Supplementary Table 1: All drugs approved between 1995-2016 that received therapeutic assessments from Patented Medicine Prices Review Board and/or La revue Prescrire*,,,,,,,,,,
Generic name,Brand name,"PMPRB breakthrough, substantial improvement and/or Prescrire bravo, a real advance",PMPRB and/or Prescrire no significant therapeutic innovation†,Review status,,,Notice of compliance or notice of compliance with conditions  date,Small molecule,Biologic,ATC group (second level)
,,,,Standard,Priority,Notice of compliance with conditions,,,,
Adapalene,Differin,,1,1,,,1995-01-24,,,anti-acne preparation
Dexrazoxane,Zinecard,1,,1,,,1995-02-07,,,all other therapeutic products
Bambuterol ,Bambec,,1,1,,,1995-02-07,,,drugs for obstructive airway diseases
Naltrexone,Revia,,1,1,,,1995-03-23,,,other nervous system drugs
Cefprozil,Cefzil,,1,1,,,1995-03-29,,,antibacterials for systemic use
Zuclopenthixol,Clopixol,,1,1,,,1995-04-24,,,psycholeptics
Zuclopenthixol,Clopixol acuphase,,1,1,,,1995-04-24,,,psycholeptics
Zuclopenthixol,Clopixol depot,,1,1,,,1995-04-24,,,psycholeptics
Lansoprazole,Prevacid,,1,1,,,1995-05-12,,,drugs for acid related disorders
Cefepime,Maxipime,,1,1,,,1995-06-02,,,antibacterials for systemic use
Interferon Beta-1B,Betaseron,,1,,1,,1995-07-19,,,immunostimulants
Famciclovir,Famvir,,1,1,,,1995-07-31,,,antivirals for systemic use
Cefpodoxime,Orelox,,1,1,,,1995-08-22,,,antibacterials for systemic use
Sevoflurane,Sevorane,,1,1,,,1995-09-18,,,anesthetics
Losartan,Cozaar,,1,1,,,1995-09-28,,,agents acting on the renin-angiotensin system
Iotrolan,Osmovist 280,,1,1,,,1995-10-04,,,contrast media
Bicalutamide,Casodex,,1,1,,,1995-11-02,,,endocrine therapy
Acarbose,Prandase,,1,1,,,1995-11-15,,,drugs used in diabetes
Mycophenolate,Cellcept,,1,1,,,1995-11-15,,,immunosuppressants
Tacrolimus,Prograf,,1,,1,,1995-12-06,,,immunosuppressants
Lamivudine,3TC,,1,,1,,1995-12-08,,,antivirals for systemic use
Alendronate,Fosamax,,1,1,,,1995-12-20,,,drugs for treatment of bone disease
Stavudine,Zerit,,1,1,,,1996-03-26,,,antivirals for systemic use
Acellular pertussis vaccine adsorbed,Acel-P,,1,,1,,1996-03-29,,,vaccines
Dorzolamide,Trusopt,,1,1,,,1996-04-25,,,ophthalmologicals
Amifostine,Ethyol,1,,,1,,1996-04-25,,,all other therapeutic products
Valacyclovir,Valtrex,,1,1,,,1996-05-01,,,antivirals for systemic use
Quinagolide,Norprolac,,1,1,,,1996-06-25,,,other gynecologicals
Meropenem,Merrem,,1,1,,,1996-07-02,,,antibacterials for systemic use
Abciximab,Reopro,1,,1,,,1996-07-04,,,antithrombotic agents
Anastrozole,Arimidex,,1,1,,,1996-08-01,,,endocrine therapy
Ritonavir,Norvir,1,,,1,,1996-08-14,,,antivirals for systemic use
Raltitrexed,Tomudex,,1,,1,,1996-09-12,,,antineoplastic agents
Indinavir,Crixivan,1,,,1,,1996-09-13,,,antivirals for systemic use
Insulin lispro,Humalog,,1,1,,,1996-10-08,,,drugs used in diabetes
Dirithromycin,Dynabac,,1,1,,,1996-10-28,,,antibacterials for systemic use
Olanzapine,Zyprexa,,1,1,,,1996-10-28,,,psycholeptics
Nalmefene,Revex,,1,1,,,1996-11-06,,,other nervous system drugs
Zolpidem,Ambien,,1,1,,,1996-11-20,,,psycholeptics
Desflurane,Suprane,,1,1,,,1996-12-03,,,anesthetics
Gemcitabine,Gemzar,,1,1,,,1996-12-23,,,antineoplastic agents
Ropivacaine,Naropin injections,,1,1,,,1996-12-24,,,anesthetics
Imiglucerase,Cerezyme,1,,,1,,1997-02-12,,,other alimentary tract and metabolism products
Atorvastatin,Lipitor,,1,,1,,1997-02-19,,,lipid modifying agents
Topiramate,Topamax,,1,1,,,1997-03-06,,,antiepileptics
Formoterol,Foradil dry powder capsules,,1,1,,,1997-03-06,,,drugs for obstructive airway diseases
Epoprostenol,Flolan,,1,,1,,1997-03-06,,,antithrombotic agents
Coagulation factor IX,Benefix,1,,,1,,1997-03-21,,,antihemorrhagics
Topotecan,Hycamtin,,1,1,,,1997-04-15,,,antineoplastic agents
Dolasetron,Anzemet,,1,1,,,1997-05-21,,,antiemetics and antinauseants
Letrozole,Femara,,1,1,,,1997-05-21,,,endocrine therapy
Fexofenadine,Allegra,,1,1,,,1997-06-11,,,antihistamines for systemic use
Latanoprost,Xalatan,,1,1,,,1997-06-16,,,ophthalmologicals
Carbetocin,Duratocin,,1,1,,,1997-06-24,,,pituitary and hypothalamic hormones and analogues
Follitropin beta,Puregon,,1,1,,,1997-07-02,,,sex hormones and modulators of the genital system
Irinotecan,Camptosar,1,,1,,,1997-07-04,,,antineoplastic agents
Donepezil,Aricept,1,,1,,,1997-08-12,,,psychoanaleptics
Ropinirole,Requip,,1,1,,,1997-08-19,,,anti-parkinson drugs
Ibandronate,Bondronat,,1,1,,,1997-08-27,,,drugs for treatment of bone disease
Glatiramer,Copaxone for injection,,1,1,,,1997-09-04,,,immunostimulants
Tolcapone,Tasmar,,1,1,,,1997-10-08,,,anti-parkinson drugs
Zafirlukast,Accolate,,1,1,,,1997-10-21,,,drugs for obstructive airway diseases
Valsartan,Diovan,,1,1,,,1997-11-03,,,agents acting on the renin-angiotensin system
Levofloxacin,Levaquin,,1,1,,,1997-11-14,,,antibacterials for systemic use
Brimonidine,Alphagan opthalmic solution,,1,1,,,1997-11-24,,,ophthalmologicals
Quetiapine,Seroquel,,1,1,,,1997-12-02,,,psycholeptics
Pramipexole,Mirapex,,1,1,,,1998-01-29,,,anti-parkinson drugs
Interferon Beta-1A,Rebif,,1,1,,,1998-02-05,,,immunostimulants
Emedastine,Emadine ophthalmic solution,,1,1,,,1998-02-16,,,ophthalmologicals
Cerivastatin,Baycol,,1,1,,,1998-02-18,,,lipid modifying agents
Grepafloxacin,Raxar,,1,1,,,1998-04-09,,,antibacterials for systemic use
Naratriptan,Amerge,,1,1,,,1998-04-28,,,analgesics
Bupropion,Wellbutrin SR,,1,1,,,1998-04-28,,,psychoanaleptics
Irbesartan,Avapro,,1,1,,,1998-06-01,,,agents acting on the renin-angiotensin system
Tamsulosin,Flomax,,1,1,,,1998-06-01,,,urologicals
Montelukast,Singulair,,1,1,,,1998-06-17,,,drugs for obstructive airway diseases
Delavirdine,Rescriptor,,1,1,,1,1998-07-22,,,antivirals for systemic use
Nelfinavir,Viracept,,1,,1,,1998-08-11,,,antivirals for systemic use
Zolmitriptan,Zomig,,1,1,,,1998-08-24,,,analgesics
Capecitabine,Xeloda,,1,,1,,1998-08-31,,,antineoplastic agents
Nevirapine,Viramune,,1,1,,1,1998-09-04,,,antivirals for systemic use
Clopidogrel,Plavix,,1,1,,,1998-10-07,,,antithrombotic agents
Brinzolamide,Azopt ophthalmic suspension,,1,1,,,1998-10-23,,,ophthalmologicals
Raloxifene,Evista,,1,1,,,1998-11-06,,,sex hormones and modulators of the genital system
Candesartan,Atacand,,1,1,,,1998-11-20,,,agents acting on the renin-angiotensin system
Tolterodine,Detrol,,1,1,,,1998-11-20,,,urologicals
Varicella vaccine,Varivax,1,,1,,,1998-12-02,,,vaccines
Alatrofloxacin,Trovan (IV),,1,1,,,1998-12-04,,,antibacterials for systemic use
Trovafloxacin,Trovan (tablets),,1,1,,,1998-12-04,,,antibacterials for systemic use
Becaplermin gel,Regranex,,1,1,,,1998-12-30,,,preparations for wounds and ulcers
Tizanidine,Zanaflex,,1,1,,,1999-01-25,,,muscle relaxants
Penciclovir,Denavir,,1,1,,,1999-02-02,,,antivirals for systemic use
Citalopram,Celexa,,1,1,,,1999-02-05,,,psychoanaleptics
Recombinant factor VIIa,Niastase,,1,,1,1,1999-02-12,,,antihemorrhagics
Modafinil,Alertec,,1,1,,,1999-02-26,,,psychoanaleptics
Sildenafil,Viagra,1,,1,,,1999-03-08,,,urologicals
Recombinant-methionyl interferon consensus 1,Infergen,,1,,1,,1999-03-11,,,immunostimulants
Efavirenz,Sustiva,,1,,1,,1999-03-19,,,antivirals for systemic use
Repaglinide,Gluconorm,,1,1,,,1999-04-06,,,drugs used in diabetes
Celecoxib,Celebrex,,1,,1,,1999-04-14,,,antiinflammaotory and antirheumatic products
Triptorelin,Trelstar,,1,1,,,1999-05-06,,,endocrine therapy
Ancestim,Stemgen,,1,1,,,1999-05-20,,,immunostimulants
Orlistat,Xenical,,1,1,,,1999-06-03,,,antiobesity preparations
Abacavir,Ziagen,,1,,1,1,1999-06-04,,,antivirals for systemic use
Eptifibatide,Integrilin,,1,1,,,1999-06-11,,,antithrombotic agents
Eprosartan,Teveten,,1,1,,,1999-07-09,,,agents acting on the renin-angiotensin system
Cidofovir,Vistide,,1,1,,,1999-07-13,,,antivirals for systemic use
Rizatriptan,Maxalt,,1,1,,,1999-07-16,,,analgesics
Trastuzumab,Herceptin,,1,,1,,1999-08-13,,,antineoplastic agents
Telmisartan,Micardis,,1,1,,,1999-08-16,,,agents acting on the renin-angiotensin system
Risedronate,Actonel,,1,1,,,1999-08-18,,,drugs for treatment of bone disease
Tirofiban,Aggrastat,,1,1,,,1999-08-19,,,antithrombotic agents
Icodextrin,Extraneal,,1,1,,,1999-09-17,,,blood substitutes and perfusion solutions
Varicella zoster vaccine,Varilrix,,1,,1,,1999-10-13,,,vaccines
Temozolomide,Temodal,,1,1,,,1999-10-25,,,antineoplastic agents
Rofecoxib,Vioxx,,1,,1,,1999-10-25,,,antiinflammaotory and antirheumatic products
Zanamivir,Relenza,,1,,1,1,1999-11-02,,,antivirals for systemic use
Melanoma theracine,Melacine,,1,,1,,1999-11-04,,,immunostimulants
Gadobutrol,Gadovist,,1,1,,,1999-11-08,,,contrast media
Dalfopristin,Synercid,,1,1,,,1999-12-10,,,antibacterials for systemic use
Oseltamivir,Tamiflu,,1,1,,,1999-12-23,,,antivirals for systemic use
Daclizumab,Zenaprax,,1,,1,,2000-01-04,,1,antineoplastic  agents
Leflunomide,Arava,,1,1,,,2000-03-16,1,,immunosuppressants
Rituximab,Rituxan,1,,,1,,2000-03-17,,1,immunosuppressants
Rosiglitazone,Avandia,,1,,1,,2000-03-21,1,,drugs used in diabetes
Oxcarbazepine,Trileptal,,1,1,,,2000-04-13,1,,antiepileptics
Rivastigmine,Exelon,,1,1,,,2000-04-13,1,,psychoanaleptics
Zaleplon,Starnoc,,1,1,,,2000-05-11,1,,psycholeptics
Verteporfin,Visudyne,1,,,1,,2000-05-31,1,,ophthalmologicals
Cabergoline,Dostinex,,1,1,,,2000-06-30,1,,anti-parkinson drugs
Exemestane,Aromasin,,1,1,,,2000-08-17,1,,endocrine therapy
Pioglitazone,Actos,,1,,1,,2000-08-17,1,,drugs used in diabetes
Zoledronic acid,Zometa,,1,,1,,2000-08-21,1,,drugs for treatment of bone disease
Riluzole,Rilutek,1,,,1,1,2000-08-30,1,,other nervous system drugs
Meloxicam,Mobic,,1,1,,,2000-08-31,1,,antiinflammaotory and antirheumatic products
Basiliximab,Simulect,,1,,1,,2000-09-01,,1,immunosuppressants
Moxifloxacin,Avelox,,1,1,,,2000-10-19,1,,antibacterials for systemic use
Peginterferon Alfa-2b,Peg-intron,,1,1,,,2000-10-20,,1,immunostimulants
Etanercept,Enbrel,1,,,1,,2000-12-01,,1,immunosuppressants
Gadoversetamide,Optimark,,1,1,,,2000-12-11,1,,contrast media
Sibutramine,Meridia,,1,1,,,2000-12-28,1,,antiobesity preparations
Sirolimus,Rapamune,,1,1,,,2001-01-05,1,,immunosuppressants
Gatifloxacin,Tequin,,1,1,,,2001-01-09,1,,antibacterials for systemic use
"Glucagon, rDNA origin",Glucagon,,1,,1,,2001-01-11,,1,pancreatic hormones
Mequinol/tretinoin,Solage,,1,1,,,2001-01-17,1,,other dermatological preparations
Amprenavir,Agenerase,,1,1,,1,2001-03-01,1,,antivirals for systemic use
Lopinavir/ritonavir,Kaletra,,1,,1,,2001-03-09,1,,antivirals for systemic use
Linezolid,Zyvoxam,,1,1,,,2001-04-02,1,,antibacterials for systemic use
Iron,Venofer,,1,,1,,2001-04-17,1,,antianemic preparations
Doxercalciferol,Hectorol,,1,1,,,2001-04-30,1,,calcium homeostasis
Rabeprazole,Pariet,,1,1,,,2001-05-07,1,,drugs for acid related disorders
Entacapone,Comtan,,1,1,,,2001-05-08,1,,anti-parkinson drugs
Eflornithine,Vaniqa,,1,1,,,2001-05-10,1,,antiprotozoals
Mirtazapine,Remeron,,1,1,,,2001-05-18,1,,psychoanaleptics
Desloratadine,Aerius,,1,1,,,2001-05-29,1,,antihistamines for systemic use
Infliximab,Remicade,,1,1,,,2001-06-06,,1,immunosuppressants
Caspofungin,Cancidas,,1,,1,,2001-07-29,1,,antimycotics for systemic use
Galantamine,Reminyl,,1,1,,,2001-07-31,1,,psychoanaleptics
Esomeprazole,Nexium,,1,1,,,2001-08-17,1,,drugs for acid related disorders
Imatinib,Gleevec,1,,,1,1,2001-09-20,1,,antineoplastic agents
Tenecteplase,Tnkase,,1,1,,,2001-10-17,,1,antithrombotic agents
Travoprost,Travatan,,1,1,,,2001-11-09,1,,ophthalmologicals
Bosentan,Tracleer,,1,,1,,2001-11-30,1,,antihypertensives
"Meningococcal group C polysaccharide, tetanus toxoid",Neisvac-C,,1,,1,,2001-12-18,,1,vaccines
Glimepiride,Amaryl,,1,1,,,2002-01-25,1,,drugs used in diabetes
Nateglinide,Starlix,,1,1,,,2002-02-13,1,,drugs used in diabetes
Alfuzosin,Xatral,,1,1,,,2002-02-21,,,urologicals
Tegaserod,Zelnorm,,1,1,,,2002-03-12,1,,drugs for constipation
Ganirelix,Orgalutran,,1,1,,,2002-05-01,1,,pituitary and hypothalamic hormones and analogues
Valganciclovir,Valcyte,,1,1,,,2002-05-03,1,,antivirals for systemic use
Palivizumab,Synagis,,1,1,,,2002-05-15,,1,immune sera and immunoglobulins
Docosanol,Abreva,,1,1,,,2002-05-24,1,,antibiotics and chemotherapeutics for dermatological use
Bimatoprost,Lumigan,,1,1,,,2002-05-24,1,,ophthalmologicals
Anakinra,Kineret,,1,,1,,2002-05-24,,1,immunosuppressants
Moroctocog alpha,Refacto,,1,,1,,2002-05-28,,1,antihemorrhagics
Peginterferon Alfa-2b ribavirin,Pegetron,,1,1,,,2002-05-31,,1,immunostimulants
Fondaparinux,Arixtra,,1,,1,,2002-06-13,1,,antithrombotic agents
Hetastarch,Hextend,,1,1,,,2002-07-08,1,,blood substitutes and perfusion solutions
Darbepoetin alpha,Aranesp,,1,1,,,2002-08-02,,1,antianemic preparations
Norelgestromin/ethinyl estradiol,Evra,,1,1,,,2002-08-20,1,,sex hormones and modulators of the genital system
Treprostinil,Remodulin,,1,,1,,2002-10-04,1,,antithrombotic agents
Bivalirudin,Angiomax,,1,1,,,2002-10-09,1,,antithrombotic agents
Tiotropium,Spiriva,,1,1,,,2002-11-20,1,,drugs for obstructive airway diseases
Valdecoxib,Betra,,1,1,,,2002-12-11,1,,antiinflammaotory and antirheumatic products
Drotrecogin Alfa,Xigris,1,,,1,,2003-01-31,,1,antithrombotic agents
Rosuvastatin,Crestor,,1,1,,,2003-02-18,1,,lipid modifying agents
Recombinant cholera toxin B subunit,Dukoral,,1,,1,,2003-02-21,,1,vaccines
Levetiracetam,Keppra,,1,1,,,2003-03-06,1,,antiepileptics
Tenofovir,Viread,,1,,1,1,2003-03-18,1,,antivirals for systemic use
Pimecrolimus,Elidel,,1,1,,,2003-03-19,1,,other dermatological preparations
Ertapenem,Invanz,,1,1,,,2003-05-12,1,,antibacterials for systemic use
Ezetimibe,Ezetrol,,1,1,,,2003-05-12,1,,lipid modifying agents
Telithromycin,Ketek,,1,1,,,2003-05-28,1,,antibacterials for systemic use
Enfuvirtide,Fuzeon,1,,,1,,2003-07-14,1,,antivirals for systemic use
Dutasteride,Avodart,,1,1,,,2003-07-22,1,,urologicals
Peginterferon Alfa-2a,Pegasys,,1,1,,,2003-08-13,,1,immunostimulants
Cetrorelix ,Cetrotide,,1,1,,,2003-08-13,1,,pituitary and hypothalamic hormones and analogues
Adefovir,Hepsera,,1,,1,,2003-08-27,1,,antivirals for systemic use
Tadalafil,Cialis,,1,1,,,2003-09-17,1,,urologicals
Almotriptan,Axert,,1,1,,,2003-10-01,1,,agents acting on the renin-angiotensin system
Rasburicase,Fasturtec,,1,,1,,2003-10-29,,1,all other therapeutic products
Atazanavir,Reyataz,,1,,1,,2003-12-05,1,,antivirals for systemic use
Gefitinib,Iressa,,1,,1,1,2003-12-17,1,,antineoplastic agents
Agalsidase Beta,Fabrazyme,,1,,1,,2004-01-23,,1,other alimentary tract and metabolism products
Agalsidase,Replagal,1,,,1,1,2004-02-06,,1,other alimentary tract and metabolism products
Fulvestrant,Faslodex,,1,1,,,2004-02-17,1,,endocrine therapy
Gemifloxacin,Factive,,1,1,,,2004-03-09,1,,antibacterials for systemic use
Pegfilgrastim,Neulasta,,1,1,,,2004-03-12,,1,immunostimulants
Vardenafil,Levitra,,1,1,,,2004-03-17,1,,urologicals
Gadobenate,Multihance,,1,1,,,2004-03-31,1,,contrast media
Miglustat,Zavesca,,1,,1,,2004-03-31,1,,other alimentary tract and metabolism products
Botulinum Toxin Type B,Myobloc,,1,1,,,2004-04-16,,1,muscle relaxants
Peginterferon Alfa-2A Ribavirin,Pegasys RBV,,1,,1,,2004-05-10,,1,immunostimulants
Ethinyl estradiol/etonogestrel,Nuvaring,,1,1,,,2004-05-11,1,,sex hormones and modulators of the genital system
Pemetrexed,Alimta,,1,,1,,2004-05-21,1,,antineoplastic agents
Laronidase,Adlurazyme,1,,,1,,2004-05-31,,1,other alimentary tract and metabolism products
Teriparatide,Forteo,,1,,1,,2004-06-03,,1,calcium homeostasis
Cinacalcet,Sensipar,1,,,1,,2004-08-04,1,,calcium homeostasis
Eletriptan,Relpax,,1,1,,,2004-08-05,1,,analgesics
Voriconazole,Vfend,,1,1,,,2004-08-20,1,,antimycotics for systemic use
Frovatriptan,Frova,,1,1,,,2004-09-03,1,,analgesics
Adalimumab,Humira,,1,1,,,2004-09-24,,1,immunosuppressants
Alefacept,Amevive,,1,1,,,2004-10-06,,1,immunosuppressants
Omalizumab,Xolair,,1,1,,,2004-11-18,,1,drugs for obstructive airway diseases
Memantine,Ebixa,,1,1,,1,2004-12-08,1,,psychoanaleptics
Fosamprenavir,Telzir,,1,1,,,2004-12-10,1,,antivirals for systemic use
Drospirenone/ethinyl estradiol,Yasmin 21/28,,1,1,,,2004-12-10,1,,sex hormones and modulators of the genital system
Atomoxetine,Strattera,,1,1,,,2004-12-24,1,,psychoanaleptics
Escitalopram,Cipralex,,1,1,,,2004-12-24,1,,psychoanaleptics
Bortezomib,Velcade,,1,1,,1,2005-01-27,1,,antineoplastic agents
Paricalcitol,Zemplar,,1,1,,,2005-03-31,1,,calcium homeostasis
Pantoprazole,Pantaloc M,,1,1,,,2005-04-22,1,,drugs for acid related disorders
Pegaptanib,Macugen,1,,,1,,2005-05-02,1,,ophthalmologicals
Ibritumomab,Zevalin,,1,,1,,2005-05-10,,1,therapeutic radiopharmaceuticals
Pregabalin,Lyrica,,1,1,,,2005-06-03,1,,antiepileptics
Lutropin Alfa,Luveris,,1,1,,,2005-06-24,,1,sex hormones and modulators of the genital system
Erlotinib,Tarceva,,1,,1,,2005-07-07,1,,antineoplastic agents
Tramadol,Tramacet,,1,1,,,2005-07-20,1,,analgesics
Sodium oxybate,Xyrem,,1,1,,,2005-08-05,1,,other nervous system drugs
Perindopril,Coversyl,,1,1,,,2005-08-23,1,,agents acting on the renin-angiotensin system
Bevacizumab,Avastin,,1,,1,,2005-09-09,,1,antineoplastic agents
Cetuximab,Erbitux,,1,,1,,2005-09-09,,1,antineoplastic agents
Insulin detemir,Levemir,,1,1,,,2005-09-29,,1,drugs used in diabetes
Pegvisomant,Somavert,,1,,1,,2005-10-17,,1,pituitary and hypothalamic hormones and analogues
Efalizumab,Raptiva,,1,1,,,2005-10-24,,1,immunosuppressants
Darifenacin,Enablex,,1,1,,,2005-11-14,1,,urologicals
Emtricitabine,Emtriva,,1,1,,,2005-11-21,1,,antivirals for systemic use
Tipranavir,Aptivus,,1,,1,,2005-11-21,1,,antivirals for systemic use
Alemtuzumab,Mabcampath,1,,1,,,2005-11-30,,1,immunosuppressants
Palifermin,Kepivance,1,,,1,,2005-12-09,,1,all other therapeutic products
Trospium,Trosec,,1,1,,,2006-01-10,1,,urologicals
Solifenacin,Vesicare,,1,1,,,2006-02-20,1,,urologicals
Histrelin,Vantas,,1,1,,,2006-03-10,1,,endocrine therapy
Insulin glulisine,Apidra,,1,1,,,2006-04-12,,1,drugs used in diabetes
Sunitinib,Sutent,,1,,1,1,2006-05-26,1,,antineoplastic agents
Entecavir,Baraclude,,1,,1,,2006-06-16,1,,pituitary and hypothalamic hormones and analogues
Abatacept,Orencia,,1,,1,,2006-06-29,,1,immunosuppressants
Recombinant human papillomavirus,Gardasil,1,,,1,,2006-07-10,,1,vaccines
Lanreotide,Somatuline autogel,,1,1,,,2006-07-17,1,,antivirals for systemic use
Sorafenib,Nexavar,,1,1,,,2006-07-28,1,,antineoplastic agents
Darunavir,Prezista,,1,1,,1,2006-07-28,1,,antivirals for systemic use
Rotaviruses,Rotateq,1,,1,,,2006-08-01,,1,vaccines
Alglucosidase Alfa,Myozyme,1,,,1,,2006-08-14,,1,other alimentary tract and metabolism products
Rasagiline,Azilect,,1,1,,,2006-08-17,1,,anti-parkinson drugs
Ciclesonide,Alvesco,,1,1,,,2006-09-11,1,,drugs for obstructive airway diseases
Tigecycline,Tygacil,,1,1,,,2006-09-14,1,,antibacterials for systemic use
Natalizumab,Tysabri,,1,,1,,2006-09-28,,1,immunosuppressants
Lanthanum,Fosrenol,,1,1,,,2006-10-17,1,,all other therapeutic products
Deferasirox,Exjade,,1,,1,1,2006-10-18,1,,all other therapeutic products
Gadofosveset ,Vasovist,,1,1,,,2006-10-31,1,,contrast media
Telbivudine,Sebivo,,1,,1,,2006-11-28,1,,antivirals for systemic use
Varenicline,Champix,,1,1,,,2007-01-24,1,,other nervous system drugs
Acamprosate,Campral,,1,1,,,2007-03-16,1,,other nervous system drugs
Dasatinib,Sprycell,1,,1,,1,2007-03-26,1,,antineoplastic agents
Posaconazole,Spriafil (Posanol),1,,,1,,2007-03-26,1,,antimycotics for systemic use
Micafungin,Mycamine,,1,1,,,2007-05-22,1,,antimycotics for systemic use
Sitaxentan,Thelin,,1,1,,,2007-05-30,1,,antihypertensives
Idursulfase,Elaprase,,1,,1,,2007-06-13,1,,other alimentary tract and metabolism products
Oxaliplatin,Eloxatin,,1,,1,,2007-06-15,1,,antineoplastic agents
Ranibizumab,Lucentis,1,,,1,,2007-06-26,,1,ophthalmologicals
Fluticasone,Avamys,,1,1,,,2007-08-14,1,,drugs for obstructive airway diseases
Aprepitant,Emend,,1,1,,,2007-08-24,1,,antiemetics and antinauseants
Maraviroc,Celsentri,,1,,1,,2007-09-21,1,,antivirals for systemic use
Daptomycin,Cubicin,,1,1,,,2007-09-24,1,,antibacterials for systemic use
Paliperidone,Invega,,1,1,,,2007-09-26,1,,psycholeptics
Duloxetine,Cymbalta,,1,1,,,2007-11-01,1,,psychoanaleptics
Nesiritide,Natrecor,,1,1,,1,2007-11-08,,1,cardiac therapy
Aliskiren,Rasilez,,1,1,,,2007-11-14,1,,agents acting on the renin-angiotensin system
Anidulafungin,Eraxis,,1,1,,,2007-11-14,1,,antimycotics for systemic use
Raltegravir,Isentress,,1,,1,1,2007-11-27,1,,antivirals for systemic use
Rivastigmine,Exelon patch,,1,1,,,2007-11-29,1,,psychoanaleptics
Sitagliptin,Januvia,,1,1,,,2007-12-14,1,,drugs used in diabetes
Temsirolimus,Torisel,,1,,1,,2007-12-21,1,,antineoplastic agents
Lenalidomide,Revlimid,1,,1,,1,2008-01-17,1,,immunosuppressants
Ambrisentan,Volibris,,1,1,,,2008-03-20,1,,antihypertensives
Etravirine,Intelence,,1,,1,,2008-03-27,1,,antivirals for systemic use
Methylnaltrexone,Relistor,1,,,1,,2008-03-28,1,,drugs for constipation
Panitumumab,Vectibix,,1,1,,1,2008-04-03,,1,antineoplastic agents
Nepafenac,Nevanac,,1,1,,,2008-04-17,1,,ophthalmologicals
Dabigatran ,Pradaxa,,1,1,,,2008-06-10,1,,antithrombotic agents
Ceftobiprole,Zeftera,,1,1,,,2008-06-26,1,,antibacterials for systemic use
Idebenone,Catena,,1,1,,1,2008-07-23,1,,psychoanaleptics
Nilotinib,Tasigna,,1,1,,1,2008-09-09,1,,antineoplastic agents
Rivaroxaban,Xarelto,,1,1,,,2008-09-15,1,,antithrombotic agents
Olmesartan,Olmetec,,1,1,,,2008-10-28,1,,agents acting on the renin-angiotensin system
Capsular polysaccharide,Synflorix,,1,1,,,2008-12-11,,1,vaccines
Ustekinumab,Stelara,,1,1,,,2008-12-12,,1,immunosuppressants
Loteprednol,Alrex,,1,1,,,2008-12-23,1,,ophthalmologicals
Eculizumab,Soliris,,1,,1,,2009-01-28,,1,immunosuppressants
Desvenlafaxine,Pristiq,,1,1,,,2009-02-04,1,,psychoanaleptics
Lisdexamfetamine,Vyvanse,,1,1,,,2009-02-19,1,,psychoanaleptics
Romiplostim,Nplate,,1,,1,,2009-02-19,,1,antihemorrhagics
Methyl aminolevulinate,Metvix,,1,1,,,2009-02-26,1,,antineoplastic agents
Eplerenone,Inspra,,1,1,,,2009-02-26,1,,diuretics
Fosaprepitant,Emend IV,,1,1,,,2009-04-01,1,,antivirals for systemic use
Golimumab,Simponi,,1,1,,,2009-04-07,,1,immunosuppressants
Lapatinib ,Tykerb,,1,1,,,2009-05-15,1,,antineoplastic agents
Vorinostat,Zolinza,,1,1,,,2009-06-11,1,,antineoplastic agents
Aripiprazole,Abilify,,1,1,,,2009-07-09,1,,psycholeptics
Clofarabine,Clolar,,1,1,,,2009-07-16,1,,antineoplastic agents
Dronedarone,Multaq,,1,,1,,2009-08-11,1,,cardiac therapy
Certolizumab pegol,Cimzia,,1,1,,,2009-08-12,,1,immunosuppressants
Doripenem,Doribax,,1,1,,,2009-09-02,1,,antibacterials for systemic use
Aztreonam,Cayston,,1,,1,1,2009-09-11,1,,antibacterials for systemic use
Saxagliptin,Onglyza,,1,1,,,2009-09-14,1,,drugs used in diabetes
Besifloxacin,Besivance,,1,1,,,2009-10-23,1,,ophthalmologicals
Azacitidine,Vidaza,,1,,1,,2009-10-23,1,,antineoplastic agents
Japanese encephalitis vaccine,Ixiaro,,1,1,,,2009-10-29,,1,vaccines
Alitretinoin,Toctino,,1,1,,,2009-11-13,1,,antineoplastic agents
Degarelix,Firmagon,,1,1,,,2009-11-16,1,,endocrine therapy
Dexmedetomidine,Precedex,,1,1,,,2009-12-09,1,,psycholeptics
Everolimus,Afinitor,,1,1,,1,2009-12-14,1,,antineoplastic agents
Thrombin alfa,Recothrom,,1,1,,,2009-12-15,,1,antihemorrhagics
Pneumococcal conjugate,Prevnar,,1,,1,,2009-12-21,,1,vaccines
Gadoxetate,Primovist,,1,1,,,2010-01-14,1,,contrast media
Recombinant human papillomavirus,Cervarix,,1,1,,,2010-02-03,,1,vaccines
Canakinumab,Ilaris,1,,,1,,2010-02-26,,1,immunosuppressants
Prasugrel,Effient,,1,1,,,2010-04-16,1,,antithrombotic agents
Tocilizumab,Actemra,,1,1,,,2010-04-30,,1,immunosuppressants
Sapropterin,Kuvan,1,,,1,,2010-04-30,1,,other alimentary tract and metabolism products
Trabectedin,Yondelis,,1,1,,,2010-05-13,1,,antineoplastic agents
Liraglutide,Victoza - 1.2 mg pen-injector,,1,1,,,2010-05-21,,1,drugs used in diabetes
Meningococcal oligosaccharides conjugated,Menveo,,1,1,,,2010-05-21,,1,vaccines
Pazopanib,Votrient,,1,1,,,2010-05-27,1,,antineoplastic agents
Paliperidone,Invega sustenna,,1,1,,,2010-06-30,1,,psycholeptics
Sevelamer,Renvela,,1,1,,,2010-07-07,1,,all other therapeutic products
Dexlansoprazole,Dexilant,,1,1,,,2010-07-22,1,,drugs for acid related disorders
Denosumab,Prolia,,1,1,,,2010-08-06,,1,drugs for treatment of bone disease
Febuxostat,Uloric,,1,1,,,2010-09-22,1,,antigout preparations
Lacosamide,Vimpat,,1,1,,,2010-09-30,1,,antiepileptics
Velaglucerase alfa,VPRIV,,1,1,,,2010-10-01,,1,other alimentary tract and metabolism products
Roflumilast,Daxas,,1,1,,,2010-11-23,1,,drugs for obstructive airway diseases
Tapentadol,Nucynta CR,,1,1,,,2010-12-02,1,,analgesics
Silodosin,Rapaflo,,1,1,,,2011-01-11,1,,urologicals
Eltrombopag,Revolade,,1,1,,,2011-01-12,1,,antihemorrhagics
Exenatide,Byetta,,1,1,,,2011-01-13,1,,drugs used in diabetes
Fingolimod,Gilenya,,1,1,,,2011-03-09,1,,immunosuppressants
Ticagrelor,Brilinta,,1,,1,,2011-05-30,1,,antithrombotic agents
Cabazitaxel,Jevtana,,1,1,,,2011-06-16,1,,antineoplastic agents
Rufinamide,Banzel,,1,1,,,2011-06-22,1,,antiepileptics
Belimumab,Benlysta,,1,1,,,2011-07-06,,1,immunosuppressants
Rilpivirine,Edurant,,1,1,,,2011-07-21,1,,antivirals for systemic use
Tolvaptan,Samsca,,1,1,,,2011-07-25,1,,diuretics
Abiraterone,Zytiga,,1,,1,,2011-07-27,1,,endocrine therapy
Linagliptin,Trajenta,,1,1,,,2011-07-28,1,,drugs used in diabetes
Boceprevir,Victrelis,1,,,1,,2011-07-29,1,,antivirals for systemic use
"Boceprevir, peginterferon alfa-2b, ribavirin",Victrelis Triple,1,,,1,,2011-08-10,1,,immunostimulants
Telaprevir,Incivek,,1,,1,,2011-08-16,1,,antivirals for systemic use
Colesevelam,Lodalis,,1,1,,,2011-09-22,1,,lipid modifying agents
Senapine,Saphris,,1,1,,,2011-10-07,1,,psycholeptics
Dienogest,Visanne,,1,1,,,2011-10-12,1,,sex hormones and modulators of the genital system
Indacaterol,Onbrez breezhaler,,1,1,,,2011-12-06,1,,drugs for obstructive airway diseases
Prucalopride,Resotran,,1,1,,,2011-12-07,1,,drugs for constipation
Plerixafor,Mozobil,,1,1,,,2011-12-08,1,,immunostimulants
Eribulin,Halaven,,1,1,,,2011-12-14,1,,antineoplastic agents
Apixaban,Eliquis,,1,1,,,2011-12-16,1,,antithrombotic agents
Vandetanib,Caprelsa,,1,1,,,2012-01-12,1,,antineoplastic agents
Ipilimumab,Yervoy,,1,1,,,2012-02-01,,1,antineoplastic agents
Fesoterodine,Toviaz,,1,1,,,2012-02-09,1,,urologicals
Fampridine,Fampyra,,1,1,,,2012-02-10,1,,other nervous system drugs
Vemurafenib,Zelboraf,1,,,1,,2012-02-15,,,antineoplastic agents
Azilsartan ,Edarbi,,1,1,,,2012-03-08,1,,agents acting on the renin-angiotensin system
Ofatumumab,Arzerra,,1,1,,,2012-03-09,,1,antineoplastic agents
Palonosetron,Aloxi,,1,1,,,2012-03-14,1,,antiemetics and antinauseants
Crizotinib,Xalkori,,1,1,,1,2012-04-25,1,,antineoplastic agents
Fidaxomicin,Dificid,,1,1,,,2012-06-07,1,,"antidiarrheals, intestinal antiinflammatory/antiinfective agents"
Lurasidone,Latuda,,1,1,,,2012-06-13,1,,psycholeptics
Ruxolitinib,Jakavi,,1,,1,,2012-06-19,1,,antineoplastic agents
Collagenase clostridium histolyticum,Xiaflex,1,,1,,,2012-07-05,,1,other drugs for disorders of the musculo-skeletal system
Axitinib,Inlyta,,1,1,,,2012-07-12,1,,antineoplastic agents
Catridecacog,Tretten,,1,,1,,2012-07-19,,1,antihemorrhagics
Bendamustine,Treanda,,1,1,,,2012-08-24,1,,antineoplastic agents
Pirfenidone,Esbriet,,1,,1,,2012-10-01,,,immunosuppressants
"Elvitegravir, emtricitabine, tenofovir, cobicistat",Stribild,,1,1,,,2012-11-26,1,,antivirals for systemic use
Ivacaftor,Kalydeco,1,,,1,,2012-11-26,1,,other respiratory system products
Stiripentol,Diacomit,,1,1,,,2012-12-21,1,,antiepileptics
Nebivolol,Bystolic,,1,1,,,2012-12-21,1,,beta blocking agents
Ingenol,Picato,,1,1,,,2013-01-30,1,,antibiotics and chemotherapeutics for dermatological use
Brentuximab,Adcetris,,1,1,,1,2013-02-01,,1,antineoplastic agents
"Meningococcal polysaccharide groups A,C,W-135 & Y conjugate vaccine, Tetanus toxoid",Nimenrix,,1,1,,,2013-03-05,,1,vaccines
Mirabegron,Myrbetriq,,1,1,,,2013-03-06,1,,urologicals
Regorafenib,Stivarga,,1,,1,,2013-03-11,1,,antineoplastic agents
Rotigotine,Neupro,,1,1,,,2013-03-21,1,,anti-parkinson drugs
Dimethyl fumarate,Tecfidera,,1,1,,,2013-04-03,1,,other nervous system drugs
Perampanel,Fycompa,,1,1,,,2013-04-04,1,,antiepileptics
Pertuzumab,Perjeta,1,,,1,,2013-04-12,,1,antineoplastic agents
Enzalutamide,Xtandi,,1,,1,,2013-05-29,1,,endocrine therapy
Ulipristal,Fibristal,,1,1,,,2013-06-24,1,,sex hormones and modulators of the genital system
Vismodegib,Erivedge,,1,1,,,2013-07-12,1,,antineoplastic agents
Dabrafenib,Tafinlar,,1,1,,,2013-07-16,1,,antineoplastic agents
Trametinib,Mekinist,,1,1,,,2013-07-18,1,,antineoplastic agents
Fluticasone and vilatnerol,Breo ellipta,,1,1,,,2013-07-23,1,,drugs for obstructive airway diseases
Aclidinium,Tudorza genuair,,1,1,,,2013-07-29,1,,drugs for obstructive airway diseases
Rifaximin,Zaxine,,1,,1,,2013-08-13,1,,"antidiarrheals, intestinal antiinflammatory/antiinfective agents"
Ocriplasmin,Jetrea,1,,,1,,2013-08-13,,1,ophthalmologicals
Trastuzumab emtansine,Kadcyla,,1,,1,,2013-09-11,,1,antineoplastic agents
Galsulfase,Naglazyme,1,,1,,,2013-09-16,,1,other alimentary tract and metabolism products
Riociguat,Adempas,,1,,1,,2013-09-19,1,,antihypertensives
Pasireotide,Signifor,1,,1,,,2013-09-23,1,,pituitary and hypothalamic hormones and analogues
Efinaconazole,Jublia,,1,1,,,2013-10-02,1,,drugs used in diabetes
Romidepsin,Istodax,,1,1,,1,2013-10-16,1,,antineoplastic agents
Dolutegravir,Tivicay,,1,1,,,2013-10-31,1,,antivirals for systemic use
Afatinib,Giotrif,,1,1,,,2013-11-01,1,,antineoplastic agents
Macitentan,Opsumit,,1,1,,,2013-11-06,1,,antihypertensives
Aflibercept,Eylea,,1,1,,,2013-11-08,,1,antineoplastic agents
Teriflunomide,Aubagio,,1,1,,,2013-11-14,1,,immunosuppressants
Simeprevir,Galexos,,1,,1,,2013-11-18,1,,antivirals for systemic use
Alogliptin,Nesina,,1,1,,,2013-11-27,1,,drugs used in diabetes
Linaclotide,Constella,,1,1,,,2013-12-02,1,,drugs for constipation
Multicomponent meningococcal B vacine,Bexsero,1,,1,,,2013-12-06,,1,vaccines
Radium-223 dichloride,Xofigo,,1,1,,,2013-12-12,,1,therapeutic radiopharmaceuticals
Sofosbuvir,Sovaldi,1,,,1,,2013-12-13,1,,antivirals for systemic use
Umeclidinium and vilanterol,Anoro ellipta,,1,1,,,2013-12-23,1,,drugs for obstructive airway diseases
Pomalidomide,Pomalyst,1,,,1,,2014-01-20,1,,immunosuppressants
Lomitapide,Juxtapid,,1,1,,,2014-02-04,1,,lipid modifying agents
Aflibercept,Zaltrap,,1,1,,,2014-02-12,,1,antineoplastic agents
Bosutinibs,Bosulif,,1,1,,1,2014-03-14,1,,antineoplastic agents
"Recombinant human coagulation Factor IX, FC fusion protein",Alprolix,,1,1,,,2014-03-20,,1,antihemmorhagics
Tofacitinib,Xeljanz,,1,1,,,2014-04-17,1,,immunosuppressants
Tesamorelin,Egrifta,,1,1,,,2014-04-29,1,,pituitary and hypothalamic hormones and analogues
Canagliflozin,Invokana,,1,1,,,2014-05-23,1,,drugs used in diabetes
Taliglucerase Alfa,Elelyso,,1,1,,,2014-05-29,,1,other alimentary tract and metabolism products
Eslicarbazepine,Aptiom,,1,1,,,2014-07-08,1,,antiepileptics
"Antihemophilic factor, FC fusion protein",Eloctate,,1,1,,,2014-08-22,,1,antihemmorhagics
Ledipasvir and sofosbuvir,Harvoni,,1,,1,,2014-10-15,1,,antivirals for systemic use
Vortioxetine,Trintellix,,1,1,,,2014-10-22,1,,psychoanaleptics
Simoctocog alfa,Nuwiq,,1,1,,,2014-10-23,,1,antihemmorhagics
Azelastine and fluticasone,Dymista,,1,1,,,2014-10-23,1,,nasal preparations
Conjugated estrogens and bazedoxifene acetate,Duavive,,1,1,,,2014-10-23,1,,sex hormones and modulators of the genital system
Apremilast,Otezla,,1,1,,,2014-11-12,1,,immunosuppressants
Ibrutinib,Imbruvica,1,,,1,1,2014-11-17,1,,antineoplastic agents
Obinutuzumab,Gazyva,1,,1,,,2014-11-25,,1,antineoplastic agents
Siltuximab,Sylvant,,1,,1,,2014-12-03,,1,immunosuppressants
Dapagliflozin,Forxiga,,1,1,,,2014-12-12,1,,drugs used in diabetes
"Ritonavir, paritaprevir, ombitasvir, dasabuvir",Holkira Pak,,1,,1,,2014-12-22,1,,antivirals for systemic use
Sodium phenylbutyrate,Pheburane,,1,,1,,2015-01-26,1,,other alimentary tract and metabolism products
Vedolizumab,Entyvio,,1,1,,,2015-01-29,,1,immunosuppressants
"Human papillomavirus 9 valent vaccine, recombinant",Gardasil 9,,1,1,,,2015-02-05,,1,vaccines
Deferiprone,Ferriprox,,1,1,,,2015-02-13,1,,all other therapeutic products
Secukinumab,Cosentyx,,1,1,,,2015-02-27,,1,immunosuppressants
Tedizolid,Sivextro,,1,1,,,2015-03-17,1,,antibacterials for systemic use
Idelalisib,Zydelig,,1,1,,1,2015-03-27,1,,antineoplastic agents
Ceritinib,Zykadia,,1,1,,1,2015-03-27,1,,antineoplastic agents
Ponatinib,Iclusig,,1,1,,1,2015-04-02,1,,antineoplastic agents
Carglumic Acid,Carbaglu,1,,,1,,2015-04-10,1,,other alimentary tract and metabolism products
Ivermectin,Rosiver,,1,1,,,2015-04-22,1,,anthelmintics
Levomilnacipran,Fetzima,,1,1,,,2015-05-08,1,,psychoanaleptics
Pembrolizumab,Keytruda,,1,1,,1,2015-05-19,,1,antineoplastic agents
Naloxegol,Movantik,,1,1,,,2015-06-02,1,,drugs for constipation
Nintedanib,Ofev,,1,1,,,2015-06-25,1,,antineoplastic agents
Ramucirumab,Cyramza,,1,1,,,2015-07-16,,1,antineoplastic agents
Empagliflozin,Jardiance,,1,1,,,2015-07-23,1,,drugs used in diabetes
Mifepristone and Misoprostol,Mifegymiso,,1,1,,,2015-07-29,1,,sex hormones and modulators of the genital system
Daclatasvir,Daklinza,,1,1,,1,2015-08-13,1,,antivirals for systemic use
Asfotase Alfa,Strensiq,1,,1,,1,2015-08-14,,1,other alimentary tract and metabolism products
Teduglutide,Revestive,,1,,1,,2015-09-04,,1,other alimentary tract and metabolism products
Evolocumab,Repatha,,1,1,,,2015-09-10,,1,lipid modifying agents
Nivolumab,Opdivo,1,,,1,,2015-09-25,,1,antineoplastic agents
Ceftolozane Sulfate and Tazobactam Sodium,Zerbaxa,,1,1,,,2015-09-30,1,,antibacterials for systemic use
"Sacubitril, Valsartan",Entresto,1,,,1,,2015-10-02,1,,agents acting on the renin-angiotensin system
Dulaglutide,Trulicity,,1,1,,,2015-11-10,,1,drugs used in diabetes
"Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Alafenamide Hemifumarate",Genvoya,,1,1,,,2015-11-27,1,,antivirals for systemic use
Mepolizumab,Nucala,,1,1,,,2015-12-03,,1,drugs for obstructive airway diseases
Lenvatinib,Lenvima,,1,1,,,2015-12-22,1,,antineoplastic agents
Blinatumomab,Blincyto,,1,1,,1,2015-12-22,,1,antineoplastic agents
Carfilzomib,Kyprolis,,1,,1,,2016-01-15,1,,antineoplastic agents
"Elbasvir, Grazoprevir",Zepatier,,1,,1,,2016-01-19,1,,antivirals for systemic use
Selexipag,Uptravi,,1,1,,,2016-01-20,1,,antithrombotic agents
"Ivacaftor, Lumacaftor",Orkambi,,1,,1,,2016-01-26,1,,other respiratory system products
Sugammadex,Bridion,,1,1,,,2016-02-05,1,,all other therapeutic products
Cobimetinib,Cotellic,,1,1,,,2016-02-22,1,,antineoplastic agents
Brivaracetam,Brivlera,,1,1,,,2016-03-09,1,,antiepileptics
Asunaprevir,Sunvepra,,1,1,,,2016-03-09,1,,antivirals for systemic use
Palbociclib,Ibrance,,1,1,,1,2016-03-16,1,,antineoplastic agents
Alirocumab,Praluent,,1,1,,,2016-04-11,,1,lipid modifying agents
Bilastine,Blexten,,1,1,,,2016-04-21,1,,antihistamines for systemic use
Idarucizumab,Praxbind,,1,1,,1,2016-04-29,,1,all other therapeutic products
Olaparib,Lynparza,,1,1,,1,2016-04-29,1,,antineoplastic agents
Ixekizumab,Taltz,,1,1,,,2016-05-25,,1,immunosuppressants
Osimertinib,Tagrisso,,1,1,,1,2016-07-05,1,,antineoplastic agents
Sofosbuvir + Velpatasvir,Epclusa,,1,,1,,2016-07-11,1,,antivirals for systemic use
Ixazomib,Ninlaro,,1,,1,,2016-08-04,1,,antineoplastic agents
Nitisinone,MDK-Nitisinone,1,,,1,,2016-09-20,1,,other alimentary tract and metabolism products
Venetoclax,Venclexta,,1,1,,1,2016-09-30,1,,antineoplastic agents
Edoxaban,Lixiana,,1,1,,,2016-11-04,1,,antithrombotic agents
Nitisinone,Nitisinone,1,,,1,,2016-11-04,1,,other alimentary tract and metabolism products
Daclizumab beta,Zinbryta,,1,1,,,2016-12-08,,1,immunosuppressants
Nitisinone,Orfadin,1,,,1,,2016-12-13,1,,other alimentary tract and metabolism products
Ivabradine,Lancora,,1,1,,,2016-12-23,1,,cardiac therapy
,,55,454,379,130,42,,286,99,
"*Prescrire evaluations as of February 20, 2018; PMPRB evaluations as of December 31, 2016; Prescrire ratings - offers an advantage, possibly helpful, nothing new, not acceptable; PMPRB ratings - category 3 = moderate, little or no improvement (prior to 2010), slight or no improvement, moderate improvement - primary, moderate improvement - secondary (2010 onwards)",,,,,,,,,,
,,,,,,,,,,