Fusion KMT2A-CBL and Interaction CBL-ZAP70 (Complex 2y1n):

(No direct effect on interaction 2y1n)

Interaction 2y1n

Fusion Effect

Interactome3D
Complex: 2y1n
CBL
  • Chain: C
  • Length: 1 - 906
  • Included in Interaction: 52 - 435
ZAP70
  • Chain: D
  • Length: 1 - 619
  • Included in Interaction: 289 - 297
Pfam
  • Cbl_N: 51-175
  • Cbl_N2: 179-262
  • Cbl_N3: 264-349
  • Prok-RING_4: 381-429
  • UBA: 856-892
COSMIC
Mutation: COSF1971
  • KMT2A genomic breakpoint: 4086+366
  • KMT2A AA breakpoint: 122
  • CBL genomic breakpoint: 1808-5749
  • CBL AA breakpoint: 1916
Other interactions affected by fusion KMT2A-CBL
    None
Jmol Rendering of 2y1n
PDBe
Reaction:
  • ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Author Description:
  • Structure of c-Cbl-ZAP-70 peptide complex
Citation: