Fusion KMT2A-CREBBP and Interaction WDR5-KMT2A (Complex 3emh):

Interaction complex 3emh chain B, from gene "KMT2A", has been found in the leading part of the KMT2A-CREBBP fusion product

Interaction 3emh

Fusion Effect

Interactome3D
Complex: 3emh
WDR5
  • Chain: A
  • Length: 1 - 334
  • Included in Interaction: 33 - 332
KMT2A
  • Chain: B
  • Length: 1 - 3969
  • Included in Interaction: 3764 - 3769
Pfam
  • zf-CXXC: 1147-1194
  • PHD: 1481-1533 <- Pfam domain included in fusion product
  • PHD: 1568-1627 <- Pfam domain included in fusion product
  • zf-HC5HC2H: 1900-1978 <- Pfam domain included in fusion product
  • FYRN: 2024-2071 <- Pfam domain included in fusion product
  • FYRC: 3666-3748 <- Pfam domain included in fusion product
  • SET: 3840-3945 <- Pfam domain included in fusion product
COSMIC
Mutation: COSF1875
  • KMT2A genomic breakpoint: 4332
  • KMT2A AA breakpoint: 1444
  • CREBBP genomic breakpoint: 1609
  • CREBBP AA breakpoint: 536
Other interactions affected by fusion KMT2A-CREBBP
  • CREBBP-ZFHX3
  •                     </ul>
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                        <img alt="Jmol Rendering of 3emh" src="/Users/joshuaburkhart/Research/ReactomeFIFusion/src/../data/output/reports/3emh/src/png/3emh.png"/>
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                        <a href="http://www.ebi.ac.uk/pdbe/entry/pdb/3emh">
                            <img alt="PDBe" src="/Users/joshuaburkhart/Research/ReactomeFIFusion/src/templates/vis/pdbe.png"/>
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                            Reaction: 
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                                <li>S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].</li>
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                            Author Description:
                            <ul>
                                <li>Structural basis of WDR5-MLL interaction</li>
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                            Citation:
                            <ul>
                                <li><a href="http://europepmc.org/abstract/MED/18840606">http://europepmc.org/abstract/MED/18840606</a></li>
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