Fusion TCF3-PBX1 and Interaction TCF3-TWIST1 (Complex 2ql2):

Interaction complex 2ql2 chain C, from gene "TCF3", has been found in the leading part of the TCF3-PBX1 fusion product

Interaction 2ql2

Fusion Effect

Interactome3D
Complex: 2ql2
TCF3
  • Chain: C
  • Length: 1 - 654
  • Included in Interaction: 550 - 609
TWIST1
  • Chain: B
  • Length: 1 - 202
  • Included in Interaction: 108 - 165
Pfam
  • HLH: 550-603 <- Pfam domain split by fusion
COSMIC
Mutation: COSF1490
  • TCF3 genomic breakpoint: 1795
  • TCF3 AA breakpoint: 598
  • PBX1 genomic breakpoint: 454
  • PBX1 AA breakpoint: 151
Other interactions affected by fusion TCF3-PBX1
  • PBX1-ZIC3
  •                     </ul>
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                        <img alt="Jmol Rendering of 2ql2" src="/Users/joshuaburkhart/Research/ReactomeFIFusion/src/../data/output/reports/2ql2/src/png/2ql2.png"/>
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                        <a href="http://www.ebi.ac.uk/pdbe/entry/pdb/2ql2">
                            <img alt="PDBe" src="/Users/joshuaburkhart/Research/ReactomeFIFusion/src/templates/vis/pdbe.png"/>
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                            Reaction: 
                            <ul>
                                <li>Biological process not assigned.</li>
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                            Author Description:
                            <ul>
                                <li>Crystal Structure of the basic-helix-loop-helix domains of the heterodimer E47/NeuroD1 bound to DNA</li>
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                            Citation:
                            <ul>
                                <li><a href="http://europepmc.org/abstract/MED/18069799">http://europepmc.org/abstract/MED/18069799</a></li>
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