB11B,NME1 GO:0032271 regulation of protein polymerization GO_REGULATION_OF_PROTEIN_POLYMERIZATION -0.223961049267011 -0.778867854645341 0.806134249560044 0.930203449695625 32 ARPC3,ACTR3,SPTB,RPS3,ARF1,CAPZB,ACTR2,MAPRE1 GO:0030098 lymphocyte differentiation GO_LYMPHOCYTE_DIFFERENTIATION -0.271320404046582 -0.743056215601348 0.806565373008632 0.930203449695625 13 DNAJA3,ADA,PIK3R1 GO:0003206 cardiac chamber morphogenesis GO_CARDIAC_CHAMBER_MORPHOGENESIS 0.232409571652065 0.769742933178599 0.806960512477292 0.930203449695625 21 BMP10,WHSC1,FHL2,TPM1,FKBP1A,TNNI3,TNNC1 GO:0050849 negative regulation of calcium mediated signaling GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING -0.32376884131812 -0.73251534275933 0.807318043698452 0.930203449695625 7 GSTO1,GSTM2 GO:0002682 regulation of immune system process GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 0.171310686111098 0.87640964047096 0.80756787617356 0.930203449695625 171 CD36,MYO1C,PSMB3,COL3A1,UBC,COL1A1,VTN,STOM,PSMB2,COL1A2,CDC37,CD59,CRK,HCLS1,MIF,WHSC1,C1QBP,PSMA6,GNAS,AMBP,HLA-DRA,PSMB1,CLU,SOD1,STX7,PSMA4,PRKACB,PHB2,PSMD14,HIST1H3A,PSMC6,GPX1,LGALS1,PSMC1,FKBP1A,PSMA5,PSMA3 GO:0019320 hexose catabolic process GO_HEXOSE_CATABOLIC_PROCESS -0.246211977570536 -0.75861406195484 0.808390883977901 0.930203449695625 20 PGM2,ENO1,GPI,PGM5,ALDH1A1,ENO3,PGK1,TPI1,PGM1 NA regulation of homeostatic process GO_REGULATION_OF_HOMEOSTATIC_PROCESS 0.19802059333044 0.813738503112838 0.809046657345554 0.930203449695625 50 CD36,GJA1,CCT8,MIF,ERO1L,ANK2,DMD,ANK3,PRKAA2,FKBP1A,TCP1,SRI,DLL1,PLN,HNRNPA1,NOL3,B2M GO:0016051 carbohydrate biosynthetic process GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS 0.207401917513763 0.795663344494649 0.809403146089967 0.930203449695625 37 GYG1,UBC,SORD GO:0006812 cation transport GO_CATION_TRANSPORT 0.186236096802634 0.832800630159523 0.81005862050074 0.930203449695625 76 CACNA2D1,ATP5I,ANXA6,SLC25A20,NDUFA4,PRKAG2,CYB5A,UQCRH,COX7A2L,PARK7,ERO1L,ANK2,COX7A2,PRKAA2,CPT1B,FKBP1A,SLC10A4,ATP5EP2,SRI,PLN,TF,ABCC9,KCNK2,NOL3 GO:1904814 regulation of protein localization to chromosome telomeric region GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION -0.309949384231686 -0.731248038939813 0.810265085392409 0.930203449695625 8 H2AFY,CCT6A GO:0035148 tube formation GO_TUBE_FORMATION 0.284846103951685 0.730143698086948 0.810514637625376 0.930203449695625 9 PFN1,PRKACB,RALA,TGM2 GO:0061025 membrane fusion GO_MEMBRANE_FUSION 0.239216023154557 0.758042612918261 0.810685277374175 0.930203449695625 18 RAB7A,NSFL1C,DYSF,STX7 NA positive regulation of sequence specific dna binding transcription factor activity GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY 0.238659654448771 0.756279557158372 0.812686087225782 0.930260855460169 18 UBC,PSMA6,PARK7,CLU,PHB2 GO:0010522 regulation of calcium ion transport into cytosol GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL -0.256673780491374 -0.745334037434023 0.814042175283403 0.930260855460169 16 HRC,CAMK2D,GSTO1,GSTM2 GO:0002066 columnar cuboidal epithelial cell development GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT -0.3578319110296 -0.723542003553382 0.814953650699856 0.930260855460169 5 PAFAH1B1 GO:0045619 regulation of lymphocyte differentiation GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION -0.320561495608426 -0.725258838605567 0.815493416292866 0.930260855460169 7 ADA,IFNA2,HMGB1 GO:0001655 urogenital system development GO_UROGENITAL_SYSTEM_DEVELOPMENT 0.213026429216783 0.782085821735451 0.815703784103804 0.930260855460169 31 LAMB2,FBN1,NID1,COL4A1,LAMA5,IQGAP1 NA regulation of rna polymerase ii transcriptional preinitiation complex assembly GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY -0.307770771493522 -0.726108147159286 0.8161678694189 0.930260855460169 8 PSMC2,CAND1,PSMC3,HMGB1 GO:0060260 regulation of transcription initiation from rna polymerase ii promoter GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER -0.307770771493522 -0.726108147159286 0.8161678694189 0.930260855460169 8 PSMC2,CAND1,PSMC3,HMGB1 GO:0014013 regulation of gliogenesis GO_REGULATION_OF_GLIOGENESIS 0.319207108680793 0.714969581914641 0.816330600487481 0.930260855460169 6 MECP2,CDH2,F2,WDR1,CTNNB1,EFEMP1 NA retrograde vesicle mediated transport golgi to er GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER -0.296684360478506 -0.726161256069874 0.816522798094488 0.930260855460169 9 TMED9,COPE,SEC22B,NAPA,ARF4 GO:0035270 endocrine system development GO_ENDOCRINE_SYSTEM_DEVELOPMENT 0.319085199093655 0.714696525193229 0.816596499002881 0.930260855460169 6 CLU,DLL1 GO:0001841 neural tube formation GO_NEURAL_TUBE_FORMATION 0.305102618977761 0.719213850689932 0.816632751179588 0.930260855460169 7 PFN1,PRKACB,RALA GO:0032292 peripheral nervous system axon ensheathment GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT 0.318729266767136 0.713899297375426 0.81726124529138 0.930260855460169 6 LAMA2,SOD1,DAG1 GO:0002521 leukocyte differentiation GO_LEUKOCYTE_DIFFERENTIATION -0.243894442123139 -0.751473406179999 0.817368784530387 0.930260855460169 20 DNAJA3,PAFAH1B1,ADA,PIK3R1 GO:0010906 regulation of glucose metabolic process GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS 0.29276432456009 0.722063591094007 0.81759265510025 0.930260855460169 8 MLYCD,PGAM2,ADIPOQ,PPP1CB,PGAM1,SORBS1,BPGM,HMGB1 GO:0002920 regulation of humoral immune response GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE -0.238528776520647 -0.754384412691319 0.818060177719834 0.930260855460169 22 C3,C5,HPX,CFB,SERPING1,C8A,CFI,C8G,C8B,CFH,C2 GO:0007007 inner mitochondrial membrane organization GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION 0.282191780821918 0.723339893228817 0.818642878166957 0.930260855460169 9 LETM1,TIMM10,AFG3L2,OPA1,CHCHD3,NDUFA13 NA hydrogen transport GO_HYDROGEN_TRANSPORT 0.211767854706453 0.782880089758978 0.819074299030667 0.930260855460169 32 ATP5I,NDUFA4,CYB5A,UQCRH,COX7A2L NA hydrogen ion transmembrane transport GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT 0.211767854706453 0.782880089758978 0.819074299030667 0.930260855460169 32 ATP5I,NDUFA4,CYB5A,UQCRH,COX7A2L GO:0002768 immune response regulating cell surface receptor signaling pathway GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY -0.203617834969575 -0.797079444417673 0.820134575569358 0.930938512008633 55 HSP90AA1,PSMD2,ARPC3,ACTR3,PSME2,PSMB6,HSP90AB1,PIK3R1,PSMA2,PSMA1,IGHG3,ACTR2,IGHG2,ACTG1,PSMC2,IGHA1 GO:1903214 regulation of protein targeting to mitochondrion GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION -0.305962903016167 -0.72184293372128 0.821170838807206 0.931588160635519 8 NPEPPS,UBE2L3,RUVBL1 GO:0032652 regulation of interleukin 1 production GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION -0.354627301827938 -0.717062231093444 0.822063005502825 0.932073695680222 5 HMGB1,HSPB1,ANXA1,APOA1 GO:0072593 reactive oxygen species metabolic process GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS -0.227715890995911 -0.758407723601519 0.823493474977515 0.933168678191224 27 PRDX3,NDUFS3,PRDX2,HBA2,HBA1,DDAH2,HBB,GPX3,MAOB,NDUFS4,PRDX4,CAT,NDUFS1,NDUFAF2,PRDX6,NNT GO:0042559 pteridine containing compound biosynthetic process GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS 0.314737871675265 0.704959251861135 0.827941502326612 0.936324049458267 6 PCBD1,SPR GO:0042558 pteridine containing compound metabolic process GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS 0.314737871675265 0.704959251861135 0.827941502326612 0.936324049458267 6 PCBD1,SPR GO:0008016 regulation of heart contraction GO_REGULATION_OF_HEART_CONTRACTION -0.205803078750728 -0.783967792486336 0.828057178290526 0.936324049458267 48 HSP90AA1,CSRP3,PKP2,ADA,HRC,MYL2,CAMK2D,GSTO1,AGT,GPD1L,GSTM2 GO:0070663 regulation of leukocyte proliferation GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION -0.264716435969384 -0.72497014667985 0.828216015158958 0.936324049458267 13 DNAJA3,ADA,ADK,HMGB1,PDE5A,CTNNB1,PRKAR1A GO:0016567 protein ubiquitination GO_PROTEIN_UBIQUITINATION -0.210681819310245 -0.775833935238686 0.829011959279149 0.936324049458267 41 PSMD2,TRIM28,PSME2,UBA1,PSMB6,PSMA2,PSMA1,NPEPPS,UBE2L3,PSMC2,UBR4,CAND1 GO:1900180 regulation of protein localization to nucleus GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS 0.214785352204638 0.768517156188645 0.829736854952888 0.936324049458267 28 CD36,CCT8,HCLS1,PARK7,RHOA,PIN1,TCP1,SRI GO:0045638 negative regulation of myeloid cell differentiation GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION -0.233563003197869 -0.747042949561495 0.829873105995827 0.936324049458267 23 PIK3R1,NME1,LTF,CTNNB1,APCS,C1QC,ADIPOQ,RARA,HIST1H4H,HIST1H4F,HIST1H4E,HIST1H4D,HIST1H4C,HIST1H4B,HIST1H4A,HIST4H4,HIST2H4B,HIST2H4A,HIST1H4L,HIST1H4K,HIST1H4J,HIST1H4I GO:1901800 positive regulation of proteasomal protein catabolic process GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS 0.25252819752224 0.726637242126568 0.830008370535714 0.936324049458267 13 BCAP31,CLU,PSMC6,PSMC1,PSMC5,CAV1 GO:2001258 negative regulation of cation channel activity GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY 0.287932864865002 0.710147449525519 0.831071806296271 0.936582254314145 8 ANK3,FKBP1A,SRI,CALM1,CAV1 GO:2001242 regulation of intrinsic apoptotic signaling pathway GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 0.211638100032107 0.770561838438491 0.831170108161259 0.936582254314145 30 MIF,BCAP31,PARK7,PPIF,CLU,SOD1,GPX1,TXNDC12 GO:0086065 cell communication involved in cardiac conduction GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION 0.257687707435853 0.723892505912021 0.831681567214175 0.936632970816637 12 GJA1,ANK2 GO:0060359 response to ammonium ion GO_RESPONSE_TO_AMMONIUM_ION 0.330243264535301 0.695965317769928 0.833075262251107 0.937235973066323 5 GNAI2,GNA11 GO:0060322 head development GO_HEAD_DEVELOPMENT -0.194509529663367 -0.798749968893054 0.83336764589437 0.937235973066323 70 HPRT1,RAN,PAFAH1B1,RTN4,ANP32B,YWHAH,BDH1,GLUD1,OXCT1,AK4,OGDH,NDUFS3,YWHAQ,ATP5F1,AQP1,PAFAH1B2,NAPA,CDK5RAP3,HNRNPD,NDRG2,ARF4,MAOB,NME1,ALDH1A2,NDUFS4,ANXA3,ACAT1,BAG3,NES,CTNNB1,HRSP12 GO:0009895 negative regulation of catabolic process GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS -0.241693204190633 -0.735301852946105 0.834336570137464 0.937235973066323 19 APOC1,HSP90AB1,HP GO:1900024 regulation of substrate adhesion dependent cell spreading GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING -0.247674661179345 -0.731142754036904 0.83502401636928 0.937235973066323 17 LIMS1,FGA,FGB,FGG GO:0007612 learning GO_LEARNING 0.285904888457416 0.705145720132035 0.837147550574945 0.937235973066323 8 ATAD1,MECP2,ITGB1 GO:0010523 negative regulation of calcium ion transport into cytosol GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL -0.327597271789844 -0.704497935497896 0.838675583577819 0.937235973066323 6 GSTO1,GSTM2 NA negative regulation of receptor activity GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY -0.327597271789844 -0.704497935497896 0.838675583577819 0.937235973066323 6 GSTO1,GSTM2 GO:0060315 negative regulation of ryanodine sensitive calcium release channel activity GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY -0.327597271789844 -0.704497935497896 0.838675583577819 0.937235973066323 6 GSTO1,GSTM2 GO:1903523 negative regulation of blood circulation GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION 0.327868852459016 0.690961405101146 0.838789174099841 0.937235973066323 5 SRI,PLN,ATP1A1,PDE5A,ATP2A2 GO:0045822 negative regulation of heart contraction GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION 0.327868852459016 0.690961405101146 0.838789174099841 0.937235973066323 5 SRI,PLN,ATP1A1,PDE5A,ATP2A2 GO:0010524 positive regulation of calcium ion transport into cytosol GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL -0.311192629762735 -0.704062117054837 0.838916220518015 0.937235973066323 7 GSTO1,GSTM2 GO:1903317 regulation of protein maturation GO_REGULATION_OF_PROTEIN_MATURATION -0.222571042295686 -0.747944829029335 0.839047360932312 0.937235973066323 28 SERPINF2,C3,C5,IFT52,CFB,SERPING1,C8A,CFI,C8G,C8B,CFH,C2 GO:0042177 negative regulation of protein catabolic process GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS 0.261015674718561 0.713097632519467 0.840098485894427 0.937235973066323 11 SDCBP,PARK7,ANXA2,PIN1 GO:0002791 regulation of peptide secretion GO_REGULATION_OF_PEPTIDE_SECRETION -0.232715456738605 -0.735998883307684 0.840378083507737 0.937235973066323 22 GLUD1,OXCT1,FGA,BRP44,FGB,FGG GO:0055072 iron ion homeostasis GO_IRON_ION_HOMEOSTASIS -0.260685971975001 -0.713932048261461 0.840392308232157 0.937235973066323 13 FTL,ACO1,HPX GO:0098900 regulation of action potential GO_REGULATION_OF_ACTION_POTENTIAL 0.260890525258302 0.712755722847115 0.840443646739381 0.937235973066323 11 CACNA2D1,ANK2,ANK3 GO:1902806 regulation of cell cycle g1 s phase transition GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION 0.274712080766467 0.704167239001486 0.840559693889103 0.937235973066323 9 UBC,PHB2,RDX,PSME1 GO:0090257 regulation of muscle system process GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS -0.203184535398149 -0.776923598440322 0.840618519667554 0.937235973066323 49 HSP90AA1,SRL,PKP2,ADA,HRC,MYL2,CAMK2D,ADK,GSTO1,AGT,GSTM2 GO:0055008 cardiac muscle tissue morphogenesis GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS 0.228419352997669 0.735504025136561 0.842776574732884 0.938609217959144 19 BMP10,XIRP2,TPM1,FKBP1A,TNNI3,TNNC1 GO:0034329 cell junction assembly GO_CELL_JUNCTION_ASSEMBLY 0.207904440567097 0.763281419311125 0.842838817899255 0.938609217959144 31 GJA1,LAMC1,KRT5,ANK2,RHOA,LAMA5,FN1,TJP1,INADL,ITGB1 GO:0009201 ribonucleoside triphosphate biosynthetic process GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS 0.228305896747963 0.735138699137513 0.843252504580825 0.938609217959144 19 ATP5I,PRKAG2,PKM2 GO:0070202 regulation of establishment of protein localization to chromosome GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME 0.29502317218664 0.695453721184146 0.844070752923813 0.938999485801117 7 CCT8,TCP1 GO:0061028 establishment of endothelial barrier GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER -0.296259978103526 -0.698951309555169 0.846131696870445 0.940302394553437 8 EZR GO:0006952 defense response GO_DEFENSE_RESPONSE -0.183456568609892 -0.813821992053785 0.846178499481106 0.940302394553437 111 RPL39,PCBP2,RPL13A,DNAJA3,LXN,TRIM28,SERPINF2,TUBB,AHCY,HP,CAMK2D,C3,FGA,SERPINA3,IGJ,C5,SERPINA1,FGB,IGHG3,SYNCRIP,DROSHA,IGHG2,CFB,SERPING1,IGHA1,AHSG,C8A,C1R,IFNA2,CFI,HMGB1,C8G,TUBB4B,ITIH4,IGKC,LTF,ATP1B1,ANXA3,C8B,CFH,C2 GO:0050867 positive regulation of cell activation GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION -0.225436740579076 -0.736780414097906 0.847195720321657 0.940620332565234 25 DNAJA3,ADA,PIK3R1,IGHG3,ADK,IGHG2,IGHA1 GO:0043407 negative regulation of map kinase activity GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY 0.265946333018699 0.705334876945397 0.847401484865791 0.940620332565234 10 APOE,GSTP1,CAV1 GO:0006940 regulation of smooth muscle contraction GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION -0.342159070118619 -0.691851261714633 0.848875429331167 0.941735835412698 5 ADA GO:0002931 response to ischemia GO_RESPONSE_TO_ISCHEMIA -0.284109520940486 -0.695383222273017 0.851498979189799 0.944124765440705 9 EEF2 GO:0001505 regulation of neurotransmitter levels GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS 0.257201646090535 0.702677665259113 0.852524276312762 0.944739926509948 11 PARK7,SNCG,PFN2,HSPA8,ALDH9A1,RAP1A,PPT1,ALDH5A1,ATP2A2,MAOA,NAPA GO:0030522 intracellular receptor signaling pathway GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY -0.256601627923109 -0.70274639031186 0.853287950031581 0.94506464625671 13 RAN,YWHAH GO:0001894 tissue homeostasis GO_TISSUE_HOMEOSTASIS -0.217935822914249 -0.738943972390089 0.85384433484224 0.945159550365611 29 FH,STRAP,SERPINA3,IGJ,IGHG3,ACTG1,IGHA1,TPP1,ALB,IGKC,LTF,HSPB1 GO:0050688 regulation of defense response to virus GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS 0.237558582636552 0.714080187231183 0.854599197691604 0.945473933313907 15 STOM,C1QBP,HIST1H3A,MDH1,PNPO,B2M,CD93,SNRPD1 GO:0051336 regulation of hydrolase activity GO_REGULATION_OF_HYDROLASE_ACTIVITY -0.175875088635666 -0.826224715841977 0.857616866337797 0.947465344113901 165 SERPINB9,DNAJA3,TOR1AIP1,LXN,ARHGDIA,SERPINF2,PSME2,SERPINF1,APOC1,PAFAH1B1,LIMS1,ARHGAP1,PPP2R1A,PRDX3,ANP32B,SPTB,RPS3,GPI,CAMK2D,C3,SERPINA3,GDI2,RANBP1,C5,PTPN1,TBC1D4,SERPINA7,SERPINA1 GO:0070584 mitochondrion morphogenesis GO_MITOCHONDRION_MORPHOGENESIS 0.289329685362517 0.682032549657171 0.858919027706344 0.947465344113901 7 NDUFS6,SLIRP,SSBP1,FIS1,DNM1L,OPA3,NUBPL GO:1902307 positive regulation of sodium ion transmembrane transport GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT -0.302916030875672 -0.685336610159374 0.859354652004051 0.947465344113901 7 ARF1,ATP1B1,ACTN4,GLRX GO:0086004 regulation of cardiac muscle cell contraction GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION -0.259565499234619 -0.694223408380895 0.860412222085089 0.947465344113901 12 PKP2,CAMK2D,DSP,JUP,ATP2A2,DSG2 GO:0090279 regulation of calcium ion import GO_REGULATION_OF_CALCIUM_ION_IMPORT -0.239831672576414 -0.707990025131484 0.860548995127365 0.947465344113901 17 HRC,CAMK2D,GSTO1,GSTM2 GO:0051169 nuclear transport GO_NUCLEAR_TRANSPORT -0.201385588064142 -0.756548723657332 0.861254999672153 0.947465344113901 45 RAN,THOC4,SRSF7,PIK3R1,RANBP1,HNRNPA2B1,RPSA,HSPA9,AGT,RAB11B GO:0045787 positive regulation of cell cycle GO_POSITIVE_REGULATION_OF_CELL_CYCLE -0.229142853134524 -0.715662248928162 0.86125915483272 0.947465344113901 21 H2AFY,PAFAH1B1,DYNC1LI1,RANBP1 GO:0051284 positive regulation of sequestering of calcium ion GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION -0.301826220513232 -0.682870953464508 0.861615540442772 0.947465344113901 7 GSTO1,GSTM2 GO:0006323 dna packaging GO_DNA_PACKAGING 0.20316900982996 0.751091202545365 0.86171505069787 0.947465344113901 32 H1F0,HIST1H1D,SET,HIST1H3A,HIST3H3,HP1BP3,RBBP7,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,TTN NA er associated ubiquitin dependent protein catabolic process GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS -0.253549402866562 -0.694387362513522 0.862428942381922 0.947465344113901 13 ERLIN2 GO:0036503 erad pathway GO_ERAD_PATHWAY -0.253549402866562 -0.694387362513522 0.862428942381922 0.947465344113901 13 ERLIN2 GO:1902532 negative regulation of intracellular signal transduction GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION 0.18510359407228 0.784714856378844 0.862549958974087 0.947465344113901 58 APOE,PRKCDBP,MIF,C1QBP,AMBP,PARK7,PPIF,CLU,PRKAA2,GPX1,FKBP1A,PIN1,LRRC4B,TXNDC12,SRI,MYADM,ITGB1,DAG1,ASPN GO:0051241 negative regulation of multicellular organismal process GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS 0.170880483038644 0.830921948853682 0.863826650943396 0.947465344113901 122 COL3A1,GJA1,COL4A2,UBC,APOE,VTN,ARHGDIB,NPPA,BMP10,C1QBP,GNAS,APOC2,SSC5D,RHOA,SOD1,PRKACB,PHB2,FN1,LGALS1,ANXA2,MECP2,PIN1,SRI,PFN2,ITGB1,DLL1,ANXA4,ASPN,PLN,CDK5RAP2,APOH,KCNK2,NOL3,B2M,CD63,PLG,APOC3,GSTP1,PGLYRP2,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,RBP4,CAV1,CD34,RARB,NUTF2 GO:0009952 anterior posterior pattern specification GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION 0.300751879699248 0.67363301079752 0.863859960115223 0.947465344113901 6 DLL1,TCAP,POFUT1,BASP1,CTNNB1,ALDH1A2 GO:0032204 regulation of telomere maintenance GO_REGULATION_OF_TELOMERE_MAINTENANCE -0.2529226467056 -0.692670886147854 0.86404309074321 0.947465344113901 13 XRCC5,CCT6A,HNRNPC GO:0017157 regulation of exocytosis GO_REGULATION_OF_EXOCYTOSIS -0.242041529784857 -0.702844639120893 0.864192801295558 0.947465344113901 16 ARF1,FGA,FGB,VAMP3,FGG GO:0046686 response to cadmium ion GO_RESPONSE_TO_CADMIUM_ION 0.241890727600998 0.696028455137166 0.864420572916667 0.947465344113901 13 SORD,CYB5A,SOD1 GO:0008037 cell recognition GO_CELL_RECOGNITION 0.222445803042365 0.716269358814198 0.865502224972039 0.948133370291246 19 CD36,CCT8,LAMA5 GO:0006085 acetyl coa biosynthetic process GO_ACETYL_COA_BIOSYNTHETIC_PROCESS -0.287690797189739 -0.678734470750795 0.867781237065165 0.950111627059351 8 BRP44,DLAT,PDHA1,BRP44L,PDHB,DLD GO:0050890 cognition GO_COGNITION -0.243197396021122 -0.693693938009963 0.868949891067538 0.950374549860172 15 SERPINF1,PAFAH1B1,GPI GO:0032410 negative regulation of transporter activity GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY -0.246893172370695 -0.690399484445694 0.8691431869458 0.950374549860172 14 CAMK2D,GSTO1,AGT,GSTM2 GO:0060548 negative regulation of cell death GO_NEGATIVE_REGULATION_OF_CELL_DEATH 0.171880303296561 0.820126754373246 0.870418052943729 0.950374549860172 109 BCL11B,UBC,APOE,CRYAB,CFL1,CD59,HCLS1,MIF,GLO1,FHL2,NACA,SET,PARK7,PPIF,CLU,CAST,SOD1,PHB2,FN1,PRKAA2,GPX1,NME2,SIRT5,PSMC1,HSPA5,MECP2,PIN1,TXNDC12 GO:0042743 hydrogen peroxide metabolic process GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS -0.242552614086604 -0.691854768156044 0.870727668845316 0.950374549860172 15 PRDX3,PRDX2,HBA2,HBA1,HBB,GPX3,MAOB,CAT GO:0051101 regulation of dna binding GO_REGULATION_OF_DNA_BINDING 0.284541723666211 0.670745959000905 0.871083879335406 0.950374549860172 7 PARK7,SRI,CALM1,TXN,CTNNB1,NME1,HMGB1 GO:0022612 gland morphogenesis GO_GLAND_MORPHOGENESIS -0.276347993035931 -0.676386195118965 0.871413732583545 0.950374549860172 9 EZR GO:0051952 regulation of amine transport GO_REGULATION_OF_AMINE_TRANSPORT 0.313142199997156 0.659925982244823 0.871676880465836 0.950374549860172 5 DPYSL2,SNCG GO:2000142 regulation of dna templated transcription initiation GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION -0.276207897002314 -0.676043297665329 0.871807729503206 0.950374549860172 9 PSMC2,CAND1,PSMC3,HMGB1,CTNNB1 GO:0051282 regulation of sequestering of calcium ion GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION 0.224360520414355 0.699642915286089 0.874707674863582 0.953018454219247 17 ERO1L,ANK2,DMD,FKBP1A,SRI,PLN,NOL3,CALM1,JPH2 GO:0006937 regulation of muscle contraction GO_REGULATION_OF_MUSCLE_CONTRACTION 0.192374871365296 0.751703905361856 0.876387973432034 0.954187322515374 40 MYL9,ANXA6,NPPA,BMP10,PPP1R12B,ANK2,DMD,SOD1,TPM1,TNNI3,SRI,TNNC1,HSPB6,PLN GO:0051149 positive regulation of muscle cell differentiation GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION 0.234162262925105 0.689601253466945 0.876730881494454 0.954187322515374 14 EHD2,BMP10,MYLK3,PIN1 GO:0007584 response to nutrient GO_RESPONSE_TO_NUTRIENT -0.205549694923422 -0.725037497434932 0.878412242306793 0.955040458273118 34 EEF2,ADA,AHCY,BDH1,OXCT1 NA establishment of localization by movement along microtubule GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE -0.283363138543653 -0.66852444272962 0.878812964529307 0.955040458273118 8 PAFAH1B1,IFT81 GO:1903318 negative regulation of protein maturation GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION -0.308156570868772 -0.662690708017952 0.878947464329318 0.955040458273118 6 SERPINF2 GO:0002065 columnar cuboidal epithelial cell differentiation GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION -0.293618503613154 -0.664301289583773 0.87966647373752 0.955040458273118 7 PAFAH1B1 GO:0014068 positive regulation of phosphatidylinositol 3 kinase signaling GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING 0.308976426676282 0.651146897054094 0.880291365886638 0.955040458273118 5 HCLS1,F2 GO:0055085 transmembrane transport GO_TRANSMEMBRANE_TRANSPORT 0.172504188490977 0.804552537213174 0.880578908762625 0.955040458273118 95 GJA1,CACNA2D1,UBC,ATP5I,ANXA6,SLC25A20,NDUFA4,PRKAG2,CYB5A GO:1901699 cellular response to nitrogen compound GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND -0.190779286008601 -0.755373911797921 0.880844088008872 0.955040458273118 58 NAMPT,EZR,PRKAR2A,PIK3R1,HNRNPA2B1,PTPN1,TBC1D4,YWHAG,AGT,DROSHA,GSTM2,NPM1,GOT1,AQP1,PRKAR2B,AIFM1,HNRNPD GO:0019751 polyol metabolic process GO_POLYOL_METABOLIC_PROCESS 0.259834671396625 0.666032096745538 0.881472592659678 0.95516797605333 9 SORD,MECP2,CALM1,SCP2 GO:0043271 negative regulation of ion transport GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT 0.217514508347627 0.700390725723282 0.882040787187969 0.95516797605333 19 APOE,PPIF,GNAO1,ANK3,FKBP1A,SRI,PLN,CALM1,CAV1 GO:0045637 regulation of myeloid cell differentiation GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION 0.204115011215271 0.723158506276668 0.882388742818191 0.95516797605333 27 HCLS1,GNAS,DLL1,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,RARA GO:0050803 regulation of synapse structure or activity GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY 0.225246982100106 0.690800426271231 0.882959483264827 0.955270820256343 16 APOE,NCAM1,MECP2,LRRC4B GO:1902883 negative regulation of response to oxidative stress GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS 0.259082243782741 0.664103405171658 0.883510313129712 0.955352024105795 9 PARK7,GPX1,NOL3,PSAP GO:0097479 synaptic vesicle localization GO_SYNAPTIC_VESICLE_LOCALIZATION -0.323689126323696 -0.654504731886021 0.884256010636333 0.955643740235607 5 ARF1 GO:0040029 regulation of gene expression epigenetic GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC -0.208405700292122 -0.713039006533165 0.884831934189677 0.955725925640042 30 RAN,ARID4A,H2AFY GO:0042255 ribosome assembly GO_RIBOSOME_ASSEMBLY 0.228066392255658 0.685547498539431 0.885283974945457 0.955725925640042 15 C1QBP,RPL24,RPL3,RPL23A,RPS14 GO:0002831 regulation of response to biotic stimulus GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS 0.214377953413234 0.700682767763124 0.886293427118483 0.956301559190711 20 STOM,MIF,C1QBP,HIST1H3A,MDH1,PNPO,B2M,CD93,SNRPD1 GO:0042572 retinol metabolic process GO_RETINOL_METABOLIC_PROCESS -0.322107209313633 -0.651306069699568 0.887487535546774 0.957075709655168 5 ALDH1A1,ALDH1A2 GO:0071495 cellular response to endogenous stimulus GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS -0.177811601017891 -0.785419318272885 0.888071458068858 0.95719135147733 108 NAMPT,EEF2,SERPINB9,EZR,FERMT2,RAN,NEDD8,SERPINF1,LIMS1,YWHAH,PARD3,PRKAR2A,PIK3R1,PTPN1,TBC1D4,FGB,YWHAG,AGT,EHD1,UBE2L3,GSTM2,GOT1,FMOD,AQP1 GO:0002761 regulation of myeloid leukocyte differentiation GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION 0.244700475578001 0.668524332874678 0.889134336600856 0.957293613440324 11 HCLS1,GNAS NA regulation of cofactor metabolic process GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS 0.229601384318769 0.67616959473359 0.890461179217747 0.957293613440324 14 PRKAG2,ME1,PRKAA2,PGAM2 GO:0070085 glycosylation GO_GLYCOSYLATION 0.226400752177744 0.680540731090762 0.890515401036902 0.957293613440324 15 SPON1,RPN1,UGGT1,SIRT5,DAG1 GO:0051701 interaction with host GO_INTERACTION_WITH_HOST 0.214860472896259 0.691844804671855 0.890583727958499 0.957293613440324 19 NCAM1,SCARB2,KPNB1,VAPB,TCP1,ITGB1,DAG1,CD81 GO:0050864 regulation of b cell activation GO_REGULATION_OF_B_CELL_ACTIVATION -0.253512877393447 -0.660871878283097 0.891026774661338 0.957293613440324 11 ADA,IGHG3,IGHG2,IGHA1,IGKC,IGHM,IGHG1 GO:0050871 positive regulation of b cell activation GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION -0.253512877393447 -0.660871878283097 0.891026774661338 0.957293613440324 11 ADA,IGHG3,IGHG2,IGHA1,IGKC,IGHM,IGHG1 GO:0016458 gene silencing GO_GENE_SILENCING -0.20998168541815 -0.699343955924661 0.892714714816638 0.957811524214336 27 RAN,H2AFY,HNRNPA2B1,DROSHA,H2AFZ,HIST1H2AE,HIST1H2AB GO:0051092 positive regulation of nf kappab transcription factor activity GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY 0.232670264723861 0.669497034955533 0.892996651785714 0.957811524214336 13 UBC,PSMA6,CLU NA regulation of sequence specific dna binding transcription factor activity GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY -0.214646752195998 -0.693479110000691 0.89341161568614 0.957811524214336 24 DNAJA3,PRDX3,RPS3,AGT,NPM1,CDK5RAP3,LTF,JUP,ANXA3,CAT,CTNNB1,HSPA1A GO:0010817 regulation of hormone levels GO_REGULATION_OF_HORMONE_LEVELS -0.19434736446509 -0.730108107266344 0.893416825126221 0.957811524214336 45 GLUD1,OXCT1,FGA,BRP44,SERPINA7,FGB,VAMP3,FGG,AGT,RAB11B GO:0045137 development of primary sexual characteristics GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS -0.2466997039961 -0.659813071689954 0.894440820212635 0.958397634464765 12 ARID4A GO:0006122 mitochondrial electron transport ubiquinol to cytochrome c GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C 0.248115147361206 0.658043541890087 0.895990862364363 0.958540719193559 10 UQCRH,MECP2,CYCS,UQCRB,UQCRQ,UQCRC1,UQCR10,UQCRC2,CYC1,UQCRFS1 GO:0035967 cellular response to topologically incorrect protein GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN -0.221029086877642 -0.681022000070573 0.896046270718232 0.958540719193559 20 PTPN1,SSR1,ACADVL,TPP1,CDK5RAP3,CASP12,VCP,PDIA6,HDGF,HSP90B1 GO:0031647 regulation of protein stability GO_REGULATION_OF_PROTEIN_STABILITY -0.195306258661499 -0.722774516477279 0.896384907771543 0.958540719193559 42 HSP90AA1,DNAJA3,HSP90AB1,ISOC2,PIK3R1 GO:0051926 negative regulation of calcium ion transport GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT 0.253897168576674 0.650812544130221 0.896483800122263 0.958540719193559 9 GNAO1,FKBP1A,SRI,PLN,CALM1 GO:0006084 acetyl coa metabolic process GO_ACETYL_COA_METABOLIC_PROCESS -0.264594835680107 -0.64761930125733 0.897560800888284 0.958558827403511 9 BRP44,DLAT,PDHA1,BRP44L,PDHB,DLD GO:0031016 pancreas development GO_PANCREAS_DEVELOPMENT 0.300546448087432 0.633381288009384 0.897607572023641 0.958558827403511 5 CLU,DLL1,ANXA1,CTNNB1,ALDH1A2 GO:0086091 regulation of heart rate by cardiac conduction GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION 0.253278513079456 0.649226749533372 0.897932845789843 0.958558827403511 9 CACNA2D1,ANK2 GO:1904358 positive regulation of telomere maintenance via telomere lengthening GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING 0.246638934817029 0.654128375317291 0.899737292975443 0.959464941208013 10 CCT8,TCP1,HNRNPA1 GO:0032206 positive regulation of telomere maintenance GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE 0.246638934817029 0.654128375317291 0.899737292975443 0.959464941208013 10 CCT8,TCP1,HNRNPA1 GO:2000258 negative regulation of protein activation cascade GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE -0.314327654106685 -0.635575681247087 0.901595450012926 0.960290610552566 5 FGA,SERPING1 GO:0002684 positive regulation of immune system process GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 0.167570247422239 0.799561325597643 0.9023000144655 0.960290610552566 109 CD36,MYO1C,PSMB3,UBC,PSMB2,CD59,CRK,HCLS1,MIF,WHSC1,C1QBP,PSMA6,GNAS,HLA-DRA,PSMB1,CLU,STX7,PSMA4,PRKACB,PSMD14,PSMC6,LGALS1,PSMC1,PSMA5,PSMA3 GO:0097066 response to thyroid hormone GO_RESPONSE_TO_THYROID_HORMONE 0.282296650717703 0.6322964396804 0.902636826944383 0.960290610552566 6 ANXA2,RDX,AKR1B1 GO:0033554 cellular response to stress GO_CELLULAR_RESPONSE_TO_STRESS -0.16978219670604 -0.800327870250045 0.90277168027629 0.960290610552566 169 ERP44,XRCC6,ERLIN2,EEF2,XRCC5,TRIM28,ESCO2,MATN2,UBA1,THOC4,PPP5C,PRDX3,OTUB1,RPS3,PIK3R1,NDUFB9,C5,PTPN1,DBNL,SSR1,NPEPPS,LONP1,GSTM3,AGT,ACADVL,GSTM2,PEA15,RUVBL1,ASCC3,NPM1,PSMC2,DCLRE1A,PRDX2,AQP1,TXNDC5,ZMAT3,P4HB,STOML2,AIFM1,TPP1,OBSCN,PSMC3,CDK5RAP3,HNRNPD,ALB,NDRG1,HMGB1 GO:0010662 regulation of striated muscle cell apoptotic process GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS 0.28223441327422 0.632157038402244 0.902902725459783 0.960290610552566 6 NACA,SIRT5,NOL3,ILK GO:0042407 cristae formation GO_CRISTAE_FORMATION 0.281613123718387 0.630765455564951 0.904032794150233 0.960736489492917 6 LETM1,AFG3L2,CHCHD3,APOO,IMMT,SAMM50 GO:0019722 calcium mediated signaling GO_CALCIUM_MEDIATED_SIGNALING -0.230756501637206 -0.658207649263699 0.904278867102396 0.960736489492917 15 HRC,CAMK2D,GSTO1,GSTM2,ATP1B1,ATP2A2,FIS1 GO:0043297 apical junction assembly GO_APICAL_JUNCTION_ASSEMBLY 0.269060657072342 0.63425267174212 0.905163353384467 0.96116764336119 7 RHOA,INADL,ITGB1 NA asymmetric protein localization GO_ASYMMETRIC_PROTEIN_LOCALIZATION -0.311787457662731 -0.630439362300045 0.905713336041659 0.961243329160492 5 NAPA,ARF4,RAB10 GO:0035265 organ growth GO_ORGAN_GROWTH -0.246505124579648 -0.642603667168079 0.906925335125385 0.961508938724759 11 SORBS2,CAMK2D,AGT GO:0051131 chaperone mediated protein complex assembly GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY -0.270180295354285 -0.637422821883454 0.907103136753829 0.961508938724759 8 HSP90AA1 GO:0031468 nuclear envelope reassembly GO_NUCLEAR_ENVELOPE_REASSEMBLY -0.292957551610566 -0.630005216986549 0.907520454835359 0.961508938724759 6 PPP2R1A GO:0000028 ribosomal small subunit assembly GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY -0.292507546578054 -0.629037481160678 0.908304025365818 0.961508938724759 6 RPSA,RPS5,RPS19 GO:0051591 response to camp GO_RESPONSE_TO_CAMP -0.245817367238651 -0.640810781968634 0.908357797191667 0.961508938724759 11 EZR GO:0050885 neuromuscular process controlling balance GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE -0.309704014594178 -0.626226606182869 0.908852531668944 0.961525755316775 5 PAFAH1B1 GO:0042391 regulation of membrane potential GO_REGULATION_OF_MEMBRANE_POTENTIAL 0.181201144236926 0.734153412260075 0.909416462707716 0.961531948639602 47 GJA1,CACNA2D1,NPPA,PARK7,ANK2,DMD,SOD1,ANK3,MECP2,SRI,HEBP2,GNA11,PLN,KCNK2,B2M GO:0009914 hormone transport GO_HORMONE_TRANSPORT 0.278532157946186 0.623864616736055 0.909816086860182 0.961531948639602 6 LTBP4,RAPGEF4 GO:0050866 negative regulation of cell activation GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION 0.235584846848416 0.64362033707825 0.912720327672696 0.96342872860407 11 APOE GO:0022406 membrane docking GO_MEMBRANE_DOCKING -0.257367748390269 -0.629930364854848 0.91287295390236 0.96342872860407 9 EZR,VAMP3,SNX3 GO:0045321 leukocyte activation GO_LEUKOCYTE_ACTIVATION -0.203481858330693 -0.677696283275893 0.913435267364705 0.96342872860407 27 HPRT1,DNAJA3,ADA,PIK3R1 GO:0032781 positive regulation of atpase activity GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY -0.230203113577502 -0.643728254635873 0.913881455830141 0.96342872860407 14 TOR1AIP1 GO:0002673 regulation of acute inflammatory response GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE 0.200942043671495 0.68183377276572 0.91400982469659 0.96342872860407 23 VTN,CD59,C1QBP,PHB2 GO:0007548 sex differentiation GO_SEX_DIFFERENTIATION -0.229076361493535 -0.640577462532556 0.916329992829285 0.965367589507452 14 ARID4A,HSD17B10,HSD17B4,PRDX4,CTNNB1 GO:0034754 cellular hormone metabolic process GO_CELLULAR_HORMONE_METABOLIC_PROCESS 0.244520547945206 0.626777528841475 0.918015713088958 0.966620650524241 9 HSD17B8,TTR,RBP4,SCP2,AKR1B1,AKR1C3,ALDH1A2,HSD17B4,ALDH1A1 GO:0051262 protein tetramerization GO_PROTEIN_TETRAMERIZATION -0.189309401221552 -0.700581803523554 0.91947081763283 0.966620650524241 42 XRCC6,HPRT1,DCXR GO:0090068 positive regulation of cell cycle process GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS -0.231466749553677 -0.633910330353819 0.919836479752965 0.966620650524241 13 H2AFY,DYNC1LI1,RANBP1 GO:0034308 primary alcohol metabolic process GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS -0.253381705883603 -0.620174172689141 0.920305168523228 0.966620650524241 9 ALDH2 GO:0002708 positive regulation of lymphocyte mediated immunity GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY 0.273054268533328 0.611595077002207 0.920407711056947 0.966620650524241 6 WHSC1,STX7,B2M,HSPD1 GO:0002705 positive regulation of leukocyte mediated immunity GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY 0.273054268533328 0.611595077002207 0.920407711056947 0.966620650524241 6 WHSC1,STX7,B2M,HSPD1 GO:0080134 regulation of response to stress GO_REGULATION_OF_RESPONSE_TO_STRESS -0.165690330088991 -0.792811368911056 0.923674799561631 0.969544692901074 190 PCBP2,HSP90AA1,CAPNS1,SERPINB9,DNAJA3,EZR,PSMD2,TRIM28,SERPINF2,PSME2,SERPINF1,PAFAH1B1,ADA,PSMB6,HSP90AB1,OTUB1,RPS3,ARF1,ERP29,HP,PIK3R1,CAMK2D,C3,FGA,PSMA2,PSMA1,C5,PTPN1,DBNL,FGB,VAMP3,CHCHD2,FGG,HPX,AGT GO:0050778 positive regulation of immune response GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE -0.173036394393398 -0.746207359018039 0.925063157731591 0.970067858889227 93 HSP90AA1,PSMD2,ARPC3,ACTR3,PSME2,ADA,PSMB6,HSP90AB1,PIK3R1,C3,PSMA2,PSMA1,C5,IGHG3,ACTR2,HPX,IGHG2,ACTG1,CFB,PSMC2,SERPING1,IGHA1,STOML2,C8A,PSMC3,C1R,CFI,CTSB,HMGB1,C8G,PSMD11,IGKC,ARPC4,C8B,PSMA7,CFH,C2 GO:0002688 regulation of leukocyte chemotaxis GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS -0.299837049425344 -0.606275440489716 0.925139417217565 0.970067858889227 5 C5,HMGB1 GO:0043388 positive regulation of dna binding GO_POSITIVE_REGULATION_OF_DNA_BINDING 0.284153005464481 0.598833217754326 0.926962248925915 0.970363431661164 5 PARK7,CALM1,TXN,NME1,HMGB1 GO:0010821 regulation of mitochondrion organization GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION -0.191884988830047 -0.676837842782971 0.926993885529085 0.970363431661164 34 YWHAH,YWHAZ,YWHAB,YWHAG,NPEPPS,YWHAQ,DYNLL2,UBE2L3,RUVBL1 GO:0046939 nucleotide phosphorylation GO_NUCLEOTIDE_PHOSPHORYLATION 0.190479086763586 0.674847827412477 0.927402862985685 0.970363431661164 27 PFKL,CMPK1,PKM2,NME2,ALDOC,PFKM,AK1 GO:0016569 covalent chromatin modification GO_COVALENT_CHROMATIN_MODIFICATION -0.215759927348201 -0.63692953789058 0.92774280809447 0.970363431661164 17 ARID4A,PPP5C GO:0003091 renal water homeostasis GO_RENAL_WATER_HOMEOSTASIS -0.267244468060616 -0.604630984022368 0.928320792938793 0.970363431661164 7 PRKAR2A,AQP1,PRKAR2B GO:0050891 multicellular organismal water homeostasis GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS -0.267244468060616 -0.604630984022368 0.928320792938793 0.970363431661164 7 PRKAR2A,AQP1,PRKAR2B GO:0090501 rna phosphodiester bond hydrolysis GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS -0.266008202592156 -0.601833977924798 0.930310374764868 0.971507284542575 7 RPSA,DROSHA,ERVK-7 GO:0032543 mitochondrial translation GO_MITOCHONDRIAL_TRANSLATION -0.265925420050184 -0.601646685405047 0.930382723194907 0.971507284542575 7 TUFM,MRPS23,NDUFA7 GO:0006813 potassium ion transport GO_POTASSIUM_ION_TRANSPORT -0.278977322511822 -0.599940734202422 0.930900012755799 0.971542217054909 6 AQP1,ATP1B1,ATP1A3 GO:0060261 positive regulation of transcription initiation from rna polymerase ii promoter GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER -0.26503213551947 -0.599625661326467 0.932046737085805 0.972233687308206 7 PSMC2,CAND1,PSMC3 GO:0006007 glucose catabolic process GO_GLUCOSE_CATABOLIC_PROCESS 0.206360234011627 0.632877458741302 0.933881385789783 0.973641652474498 16 PFKL,PKM2,ALDOC,PFKM GO:0021915 neural tube development GO_NEURAL_TUBE_DEVELOPMENT 0.243953149297766 0.601677432198482 0.934606989356196 0.973892493319793 8 PFN1,PRKACB,RALA GO:0045670 regulation of osteoclast differentiation GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION -0.290986435922449 -0.588379354564525 0.937991653432803 0.976845051866211 5 PIK3R1,LTF,CTNNB1,CA2 GO:0002573 myeloid leukocyte differentiation GO_MYELOID_LEUKOCYTE_DIFFERENTIATION -0.260992561556335 -0.590486270722477 0.938413398929243 0.976845051866211 7 PAFAH1B1 GO:0007613 memory GO_MEMORY -0.288784086013365 -0.583926166862065 0.941056985633564 0.979089340493366 5 SERPINF1 GO:2000573 positive regulation of dna biosynthetic process GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS 0.220969748452626 0.603691730965552 0.942519213953702 0.979896643175073 11 CCT8,TCP1,HNRNPA1 GO:0090281 negative regulation of calcium ion import GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT -0.257856183926212 -0.583390329292787 0.94329691795688 0.979896643175073 7 GSTO1,GSTM2 GO:1903170 negative regulation of calcium ion transmembrane transport GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT -0.257856183926212 -0.583390329292787 0.94329691795688 0.979896643175073 7 GSTO1,GSTM2 GO:0048878 chemical homeostasis GO_CHEMICAL_HOMEOSTASIS -0.166878327194546 -0.735969360448572 0.944109270204882 0.980233409809412 107 CLIC4,GCDH,CSRP3,FTL,PKP2,SERPINF1,HRC,IVD,ARF1,GPI,PRKAR2A,PIK3R1,CAMK2D,ACAD10,ETFA,ACO1,HPX,AGT,RAB11B,EHD1 GO:0009314 response to radiation GO_RESPONSE_TO_RADIATION -0.194450083328834 -0.628227864371824 0.945721572722138 0.980396813420671 24 XRCC6,XRCC5 GO:0030316 osteoclast differentiation GO_OSTEOCLAST_DIFFERENTIATION -0.284928252293332 -0.576129607725866 0.945876574214278 0.980396813420671 5 PAFAH1B1 GO:0002709 regulation of t cell mediated immunity GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY 0.271174863387978 0.571482662135739 0.946742852157983 0.980396813420671 5 STX7,B2M,HSPD1 GO:0009185 ribonucleoside diphosphate metabolic process GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS 0.184383810265902 0.640186772831071 0.947611784927494 0.980396813420671 25 PFKL,ENTPD4,PKM2,ALDOC,PFKM,AK1 GO:0002262 myeloid cell homeostasis GO_MYELOID_CELL_HOMEOSTASIS -0.205728819159649 -0.607317416763221 0.947614836393903 0.980396813420671 17 ARID4A,GPI GO:1902236 negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 0.245723870490829 0.579241212986851 0.947829781524632 0.980396813420671 7 PARK7,TXNDC12,OPA1 GO:0050865 regulation of cell activation GO_REGULATION_OF_CELL_ACTIVATION -0.180424449573333 -0.660900673260078 0.947949865416054 0.980396813420671 40 DNAJA3,CYGB,ADA,PIK3R1,VAMP3,IGHG3,ADK,IGHG2,IGHA1,IFNA2,HMGB1,IGKC,PDE5A,CTNNB1,PRKAR1A,IGHM GO:0051651 maintenance of location in cell GO_MAINTENANCE_OF_LOCATION_IN_CELL 0.191159598310318 0.624794827527688 0.948172615369992 0.980396813420671 20 APOE,ANK3,VPS13A,HSPA5,SRI,DAG1,FLNA,CAV1 GO:0051291 protein heterooligomerization GO_PROTEIN_HETEROOLIGOMERIZATION 0.173860497901318 0.675528269967222 0.948718596136851 0.980456480207307 39 COL1A1,PCBD1,COL1A2,HIST1H3A,HIST3H3,ANXA2,CDH2,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4 GO:0006090 pyruvate metabolic process GO_PYRUVATE_METABOLIC_PROCESS -0.184563921261985 -0.641856724054151 0.94978630688008 0.980892175895138 32 ENO1,ME3,GPI,BRP44,OGDH,ENO3,DLAT,PDHA1,PGK1,TPI1,PGM1,BRP44L,PDHB,HK1,BPGM GO:0042445 hormone metabolic process GO_HORMONE_METABOLIC_PROCESS -0.208390646492435 -0.59441149689458 0.95037908496732 0.980892175895138 15 AGT,ALDH1A1,HSD17B4,ALDH1A2,CTSZ,ALDH9A1,CPA3,AKR1C3,AKR1B1,CRYM,SCP2,RBP4,TTR,CTSG,HSD17B8 GO:0050709 negative regulation of protein secretion GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION -0.208194802034396 -0.593852872026235 0.950605664488017 0.980892175895138 15 EZR,ERP29 GO:0031294 lymphocyte costimulation GO_LYMPHOCYTE_COSTIMULATION 0.253657557111461 0.568149745495888 0.952182583647241 0.982014703627971 6 HLA-DRA,LGALS1,CAV1,CDC42 GO:0030856 regulation of epithelial cell differentiation GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION -0.23160368162931 -0.566870528972595 0.955406712274795 0.984834023741164 9 H2AFY NA regulation of protein complex assembly GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY 0.164112259939935 0.69379170463172 0.957210943465782 0.985841759232763 57 CD36,FAM21C,HCLS1,SPTAN1,SPTBN1,ARPC5L,PFN1,PARK7,CLU,TMOD1,HIST3H3,PSMC6,PSMC1,MYADM,PFN2,RDX,TMOD3,FSCN1 GO:0014912 negative regulation of smooth muscle cell migration GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION 0.263263250181053 0.554809473032615 0.957429175844547 0.985841759232763 5 TPM1,LRP1,ILK GO:1901615 organic hydroxy compound metabolic process GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS 0.163710515488821 0.689646284251194 0.958457985619063 0.985841759232763 56 APOE,SORD,PRKAG2,DDT,DBI,FABP5,PARK7,CYB5R1,APOA4,PRKAA2,FDPS,MECP2,ACADM,PNPO,SULT1A2,SULT1A3,TMLHE,ADH1B,TTR,PON1 GO:2001234 negative regulation of apoptotic signaling pathway GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY -0.181623252536097 -0.626343282438001 0.958966769810305 0.985841759232763 31 FGA,NDUFS3,PTPN1,FGB,FGG,PEA15,VDAC2 GO:0035303 regulation of dephosphorylation GO_REGULATION_OF_DEPHOSPHORYLATION -0.198332894276822 -0.585484432873261 0.959562329847925 0.985841759232763 17 PPP1R14C,PPP2R1A,YWHAB GO:0046683 response to organophosphorus GO_RESPONSE_TO_ORGANOPHOSPHORUS -0.209084061361192 -0.572611602594157 0.960242824057829 0.985841759232763 13 EZR GO:0007498 mesoderm development GO_MESODERM_DEVELOPMENT -0.257124180198061 -0.552945551488987 0.960548134919912 0.985841759232763 6 GPI GO:1903706 regulation of hemopoiesis GO_REGULATION_OF_HEMOPOIESIS 0.171823727479853 0.645571996767024 0.960716420884815 0.985841759232763 34 HCLS1,GNAS,SOD1,LGALS1,DLL1,PGLYRP2,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4,LGALS3,HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,RARA GO:0019216 regulation of lipid metabolic process GO_REGULATION_OF_LIPID_METABOLIC_PROCESS -0.172715298691943 -0.651774406745052 0.960802949610815 0.985841759232763 46 ERLIN2,H2AFY,APOC1,ARF1,PIK3R1,C3,SERPINA3 GO:0042592 homeostatic process GO_HOMEOSTATIC_PROCESS -0.157751127426859 -0.752537294325328 0.96241962578926 0.986057436078405 186 ERP44,XRCC6,CLIC4,GCDH,CSRP3,DNAJA3,XRCC5,ARID4A,FTL,PKP2,SERPINF1,HRC,IVD,ARF1,GPI,PRKAR2A,FH,PIK3R1,STRAP,CAMK2D,ACAD10,SERPINA3,IGJ,ETFA,ACO1,IGHG3,HPX,AGT,RAB11B,EHD1,ACADVL,ACTG1,GOT1,DCLRE1A,AQP1,IGHA1,TXNDC5,P4HB,STOML2,PTGES2,PRKAR2B,AIFM1,TPP1 GO:0051098 regulation of binding GO_REGULATION_OF_BINDING 0.172018627467481 0.631533514932102 0.962676994424984 0.986057436078405 31 VTN,PCBD1,PARK7,ANXA2,FKBP1A,HSPA5,PIN1,SRI,PLN,B2M,PON1,CALM1,CAV1,ADD1,CDC42,LRPAP1 GO:0048145 regulation of fibroblast proliferation GO_REGULATION_OF_FIBROBLAST_PROLIFERATION 0.208510326691727 0.569652456619908 0.962722628744995 0.986057436078405 11 MIF,FN1,ANXA2,GSTP1,FBLN1,S100A6 GO:0046689 response to mercury ion GO_RESPONSE_TO_MERCURY_ION 0.225872689938398 0.557084425747742 0.963072976439614 0.986057436078405 8 PARK7,FN1,PGAM2,GSTP1 GO:1904872 regulation of telomerase rna localization to cajal body GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY 0.217780976029418 0.558236201953021 0.963479520909276 0.986057436078405 9 CCT8,TCP1 GO:0003208 cardiac ventricle morphogenesis GO_CARDIAC_VENTRICLE_MORPHOGENESIS 0.192793251463865 0.579519542397887 0.964224552513665 0.986057436078405 15 BMP10,TPM1,FKBP1A,TNNI3,TNNC1 NA positive regulation of protein complex assembly GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY 0.17282736035035 0.618388498678883 0.965190645901479 0.986057436078405 28 CD36,FAM21C,ARPC5L,PFN1,PSMC6,PSMC1 GO:0046928 regulation of neurotransmitter secretion GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION 0.256147540983607 0.53981359773527 0.965476631845245 0.986057436078405 5 SNCG,PFN2 GO:0051588 regulation of neurotransmitter transport GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT 0.256147540983607 0.53981359773527 0.965476631845245 0.986057436078405 5 SNCG,PFN2 GO:0051646 mitochondrion localization GO_MITOCHONDRION_LOCALIZATION -0.251839683526469 -0.541581241356178 0.96592379321027 0.986057436078405 6 MFN2,ALB GO:1903573 negative regulation of response to endoplasmic reticulum stress GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS 0.219568655119194 0.541536376897267 0.970363869574023 0.990086712451543 8 PARK7,TXNDC12,USP14,OPA1 GO:2000144 positive regulation of dna templated transcription initiation GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION -0.22622231131691 -0.533714954540023 0.971529864847841 0.990772965268901 8 PSMC2,CAND1,PSMC3,CTNNB1 GO:0060191 regulation of lipase activity GO_REGULATION_OF_LIPASE_ACTIVITY 0.183676171081513 0.563308667205963 0.972660011743981 0.990965475221281 16 APOC2,RHOA,APOA4,ABL2,APOH,APOC3 GO:1903115 regulation of actin filament based movement GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT -0.191218281877854 -0.545429207489652 0.973263616557734 0.990965475221281 15 PKP2,CAMK2D GO:0043666 regulation of phosphoprotein phosphatase activity GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY -0.232162519919075 -0.525259339848876 0.973737519895818 0.990965475221281 7 PPP2R1A GO:0030104 water homeostasis GO_WATER_HOMEOSTASIS -0.223959080960365 -0.528375428655835 0.973743408857775 0.990965475221281 8 PRKAR2A,AQP1,PRKAR2B GO:0010921 regulation of phosphatase activity GO_REGULATION_OF_PHOSPHATASE_ACTIVITY 0.203919892832987 0.540830215199696 0.974186179326099 0.990965475221281 10 SET,CEP192,FKBP1A,CALM1,ENSA GO:1902105 regulation of leukocyte differentiation GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION -0.18149110624431 -0.552149354639785 0.976543231169906 0.992816348344597 19 ADA,PIK3R1,IFNA2,HMGB1,NME1,LTF,CTNNB1,APCS,ANXA1,CA2,C1QC GO:0046031 adp metabolic process GO_ADP_METABOLIC_PROCESS -0.17442928671918 -0.563544825507626 0.976994573868985 0.992816348344597 24 ENO1,GPI,AK4,OGDH GO:0008637 apoptotic mitochondrial changes GO_APOPTOTIC_MITOCHONDRIAL_CHANGES -0.199874101428973 -0.521043247150357 0.978919817493722 0.993857940330564 11 MTCH2,DNM1L,FIS1,ACAA2,NDUFS1,TIMM50,SLC25A4 GO:0034110 regulation of homotypic cell cell adhesion GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION -0.17157146692544 -0.560736001256948 0.979095679433011 0.993857940330564 25 DNAJA3,ADA,PIK3R1 GO:0014074 response to purine containing compound GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND -0.183642620693428 -0.533264814444097 0.979504414299894 0.993857940330564 16 EZR GO:0071396 cellular response to lipid GO_CELLULAR_RESPONSE_TO_LIPID -0.162596689510045 -0.598760870265689 0.980479688992851 0.994345058332144 41 SERPINB9,RAN,SERPINF1,YWHAH GO:0050905 neuromuscular process GO_NEUROMUSCULAR_PROCESS -0.207899299675592 -0.508851954127228 0.981553780579534 0.994931848260325 9 PAFAH1B1 GO:0002263 cell activation involved in immune response GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 0.195915359645139 0.519600832688682 0.982067390062821 0.994950211526814 10 S100A13,LGALS1,DLL1,HSPD1,STXBP2 NA cell proliferation GO_CELL_PROLIFERATION -0.157375314057797 -0.616059138007185 0.983533902691511 0.995933472821258 55 HPRT1,EEF2,XRCC5,SERPINF1,PAFAH1B1,DAZAP1,ADK,MAPRE1,AGT,UBE2L3,ASCC3,CDV3,PDXK,CDK5RAP3,IFNA2,HMGB1 GO:0003229 ventricular cardiac muscle tissue development GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT -0.172783125278108 -0.510060776768207 0.987185489604467 0.997078344314842 17 PKP2,MYL2 NA negative regulation of cell proliferation GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION 0.146648965565802 0.623887479737514 0.98796426393786 0.997078344314842 59 BCL11B,GJA1,APOE,ENG,FABP3,PDCD5,CDH13,TPM1,PHB2 GO:0009416 response to light stimulus GO_RESPONSE_TO_LIGHT_STIMULUS 0.172073931208313 0.506752869433068 0.988184471687099 0.997078344314842 14 CLU,GPX1,MECP2,ITGB1,GNA11,DYNLRB1,CIRBP GO:0006887 exocytosis GO_EXOCYTOSIS 0.145937781972786 0.620861897267391 0.988759576893508 0.997078344314842 59 CD36,S100A13,SCRN1,LGALS3BP,CYB5R1,CLU,SOD1,RAPGEF4,MYH10,FN1,LAMP2,RALA,SCRN2,TF,APOH,PSAP,CD63,PLG GO:0007098 centrosome cycle GO_CENTROSOME_CYCLE 0.226586373589949 0.477515439171077 0.989706235142739 0.997078344314842 5 CEP192,CDK5RAP2,CETN2 GO:0010518 positive regulation of phospholipase activity GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY 0.211314802694621 0.473309183994495 0.990671393751385 0.997078344314842 6 APOC2,ABL2,ARL1 GO:0032469 endoplasmic reticulum calcium ion homeostasis GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS -0.217300625526255 -0.467304996861681 0.990742934198298 0.997078344314842 6 CAMK2D,ATP2A2,FIS1 GO:1903779 regulation of cardiac conduction GO_REGULATION_OF_CARDIAC_CONDUCTION 0.158437276665987 0.510163666914414 0.991195297813102 0.997078344314842 19 NPPA,ANK2,TNNI3,SRI,PLN,ABCC9,CALM1,CAV1 GO:0060249 anatomical structure homeostasis GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS -0.148537706558155 -0.579317183066078 0.991587512562 0.997078344314842 54 XRCC6,XRCC5,FH,STRAP,SERPINA3,IGJ,IGHG3,ACTG1,DCLRE1A,IGHA1,TPP1,ALB,IGKC,LTF,HSPB1 GO:0010517 regulation of phospholipase activity GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY 0.184246575342466 0.472277745821728 0.99236986890665 0.997078344314842 9 APOC2,ABL2,LRP1,ARL1 GO:0050829 defense response to gram negative bacterium GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM 0.21994895655285 0.463527532214379 0.992454146947855 0.997078344314842 5 SSC5D,B2M GO:0030001 metal ion transport GO_METAL_ION_TRANSPORT 0.143957742104049 0.559342263744883 0.99252619618735 0.997078344314842 39 CACNA2D1,ANXA6,ERO1L,ANK2,FKBP1A,SLC10A4,SRI,PLN,TF,ABCC9,KCNK2,NOL3 GO:0051054 positive regulation of dna metabolic process GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS 0.152881670016261 0.50634569080371 0.992709628071517 0.997078344314842 21 CCT8,WHSC1,PFN1,TCP1,UBE2N,HNRNPA1 GO:0048278 vesicle docking GO_VESICLE_DOCKING 0.219436277660243 0.462447096163973 0.992737661657907 0.997078344314842 5 STX7,USO1,STXBP2 GO:0046903 secretion GO_SECRETION -0.14489023051132 -0.61402061438959 0.993399133440741 0.997078344314842 84 SERPINF2,PAM,PAFAH1B1,ADA,ERP29,TUBA4A,FGA,SERPINA3,SERPINA1,FGB,VAMP3,FGG,AGT,RAB11B,SERPINA4,AQP1,SERPING1,AHSG,PTGES2,TMSB4X,SEC22B,ALB,HMGB1,NME1,ITIH4,ACTN4,ANXA3,ACTN1 GO:0006757 atp generation from adp GO_ATP_GENERATION_FROM_ADP 0.151011120149739 0.493571694033145 0.993774060168243 0.997078344314842 20 PFKL,PKM2,ALDOC,PFKM GO:0002576 platelet degranulation GO_PLATELET_DEGRANULATION -0.145200565932896 -0.547942269368716 0.993871364195002 0.997078344314842 46 SERPINF2,TUBA4A,FGA,SERPINA3,SERPINA1,FGB,FGG,SERPINA4,SERPING1,AHSG,TMSB4X,ALB,ITIH4,ACTN4,ACTN1 GO:0032940 secretion by cell GO_SECRETION_BY_CELL 0.138966612173039 0.616303787685982 0.994117807994309 0.997078344314842 73 CD36,S100A13,SCRN1,LGALS3BP,GNAS,LTBP4,CYB5R1,CLU,SOD1,RAPGEF4,MYH10,FN1,SNCG,MECP2,LAMP2,RALA,SCRN2,TF,APOH,PSAP,CD63,PLG,HSPA8,CALM1,CANX,FLNA GO:0045740 positive regulation of dna replication GO_POSITIVE_REGULATION_OF_DNA_REPLICATION 0.163434608145365 0.470274900371574 0.994419642857143 0.997078344314842 13 CCT8,TCP1,HNRNPA1 GO:0045055 regulated exocytosis GO_REGULATED_EXOCYTOSIS -0.14424318335877 -0.560346369804057 0.994623830561331 0.997078344314842 53 SERPINF2,TUBA4A,FGA,SERPINA3,SERPINA1,FGB,VAMP3,FGG,RAB11B,SERPINA4,SERPING1,AHSG,TMSB4X,ALB,ITIH4,ACTN4,ANXA3,ACTN1 GO:1904356 regulation of telomere maintenance via telomere lengthening GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING 0.161976664378861 0.45502245583706 0.99567999630374 0.997078344314842 12 CCT8,TCP1,HNRNPA1,HNRNPU NA positive regulation of receptor activity GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY -0.194517655387327 -0.440089189647461 0.995767616842715 0.997078344314842 7 GSTO1,GSTM2 GO:0006577 amino acid betaine metabolic process GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS -0.216530054644809 -0.437827328245938 0.996085238394209 0.997078344314842 5 CRAT,ALDH7A1,ALDH9A1,TMLHE,ACADM GO:0051220 cytoplasmic sequestering of protein GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN -0.197539302802461 -0.424808272192521 0.99701149844197 0.997508265506466 6 YWHAB,HK1,PDIA3,FLNA,SRI,HSPA5 GO:0006734 nadh metabolic process GO_NADH_METABOLIC_PROCESS -0.132429602196007 -0.427852561145554 0.998836034987419 0.998836034987419 24 ENO1,GPI,OGDH,GPD1L