Fusion Event RSPO3-PTPRK Affects Interaction 4nn7

Interaction chain C in leading part of fusion product

Interactome3D

Interaction Complex: 4nn7
TEK
    Chain: B
    Length: 1 - 1124
    Included in Interaction: 641 - 718
PTPRK
    Chain: C
    Length: 1 - 1439
    Included in Interaction: 504 - 576

PDBe

Reaction: Biological process not assigned.
Author Description: Cytokine receptor complex - Crystal form 2
Citation: http://europepmc.org/abstract/MED/24632570

Pfam

MAM: 36-193
I-set: 197-288
fn3: 292-376
fn3: 493-583
Y_phosphatase: 910-1140
Y_phosphatase: 1200-1434

COSMIC

Mutation: COSF1312
First Gene in Fusion: PTPRK, genomic breakpoint: 416, AA breakpoint: 138
Second Gene in Fusion: RSPO3, genomic breakpoint: 687, AA breakpoint: 229

Jmol

4nn7 Jmol Rendering

Interaction Schematic

4nn7 Interaction Schematic

Fusion Effect Schematic

4nn7 Fusion Effect Schematic