Fusion PTPRK-RSPO3 and Interaction TEK-PTPRK (Complex 4nn7):

Interaction complex 4nn7 chain C, from gene "PTPRK", has been found in the leading part of the PTPRK-RSPO3 fusion product

Interaction 4nn7

Fusion Effect

Interactome3D
Complex: 4nn7
TEK
  • Chain: B
  • Length: 1 - 1124
  • Included in Interaction: 641 - 718
PTPRK
  • Chain: C
  • Length: 1 - 1439
  • Included in Interaction: 504 - 576
Pfam
  • MAM: 36-193 <- Pfam domain split by fusion
  • I-set: 197-288 <- Pfam domain included in fusion product
  • fn3: 292-376 <- Pfam domain included in fusion product
  • fn3: 493-583 <- Pfam domain included in fusion product
  • Y_phosphatase: 910-1140 <- Pfam domain included in fusion product
  • Y_phosphatase: 1200-1434 <- Pfam domain included in fusion product
COSMIC
Mutation: COSF1312
  • PTPRK genomic breakpoint: 416
  • PTPRK AA breakpoint: 138
  • RSPO3 genomic breakpoint: 687
  • RSPO3 AA breakpoint: 229
Other interactions affected by fusion PTPRK-RSPO3
    None
Jmol Rendering of 4nn7
PDBe
Reaction:
  • Biological process not assigned.
Author Description:
  • Cytokine receptor complex - Crystal form 2
Citation: