Fusion HACL1-RAF1 and Interaction RAF1-YWHAZ (Complex 4fj3):

(No direct effect on interaction 4fj3)

Interaction 4fj3

Fusion Effect

Interactome3D
Complex: 4fj3
RAF1
  • Chain: P
  • Length: 1 - 648
  • Included in Interaction: 230 - 246
YWHAZ
  • Chain: B
  • Length: 1 - 245
  • Included in Interaction: 2 - 230
Pfam
  • RBD: 57-129
  • C1_1: 139-187
  • Pkinase_Tyr: 349-606
COSMIC
Mutation: COSF1733
  • HACL1 genomic breakpoint: 2072
  • HACL1 AA breakpoint: 690
  • RAF1 genomic breakpoint: 1275
  • RAF1 AA breakpoint: 425
Other interactions affected by fusion HACL1-RAF1
    None
Jmol Rendering of 4fj3
PDBe
Reaction:
  • ATP + a protein = ADP + a phosphoprotein.
Author Description:
  • 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide
Citation: